Victor M Bolanos-Garcia

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Aurora kinases
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1 GA Cambridge, UK
    Int J Biochem Cell Biol 37:1572-7. 2005
  2. pmc Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases
    Semin Lee
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 287:5988-6001. 2012
  3. pmc Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition
    Sheena D'Arcy
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:14764-76. 2010
  4. pmc Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 19:1691-700. 2011
  5. doi request reprint Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    Philos Trans A Math Phys Eng Sci 370:3023-39. 2012
  6. pmc BUB1 and BUBR1: multifaceted kinases of the cell cycle
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, England
    Trends Biochem Sci 36:141-50. 2011
  7. ncbi request reprint Assessment of the mitotic spindle assembly checkpoint (SAC) as the target of anticancer therapies
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK
    Curr Cancer Drug Targets 9:131-41. 2009
  8. pmc The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 17:105-16. 2009
  9. ncbi request reprint The N-terminal, TPR-containing domain of the mitotic checkpoint protein BUBR1 does not bind fatty acids
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, Cambridgeshire CB2 1GA, UK
    Comput Biol Chem 32:139-40; discussion 145-6. 2008
  10. ncbi request reprint On the structure and function of apolipoproteins: more than a family of lipid-binding proteins
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Prog Biophys Mol Biol 83:47-68. 2003

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Aurora kinases
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1 GA Cambridge, UK
    Int J Biochem Cell Biol 37:1572-7. 2005
    ..This property has boosted the search and development of inhibitors of Aurora kinases, which might also function as novel antioncogenic agents...
  2. pmc Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases
    Semin Lee
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 287:5988-6001. 2012
    ..Taken together, our multidisciplinary strategy provides new insights into the evolution, structural organization, and function of Mps1 N-terminal region...
  3. pmc Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition
    Sheena D'Arcy
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:14764-76. 2010
    ..Our studies pave the way for future structure-directed engineering aimed at dissecting the roles of kinetochore-bound and other pools of BubR1 in vivo...
  4. pmc Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 19:1691-700. 2011
    ..We also show that substitution of several BUBR1 residues engaged in binding Blinkin leads to defects in the SAC, thus providing the first molecular details of the recognition mechanism underlying kinetochore-SAC signaling...
  5. doi request reprint Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    Philos Trans A Math Phys Eng Sci 370:3023-39. 2012
    ..Deciphering the nature of the interactions is central to understanding the mechanisms that control the flow of information in cell signalling and regulation...
  6. pmc BUB1 and BUBR1: multifaceted kinases of the cell cycle
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, England
    Trends Biochem Sci 36:141-50. 2011
    ....
  7. ncbi request reprint Assessment of the mitotic spindle assembly checkpoint (SAC) as the target of anticancer therapies
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK
    Curr Cancer Drug Targets 9:131-41. 2009
    ....
  8. pmc The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 17:105-16. 2009
    ..The structure provides insight into the molecular basis of Blinkin-specific recognition by BUB1 and, on a broader perspective, of the mechanism that mediates kinetochore localization of BUB1 in checkpoint-activated cells...
  9. ncbi request reprint The N-terminal, TPR-containing domain of the mitotic checkpoint protein BUBR1 does not bind fatty acids
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, Cambridgeshire CB2 1GA, UK
    Comput Biol Chem 32:139-40; discussion 145-6. 2008
  10. ncbi request reprint On the structure and function of apolipoproteins: more than a family of lipid-binding proteins
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Prog Biophys Mol Biol 83:47-68. 2003
    ..This review summarizes these contributions, which have not only allowed the identification of the apolipoprotein domains that determine substrate binding specificity and/or affinity but also the plausible molecular mechanism(s) involved...
  11. pmc The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity
    V M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Biophys J 89:2640-9. 2005
    ..The presence of the putative TPR motif strongly suggests that the N-terminal domain of BUBR1 is involved in direct protein-protein interactions and/or protein-lipid interactions...
  12. ncbi request reprint MET meet adaptors: functional and structural implications in downstream signalling mediated by the Met receptor
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, CB2 1GA Cambridge, United Kingdom
    Mol Cell Biochem 276:149-57. 2005
    ..In the light of these advances, the present work discusses the molecular basis of Met-substrate recognition and its functional implications in signalling events mediated by this pleiotropic receptor...
  13. ncbi request reprint Structural analysis and classification of native proteins from E. coli commonly co-purified by immobilised metal affinity chromatography
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, England
    Biochim Biophys Acta 1760:1304-13. 2006
    ..We propose a classification of these E. coli native proteins based on their physicochemical, structural and functional properties...
  14. ncbi request reprint Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Trends Biochem Sci 31:654-61. 2006
    ....
  15. doi request reprint Characterization of the tetratricopeptide-containing domain of BUB1, BUBR1, and PP5 proves that domain amphiphilicity over amino acid sequence specificity governs protein adsorption and interfacial activity
    Sylvie Beaufils
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Phys Chem B 112:7984-91. 2008
    ..Our studies demonstrate that domain amphiphilicity is of higher importance than amino acid sequence specificity in the determination of protein adsorption and interfacial activity...
  16. ncbi request reprint Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop
    Loic Bertrand
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, England
    Acta Crystallogr D Biol Crystallogr 60:1698-704. 2004
    ..This binding site corresponds to the solvent-accessible part of the conserved zinc-finger motif...
  17. pmc Structural insights into the role of domain flexibility in human DNA ligase IV
    Takashi Ochi
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Structure 20:1212-22. 2012
    ..Our results suggest that the flexibility of the catalytic region is limited in a manner that affects the formation of the LigIV/XRCC4/XLF-Cernunnos complex...
  18. pmc Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
    Yi Li
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    EMBO J 27:290-300. 2008
    ..Our data are most consistent with head-to-head interactions in a 2:2:1 XRCC4:XLF:Ligase IV complex...
  19. doi request reprint CENP-C is a structural platform for kinetochore assembly
    Marcin R Przewloka
    Department of Genetics, University of Cambridge, Cambridge, UK
    Curr Biol 21:399-405. 2011
    ..Thus, the N-terminal part of Drosophila CENP-C is sufficient to recruit core kinetochore components and acts as the principal linkage between centromere and kinetochore during mitosis...
  20. doi request reprint Perspectives on protein crystallisation
    Takashi Ochi
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road CB2 1GA Cambridge, UK
    Prog Biophys Mol Biol 101:56-63. 2009
    ..Some advantages and disadvantages, limitations, and plausible applications to high-resolution X-ray crystallography are discussed...
  21. ncbi request reprint Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin
    Barbara M Harvey
    The University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Chembiochem 7:1435-42. 2006
    ..These findings require a reassessment of the role of other enzymes implicated in the late stages of polyether ionophore biosynthesis...
  22. doi request reprint New directions in conventional methods of protein crystallization
    Victor M Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK
    Prog Biophys Mol Biol 101:3-12. 2009
    ..New directions for rendering proteins and protein complexes to become more amenable to crystallization are also presented...
  23. pmc Surface rheology and adsorption kinetics reveal the relative amphiphilicity, interfacial activity, and stability of human exchangeable apolipoproteins
    Victor Martin Bolanos-Garcia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1TN, United Kingdom
    Biophys J 94:1735-45. 2008
    ..Our studies render further insights into the interfacial properties of exchangeable apolipoproteins, including the kinetics of their adsorption and the physical properties of the interfacial layer...