B R Bloem

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi The multiple tasks test. Strategies in Parkinson's disease
    B R Bloem
    Department of Neurology, University Hospital St Radboud, Nijmegen, The Netherlands
    Exp Brain Res 137:478-86. 2001
  2. ncbi The Multiple Tasks Test: development and normal strategies
    B R Bloem
    Department of Neurology, Radboud Oost, University Medical Centre, St Radboud, 6500 H13 Nijmegen, The Netherlands
    Gait Posture 14:191-202. 2001
  3. ncbi Prospective assessment of falls in Parkinson's disease
    B R Bloem
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    J Neurol 248:950-8. 2001
  4. doi Effect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease
    J E Visser
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 157:798-812. 2008
  5. doi First trial reactions and habituation rates over successive balance perturbations in Parkinson's disease
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 217:123-9. 2012
  6. doi Balance control in patients with distal versus proximal muscle weakness
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Neuroscience 164:1876-86. 2009
  7. doi Dynamic posturography in Parkinson's disease: diagnostic utility of the "first trial effect"
    J E Visser
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 168:387-94. 2010
  8. doi Split-belt locomotion in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands
    Neuroscience 236:110-6. 2013
  9. doi The effects of vibrotactile biofeedback training on trunk sway in Parkinson's disease patients
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 18:1017-21. 2012
  10. ncbi Is lower leg proprioception essential for triggering human automatic postural responses?
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Exp Brain Res 130:375-91. 2000

Collaborators

Detail Information

Publications48

  1. ncbi The multiple tasks test. Strategies in Parkinson's disease
    B R Bloem
    Department of Neurology, University Hospital St Radboud, Nijmegen, The Netherlands
    Exp Brain Res 137:478-86. 2001
    ..In addition, impaired motor learning may partially explain the higher error rate in PD. Future studies must determine if impaired MTT performance can predict actual falls in daily life...
  2. ncbi The Multiple Tasks Test: development and normal strategies
    B R Bloem
    Department of Neurology, Radboud Oost, University Medical Centre, St Radboud, 6500 H13 Nijmegen, The Netherlands
    Gait Posture 14:191-202. 2001
    ..Motor learning influenced performance among subjects who received the MTT in order of increasing difficulty. Further studies must determine whether the MTT can be used to evaluate balance disorders...
  3. ncbi Prospective assessment of falls in Parkinson's disease
    B R Bloem
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    J Neurol 248:950-8. 2001
    ..Recurrent fallers were best predicted by disease severity and presence of prior falls. Strategies to prevent falls in PD should particularly focus at intrinsic (patient-related) factors, such as minimising the use of benzodiazepines...
  4. doi Effect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease
    J E Visser
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 157:798-812. 2008
    ..In contrast, protective arm movements did appear to be levodopa-responsive. Future studies should focus on identifying subgroups of optimal responders, particularly patients with levodopa-induced dyskinesias...
  5. doi First trial reactions and habituation rates over successive balance perturbations in Parkinson's disease
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 217:123-9. 2012
    ..We studied balance reactions in Parkinson's disease using posturography, specifically focusing on the responses to the first, fully unpractised balance disturbance, and on the subsequent habituation rates...
  6. doi Balance control in patients with distal versus proximal muscle weakness
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Neuroscience 164:1876-86. 2009
    ..This observation, together with the retained ability of patients to use compensatory arm movements, provides targets that may be amenable to improvement with therapeutic intervention...
  7. doi Dynamic posturography in Parkinson's disease: diagnostic utility of the "first trial effect"
    J E Visser
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 168:387-94. 2010
    ..Early masseter activity warrants further studies to evaluate a potential startle component in the pathophysiology of balance disorders...
  8. doi Split-belt locomotion in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, The Netherlands
    Neuroscience 236:110-6. 2013
    ..We examined if stride time variability and deficits in interlimb coordination between the upper and lower limbs would increase during split-belt locomotion in PD, and particularly so in patients with FOG...
  9. doi The effects of vibrotactile biofeedback training on trunk sway in Parkinson's disease patients
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 18:1017-21. 2012
    ..Specifically, we investigated the effect of artificial vibrotactile biofeedback on trunk sway in PD...
  10. ncbi Is lower leg proprioception essential for triggering human automatic postural responses?
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    Exp Brain Res 130:375-91. 2000
    ..Considering these body segment displacements, any automatic postural response with an onset within the first 200 ms could well be triggered by receptors located at the knee, hip or trunk. (ABSTRACT TRUNCATED)..
  11. ncbi Evaluation of a Patient-Specific Index as an outcome measure for physiotherapy in Parkinson's disease
    M J Nijkrake
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Phys Rehabil Med 45:507-12. 2009
    ..The aim of this paper was to develop and evaluate a patient-specific index for physiotherapy in Parkinson's disease (PSI-PD)...
  12. doi Walking patterns in Parkinson's disease with and without freezing of gait
    W Nanhoe-Mahabier
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 182:217-24. 2011
    ....
  13. doi Epidemiology and pathophysiology of falls in facioscapulohumeral disease
    C G C Horlings
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1357-63. 2009
    ..Here falls in patients with facioscapulohumeral disease (FSHD) who suffered from lower limb muscle weakness were examined. This study provides insights into the prevalence, relevance and pathophysiology of falls in FSHD...
  14. doi Side of symptom onset affects motor dysfunction in Parkinson's disease
    C A Haaxma
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 170:1282-5. 2010
    ..We conclude that the side of symptom onset affects motor dysfunction in PD, and suggest that the non-dominant right hemisphere may be more susceptible to dopaminergic denervation than the dominant left hemisphere...
  15. doi Multidisciplinary care for patients with Parkinson's disease
    M A van der Marck
    Nijmegen Centre for Evidence Based Practice, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 15:S219-23. 2009
    ..We conclude by providing recommendations for current multidisciplinary care in PD, while highlighting the need for future clinical trials to evaluate the cost-effectiveness of a multidisciplinary team approach...
  16. ncbi CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy
    W F Abdo
    Institute of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Parkinsonism Relat Disord 13:480-2. 2007
    ..It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile...
  17. doi Sleep matters in Parkinson's disease: use of a priority list to assess the presence of sleep disturbances
    M Louter
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Neurol 20:259-65. 2013
    ..Furthermore, we determined whether relevance as perceived by patients correlated with the subjective presence of sleep disruption scored with a rating scale...
  18. doi CSF α-synuclein does not differentiate between parkinsonian disorders
    M B Aerts
    Department of Neurology, Parkinson Center Nijmegen ParC, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 33:430.e1-3. 2012
    ..Adjustment for age, disease severity or presence of erythrocytes or blood pigments in CSF did not alter these results. Our results imply that CSF α-synuclein is currently unsuitable as biomarker to differentiate between PD and AP...
  19. doi Clinimetric analyses of the Modified Parkinson Activity Scale
    S H J Keus
    Parkinson Centre Nijmegen, Department of Neurology, 935, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Parkinsonism Relat Disord 15:263-9. 2009
    ....
  20. ncbi Startle responses in Parkinson patients during human gait
    P H J A Nieuwenhuijzen
    Department of Rehabilitation Medicine, Radboud University of Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Exp Brain Res 171:215-24. 2006
    ..It is argued that the observed changes might contribute to the high incidence of falls in patients with Parkinson's disease...
  21. pmc Recent advances in functional neuroimaging of gait
    M Bakker
    F C Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands
    J Neural Transm 114:1323-31. 2007
    ..We provide a critical discussion of advantages and disadvantages of each approach, emphasizing crucial issues to be addressed for a better understanding of the neural control of human gait...
  22. ncbi Falls in the elderly. I. Identification of risk factors
    B R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Wien Klin Wochenschr 113:352-62. 2001
    ..The identified risk factors can serve as a template for the design of prevention strategies, which are discussed in the companion article...
  23. ncbi CSF hypocretin-1 levels are normal in multiple-system atrophy
    W F Abdo
    Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P O Box 9101, 6500 Nijmegan, HB, The Netherlands
    Parkinsonism Relat Disord 14:342-4. 2008
    ..We did not observe any differences from control values...
  24. ncbi Assessing the interplay between cognition and gait in the clinical setting
    A H Snijders
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Neural Transm 114:1315-21. 2007
    ..Combining these assessments may lead to a better appreciation of the fascinating but complex interplay between cognition and gait...
  25. doi Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome
    M B Aerts
    Department of Neurology, Parkinson Center Nijmegen ParC, Radboud University Nijmegen Medical Centre, The Netherlands
    Mov Disord 26:169-73. 2011
    ..2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD...
  26. doi Prospective analysis of falls in dominant ataxias
    E M R Fonteyn
    Department of Neurology and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Neurol 69:53-7. 2013
    ..This study confirms that falls are a frequent and serious complication of SCA, and that the presence of nonataxia symptoms is an important etiological factor in its occurrence...
  27. doi Decomposing effects of dopaminergic medication in Parkinson's disease on probabilistic action selection - learning or performance?
    P Smittenaar
    The Wellcome Trust Centre for Neuroimaging, University College London, London, UK
    Eur J Neurosci 35:1144-51. 2012
    ....
  28. pmc Improving community healthcare for patients with Parkinson's disease: the dutch model
    S H J Keus
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Parkinsons Dis 2012:543426. 2012
    ..This comprehensive approach is likely to be feasible for other countries as well, so we currently collaborate in a European collaboration to improve community care for persons with Parkinson's disease...
  29. ncbi Allied health care interventions and complementary therapies in Parkinson's disease
    M J Nijkrake
    Parkinson Center Nijmegen ParC, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 13:S488-94. 2007
    ..Finally, we discuss the need for an improved organization of allied health care, and identify topics for future research to further underpin the pros and cons of allied health care and complementary therapies in PD...
  30. ncbi Quality indicators for physiotherapy in Parkinson's disease
    M J Nijkrake
    Donders Center for Brain, Cognition and Behavior, Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Phys Rehabil Med 45:239-45. 2009
    ..The aim of this study was to develop quality indicators for physiotherapy in Parkinson's disease (PD) according to international criteria...
  31. doi Trunk sway analysis to quantify the warm-up phenomenon in myotonia congenita patients
    C G C Horlings
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    J Neurol Neurosurg Psychiatry 80:207-12. 2009
    ..A new approach is presented to quantify this warm-up phenomenon under clinically relevant gait and balance tasks...
  32. ncbi Motor imagery of gait: a quantitative approach
    M Bakker
    F C Donders Centre for Cognitive Neuroimaging, Radboud University, PO Box 9101, 6500, Nijmegen, The Netherlands
    Exp Brain Res 179:497-504. 2007
    ..These results open the possibility of using this protocol for exploring neurophysiological correlates of gait control in humans...
  33. ncbi Clinimetrics of postural instability in Parkinson's disease
    B R Bloem
    Department of Neurology, Leiden University Medical Centre, The Netherlands
    J Neurol 245:669-73. 1998
    ..43; P = 0.11). These results cast doubt on the use of the retropulsion test as a measure of postural instability in Parkinson's disease...
  34. pmc Ten steps to identify atypical parkinsonism
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 77:1367-9. 2006
    ..Balance impairment is a frequently encountered problem in patients with Parkinson's disease. A profound balance disorder, however, is an atypical feature...
  35. ncbi Why old people fall (and how to stop them)
    N C Voermans
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Pract Neurol 7:158-71. 2007
  36. ncbi CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurology 67:474-9. 2006
    ..Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease..
  37. doi Are postural responses to backward and forward perturbations processed by different neural circuits?
    J Nonnekes
    Radboud University Medical Centre, Nijmegen Centre for Evidence Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands
    Neuroscience 245:109-20. 2013
    ..These findings give directions for future studies investigating whether deficits in startle pathways may explain the prominent backward instability seen in patients with Parkinson's disease and progressive supranuclear palsy...
  38. pmc Move for change part I: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's disease
    B R Bloem
    Parkinson Centre Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Neurol 19:402-10. 2012
    ..Move for Change is a three-part series of pan-European patient surveys based on this Charter...
  39. ncbi Dynamic posturography using a new movable multidirectional platform driven by gravity
    D A C M Commissaris
    Department of Medical Physics and Biophysics, University of Nijmegen, Nijmegen, The Netherlands
    J Neurosci Methods 113:73-84. 2002
    ..We conclude that this gravity-driven multidirectional platform provides a useful and versatile tool for dynamic posturography...
  40. ncbi Falls in the elderly. II. Strategies for prevention
    I Boers
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Wien Klin Wochenschr 113:398-407. 2001
    ..In addition, prevention is important for health policy makers who aim to reduce falls in the general population by reducing or eliminating commonly present risk factors (even if they are only weakly associated with falls)...
  41. ncbi An uncommon cause of stroke in young adults
    M J van Putten
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Arch Neurol 56:1018-20. 1999
    ..Underlying vessel wall disorders of the aorta, such as Erdheim Gsell cystic medionecrosis, should be considered in young patients with spontaneous arterial dissection...
  42. pmc Diurnal and nocturnal drooling in Parkinson's disease
    J G Kalf
    Nijmegen Centre for Evidence Based Practice, Department of Rehabilitation, Radboud University Nijmegen Medical Centre, Internal code 897, 6500 HB Nijmegen, The Netherlands
    J Neurol 259:119-23. 2012
    ..This is less than usually reported. Diurnal drooling typically appeared later in the disease course. The association with oral motor behavior should encourage the development of behavioral treatment approaches...
  43. ncbi Diagnostic value of asymmetric striatal D2 receptor upregulation in Parkinson's disease: an [123I]IBZM and [123I]FP-CIT SPECT study
    C C P Verstappen
    Department of Neurology 935, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:502-7. 2007
    ..The aim of this study was to evaluate whether the highest striatal D2 binding is found contralateral to the most affected side in PD, and whether this upregulation can be used as a diagnostic tool...
  44. doi The ParkinsonNet trial: design and baseline characteristics
    Samyra H J Keus
    Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Mov Disord 25:830-7. 2010
    ..Baseline characteristics of participants in the ParkinsonNet and control clusters were comparable. With 699 participating patients, this is the largest allied health study in PD to date...
  45. doi Imaging the impact of genes on Parkinson's disease
    J P M van der Vegt
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuroscience 164:191-204. 2009
    ..We also discuss how functional and structural neuroimaging can be used to better characterize these genotype-phenotype correlations...
  46. ncbi Hemispheric asymmetry and somatotopy of afferent inhibition in healthy humans
    R C G Helmich
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Exp Brain Res 167:211-9. 2005
    ..This suggests that SAI induced by electrical D2 stimulation is not focal and somatotopically specific, but a more widespread inhibitory phenomenon...
  47. doi Myoclonus-dystonia: clinical and genetic evaluation of a large cohort
    K Ritz
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:653-8. 2009
    ..The lack of stringent clinical inclusion criteria and limitations of mutation screens by direct sequencing might explain this observation...
  48. doi Weight loss in neurodegenerative disorders
    N A Aziz
    Department of Neurology, Leiden University Medical Centre, Albinusdreef 2, Leiden, The Netherlands
    J Neurol 255:1872-80. 2008
    ..Moreover, there are indications for defects in the systemic energy homeostasis and gastrointestinal function, which may also serve as therapeutic targets. However, the clinical merits of such interventions have yet to be demonstrated...