J E Blundell

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Regulation of appetite: role of leptin in signalling systems for drive and satiety
    J E Blundell
    Psychobiology Group, School of Psychology, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Int J Obes Relat Metab Disord 25:S29-34. 2001
  2. ncbi request reprint Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats
    R J Rodgers
    School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Regul Pept 96:71-84. 2000
  3. ncbi request reprint Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S
    Y Ishii
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, LS2 9JT, UK
    Behav Brain Res 160:11-24. 2005
  4. ncbi request reprint Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    Behav Brain Res 157:331-41. 2005
  5. doi request reprint Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS29JT, UK
    Physiol Behav 94:422-31. 2008
  6. doi request reprint Sibutramine & naloxone: infra-additive interaction in the regulation of appetite?
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Behav Brain Res 207:174-81. 2010
  7. ncbi request reprint SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    R J Rodgers
    School of Psychology, University of Leeds, UK
    Eur J Neurosci 13:1444-52. 2001
  8. ncbi request reprint Routes to obesity: phenotypes, food choices and activity
    J E Blundell
    BioPsychology Group, University of Leeds, UK
    Br J Nutr 83:S33-8. 2000
  9. doi request reprint Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 198:359-65. 2009
  10. doi request reprint Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in rats
    A J Tallett
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Pharmacol Biochem Behav 97:92-100. 2010

Detail Information

Publications49

  1. ncbi request reprint Regulation of appetite: role of leptin in signalling systems for drive and satiety
    J E Blundell
    Psychobiology Group, School of Psychology, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Int J Obes Relat Metab Disord 25:S29-34. 2001
    ..However, the so-called long-term regulation of body weight has recently been given substance by the identification of a chemical signal believed to link the brain with adipose tissue stores...
  2. ncbi request reprint Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats
    R J Rodgers
    School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Regul Pept 96:71-84. 2000
    ..Further studies will be required to confirm the identity of the specific orexin receptors (i.e. OX(1) or OX(2)) involved in mediating the dose-dependent behavioural effects reported...
  3. ncbi request reprint Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S
    Y Ishii
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, LS2 9JT, UK
    Behav Brain Res 160:11-24. 2005
    ..However, unlike the immediate short-circuiting of the satiety sequence induced by CCK-8S, the slower response to SB-334867 implies a more indirect mechanism of action...
  4. ncbi request reprint Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    Behav Brain Res 157:331-41. 2005
    ....
  5. doi request reprint Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS29JT, UK
    Physiol Behav 94:422-31. 2008
    ....
  6. doi request reprint Sibutramine & naloxone: infra-additive interaction in the regulation of appetite?
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Behav Brain Res 207:174-81. 2010
    ..g. rimonabant, bupropion), would not support naloxone-sibutramine polytherapy in the clinical management of obesity...
  7. ncbi request reprint SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats
    R J Rodgers
    School of Psychology, University of Leeds, UK
    Eur J Neurosci 13:1444-52. 2001
    ..Together, these findings strongly support the view that orexin-A is involved in the regulation of feeding patterns and that this influence is mediated through the orexin-1 receptor...
  8. ncbi request reprint Routes to obesity: phenotypes, food choices and activity
    J E Blundell
    BioPsychology Group, University of Leeds, UK
    Br J Nutr 83:S33-8. 2000
    ..The use of phenotypes has allowed the identification of different potential routes to weight gain. Different strategies are required to prevent age-related increase in body weight in these quite different individuals...
  9. doi request reprint Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Behav Brain Res 198:359-65. 2009
    ..Current data support the conclusion that the acute anorectic and weight loss efficacy of sibutramine in adult male rats is not secondary to behavioural disruption but, instead, is due largely to an acceleration in behavioural satiety...
  10. doi request reprint Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in rats
    A J Tallett
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Pharmacol Biochem Behav 97:92-100. 2010
    ....
  11. doi request reprint Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Pharmacol Biochem Behav 91:358-66. 2009
    ..g. 'neutral' CB1 receptor antagonists), current data constitute further proof of concept regarding the anorectic efficacy, selectivity and added value of low-dose polytherapy with opioid and CB1 receptor antagonists...
  12. ncbi request reprint Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 81:129-40. 2004
    ..Overall, the divergent profiles obtained with equianorectic doses of LiCl and SB-334867 provide convincing evidence for the behavioural selectivity of SB-334867-induced anorexia...
  13. ncbi request reprint A medium-term intervention study on the impact of high- and low-fat snacks varying in sweetness and fat content: large shifts in daily fat intake but good compensation for daily energy intake
    C L Lawton
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Br J Nutr 80:149-61. 1998
    ....
  14. ncbi request reprint Behaviourally-selective hypophagic effects of naloxone in non-deprived male rats presented with palatable food
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Behav Brain Res 187:417-27. 2008
    ....
  15. ncbi request reprint Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating
    J E Blundell
    Department of Psychology, University of Leeds, United Kingdom
    J Am Diet Assoc 97:S63-9. 1997
    ..A first stage in a health program should be to prevent passive overconsumption...
  16. ncbi request reprint Control of food intake in the obese
    J E Blundell
    Department of Psychobiology, University of Leeds, UK
    Obes Res 9:263S-270S. 2001
    ..Because energy expenditure is only loosely coupled to energy intake, sedentariness does not down-regulate food intake...
  17. ncbi request reprint Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss
    N A King
    BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Int J Obes (Lond) 32:177-84. 2008
    ..To identify and characterize the individual variability in compensation for exercise-induced changes in energy expenditure (EE)...
  18. ncbi request reprint Effects of sweetness and energy in drinks on food intake following exercise
    N A King
    Department of Psychology, University of Leeds, UK
    Physiol Behav 66:375-9. 1999
    ..The results may also have implications for the effect on short-term appetite control of different types of drinks used to quench thirst during and after exercise...
  19. doi request reprint Night and day: diurnal differences in the behavioural satiety sequence in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 97:125-30. 2009
    ..The potential contribution of diurnal differences in rate of eating is discussed as are the implications of these findings for future studies on the neurobiology of feeding behaviour...
  20. doi request reprint Acute compensatory eating following exercise is associated with implicit hedonic wanting for food
    G Finlayson
    BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Physiol Behav 97:62-7. 2009
    ..Some individuals could be resistant to the beneficial effects of exercise due to a predisposition to compensate for exercise-induced energy expenditure as a result of implicit changes in food preferences...
  21. ncbi request reprint Palatability, food intake and the behavioural satiety sequence in male rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
    Physiol Behav 80:37-47. 2003
    ..Data are discussed in relation to the specific behavioural signature to quinine-induced anorexia and its potential utility in identifying appetite suppressants that may modify intake via changes in taste sensitivity and/or palatability...
  22. ncbi request reprint Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats
    A J Tallett
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Psychopharmacology (Berl) 195:27-39. 2007
    ..Although the CB1 receptor antagonist/inverse agonist rimonabant acutely suppresses food intake in rodents, the behavioural specificity of this effect remains unclear...
  23. ncbi request reprint Lean male high- and low-fat phenotypes--different routes for achieving energy balance
    J Cooling
    BioPyschology Group, School of Psychology, University of Leeds, UK
    Int J Obes Relat Metab Disord 24:1561-6. 2000
    ..This study investigated how energy expenditure may contribute to energy balance in lean male individuals consuming a diet either high or low in fat...
  24. ncbi request reprint Separate systems for serotonin and leptin in appetite control
    J C Halford
    Department of Psychology, University of Liverpool, UK
    Ann Med 32:222-32. 2000
    ..At a conceptual level, these may represent the distinction between 'satiety' and 'drive'. Interestingly, both 5-HT and leptin modulate the action of NPY, which may form a part of a common output pathway for the expression of appetite...
  25. ncbi request reprint High-fat and low-fat (behavioural) phenotypes: biology or environment?
    J E Blundell
    Department of Psychology, University of Leeds, UK
    Proc Nutr Soc 58:773-7. 1999
    ..These striking differences suggest that HF and LF can be used as a conceptual tool to investigate the relationship between biology and the environment (diet) in the control of body weight...
  26. ncbi request reprint Selective effects of acute exercise and breakfast interventions on mood and motivation to eat
    A Lluch
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Physiol Behav 68:515-20. 2000
    ..In these healthy young adults, the condition inducing the largest energy deficit (exercise and low-energy breakfast) was not associated with the lowest mental states...
  27. ncbi request reprint The control of appetite: basic concepts and practical implications
    J E Blundell
    School of Psychology, University of Leeds
    Schweiz Med Wochenschr 129:182-8. 1999
    ....
  28. ncbi request reprint The degree of saturation of fatty acids influences post-ingestive satiety
    C L Lawton
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Br J Nutr 83:473-82. 2000
    ..Overall, the results of these short-term studies indicate that PUFA may exert a relatively stronger control over appetite than MUFA and SFA...
  29. ncbi request reprint No energy compensation at the meal following exercise in dietary restrained and unrestrained women
    A Lluch
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Br J Nutr 84:219-25. 2000
    ..In restrained eaters, exercise was more effective in creating an energy deficit than in unrestrained eaters. Exercise may help restrained eaters to maintain control over appetite...
  30. doi request reprint Disinhibition: its effects on appetite and weight regulation
    E J Bryant
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Obes Rev 9:409-19. 2008
    ..We propose that the trait of Disinhibition be more appropriately renamed as 'opportunistic eating' or 'thrifty behaviour'...
  31. ncbi request reprint Physical activity and regulation of food intake: current evidence
    J E Blundell
    BioPsychology Group, School of Psychology, University of Leeds, United Kingdom
    Med Sci Sports Exerc 31:S573-83. 1999
    ..The evidence was reviewed on how physical activity could influence the regulation of food intake by either adjusting the sensitivity of appetite control mechanisms or by generating an energy deficit that could adjust the drive to eat...
  32. ncbi request reprint Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequence
    J C Halford
    Department of Psychology, University of Leeds, UK
    Pharmacol Biochem Behav 54:745-51. 1996
    ..Fluoxetine-induced suppression of eating at this dose is consistent with the normal operation of satiety. Fluoxetine-induced slowing of behavior appears to be mediated by a separate mechanism...
  33. ncbi request reprint Habitual high and low consumers of artificially-sweetened beverages: effects of sweet taste and energy on short-term appetite
    K M Appleton
    School of Psychology, Queen s University of Belfast, 18 30 Malone Road, Belfast, BT9 5BP, UK
    Physiol Behav 92:479-86. 2007
    ..This lack of response suggests an adaptation to sweet taste as a result of the habitual dietary pattern of these consumers...
  34. ncbi request reprint High-fat and low-fat phenotypes: habitual eating of high- and low-fat foods not related to taste preference for fat
    J Cooling
    BioPsychology Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Eur J Clin Nutr 55:1016-21. 2001
    ..To characterize taste preferences in habitual high fat (HF) and low fat (LF) phenotypes...
  35. ncbi request reprint Macronutrients and mental performance
    L Dye
    BioPsychology Group, School of Psychology, University of Leeds, Leeds, UK
    Nutrition 16:1021-34. 2000
    ..Other factors that modify effects include time of day, circadian rhythms, type of task, habitual diet, and vulnerability of the population...
  36. ncbi request reprint The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake
    M Hopkins
    1 Faculty of Health and Wellbeing, Department of Sport, Academy of Sport and Physical Activity, Sheffield Hallam University, Sheffield, UK 2 Faculty of Medicine and Health, Institute of Psychological Sciences, University of Leeds, Leeds, UK
    Eur J Clin Nutr 68:581-6. 2014
    ..Importantly, those who experienced a downregulation in REE also experienced an upregulation in EI, indicating that the adaptive metabolic response to EX influences both physiological and behavioural components of energy balance. ..
  37. ncbi request reprint Resistance and susceptibility to weight gain: individual variability in response to a high-fat diet
    J E Blundell
    Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    Physiol Behav 86:614-22. 2005
    ..5 MJ. This profile of characteristics helps to define the symptomatology of a thrifty phenotype...
  38. ncbi request reprint The role of reduced fat diets and fat substitutes in the regulation of energy and fat intake and body weight
    C L Lawton
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Curr Opin Lipidol 9:41-5. 1998
    ..Effects on the proportion of the diet consumed as fat are encouraging (with most studies showing a decrease towards dietary recommendations), whilst effects on energy intake and body weight remain equivocal...
  39. ncbi request reprint Cross talk between physical activity and appetite control: does physical activity stimulate appetite?
    J E Blundell
    BioPsychology Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Proc Nutr Soc 62:651-61. 2003
    ..The next stage is to further characterize the compensators and non-compensators, and to identify the mechanisms (physiological or behavioural) that are responsible for the rate of compensation and its limits...
  40. ncbi request reprint Effects of systematic variation in presatiation and fasting on the behavioural satiety sequence in male rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 79:227-38. 2003
    ..e., a delay) in the BSS, confirming the greater sensitivity of this measure relative to food intake per se. The potential utility of these reference profiles is discussed in relation to drug-induced changes in food intake and the BSS...
  41. ncbi request reprint Characterization of obese individuals who claim to detect no relationship between their eating pattern and sensations of hunger or fullness
    B Barkeling
    Obesity Unit, Karolinska University Hospital Huddinge, Karolinska Insitutet, Stockholm, Sweden
    Int J Obes (Lond) 31:435-9. 2007
    ..To study the phenomenon that obese subjects show considerable individual variability in their reported relationships between eating and sensations of hunger and fullness...
  42. ncbi request reprint Orexins and appetite regulation
    R J Rodgers
    School of Psychology, University of Leeds, Leeds, UK
    Neuropeptides 36:303-25. 2002
    ..e., finding and ingesting food without oneself becoming a meal for someone else...
  43. ncbi request reprint The effect of graded levels of exercise on energy intake and balance in free-living women
    R J Stubbs
    The Rowett Research Institute, Bucksburn, Aberdeen, UK
    Int J Obes Relat Metab Disord 26:866-9. 2002
    ..We assessed the effect of graded increases in exercised-induced energy expenditure (EE) on appetite, daily energy intake (EI), total daily EE and body weight in six lean women using a within-subject, repeated measures design...
  44. ncbi request reprint A novel technique to demonstrate disturbed appetite profiles in haemodialysis patients
    M J Wright
    Renal Unit, Wellcome Wing, Leeds General Infirmary, Leeds, UK
    Nephrol Dial Transplant 16:1424-9. 2001
    ..This does not correlate with their hunger score, but does correlate with their fullness rating. Nutrient intake is reduced, suggesting a resetting of appetite control for the HD group. The EARS may be useful for intervention studies...
  45. ncbi request reprint Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
    M Tschop
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
    Nature 430:1 p following 165; discussion 2 p following 165. 2004
    ..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36...
  46. doi request reprint Overconsumption and obesity: peptides and susceptibility to weight gain
    J E Blundell
    BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Regul Pept 149:32-8. 2008
    ..The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain...
  47. ncbi request reprint Effects of a sweet and a nonsweet lunch on short-term appetite: differences in female high and low consumers of sweet/low-energy beverages
    K M Appleton
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    J Hum Nutr Diet 17:425-34. 2004
    ..This study investigates the proposal that the effects of sweet tastes on appetite may differ as a result of differing habitual experiences of sweetness with or without energy...
  48. ncbi request reprint Differences in postprandial responses to fat and carbohydrate loads in habitual high and low fat consumers (phenotypes)
    J E Blundell
    BioPsychology Group, School of Psychology, University of Leeds, LS2 9JT, UK
    Br J Nutr 88:125-32. 2002
    ..In contrast, a low consumer of fat is associated with relatively lower energy expenditure at rest and lower fat oxidation, which has implications for weight gain if high-fat foods or meals are periodically introduced to the diet...
  49. ncbi request reprint PYY3-36 as an anti-obesity drug target
    M M Boggiano
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
    Obes Rev 6:307-22. 2005
    ..We review the studies that are in the public domain which support or challenge PYY3-36 as a potential anti-obesity target...