Affiliation: University of Birmingham
- Membrane targeting of protein tyrosine phosphatase PTPL1 through its FERM domain via binding to phosphatidylinositol 4,5-biphosphateGuillaume Bompard
INSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers, Montpellier, France
J Cell Sci 116:2519-30. 2003..These results identify the crucial role of the FERM domain in PTPL1 intracellular targeting and demonstrate that localization of PTPL1 is regulated by phosphoinositide metabolism...
- Regulation of WASP/WAVE proteins: making a long story shortGuillaume Bompard
School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK
J Cell Biol 166:957-62. 2004..New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models...
- Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-BGuillaume Bompard
School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK
J Cell Sci 118:5393-403. 2005..Thus, MIM-B is unlikely to be a metastasis suppressor but acts as a scaffold protein that interacts with Rac, actin and actin-associated proteins to modulate lamellipodia formation...
- [PTPL1, a proapoptotic protein tyrosine phosphatase in breast cancers]Gilles Freiss
INSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers, 60, rue de Navacelles, 34090 Montpellier
Bull Cancer 91:325-32. 2004..Altogether PTPL1 has to be regarded as a unique marker of mammary tumor response to antiestrogens and a potential therapeutic target to activate apoptotic stimuli in tumor cells...
- Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53Thomas H Millard
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, UK
EMBO J 24:240-50. 2005..This study promotes an expanded view of IRSp53 as an actin regulator that integrates scaffolding and effector functions...
- Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cellsGuillaume Bompard
INSERM, Unit 540, Molecular and Cellular Endocrinology of Cancers, 60 rue de Navacelles, 34090 Montpellier, France
J Biol Chem 277:47861-9. 2002..Our data therefore suggest new therapeutic routes and strengthen the importance of identifying endogenous regulators and substrates of this phosphatase in breast tumors...
- The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylationMathilde Dromard
INSERM U826, Contrôle de la progression des cancers hormono dépendants, Centre de Recherche en Cancerologie, Universite Montpellier I, CRLC Val d Aurelle Paul Lamarque, 34298 Montpellier, France
Cancer Res 67:6806-13. 2007..Altogether, these data provide the first evidence for a direct positive role of the putative tumor suppressor gene PTPL1/PTPN13 on apoptosis and identify its target in the IRS-1/PI3K/Akt signaling pathway...
- Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathwayGuillaume Bompard
CRBM, CNRS UMR 5237, Universite Montpellier I et II, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
BMC Cell Biol 9:42. 2008..The mechanisms of contractile ring formation are not fully understood but involve recruitment of preexisting actin filaments and de novo actin polymerisation...