A Blann

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint The endothelium in atherothrombotic disease: assessment of function, mechanisms and clinical implications
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 9:297-306. 1998
  2. ncbi request reprint Endothelial integrity, soluble adhesion molecules and platelet markers in type 1 diabetes mellitus
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Diabet Med 15:634-42. 1998
  3. ncbi request reprint von Willebrand factor, fibrinogen and other plasma proteins as determinants of plasma viscosity
    A Blann
    Department of Medicine, The City Hospital, Birmingham, UK
    Atherosclerosis 139:317-22. 1998
  4. ncbi request reprint Soluble adhesion molecules, endothelial markers and atherosclerosis risk factors in abdominal aortic aneurysm: a comparison with claudicants and healthy controls
    A D Blann
    University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 9:479-84. 1998
  5. ncbi request reprint The influence of acute smoking on leucocytes, platelets and the endothelium
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Atherosclerosis 141:133-9. 1998
  6. ncbi request reprint Soluble intercelluar adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke
    A Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 10:277-84. 1999
  7. ncbi request reprint Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]
    S K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 258:336-43. 2005
  8. pmc Localisation of members of the vascular endothelial growth factor (VEGF) family and their receptors in human atherosclerotic arteries
    F Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Clin Pathol 57:266-72. 2004
  9. pmc Platelet activation, haemorheology and thrombogenesis in acute atrial fibrillation: a comparison with permanent atrial fibrillation
    S Kamath
    Heart 89:1093-5. 2003
  10. ncbi request reprint Von Willebrand factor and forearm blood flow as indicators of endothelial dysfunction
    A D Blann
    Atherosclerosis 176:423-4; author reply 425. 2004

Collaborators

Detail Information

Publications65

  1. ncbi request reprint The endothelium in atherothrombotic disease: assessment of function, mechanisms and clinical implications
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 9:297-306. 1998
    ....
  2. ncbi request reprint Endothelial integrity, soluble adhesion molecules and platelet markers in type 1 diabetes mellitus
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Diabet Med 15:634-42. 1998
    ....
  3. ncbi request reprint von Willebrand factor, fibrinogen and other plasma proteins as determinants of plasma viscosity
    A Blann
    Department of Medicine, The City Hospital, Birmingham, UK
    Atherosclerosis 139:317-22. 1998
    ..These data may have implications for the pathogenesis of cardiovascular disease...
  4. ncbi request reprint Soluble adhesion molecules, endothelial markers and atherosclerosis risk factors in abdominal aortic aneurysm: a comparison with claudicants and healthy controls
    A D Blann
    University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 9:479-84. 1998
    ..05). Levels were higher in AAA patients than in peripheral arterial disease patients (P < 0.05). Our laboratory data suggest that the pathophysiology AAA and peripheral arterial disease are not identical...
  5. ncbi request reprint The influence of acute smoking on leucocytes, platelets and the endothelium
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Atherosclerosis 141:133-9. 1998
    ..We conclude that the acute smoking of two cigarettes in succession will activate leucocytes and cause endothelial cell damage, but will not immediately influence platelet activity...
  6. ncbi request reprint Soluble intercelluar adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke
    A Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 10:277-84. 1999
    ..These changes may perhaps be part of the complex pathophysiological responses to infarction and repair of brain tissue following stroke...
  7. ncbi request reprint Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]
    S K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 258:336-43. 2005
    ..Accordingly, the angiogenic growth factors VEGF, angiopoietin 1 and 2 (Ang 1 & 2) and soluble angiopoietin receptor Tie-2 in plasma and in platelets were assessed in terms of the presence or absence of hypertensive TOD...
  8. pmc Localisation of members of the vascular endothelial growth factor (VEGF) family and their receptors in human atherosclerotic arteries
    F Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Clin Pathol 57:266-72. 2004
    ..The existence of single or multiple VEGF isoforms and receptors suggests that these proteins may have overlapping but distinct functions, which may be reflected in their cell expression and distribution...
  9. pmc Platelet activation, haemorheology and thrombogenesis in acute atrial fibrillation: a comparison with permanent atrial fibrillation
    S Kamath
    Heart 89:1093-5. 2003
  10. ncbi request reprint Von Willebrand factor and forearm blood flow as indicators of endothelial dysfunction
    A D Blann
    Atherosclerosis 176:423-4; author reply 425. 2004
  11. ncbi request reprint Plasma and platelet-derived vascular endothelial growth factor and angiopoietin-1 in hypertension: effects of antihypertensive therapy
    S K Nadar
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Intern Med 256:331-7. 2004
    ..Although platelet-derived growth factors are important in the pathogenesis and metastasis of malignancy, their role in the pathogenesis of complications and the response to treatment in hypertension is less known...
  12. ncbi request reprint Increased soluble ICAM-1 and IL-6 are not speciofic plasma markers of endothelial dysfunction
    A D Blann
    Atherosclerosis 174:189-90; author reply 191-2. 2004
  13. ncbi request reprint Platelet and haemorheological markers in 'high risk' hypertensives are improved by tighter blood pressure control and cardiovascular risk management: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
    C G C Spencer
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 255:59-67. 2004
    ..To investigate the impact of intensified cardiovascular risk management on soluble markers of platelet, endothelial and rheological function in a population of middle-aged hypertensive patients at high risk of cardiovascular complications...
  14. ncbi request reprint Prognostic value of interleukin-6, plasma viscosity, fibrinogen, von Willebrand factor, tissue factor and vascular endothelial growth factor levels in congestive heart failure
    B S P Chin
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur J Clin Invest 33:941-8. 2003
    ....
  15. pmc Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease
    N A Chung
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Heart 89:1411-5. 2003
    ..Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis...
  16. ncbi request reprint Oxidised and native low-density lipoproteins induce the release of von Willebrand factor from human endothelial cells in vitro
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Biomed Sci 60:155-60. 2003
    ....
  17. ncbi request reprint A comparison of flow-mediated dilatation and von Willebrand factor as markers of endothelial cell function in health and in hypertension: relationship to cardiovascular risk and effects of treatment: a substudy of the Anglo-Scandinavian Cardiac Outcomes T
    D C Felmeden
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 14:425-31. 2003
    ..These methods might therefore be useful indices to identify patients at risk of future cardiovascular events, and may also assist in the understanding of early developments in the pathogenesis of vascular risk in hypertension...
  18. ncbi request reprint Basic fibrobrast growth factor induces the secretion of vascular endothelial growth factor by human aortic smooth muscle cells but not by endothelial cells
    F Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur J Clin Invest 33:833-9. 2003
    ..Inappropriate production of, and/or response to, these growth factors (such as vascular endothelial growth factor, VEGF, and basic fibroblast growth factor (bFGF)) may contribute to atherogenesis and therefore to disease progression...
  19. ncbi request reprint Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1
    G J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur J Clin Invest 33:883-90. 2003
    ..These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), which act through receptors Flt-1 and Tie-2...
  20. ncbi request reprint The effect of multi-factorial intervention on plasma von Willebrand factor, soluble E-selectin and tissue factor in diabetes mellitus: implications for atherosclerotic vascular disease
    H S Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Diabet Med 22:249-55. 2005
    ....
  21. ncbi request reprint Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Thromb Thrombolysis 25:185-9. 2008
    ..The correlation between sP-selectin and VEGF in SCD and HbSC disease is consistent with the view that VEGF is released from platelets during in vivo activation...
  22. ncbi request reprint Diagnosis, treatment and management of venous thromboembolism: recent developments relevant to biomedical scientists
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Biomed Sci 64:136-41. 2007
    ....
  23. ncbi request reprint Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease
    A D Blann
    Department of Haematology, City Hospital, Birmingham, B18 7QH, UK
    Br J Biomed Sci 64:124-6. 2007
    ..001), but only sP-selectin was higher in present sickle crisis (P<0.001). We suggest that increased NTBI associated with blood transfusion iron overload in SCD may promote platelet activation...
  24. ncbi request reprint Soluble CD40 ligand and atrial fibrillation: relationship to platelet activation, and endothelial damage/dysfunction
    A D Blann
    Int J Cardiol 127:135-7. 2008
    ..We find that sCD40L is marginally raised in AF but the stimulus for this is unclear. The lack of clear correlation with relevant plasma markers suggests that the source is unlikely to be the endothelium or platelet alone...
  25. ncbi request reprint Prognostic value of plasma soluble P-selectin and von Willebrand factor as indices of platelet activation and endothelial damage/dysfunction in high-risk patients with hypertension: a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial
    G I Varughese
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 261:384-91. 2007
    ....
  26. ncbi request reprint Haemorheological, platelet and endothelial indices in relation to global measures of cardiovascular risk in hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial
    C G C Spencer
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 261:82-90. 2007
    ..e. Framingham coronary heart disease (CHD), stroke and cardiovascular death score, the Pocock cardiovascular risk score and the sum of individual risk factors]...
  27. pmc Plasma haemostatic markers, endothelial function and ambulatory blood pressure changes with home versus hospital cardiac rehabilitation: the Birmingham Rehabilitation Uptake Maximisation Study
    K W Lee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Heart 92:1732-8. 2006
    ....
  28. pmc Plasma vascular endothelial growth factor, angiopoietin-2, and soluble angiopoietin receptor tie-2 in diabetic retinopathy: effects of laser photocoagulation and angiotensin receptor blockade
    P L Lip
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Ophthalmol 88:1543-6. 2004
    ....
  29. ncbi request reprint Platelet P-selectin and platelet mass, volume and component in sickle cell disease: relationship to genotype
    J S Mohan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, England, UK
    Thromb Res 117:623-9. 2006
    ..We hypothesised altered whole platelet P-selectin (pPsel), and morphological platelet indices mass, volume and component in SCD and two of its major genotypes...
  30. pmc The angiopoietin/Tie-2 system in proliferative sickle retinopathy: relation to vascular endothelial growth factor, its soluble receptor Flt-1 and von Willebrand factor, and to the effects of laser treatment
    J S Mohan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, The Birmingham and Midland Eye Centre, City Hospital, UK
    Br J Ophthalmol 89:815-9. 2005
    ..In addition, to determine changes with panretinal laser photocoagulation (PRP) therapy...
  31. ncbi request reprint Analysis of combination anti-angiogenesis therapy on markers of coagulation, platelet activation and angiogenesis in patients with advanced cancer
    G J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Cancer Lett 219:163-7. 2005
    ..We provide further evidence linking coagulation and angiogenesis but combination anti-angiogenesis therapy does not influence plasma soluble P-selectin, TF or VEGF...
  32. ncbi request reprint Soluble P selectin in systemic sclerosis: relationship with von Willebrand factor, autoantibodies and diffuse or localised/limited disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 109:203-6. 2003
  33. ncbi request reprint Assessment of endothelial damage and dysfunction: observations in relation to heart failure
    A Y Chong
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    QJM 96:253-67. 2003
  34. ncbi request reprint Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis
    G J Byrne
    Department of Academic Surgery, University Hospital of South Manchester, U K
    J Natl Cancer Inst 92:1329-36. 2000
    ..We examined the potential of three serum glycoproteins-vascular cell adhesion molecule-1 (VCAM-1), endothelial selectin (E-selectin), and von Willebrand factor (VWF)-to serve as markers for angiogenesis...
  35. ncbi request reprint Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response
    A D Blann
    University Department of Surgery, University Hospital of South Manchester, Manchester, UK
    Blood Coagul Fibrinolysis 13:165-8. 2002
    ..We conclude that raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation, and that raised vWf seems likely to be independent of the acute phase response...
  36. ncbi request reprint Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis
    S S Marwah
    Department of Haematology, City Hospital Trust, Birmingham, United Kingdom
    Am J Hematol 69:144-6. 2002
    ..001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect...
  37. ncbi request reprint Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hematol 69:135-7. 2002
    ..In 24 type 1 VWD patients, VWF and P selectin correlated inversely (P = 0.005) but in 14 type 2 VWD patients there was no correlation (P = 0.997). These data imply major differences in VWF/P-selectin regulation between types 1 and 2 VWD...
  38. ncbi request reprint Effects of acute exercise on hemorheological, endothelial, and platelet markers in patients with chronic heart failure in sinus rhythm
    C R Gibbs
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Clin Cardiol 24:724-9. 2001
    ..Although moderate exercise should be encouraged in patients with CHF, vigorous exercise should probably be avoided in view of its potential prothrombotic effects in this high-risk group of patients...
  39. ncbi request reprint Changes in endothelial, leucocyte and platelet markers following contrast medium injection during angiography in patients with peripheral artery disease
    A D Blann
    Department of Surgery, South Manchester University Hospital, Nell Lane, Manchester M20 8LR, UK
    Br J Radiol 74:811-7. 2001
    ..05). The following day both vWf (p<0.01) and soluble P-selectin (p<0.05) were increased. These data point to both early and late effects of contrast medium on markers of endothelial, platelet and leucocyte function...
  40. ncbi request reprint Plasma von Willebrand factor, fibrinogen and soluble P-selectin levels in paroxysmal, persistent and permanent atrial fibrillation. Effects of cardioversion and return of left atrial function
    F L Li-Saw-Hee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 22:1741-7. 2001
    ..Cardioversion of persistent atrial fibrillation did not significantly alter indices of hypercoagulability even after 3 months maintenance of sinus rhythm, despite the return of atrial systole...
  41. ncbi request reprint Plasma levels of vascular endothelial growth factor (VEGF) and its receptor, Flt-1, in haematological cancers: a comparison with breast cancer
    F M Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, Birmingham, United Kingdom
    Am J Hematol 66:59-61. 2001
    ..0238). There was no difference in levels of sFlt-1. Our data point to changes in levels of plasma VEGF, but not sFlt-1, in haematological cancer that may have pathophysiological consequences...
  42. ncbi request reprint Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction
    P L Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    Ophthalmology 108:705-10. 2001
    ..The interaction between abnormal angiogenesis and the components of Virchow's triad for thrombogenesis may in part contribute to the pathogenesis of ARMD...
  43. ncbi request reprint Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy
    C R Gibbs
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Circulation 103:1746-51. 2001
    ..These positive effects of ACE inhibitors may offer an explanation for the observed reduction in ischemic events in clinical trials...
  44. ncbi request reprint High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene
    P W Kamphuisen
    Haemostasis and Thrombosis Research Centre, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 115:156-8. 2001
    ..Our data do not support the hypothesis that a single functional sequence variation in the factor VIII or VWF gene explains the majority of high factor VIII levels and thrombotic risk...
  45. ncbi request reprint Effect of aortic valve replacement on plasma soluble P-selectin, von Willebrand factor, and fibrinogen
    I R Goldsmith
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:107-10, A9. 2001
    ....
  46. ncbi request reprint Baseline abnormalities of endothelial function and thrombogenesis in relation to prognosis in essential hypertension
    G Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:35-41. 2002
    ..However, only high baseline systolic blood pressures were associated with a shortened event-free survival...
  47. ncbi request reprint Changes in von Willebrand factor and soluble ICAM, but not soluble VCAM, soluble E selectin or soluble thrombomodulin, reflect the natural history of the progression of atherosclerosis
    A D Blann
    Atherosclerosis 165:389-91. 2002
  48. pmc Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma
    P L Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Br J Ophthalmol 86:1299-302. 2002
    ....
  49. ncbi request reprint Influence of the risk factors for atherosclerosis on levels of soluble adhesion molecules and endothelial markers in peripheral vascular disease
    A D Blann
    Thromb Haemost 88:366-7. 2002
  50. ncbi request reprint A study of platelet activation in atrial fibrillation and the effects of antithrombotic therapy
    S Kamath
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 23:1788-95. 2002
    ..The aim of this cross-sectional study was to investigate new aspects of platelet biology in AF, predominantly focusing on platelet activation and the effects of concomitant antiplatelet and anticoagulant therapy...
  51. ncbi request reprint A study of platelet activation in paroxysmal, persistent and permanent atrial fibrillation
    S Kamath
    Haemostatis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:627-36. 2002
    ..Cardioversion of persistent AF to sinus rhythm appears to decrease the platelet activation, but whether this translates into a beneficial reduction in thromboembolic risk requires further study...
  52. ncbi request reprint Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:647-51. 2002
    ..5-15) before drinking red wine to 16 ng/ml (interquartile range, 14-20) 4 h later (P = 0.0067). We conclude that an acute bolus of red wine, but not white wine, activates platelets but has no substantial effect on the endothelium...
  53. ncbi request reprint Physical activity in relation to indices of endothelial function and angiogenesis factors in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
    D C Felmeden
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 253:81-91. 2003
    ..We investigated the association between physical activity and the degree of hypertension, as well as the relation to indices of endothelial damage/dysfunction and angiogenesis...
  54. ncbi request reprint Relationship between plasma markers of endothelial cell integrity and the Framingham cardiovascular disease risk-factor scores in apparently healthy individuals
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:513-8. 2002
    ....
  55. ncbi request reprint Oxidative stress in malignant and non-malignant phase hypertension
    G Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Hum Hypertens 16:333-6. 2002
    ..These observations raise the possibility abnormal oxidative stress is probably not the mechanism responsible for the endothelial damage seen in malignant phase hypertension...
  56. ncbi request reprint Sequential alterations in haemorheology, endothelial dysfunction, platelet activation and thrombogenesis in relation to prognosis following acute stroke: The West Birmingham Stroke Project
    G Y H Lip
    Haemostasis Thrombosis Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:339-47. 2002
    ....
  57. ncbi request reprint Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation
    F L Li-Saw-Hee
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Clin Cardiol 24:409-14. 2001
    ..Nevertheless, acute exercise does not appear to have a significant influence on endothelial dysfunction or platelet activation in patients with AF...
  58. pmc Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer
    P H Jones
    Cancer Research UK Medical Oncology Unit, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Br J Cancer 91:30-6. 2004
    ..The combination of marimastat, fragmin and captopril is well tolerated and has in vivo activity. Inhibition of PHA-stimulated TNF-alpha release from lymphocytes is a surrogate pharmacodynamic marker of metalloprotease inhibition...
  59. pmc Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer
    P K Y Goon
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    Neoplasia 8:79-88. 2006
    ....
  60. ncbi request reprint Angiogenesis in myocardial infarction. An acute or chronic process?
    N A Y Chung
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 23:1604-8. 2002
    ....
  61. ncbi request reprint Factors predicting the development of metabolic syndrome and type II diabetes against a background of hypertension
    H S Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur J Clin Invest 35:324-9. 2005
    ..We hypothesized that patients with hypertension developing MetS are at increased risk of type II diabetes and CHD compared with patients who do not develop MetS...
  62. ncbi request reprint Plasma von Willebrand factor levels and surrogates of atherosclerosis
    G Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Thromb Haemost 3:659-61. 2005
  63. pmc Incremental shuttle walking is associated with activation of haemostatic and haemorheological markers in patients with coronary artery disease: the Birmingham rehabilitation uptake maximization study (BRUM)
    K W Lee
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Heart 91:1413-7. 2005
    ..ISWT is a standardised walking test that provokes maximal performance and correlates strongly with maximum oxygen uptake...
  64. ncbi request reprint Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension
    F M Belgore
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:805-7, A9. 2001
    ..This raises the possibility that abnormal angiogenesis may contribute to the pathogenesis of complications related to hypertension and merits exploration in larger studies...
  65. ncbi request reprint Angiogenesis: basic pathophysiology and implications for disease
    D C Felmeden
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, B18 7QH, Birmingham, UK
    Eur Heart J 24:586-603. 2003