Affiliation: University of Southampton
- Atypical inflammation in the central nervous system in prion diseaseV Hugh Perry
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
Curr Opin Neurol 15:349-54. 2002..There is also now evidence to suggest that a peripheral infection, and its consequent systemic cytokine expression, may drive central nervous system cytokine expression and perhaps exacerbate disease...
- Review: activation patterns of microglia and their identification in the human brainD Boche
Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
Neuropathol Appl Neurobiol 39:3-18. 2013....
- Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesisDelphine Boche
Division of Clinical Neurosciences, School of Medicine, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
Acta Neuropathol 120:369-84. 2010..The information obtained will be important in helping to understand the pathogenesis not only of AD but also of other neurodegenerative disorders associated with protein aggregation...
- Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's diseaseDelphine Boche
Southampton General Hospital, University of Southampton, UK
Acta Neuropathol 120:13-20. 2010..However, the continuing progression of cognitive decline in AD patients after Abeta immunisation may be explained by its lack of apparent effect on tangles...
- Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brainD Boche
Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
Brain 131:3299-310. 2008..The extent to which these vascular alterations following Abeta immunization in Alzheimer's disease are reflected in changes in cognitive function remains to be determined...
- The role of the immune system in clearance of Abeta from the brainDelphine Boche
Division of Clinical Neurosciences, University of Southampton, Southampton, UK
Brain Pathol 18:267-78. 2008..In animal models, immunotherapy at an early age can protect against Abeta accumulation and it will be interesting to see if this can usefully be applied to humans to prevent AD...
- TGFbeta1 regulates the inflammatory response during chronic neurodegenerationDelphine Boche
CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
Neurobiol Dis 22:638-50. 2006..These data suggest that TGFbeta1 plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage...
- Immunotherapy for Alzheimer's disease and other dementiasDelphine Boche
Division of Clinical Neurosciences, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
Curr Opin Neurol 18:720-5. 2005..The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-beta accumulation in Alzheimer's disease...
- Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivoDelphine Boche
CNS Inflammation Group, Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
J Cereb Blood Flow Metab 23:1174-82. 2003..We have demonstrated in vivo that the cerebral tolerance phenomenon induced by LPS pretreatment is mediated by TGF-beta 1 cytokine...
- Abeta species removal after abeta42 immunizationJames A R Nicoll
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
J Neuropathol Exp Neurol 65:1040-8. 2006..Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study...
- Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion diseaseColm Cunningham
CNS Inflammation Group, School of Biological Sciences, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
J Virol 79:5174-84. 2005..We also propose that serum cytokine and APP measurements are not useful during preclinical disease. Possible consequences of the clear chronic elevation of APPs in the CNS are discussed...
- Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trialClive Holmes
Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
Lancet 372:216-23. 2008..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
- Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapyRoy O Weller
Clinical Neurosciences, University of Southampton School of Medicine, LD74, South Laboratory and Pathology Block, Southampton General Hospital, Southampton SO166YD, UK
Acta Neuropathol 118:87-102. 2009..Drainage of Abeta along perivascular pathways in ageing artery walls may need to be improved to maximise the potential for improvement of cognitive function with immunotherapy...
- Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brainIan Galea
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Glia 49:375-84. 2005....
- Inflammation in Alzheimer's disease: relevance to pathogenesis and therapyElina Zotova
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Mailpoint 806, Level D, South Pathology Block, Southampton General Hospital, Southampton, SO16 6YD, UK
Alzheimers Res Ther 2:1. 2010....