Research Topics
| J E BlundellSummaryAffiliation: University of Leeds Country: UK Publications
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Detail Information
Publications
Regulation of appetite: role of leptin in signalling systems for drive and satietyJ E Blundell
Psychobiology Group, School of Psychology, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK
Int J Obes Relat Metab Disord 25:S29-34. 2001..However, the so-called long-term regulation of body weight has recently been given substance by the identification of a chemical signal believed to link the brain with adipose tissue stores...- Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in ratsR J Rodgers
School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
Regul Pept 96:71-84. 2000..Further studies will be required to confirm the identity of the specific orexin receptors (i.e. OX(1) or OX(2)) involved in mediating the dose-dependent behavioural effects reported... - Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8SY Ishii
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, LS2 9JT, UK
Behav Brain Res 160:11-24. 2005..However, unlike the immediate short-circuiting of the satiety sequence induced by CCK-8S, the slower response to SB-334867 implies a more indirect mechanism of action... - Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867Y Ishii
Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
Behav Brain Res 157:331-41. 2005.... 
Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratchingA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS29JT, UK
Physiol Behav 94:422-31. 2008....- Sibutramine & naloxone: infra-additive interaction in the regulation of appetite?A J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
Behav Brain Res 207:174-81. 2010..g. rimonabant, bupropion), would not support naloxone-sibutramine polytherapy in the clinical management of obesity... - SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in ratsR J Rodgers
School of Psychology, University of Leeds, UK
Eur J Neurosci 13:1444-52. 2001..Together, these findings strongly support the view that orexin-A is involved in the regulation of feeding patterns and that this influence is mediated through the orexin-1 receptor... - Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in ratsA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
Pharmacol Biochem Behav 91:358-66. 2009..g. 'neutral' CB1 receptor antagonists), current data constitute further proof of concept regarding the anorectic efficacy, selectivity and added value of low-dose polytherapy with opioid and CB1 receptor antagonists... - Routes to obesity: phenotypes, food choices and activityJ E Blundell
BioPsychology Group, University of Leeds, UK
Br J Nutr 83:S33-8. 2000..The use of phenotypes has allowed the identification of different potential routes to weight gain. Different strategies are required to prevent age-related increase in body weight in these quite different individuals... - Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in ratsA J Tallett
Institute of Psychological Sciences, University of Leeds, Leeds, UK
Pharmacol Biochem Behav 97:92-100. 2010.... - Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male ratsA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
Behav Brain Res 198:359-65. 2009..Current data support the conclusion that the acute anorectic and weight loss efficacy of sibutramine in adult male rats is not secondary to behavioural disruption but, instead, is due largely to an acceleration in behavioural satiety... - Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eatingJ E Blundell
Department of Psychology, University of Leeds, United Kingdom
J Am Diet Assoc 97:S63-9. 1997..A first stage in a health program should be to prevent passive overconsumption... - Behaviourally-selective hypophagic effects of naloxone in non-deprived male rats presented with palatable foodA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
Behav Brain Res 187:417-27. 2008.... - Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in ratsY Ishii
Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
Physiol Behav 81:129-40. 2004..Overall, the divergent profiles obtained with equianorectic doses of LiCl and SB-334867 provide convincing evidence for the behavioural selectivity of SB-334867-induced anorexia... - A medium-term intervention study on the impact of high- and low-fat snacks varying in sweetness and fat content: large shifts in daily fat intake but good compensation for daily energy intakeC L Lawton
BioPsychology Group, School of Psychology, University of Leeds, UK
Br J Nutr 80:149-61. 1998.... - Control of food intake in the obeseJ E Blundell
Department of Psychobiology, University of Leeds, UK
Obes Res 9:263S-270S. 2001..Because energy expenditure is only loosely coupled to energy intake, sedentariness does not down-regulate food intake... - Night and day: diurnal differences in the behavioural satiety sequence in male ratsA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
Physiol Behav 97:125-30. 2009..The potential contribution of diurnal differences in rate of eating is discussed as are the implications of these findings for future studies on the neurobiology of feeding behaviour... - Effects of sweetness and energy in drinks on food intake following exerciseN A King
Department of Psychology, University of Leeds, UK
Physiol Behav 66:375-9. 1999..The results may also have implications for the effect on short-term appetite control of different types of drinks used to quench thirst during and after exercise... - Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight lossN A King
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, UK
Int J Obes (Lond) 32:177-84. 2008..To identify and characterize the individual variability in compensation for exercise-induced changes in energy expenditure (EE)... - Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male ratsA J Tallett
Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, UK
Psychopharmacology (Berl) 195:27-39. 2007..Although the CB1 receptor antagonist/inverse agonist rimonabant acutely suppresses food intake in rodents, the behavioural specificity of this effect remains unclear... - Lean male high- and low-fat phenotypes--different routes for achieving energy balanceJ Cooling
BioPyschology Group, School of Psychology, University of Leeds, UK
Int J Obes Relat Metab Disord 24:1561-6. 2000..This study investigated how energy expenditure may contribute to energy balance in lean male individuals consuming a diet either high or low in fat... - Palatability, food intake and the behavioural satiety sequence in male ratsY Ishii
Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, LS2 9JT, Leeds, UK
Physiol Behav 80:37-47. 2003..Data are discussed in relation to the specific behavioural signature to quinine-induced anorexia and its potential utility in identifying appetite suppressants that may modify intake via changes in taste sensitivity and/or palatability... - Separate systems for serotonin and leptin in appetite controlJ C Halford
Department of Psychology, University of Liverpool, UK
Ann Med 32:222-32. 2000..At a conceptual level, these may represent the distinction between 'satiety' and 'drive'. Interestingly, both 5-HT and leptin modulate the action of NPY, which may form a part of a common output pathway for the expression of appetite... - High-fat and low-fat (behavioural) phenotypes: biology or environment?J E Blundell
Department of Psychology, University of Leeds, UK
Proc Nutr Soc 58:773-7. 1999..These striking differences suggest that HF and LF can be used as a conceptual tool to investigate the relationship between biology and the environment (diet) in the control of body weight... - Acute compensatory eating following exercise is associated with implicit hedonic wanting for foodG Finlayson
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
Physiol Behav 97:62-7. 2009..Some individuals could be resistant to the beneficial effects of exercise due to a predisposition to compensate for exercise-induced energy expenditure as a result of implicit changes in food preferences... - Disinhibition: its effects on appetite and weight regulationE J Bryant
Institute of Psychological Sciences, University of Leeds, Leeds, UK
Obes Rev 9:409-19. 2008..We propose that the trait of Disinhibition be more appropriately renamed as 'opportunistic eating' or 'thrifty behaviour'... - Selective effects of acute exercise and breakfast interventions on mood and motivation to eatA Lluch
BioPsychology Group, School of Psychology, University of Leeds, UK
Physiol Behav 68:515-20. 2000..In these healthy young adults, the condition inducing the largest energy deficit (exercise and low-energy breakfast) was not associated with the lowest mental states... - Physical activity and regulation of food intake: current evidenceJ E Blundell
BioPsychology Group, School of Psychology, University of Leeds, United Kingdom
Med Sci Sports Exerc 31:S573-83. 1999..The evidence was reviewed on how physical activity could influence the regulation of food intake by either adjusting the sensitivity of appetite control mechanisms or by generating an energy deficit that could adjust the drive to eat... - No energy compensation at the meal following exercise in dietary restrained and unrestrained womenA Lluch
BioPsychology Group, School of Psychology, University of Leeds, UK
Br J Nutr 84:219-25. 2000..In restrained eaters, exercise was more effective in creating an energy deficit than in unrestrained eaters. Exercise may help restrained eaters to maintain control over appetite... - The control of appetite: basic concepts and practical implicationsJ E Blundell
School of Psychology, University of Leeds
Schweiz Med Wochenschr 129:182-8. 1999.... - The degree of saturation of fatty acids influences post-ingestive satietyC L Lawton
BioPsychology Group, School of Psychology, University of Leeds, UK
Br J Nutr 83:473-82. 2000..Overall, the results of these short-term studies indicate that PUFA may exert a relatively stronger control over appetite than MUFA and SFA... - Macronutrients and mental performanceL Dye
BioPsychology Group, School of Psychology, University of Leeds, Leeds, UK
Nutrition 16:1021-34. 2000..Other factors that modify effects include time of day, circadian rhythms, type of task, habitual diet, and vulnerability of the population... - Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequenceJ C Halford
Department of Psychology, University of Leeds, UK
Pharmacol Biochem Behav 54:745-51. 1996..Fluoxetine-induced suppression of eating at this dose is consistent with the normal operation of satiety. Fluoxetine-induced slowing of behavior appears to be mediated by a separate mechanism... - Habitual high and low consumers of artificially-sweetened beverages: effects of sweet taste and energy on short-term appetiteK M Appleton
School of Psychology, Queen s University of Belfast, 18 30 Malone Road, Belfast, BT9 5BP, UK
Physiol Behav 92:479-86. 2007..This lack of response suggests an adaptation to sweet taste as a result of the habitual dietary pattern of these consumers... - High-fat and low-fat phenotypes: habitual eating of high- and low-fat foods not related to taste preference for fatJ Cooling
BioPsychology Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
Eur J Clin Nutr 55:1016-21. 2001..To characterize taste preferences in habitual high fat (HF) and low fat (LF) phenotypes... - The role of reduced fat diets and fat substitutes in the regulation of energy and fat intake and body weightC L Lawton
BioPsychology Group, School of Psychology, University of Leeds, UK
Curr Opin Lipidol 9:41-5. 1998..Effects on the proportion of the diet consumed as fat are encouraging (with most studies showing a decrease towards dietary recommendations), whilst effects on energy intake and body weight remain equivocal... - Cross talk between physical activity and appetite control: does physical activity stimulate appetite?J E Blundell
BioPsychology Group, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
Proc Nutr Soc 62:651-61. 2003..The next stage is to further characterize the compensators and non-compensators, and to identify the mechanisms (physiological or behavioural) that are responsible for the rate of compensation and its limits... - Resistance and susceptibility to weight gain: individual variability in response to a high-fat dietJ E Blundell
Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
Physiol Behav 86:614-22. 2005..5 MJ. This profile of characteristics helps to define the symptomatology of a thrifty phenotype... - Effects of systematic variation in presatiation and fasting on the behavioural satiety sequence in male ratsY Ishii
Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
Physiol Behav 79:227-38. 2003..e., a delay) in the BSS, confirming the greater sensitivity of this measure relative to food intake per se. The potential utility of these reference profiles is discussed in relation to drug-induced changes in food intake and the BSS... - Physiology: does gut hormone PYY3-36 decrease food intake in rodents?M Tschop
Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
Nature 430:1 p following 165; discussion 2 p following 165. 2004..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36... - Effects of a sweet and a nonsweet lunch on short-term appetite: differences in female high and low consumers of sweet/low-energy beveragesK M Appleton
Department of Experimental Psychology, University of Bristol, Bristol, UK
J Hum Nutr Diet 17:425-34. 2004..This study investigates the proposal that the effects of sweet tastes on appetite may differ as a result of differing habitual experiences of sweetness with or without energy... - Orexins and appetite regulationR J Rodgers
School of Psychology, University of Leeds, Leeds, UK
Neuropeptides 36:303-25. 2002..e., finding and ingesting food without oneself becoming a meal for someone else... - The effect of graded levels of exercise on energy intake and balance in free-living womenR J Stubbs
The Rowett Research Institute, Bucksburn, Aberdeen, UK
Int J Obes Relat Metab Disord 26:866-9. 2002..We assessed the effect of graded increases in exercised-induced energy expenditure (EE) on appetite, daily energy intake (EI), total daily EE and body weight in six lean women using a within-subject, repeated measures design... - Characterization of obese individuals who claim to detect no relationship between their eating pattern and sensations of hunger or fullnessB Barkeling
Obesity Unit, Karolinska University Hospital Huddinge, Karolinska Insitutet, Stockholm, Sweden
Int J Obes (Lond) 31:435-9. 2007..To study the phenomenon that obese subjects show considerable individual variability in their reported relationships between eating and sensations of hunger and fullness... - Differences in postprandial responses to fat and carbohydrate loads in habitual high and low fat consumers (phenotypes)J E Blundell
BioPsychology Group, School of Psychology, University of Leeds, LS2 9JT, UK
Br J Nutr 88:125-32. 2002..In contrast, a low consumer of fat is associated with relatively lower energy expenditure at rest and lower fat oxidation, which has implications for weight gain if high-fat foods or meals are periodically introduced to the diet... - A novel technique to demonstrate disturbed appetite profiles in haemodialysis patientsM J Wright
Renal Unit, Wellcome Wing, Leeds General Infirmary, Leeds, UK
Nephrol Dial Transplant 16:1424-9. 2001..This does not correlate with their hunger score, but does correlate with their fullness rating. Nutrient intake is reduced, suggesting a resetting of appetite control for the HD group. The EARS may be useful for intervention studies... - Overconsumption and obesity: peptides and susceptibility to weight gainJ E Blundell
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
Regul Pept 149:32-8. 2008..The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain... - PYY3-36 as an anti-obesity drug targetM M Boggiano
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
Obes Rev 6:307-22. 2005..We review the studies that are in the public domain which support or challenge PYY3-36 as a potential anti-obesity target...