Affiliation: University of Southampton
Boche D, Perry V, Nicoll J. Review: activation patterns of microglia and their identification in the human brain. Neuropathol Appl Neurobiol. 2013;39:3-18 pubmed publisher
Rakic S, Hung Y, Smith M, So D, Tayler H, Varney W, et al
. Systemic infection modifies the neuroinflammatory response in late stage Alzheimer's disease. Acta Neuropathol Commun. 2018;6:88 pubmed publisher
..However, rather than promoting pro-inflammatory changes, as observed in experimental models, they seem to promote an anti-inflammatory, potentially immunosuppressive, environment in the human brain. ..
Boche D, Denham N, Holmes C, Nicoll J. Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathol. 2010;120:369-84 pubmed publisher
..The information obtained will be important in helping to understand the pathogenesis not only of AD but also of other neurodegenerative disorders associated with protein aggregation. ..
Boche D, Donald J, Love S, Harris S, Neal J, Holmes C, et al
. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta Neuropathol. 2010;120:13-20 pubmed publisher
..However, the continuing progression of cognitive decline in AD patients after Abeta immunisation may be explained by its lack of apparent effect on tangles. ..
Minett T, Classey J, Matthews F, Fahrenhold M, Taga M, Brayne C, et al
. Microglial immunophenotype in dementia with Alzheimer's pathology. J Neuroinflammation. 2016;13:135 pubmed publisher
Franco Bocanegra D, Nicoll J, Boche D. Innate immunity in Alzheimer's disease: the relevance of animal models?. J Neural Transm (Vienna). 2018;125:827-846 pubmed publisher
Moro M, Phillips A, Gaimster K, Paul C, Mudher A, Nicoll J, et al
. Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease. Acta Neuropathol Commun. 2018;6:3 pubmed publisher
..010 in YC).Our analyses suggest that IsoD-A? accumulation starts with ageing; whereas pE3-A? deposition is more closely linked to AD. Our findings support the importance of age-related modifications of A? in AD pathogenesis. ..
Boche D, Zotova E, Weller R, Love S, Neal J, Pickering R, et al
. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain. 2008;131:3299-310 pubmed publisher
..The extent to which these vascular alterations following Abeta immunization in Alzheimer's disease are reflected in changes in cognitive function remains to be determined. ..