W Bodmer

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Common and rare variants in multifactorial susceptibility to common diseases
    Walter Bodmer
    Cancer and Immunogenetics Laboratory, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nat Genet 40:695-701. 2008
  2. pmc Cytostatic drug treatment causes seeding of gene promoter methylation
    Anders Bredberg
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Eur J Cancer 43:947-54. 2007
  3. ncbi request reprint Sam Karlin: a personal appreciation
    Walter Bodmer
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Theor Popul Biol 75:230-2. 2009
  4. pmc Cancer genetics: colorectal cancer as a model
    Walter F Bodmer
    CR UK Cancer and Immunogenetics Laboratory, Weatherall Institute for Molecular Medicine, Oxford University, Oxford, OX3 9DS, UK
    J Hum Genet 51:391-6. 2006
  5. ncbi request reprint Prostate Cancer Charitable Trust 2004 Forum: a personal overview
    W Bodmer
    CRUK Cancer and Immunogenetics Laboratory, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Prostate Cancer Prostatic Dis 7:277-81. 2004
  6. ncbi request reprint RA Fisher, statistician and geneticist extraordinary: a personal view
    Walter Bodmer
    Sir Walter Bodmer, Hertford College, Catte Street, Oxford OX1 3BW
    Int J Epidemiol 32:938-42; discussion 945-8. 2003
  7. pmc The Eurasian heartland: a continental perspective on Y-chromosome diversity
    R S Wells
    Imperial Cancer Research Fund Cancer and Immunogenetics Laboratory and Wellcome Trust Centre for Human Genetics, University of Oxford, Headington OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 98:10244-9. 2001
  8. ncbi request reprint A mutated HLA-A*0101 allele in the colorectal cell line HCA-7
    D C Bicknell
    Cancer and Immunogenetics Laboratory, Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Tissue Antigens 66:231-7. 2005
  9. ncbi request reprint The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles
    M J Browning
    Cancer Immunology Laboratory, ICRF, John Radcliffe Hospital, Oxford, United Kingdom
    Tissue Antigens 45:177-87. 1995
  10. ncbi request reprint Nomenclature for factors of the HLA system, 1998
    J G Bodmer
    ICRF Cancer and Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Tissue Antigens 53:407-46. 1999

Collaborators

Detail Information

Publications25

  1. pmc Common and rare variants in multifactorial susceptibility to common diseases
    Walter Bodmer
    Cancer and Immunogenetics Laboratory, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nat Genet 40:695-701. 2008
    ....
  2. pmc Cytostatic drug treatment causes seeding of gene promoter methylation
    Anders Bredberg
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Eur J Cancer 43:947-54. 2007
    ..Taken together, our findings suggest activation in cancer cells of an epigenetic process enabling a tumour to generate drug-resistant variant cells...
  3. ncbi request reprint Sam Karlin: a personal appreciation
    Walter Bodmer
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Theor Popul Biol 75:230-2. 2009
    ..Subsequently Karlin established a similar programme in Israel. The overall contributions of Karlin to population genetics and molecular biology are briefly reviewed from a personal perspective...
  4. pmc Cancer genetics: colorectal cancer as a model
    Walter F Bodmer
    CR UK Cancer and Immunogenetics Laboratory, Weatherall Institute for Molecular Medicine, Oxford University, Oxford, OX3 9DS, UK
    J Hum Genet 51:391-6. 2006
    ..The evidence for this from our work on multiple adenoma cases, and certain other examples, is discussed...
  5. ncbi request reprint Prostate Cancer Charitable Trust 2004 Forum: a personal overview
    W Bodmer
    CRUK Cancer and Immunogenetics Laboratory, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Prostate Cancer Prostatic Dis 7:277-81. 2004
  6. ncbi request reprint RA Fisher, statistician and geneticist extraordinary: a personal view
    Walter Bodmer
    Sir Walter Bodmer, Hertford College, Catte Street, Oxford OX1 3BW
    Int J Epidemiol 32:938-42; discussion 945-8. 2003
  7. pmc The Eurasian heartland: a continental perspective on Y-chromosome diversity
    R S Wells
    Imperial Cancer Research Fund Cancer and Immunogenetics Laboratory and Wellcome Trust Centre for Human Genetics, University of Oxford, Headington OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 98:10244-9. 2001
    ..The genetic results are interpreted in the context of Eurasian linguistic patterns...
  8. ncbi request reprint A mutated HLA-A*0101 allele in the colorectal cell line HCA-7
    D C Bicknell
    Cancer and Immunogenetics Laboratory, Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Tissue Antigens 66:231-7. 2005
    ..This has probably then been selected for in the tumour to enable escape from immune attack against an HLA-A*0101-restricted tumour-specific determinant that has also arisen as a result of the tumour being MMR defective...
  9. ncbi request reprint The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles
    M J Browning
    Cancer Immunology Laboratory, ICRF, John Radcliffe Hospital, Oxford, United Kingdom
    Tissue Antigens 45:177-87. 1995
    ..Thus the novel A and B alleles are not specific to the Daudi tumor. Overall, this analysis of a single East African cell illustrates the power of molecular methods to define new class I HLA alleles in non-caucasoid populations...
  10. ncbi request reprint Nomenclature for factors of the HLA system, 1998
    J G Bodmer
    ICRF Cancer and Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Tissue Antigens 53:407-46. 1999
  11. pmc Alkaline-mediated differential interaction (AMDI): a simple automatable single-nucleotide polymorphism assay
    S Bartlett
    Imperial Cancer Research Fund Cancer and Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 98:2694-7. 2001
    ..We believe the detection system that we call AMDI (alkaline-mediated differential interaction) satisfies the above criteria and is suitable for general high-throughput SNP typing...
  12. pmc Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas
    Nicola S Fearnhead
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, England
    Proc Natl Acad Sci U S A 101:15992-7. 2004
    ..This overall difference is highly significant, suggesting that many rare variants collectively contribute to the inherited susceptibility to colorectal adenomas...
  13. ncbi request reprint Genotyping possible polymorphic variants of human mismatch repair genes in healthy Korean individuals and sporadic colorectal cancer patients
    Jin C Kim
    Department of Surgery, University of Ulsan College of Medicine, and Laboratory of Cancer Biology and Genetics, Asan Institute for Life Sciences, 388 1 Poongnap 2 Dong Songpa Ku, Seoul 138 736, Korea
    Fam Cancer 3:129-37. 2004
    ..Further verification in other ethnic groups may provide the genotypic and phenotypic significance of single nucleotide variants found in mismatch repair genes...
  14. pmc Examples of mathematical modeling: tales from the crypt
    Matthew D Johnston
    Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK
    Cell Cycle 6:2106-12. 2007
    ..We use the model to argue why tumorigenesis is observed to occur in stages with long lag phases between periods of rapid growth, and we identify the key parameters...
  15. ncbi request reprint Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model
    Nicola S Fearnhead
    Cancer Research U K Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Oxford, UK
    Cell Cycle 4:521-5. 2005
    ..Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes...
  16. pmc Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
    Matthew D Johnston
    Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24 29 St Giles, Oxford OX1 3LB, United Kingdom
    Proc Natl Acad Sci U S A 104:4008-13. 2007
    ..The second model can be used to explain the long lag phases in tumor growth, during which new, higher equilibria are reached, before unlimited growth in cell numbers ensues...
  17. pmc Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells
    Muhammad Emaduddin
    Cell Signalling Group and Cancer and Immunogenetics Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 105:2358-62. 2008
    ..If this also is true for CRC patients, tumors with low-SFK activity may be particularly sensitive to SFK inhibitors, and such patients should be targeted in clinical trials testing SFK inhibitors...
  18. pmc Multigene amplification and massively parallel sequencing for cancer mutation discovery
    Fredrik Dahl
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 104:9387-92. 2007
    ..Seven cancer cell lines and one normal genomic DNA sample were studied with multiple mutations and polymorphisms identified among the 10 genes. Mutations and polymorphisms in the TP53 gene were confirmed by traditional sequencing...
  19. ncbi request reprint Enhancement of colorectal tumor targeting using a novel biparatopic monoclonal antibody against carcinoembryonic antigen in experimental radioimmunoguided surgery
    Jin C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Seoul, Korea
    Int J Cancer 97:542-7. 2002
    ..The biparatopic MAb using 2 anti-CEA MAbs against different epitopes achieved a great affinity and avidity with accurate localization of colorectal carcinoma in experimental radioimmunoguided surgery...
  20. pmc Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
    Ying Liu
    Cancer Research UK Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Proc Natl Acad Sci U S A 103:976-81. 2006
    ....
  21. ncbi request reprint Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis
    Nicola S Fearnhead
    Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DZ, UK
    Br Med Bull 64:27-43. 2002
    ..The latter part of this paper focuses on the key genetic events underlying this process and provides an overview of the genetic mechanisms responsible for colorectal tumorigenesis...
  22. pmc Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, London Institute, Cancer Research United Kingdom, London, UK
    Am J Pathol 162:1545-8. 2003
    ..Somatic inactivation of the DNA glycosylases involved in the BER pathway however does not appear to be involved in colorectal tumorigenesis...
  23. ncbi request reprint Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission
    Sean L Preston
    Histopathology Unit, London Research Institute, Cancer Research UK, London WC2A 3PX, United Kingdom
    Cancer Res 63:3819-25. 2003
    ..Both sporadic and FAP adenomas start as a unicryptal adenomas and grow initially by crypt fission--a bottom-up pattern. Later, in sporadic adenomas, there is evidence of growth down into adjacent crypts (top-down)...
  24. pmc The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
    Helena Brentani
    Laboratório de Genética Molecular do Câncer, Departmento de Radiologia, Universidade de Sao Paulo, Travessa da Rua Dr Ovídeo Pires de Campos S N, 4deg, Brazil
    Proc Natl Acad Sci U S A 100:13418-23. 2003
    ....
  25. ncbi request reprint MSI-low, a real phenomenon which varies in frequency among cancer types
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 201:389-94. 2003
    ..PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem...