Kristien Boelaert

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells
    Gregory D Lewy
    FRCP, PhD, Senior Clinical Lecturer and Honorary Consultant Physician, Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, United Kingdom
    Endocrinology 154:4408-22. 2013
  2. doi request reprint Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine
    Kristien Boelaert
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:1869-82. 2013
  3. doi request reprint Thyroid dysfunction in the elderly
    Kristien Boelaert
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Endocrinol 9:194-204. 2013
  4. ncbi request reprint Thyroid hormone in health and disease
    K Boelaert
    Division of Medical Sciences, IBR Building, 2nd Floor, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    J Endocrinol 187:1-15. 2005
  5. ncbi request reprint PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Mol Endocrinol 33:663-77. 2004
  6. ncbi request reprint Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism
    K Boelaert
    Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 70:129-38. 2009
  7. ncbi request reprint The association between serum TSH concentration and thyroid cancer
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, IBR Building 2nd Floor, Birmingham, UK
    Endocr Relat Cancer 16:1065-72. 2009
  8. ncbi request reprint Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Med 123:183.e1-9. 2010
  9. ncbi request reprint Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:4295-301. 2006
  10. pmc Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment
    Martin L Read
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, United Kingdom
    Cancer Res 71:6153-64. 2011

Collaborators

Detail Information

Publications32

  1. doi request reprint Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells
    Gregory D Lewy
    FRCP, PhD, Senior Clinical Lecturer and Honorary Consultant Physician, Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, United Kingdom
    Endocrinology 154:4408-22. 2013
    ..These results define hPTTG as having a central role in thyroid autocrine signaling mechanisms via growth factors, with profound implications for promotion of transformed cell growth. ..
  2. doi request reprint Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine
    Kristien Boelaert
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:1869-82. 2013
    ..Hyperthyroidism is common, but opinions regarding optimal therapy with antithyroid drugs or radioiodine (131-I) differ. There are no randomized trials comparing these options in terms of mortality...
  3. doi request reprint Thyroid dysfunction in the elderly
    Kristien Boelaert
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Endocrinol 9:194-204. 2013
    ..This Review describes the current evidence on the prevalence, diagnosis, management and long-term consequences of thyroid dysfunction in the elderly...
  4. ncbi request reprint Thyroid hormone in health and disease
    K Boelaert
    Division of Medical Sciences, IBR Building, 2nd Floor, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    J Endocrinol 187:1-15. 2005
    ..Furthermore we will describe some recent developments in our understanding of the relationship between thyroid status and health...
  5. ncbi request reprint PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    J Mol Endocrinol 33:663-77. 2004
    ..Taken together, our data suggest that PXXP structure and phosphorylation are likely to exert independent and critical influences upon PTTG's diverse actions in vitro...
  6. ncbi request reprint Prediction of cure and risk of hypothyroidism in patients receiving 131I for hyperthyroidism
    K Boelaert
    Division of Medical Sciences, University Hospital Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 70:129-38. 2009
    ..There is little consensus regarding the most appropriate dose of radioiodine ((131)I) to be administered to patients with hyperthyroidism...
  7. ncbi request reprint The association between serum TSH concentration and thyroid cancer
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, IBR Building 2nd Floor, Birmingham, UK
    Endocr Relat Cancer 16:1065-72. 2009
    ..4 muU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context...
  8. ncbi request reprint Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Med 123:183.e1-9. 2010
    ..Common autoimmune disorders tend to coexist in the same subjects and to cluster in families...
  9. ncbi request reprint Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:4295-301. 2006
    ..Thyroid nodules and goiter are common, and fine-needle aspiration biopsy (FNAB) is the first investigation of choice in distinguishing benign from malignant disease...
  10. pmc Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment
    Martin L Read
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, United Kingdom
    Cancer Res 71:6153-64. 2011
    ..Together, our findings indicate that overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake...
  11. ncbi request reprint The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells
    Martin L Read
    School of Clinical and Experimental Medicine M L R, R I S, J C W F, B M, G A R, R J W, V E S, P K K, N S, O M D, K B, J A F, C J M and School of Cancer Sciences A S T, University of Birmingham, Birmingham, United Kingdom Department of Medical Sciences T G, University of Ferrara, Ferrara, Italy Department of Pediatrics A L S, University of British Columbia, Vancouver, British Columbia, Canada and University Hospitals Birmingham National Health Service Foundation Trust J C W, Birmingham, United Kingdom
    Endocrinology 155:1222-34. 2014
    ....
  12. doi request reprint Thyrotoxicosis
    Jayne A Franklyn
    Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Lancet 379:1155-66. 2012
    ..Total thyroidectomy is an option in selected cases. Future efforts are likely to concentrate on novel and safe ways to modulate the underlying disease process rather than stopping excess thyroid hormone production...
  13. ncbi request reprint Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway
    D S Kim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:4603-11. 2006
    ..We recently reported that the proangiogenic pituitary tumor transforming gene (PTTG) stimulates VEGF and up-regulates inhibitor of DNA binding-3 (ID3), an important gene in VEGF-dependent angiogenesis...
  14. ncbi request reprint Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer
    D S Kim
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:1119-28. 2006
    ..PTTG has been shown to promote angiogenesis, a key rate-limiting step in tumor progression, by up-regulation of fibroblast growth factor-2 and vascular endothelial growth factor...
  15. pmc A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer
    Vicki E Smith
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham B15 2TH, UK
    J Cell Sci 122:3393-402. 2009
    ..Given that PBF is overexpressed in thyroid cancer, these findings have profound implications for thyroid cancer ablation using radioiodine...
  16. pmc Pituitary tumor transforming gene binding factor: a new gene in breast cancer
    Rachel J Watkins
    School of Clinical and Experimental Medicine, Centre for Liver Research, Institute of Biomedical Research, and Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, United Kingdom
    Cancer Res 70:3739-49. 2010
    ..Furthermore, the number of ERE half-sites in the PBF promoter may significantly alter the response to estrogen treatment in individual subjects...
  17. ncbi request reprint A potential role for PTTG/securin in the developing human fetal brain
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    FASEB J 17:1631-9. 2003
    ..We propose a potential role for human PTTG/securin in modulating cell proliferation and FGF-2 expression during human neurogenesis...
  18. ncbi request reprint Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours
    L A Tannahill
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK
    Clin Endocrinol (Oxf) 56:735-43. 2002
    ..We hypothesized that aberrant expression of deiodinase enzymes and/or altered enzyme activity in pituitary tumours may change tissue concentrations of THs and influence their growth and secretory characteristics...
  19. ncbi request reprint Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors
    C J McCabe
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    J Clin Endocrinol Metab 87:4238-44. 2002
    ....
  20. ncbi request reprint Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour
    C J McCabe
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 58:141-50. 2003
    ....
  21. ncbi request reprint PTTG and PBF repress the human sodium iodide symporter
    K Boelaert
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Oncogene 26:4344-56. 2007
    ....
  22. ncbi request reprint Pituitary tumor transforming gene and fibroblast growth factor-2 expression: potential prognostic indicators in differentiated thyroid cancer
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 88:2341-7. 2003
    ..64; P = 0.003). We conclude that PTTG and FGF-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer...
  23. ncbi request reprint Pituitary tumor transforming gene binding factor: a novel transforming gene in thyroid tumorigenesis
    Anna L Stratford
    Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TH, United Kingdom
    J Clin Endocrinol Metab 90:4341-9. 2005
    ..Pituitary tumor transforming gene (PTTG) is a protooncogene implicated in the pathogenesis of multiple tumor types, which stimulates fibroblast growth factor-2 secretion via PTTG binding factor (PBF)...
  24. ncbi request reprint Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation
    E H Rabbitt
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Oncogene 22:1663-7. 2003
    ..We propose that abnormal expression of 11 beta-HSD2 acts as a proproliferative prereceptor determinant of pituitary cell growth, and may provide a novel target for future tumor therapy...
  25. ncbi request reprint Older subjects with hyperthyroidism present with a paucity of symptoms and signs: a large cross-sectional study
    K Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 95:2715-26. 2010
    ..The absence of classical symptoms and signs of hyperthyroidism often results in delayed diagnosis and treatment...
  26. ncbi request reprint Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype
    N Manji
    Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Second Floor, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:4873-80. 2006
    ..Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations...
  27. ncbi request reprint Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects
    N Manji
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 64:125-8. 2006
    ..Overt thyroid dysfunction is well recognized to affect weight, but the influence of minor perturbations of thyroid function remains unclear...
  28. ncbi request reprint Separase, securin and Rad21 in neural cell growth
    H N Pemberton
    Divisions of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    J Cell Physiol 213:45-53. 2007
    ..Our data suggest that the co-ordinated expression of separase, securin and Rad21 is fundamental for the developing brain...
  29. ncbi request reprint Differences in the Recurrence and Mortality Outcomes Rates of Incidental and Nonincidental Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis of 21 329 Person-Years of Follow-up
    Hisham Mehanna
    Institute of Head and Neck Studies and Education, School of Cancer Sciences H M, T A, N C, University of Birmingham, Birmingham B15 2TT, United Kingdom Cancer Research Clinical Trials Unit, School of Cancer Sciences B C, E M, University of Birmingham, Birmingham B15 2TT, United Kingdom University Hospitals Birmingham NHS Foundation Trust J W, University of Birmingham, Birmingham B15 2TT, United Kingdom and School of Clinical and Experimental Medicine C M, K B, J A F, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 99:2834-43. 2014
    ..There is controversy as to whether papillary thyroid microcarcinoma (PTMC) represents more than one disease entity with different outcomes, requiring different treatment...
  30. pmc Patient information in graves' disease and thyroid-associated ophthalmopathy: readability assessment of online resources
    Matthew R Edmunds
    1 Academic Unit of Ophthalmology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Thyroid 24:67-72. 2014
    ..In this study we assessed the readability of online literature specifically for Graves' disease (GD) and thyroid-associated ophthalmopathy (TAO)...
  31. ncbi request reprint Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies
    S Chan
    Department of Fetal Medicine, Division of Reproductive and Child Health, University of Birmingham, Birmingham, United Kingdom B15 2TG
    J Clin Endocrinol Metab 88:4488-95. 2003
    ..The lack of difference in deiodinase expression in normal placentas and those found in IUGR argues against placental deiodinases being responsible for the hypothyroxemia in circulating fetal thyroid hormones observed in this condition...
  32. ncbi request reprint Radiotherapy for non-functioning pituitary adenomas
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Endocrinol 144:569-75. 2001
    ..This article reviews the evidence relating to the potential side-effects of RT and weighs these risks against the clinically beneficial effects of preventing pituitary tumour regrowth...