A Blann

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Arterial and venous thrombosis in cancer patients
    Andrew D Blann
    University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Cardiol Res Pract 2011:394740. 2011
  2. doi Vascular and platelet responses to aspirin in patients with coronary artery disease
    Andrew D Blann
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    Eur J Clin Invest 43:91-9. 2013
  3. doi Renal function and aspirin resistance in patients with coronary artery disease
    A D Blann
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, UK
    Thromb Res 130:e103-6. 2012
  4. doi Endothelial cell activation markers in cancer
    Andrew D Blann
    University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham, UK
    Thromb Res 129:S122-6. 2012
  5. pmc Validation of the Edinburgh Claudication Questionnaire in 1st generation Black African-Caribbean and South Asian UK migrants: a sub-study to the Ethnic-Echocardiographic Heart of England Screening (E-ECHOES) study
    Philip C Bennett
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Department of Vascular Surgery, Edgbaston, Birmingham B15 2TT, UK
    BMC Med Res Methodol 11:85. 2011
  6. doi Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: a comparison with plasma vascular markers
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK
    Prostate 71:1047-53. 2011
  7. pmc Venous thromboembolism
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH
    BMJ 332:215-9. 2006
  8. ncbi Abnormal vascular, platelet and coagulation markers in primary thrombocythaemia are not reversed by treatments that reduce the platelet count
    Andrew Blann
    University Department of Medicine, Haematology City Hospital, Dudley Road Birmingham, B18 7QH, UK
    Platelets 15:447-9. 2004
  9. ncbi Soluble CD40L in peripheral artery disease. Relationship with disease severity, platelet markers and the effects of angioplasty
    Andrew D Blann
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, Birmingham, UK
    Thromb Haemost 93:578-83. 2005
  10. ncbi Circulating endothelial cells. Biomarker of vascular disease
    Andrew D Blann
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Thromb Haemost 93:228-35. 2005

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Arterial and venous thrombosis in cancer patients
    Andrew D Blann
    University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Cardiol Res Pract 2011:394740. 2011
    ..The objective of this communication is to summarise current views on the epidemiology and pathophysiology of arterial and venous thrombosis in cancer...
  2. doi Vascular and platelet responses to aspirin in patients with coronary artery disease
    Andrew D Blann
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    Eur J Clin Invest 43:91-9. 2013
    ....
  3. doi Renal function and aspirin resistance in patients with coronary artery disease
    A D Blann
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, UK
    Thromb Res 130:e103-6. 2012
    ..Nevertheless, we suspect that failure of patients to be fully responsive to aspirin may be important in the pathophysiology of thrombosis in renal dysfunction...
  4. doi Endothelial cell activation markers in cancer
    Andrew D Blann
    University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham, UK
    Thromb Res 129:S122-6. 2012
    ..This, in turn, provides the basis for the viewpoint that vascular health is valuable and should be protected and maintained, possibly the use of vascular-friendly treatments...
  5. pmc Validation of the Edinburgh Claudication Questionnaire in 1st generation Black African-Caribbean and South Asian UK migrants: a sub-study to the Ethnic-Echocardiographic Heart of England Screening (E-ECHOES) study
    Philip C Bennett
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Department of Vascular Surgery, Edgbaston, Birmingham B15 2TT, UK
    BMC Med Res Methodol 11:85. 2011
    ..We also determined the diagnostic accuracy of translated versions of the ECQ in 1st generation South Asian UK migrants, as this has not been investigated before...
  6. doi Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: a comparison with plasma vascular markers
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK
    Prostate 71:1047-53. 2011
    ..However, there are no reports where these indices are compared. Accordingly, we hypothesized altered EPCs and CECs in prostate cancer that would correlate with vWf, sEsel, and prostate specific antigen (PSA)...
  7. pmc Venous thromboembolism
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH
    BMJ 332:215-9. 2006
  8. ncbi Abnormal vascular, platelet and coagulation markers in primary thrombocythaemia are not reversed by treatments that reduce the platelet count
    Andrew Blann
    University Department of Medicine, Haematology City Hospital, Dudley Road Birmingham, B18 7QH, UK
    Platelets 15:447-9. 2004
    ..This may account for continuing risk of pathology in those whose platelet counts have been normalised...
  9. ncbi Soluble CD40L in peripheral artery disease. Relationship with disease severity, platelet markers and the effects of angioplasty
    Andrew D Blann
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, Birmingham, UK
    Thromb Haemost 93:578-83. 2005
    ..Failure to correlate with other markers suggest the platelet may not be the sole source of sCD40L, and that other cells may contribute to plasma levels...
  10. ncbi Circulating endothelial cells. Biomarker of vascular disease
    Andrew D Blann
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Thromb Haemost 93:228-35. 2005
    ..The objective of the present communication is to condense existing data on CECs, briefly compare them with progenitor cells, and summarise possible mechanism(s) by which they may contribute to vascular pathology...
  11. ncbi How a damaged blood vessel wall contibutes to thrombosis and hypertenasion
    Andrew D Blann
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine City Hospital, Birmingham, United Kingdom
    Pathophysiol Haemost Thromb 33:445-8. 2003
    ....
  12. ncbi Good analytical practice: statistics and handling data in biomedical science: A primer and directions for authors. Part 2: analysis of data from three or more groups, and instructions for authors
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QL, UK
    Br J Biomed Sci 66:42-6. 2009
    ..e., statistical software packages), and will conclude with a statement on appropriate descriptors of data, their analyses and presentation, for authors considering submitting their data to this journal...
  13. ncbi Assessment of endothelial dysfunction: focus on atherothrombotic disease
    Andrew D Blann
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine City Hospital, Birmingham, United Kingdom
    Pathophysiol Haemost Thromb 33:256-61. 2003
    ..The assessment of vascular damage is becoming recognised as having an increasingly prominent part in the pathophysiology of cardiovascular disease...
  14. ncbi The adhesion molecule P-selectin and cardiovascular disease
    Andrew D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 24:2166-79. 2003
    ..In doing so we shall focus primarily on human biology but will note a small number of excellent lessons provided by non-human work...
  15. ncbi Oxidised and native low-density lipoproteins induce the release of von Willebrand factor from human endothelial cells in vitro
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Biomed Sci 60:155-60. 2003
    ....
  16. ncbi Circulating endothelial cells and endothelial progenitor cells: two sides of the same coin, or two different coins?
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Atherosclerosis 188:12-8. 2006
    ..The current document reviews this evidence, presenting a view of some degree of shared ancestry that may have implications for pathophysiology and cell biology...
  17. ncbi Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years
    Andrew D Blann
    University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Haemost 95:49-55. 2006
    ..Despite this, vWf remains the most important plasma marker of endothelial damage/dysfunction and as such attracts clinical attention...
  18. ncbi Platelets: the universal killer?
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Biochim Biophys Acta 1772:715-7. 2007
    ..Thus, one way forward in postponing an occlusive thrombotic event is to minimise platelet activation, new tools and treatments for which are eagerly sought...
  19. doi The angiome: a new concept in cancer biology
    A D Blann
    Department of Medicine, Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK
    J Clin Pathol 64:637-43. 2011
    ....
  20. doi Platelet activation as a marker of heart attack
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Clin Chim Acta 412:841-2. 2011
    ..If confirmed, this will be a major step forward in the management of acute chest pain...
  21. doi Increased levels of plasma haemoxygenase-1 in prostate cancer
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK
    Prostate Cancer Prostatic Dis 14:114-7. 2011
    ..This observation may have implications for the pathogenesis of prostate cancer...
  22. doi Microparticles and arterial disease
    Andrew Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, United Kingdom
    Semin Thromb Hemost 35:488-96. 2009
    ..This article reviews the definitions, mechanisms of production, and links with pathophysiology of MPs in arterial disease, and thus whether or not they can contribute to improved patient care...
  23. pmc The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants
    Andrew D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Vasc Health Risk Manag 5:693-704. 2009
    ..It will conclude with a brief synopsis of new agents which may supersede warfarin and heparin...
  24. ncbi Good analytical practice: statistics and handling data in biomedical science. A primer and directions for authors. Part 1: Introduction. Data within and between one or two sets of individuals
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Br J Biomed Sci 65:209-17. 2008
    ..e., statistical software packages), and will conclude with a statement on appropriate descriptors of data, their analyses, and presentation for authors considering submission of their data to this journal...
  25. ncbi Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Thromb Thrombolysis 25:185-9. 2008
    ..The correlation between sP-selectin and VEGF in SCD and HbSC disease is consistent with the view that VEGF is released from platelets during in vivo activation...
  26. ncbi Diagnosis, treatment and management of venous thromboembolism: recent developments relevant to biomedical scientists
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Biomed Sci 64:136-41. 2007
    ....
  27. ncbi Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease
    A D Blann
    Department of Haematology, City Hospital, Birmingham, B18 7QH, UK
    Br J Biomed Sci 64:124-6. 2007
    ..001), but only sP-selectin was higher in present sickle crisis (P<0.001). We suggest that increased NTBI associated with blood transfusion iron overload in SCD may promote platelet activation...
  28. ncbi Effects of C-reactive protein on the release of von Willebrand factor, E-selectin, thrombomodulin and intercellular adhesion molecule-1 from human umbilical vein endothelial cells
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 14:335-40. 2003
    ....
  29. ncbi Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity
    Andrew D Blann
    Department of Haematology, City Hospital, Birmingham B18 7QH, UK
    Blood Coagul Fibrinolysis 14:255-9. 2003
    ..Our data suggest that changes in endothelial and platelet function in sickle cell disease are unrelated to reduced antioxidant capacity...
  30. ncbi Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hematol 69:135-7. 2002
    ..In 24 type 1 VWD patients, VWF and P selectin correlated inversely (P = 0.005) but in 14 type 2 VWD patients there was no correlation (P = 0.997). These data imply major differences in VWF/P-selectin regulation between types 1 and 2 VWD...
  31. ncbi Soluble intercelluar adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke
    A Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 10:277-84. 1999
    ..These changes may perhaps be part of the complex pathophysiological responses to infarction and repair of brain tissue following stroke...
  32. ncbi von Willebrand factor and soluble thrombomodulin as predictors of adverse events among subjects with peripheral or coronary atherosclerosis
    A D Blann
    University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 10:375-80. 1999
    ..05). We conclude that von Willebrand factor is a marginally better predictor of cardiovascular events than soluble thrombomodulin...
  33. ncbi Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 12:43-50. 2001
    ..We conclude that the platelet marker soluble P-selectin is raised in both haematological and breast cancer, and is higher in the former, but is unrelated to the type or stage of breast cancer...
  34. ncbi Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response
    A D Blann
    University Department of Surgery, University Hospital of South Manchester, Manchester, UK
    Blood Coagul Fibrinolysis 13:165-8. 2002
    ..We conclude that raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation, and that raised vWf seems likely to be independent of the acute phase response...
  35. ncbi Differences in free and total tissue factor pathway inhibitor, and tissue factor in peripheral artery disease compared to healthy controls
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University, Department of Medicine, City Hospital, B18 7QH, Birmingham, UK
    Atherosclerosis 152:29-34. 2000
    ..21, P=0.178). We suggest that reduced levels of total TFPI and raised levels of TF may contribute to the process of atherogenesis and the increased risk of thrombosis among patients with cardiovascular disease...
  36. ncbi Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:647-51. 2002
    ..5-15) before drinking red wine to 16 ng/ml (interquartile range, 14-20) 4 h later (P = 0.0067). We conclude that an acute bolus of red wine, but not white wine, activates platelets but has no substantial effect on the endothelium...
  37. ncbi Racial background is a determinant of average warfarin dose required to maintain the INR between 2.0 and 3.0
    A Blann
    Department of Haematology, City Hospital, Birmingham
    Br J Haematol 107:207-9. 1999
    ..Despite small numbers, we conclude that racial background, but not body mass index, is a determinant of warfarin dosage. The reasons for this could be genetic, cultural (diet related), or both...
  38. ncbi Relationship between plasma markers of endothelial cell integrity and the Framingham cardiovascular disease risk-factor scores in apparently healthy individuals
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:513-8. 2002
    ....
  39. ncbi Relationship between endothelial cell markers and arterial stenosis in peripheral and carotid artery disease
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Thromb Res 97:209-16. 2000
    ..39, p = 0.008). Our data suggest that von Willebrand factor is the most sensitive marker of peripheral atherosclerosis and that none of the plasma markers seems to be a useful marker of the degree of carotid artery stenosis...
  40. ncbi Increased soluble P-selectin levels following deep venous thrombosis: cause or effect?
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Br J Haematol 108:191-3. 2000
    ..1 (95% CI 1. 2-3.6). These high levels may be a reflection of a generalized hypercoagulable state that, with factors such as the presence of persistent thrombin generation, could be responsible for excess platelet activation...
  41. ncbi Endothelial cell activation, injury, damage and dysfunction: separate entities or mutual terms?
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 11:623-30. 2000
    ..A better understanding of the events, including apoptosis, that lead to vascular dysfunction may be useful in developing our understanding of vascular biology...
  42. ncbi Increased platelet glycoprotein V levels in patients with coronary and peripheral atherosclerosis--the influence of aspirin and cigarette smoking
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 86:777-83. 2001
    ..Our data indicate that soluble gpV may be a useful new marker of platelet activation in atherosclerosis, but may be influenced by smoking status and blood pressure...
  43. ncbi Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:1160-3. 2001
    ..e., modulation of angiogenesis) by which lipid-lowering therapy may reduce cardiovascular events beyond lipid reduction alone...
  44. ncbi Soluble P selectin in systemic sclerosis: relationship with von Willebrand factor, autoantibodies and diffuse or localised/limited disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 109:203-6. 2003
  45. ncbi Increased serum VEGF in 13 children with Wilms' tumour falls after surgery but rising levels predict poor prognosis
    A D Blann
    University Department of Surgery, University Hospital of South Manchester, Nell Lane, Didsbury, M20 8LR, Manchester, UK
    Cancer Lett 173:183-6. 2001
    ..3 ng/ml (0.5-1.9) in the survivors and were 20.0 ng/ml (15-104) in those who died. These data indicate a rapid reduction in raised VEGF following surgery for Wilms' tumour, but that rising levels predict poor prognosis...
  46. ncbi Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]
    S K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 258:336-43. 2005
    ..Accordingly, the angiogenic growth factors VEGF, angiopoietin 1 and 2 (Ang 1 & 2) and soluble angiopoietin receptor Tie-2 in plasma and in platelets were assessed in terms of the presence or absence of hypertensive TOD...
  47. ncbi Platelet microparticles and soluble P selectin in peripheral artery disease: relationship to extent of disease and platelet activation markers
    Kiat T Tan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Ann Med 37:61-6. 2005
    ..Furthermore, we tested the hypothesis that PMP levels are correlated with other markers of platelet activation, such as soluble P-selectin, membrane bound P-selectin (CD62P) and 63...
  48. ncbi Elevated platelet microparticle levels in nonvalvular atrial fibrillation: relationship to p-selectin and antithrombotic therapy
    Anirban Choudhury
    City Hospital, Haemostasis, Thrombosis and Vascular Biology Unit, Dudley Rd, Birmingham, UK
    Chest 131:809-15. 2007
    ....
  49. ncbi Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management
    Dirk C Felmeden
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hypertens 16:11-20. 2003
    ..We hypothesized that these markers would correlate with the Framingham cardiovascular risk score and would be responsive to treatment...
  50. ncbi Relationship of homocysteine to markers of platelet and endothelial activation in "high risk" hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial
    Charles G C Spencer
    City Hospital Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, Birmingham B18 7QH, United Kingdom
    Int J Cardiol 94:293-300. 2004
    ..To examine the relationship between plasma homocysteine (HCY) and rheological, endothelial and platelet markers in "high risk" hypertensive patients...
  51. ncbi Relation of thrombogenesis in systemic hypertension to angiogenesis and endothelial damage/dysfunction (a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial [ASCOT])
    Dirk C Felmeden
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 92:400-5. 2003
    ..quot; Furthermore, these processes are beneficially affected by intensive blood pressure and lipid treatment...
  52. ncbi Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor
    Andrew J Makin
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Eur Heart J 25:371-6. 2004
    ....
  53. ncbi Circulating endothelial cells in atrial fibrillation with and without acute cardiovascular disease
    Bethan Freestone
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 94:702-6. 2005
    ..However, following clinical complications, such as stroke or significant haemodynamic compromise, further endothelial disturbance (as indicated by high levels of sTM and CECs) suggests additional endothelial damage...
  54. ncbi Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes
    Aun Yeong Chong
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 97:671-5. 2006
    ..High levels of vWF were associated with a worse short-term outcome. These endothelial markers were unrelated to plasma BNP levels and may imply a different release mechanism...
  55. ncbi Platelet surface CD62P and CD63, mean platelet volume, and soluble/platelet P-selectin as indexes of platelet function in atrial fibrillation: a comparison of "healthy control subjects" and "disease control subjects" in sinus rhythm
    Anirban Choudhury
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    J Am Coll Cardiol 49:1957-64. 2007
    ....
  56. ncbi Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II diabetes
    Andrew D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, U K
    Clin Sci (Lond) 102:187-94. 2002
    ..Our data point to changes in plasma levels of VEGF and its receptor sFlt-1 in diabetes and atherosclerosis that may have relevance for therapy and angiogenesis in these conditions...
  57. pmc Circulating endothelial cells and circulating progenitor cells in breast cancer: relationship to endothelial damage/dysfunction/apoptosis, clinicopathologic factors, and the Nottingham Prognostic Index
    Patrick K Y Goon
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Neoplasia 11:771-9. 2009
    ..These were compared with clinicopathophysiologic features and the Nottingham Prognostic Index (NPI). An additional blood sample was taken 6 to 8 weeks after surgery from 15 women to test the effect of tumor removal...
  58. ncbi Is the hypercoagulable state in atrial fibrillation mediated by vascular endothelial growth factor?
    Natali A Y Chung
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Stroke 33:2187-91. 2002
    ..We investigated their roles in chronic atrial fibrillation (AF), a condition also associated with increased risk of stroke and thromboembolism, as well as a prothrombotic or hypercoagulable state...
  59. ncbi Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients
    Graham J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Cancer Lett 251:296-301. 2007
    ..Abnormalities in coagulation/platelet activation and angiogenesis are present in all common human cancers. We hypothesized that surgical treatment of prostate cancer would modulate these abnormalities...
  60. ncbi High pulse pressure and nondipping circadian blood pressure in patients with coronary artery disease: Relationship to thrombogenesis and endothelial damage/dysfunction
    Kaeng W Lee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England, UK
    Am J Hypertens 18:104-15. 2005
    ....
  61. ncbi von Willebrand factor, fibrinogen and other plasma proteins as determinants of plasma viscosity
    A Blann
    Department of Medicine, The City Hospital, Birmingham, UK
    Atherosclerosis 139:317-22. 1998
    ..These data may have implications for the pathogenesis of cardiovascular disease...
  62. ncbi Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients
    Sunil Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England
    Am J Hypertens 19:970-7; discussion 978. 2006
    ....
  63. ncbi Circulating endothelial cells in acute ischaemic stroke
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 94:707-12. 2005
    ..The latter correlate well with established plasma markers of endothelial dysfunction or damage, thus unequivocally confirming severe vasculopathy in this condition. However, the greatest influence on CECs numbers was clinical group...
  64. ncbi Effects of percutaneous coronary intervention on peripheral venous blood circulating endothelial cells and plasma indices of endothelial damage/dysfunction
    Christopher J Boos
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Chest 132:1920-6. 2007
    ....
  65. ncbi Increased circulating endothelial cells in acute heart failure: comparison with von Willebrand factor and soluble E-selectin
    Aun Yeong Chong
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, United Kingdom
    Eur J Heart Fail 8:167-72. 2006
    ....
  66. ncbi Platelet-derived VEGF, Flt-1, angiopoietin-1 and P-selectin in breast and prostate cancer: further evidence for a role of platelets in tumour angiogenesis
    Graham J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Ann Med 36:273-7. 2004
    ..Recently, platelets have been postulated to have a major role in both these processes, suggesting that antiplatelet strategies may be useful in cancer treatment...
  67. ncbi Platelet activation, coagulation and angiogenesis in breast and prostate carcinoma
    Graham J Caine
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 92:185-90. 2004
    ..In conclusion, strong relationships between IL6 and VEGF, but not with coagulation or platelet markers, and release of VEGF from IL-6 stimulated platelets, suggest a role for inflammation and platelets in angiogenesis...
  68. ncbi Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor intervention
    Hoong Sern Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham, B18 7QH, England, UK
    Circulation 109:2524-8. 2004
    ....
  69. ncbi Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Thromb Haemost 92:1342-8. 2004
    ..Further study of platelet activation and the role of P-selectin is warranted...
  70. ncbi Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes
    Kaeng W Lee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Blood 105:526-32. 2005
    ..CECs at 48 hours were the only independent predictor of both death and MACE at 30 days and 1 year, indicating the crucial role of endothelial/vascular damage in ACS pathophysiology...
  71. ncbi Platelet adhesion in hypertension: application of a novel assay of platelet adhesion
    Sunil K Nadar
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Ann Med 37:55-60. 2005
    ..The increased risk of thromboembolism in hypertension may be related to a prothrombotic or hypercoagulable state, with abnormalities in haemostasis and platelet function...
  72. ncbi Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide
    Aun Yeong Chong
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England, UK
    Circulation 110:1794-8. 2004
    ..However, the relations between these parameters are unclear...
  73. ncbi Indices of angiogenesis, platelet activation, and endothelial damage/dysfunction in relation to ethnicity and coronary artery disease: differences in central versus peripheral levels
    Rumi J Jaumdally
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Ann Med 39:628-33. 2007
    ....
  74. ncbi Thrombomodulin, von Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 113:123-8. 2004
    ....
  75. ncbi Platelet P-selectin levels in relation to plasma soluble P-selectin and beta-thromboglobulin levels in atrial fibrillation
    Sridhar Kamath
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Stroke 33:1237-42. 2002
    ..pP-selectin was compared with sP-selectin and plasma beta-thromboglobulin levels (enzyme-linked immunosorbent assay). Results were compared with those of 23 healthy controls (mean [SD] age, 74 [9] years; 7 men) in sinus rhythm...
  76. ncbi Soluble E-selectin, von Willebrand factor, soluble thrombomodulin, and total body nitrate/nitrite product as indices of endothelial damage/dysfunction in paroxysmal, persistent, and permanent atrial fibrillation
    Bethan Freestone
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Chest 132:1253-8. 2007
    ..We hypothesized that the levels of these markers of endothelial function would be abnormal in patients with paroxysmal, persistent, and permanent AF...
  77. ncbi Platelet activation in coronary artery disease: intracardiac vs peripheral venous levels and the effects of angioplasty
    Rumi J Jaumdally
    University Department of Medicine, City Hospital, Haemostasis, Thrombosis, and Vascular Biology Unit, Dudley Rd, Birmingham B18 7QH, UK
    Chest 132:1532-9. 2007
    ..Furthermore, how percutaneous coronary interventions (PCIs) affect levels of peripheral/cardiac platelet indexes is unclear...
  78. ncbi Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention
    Hoong Sern Lim
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Diabetes Care 27:2918-24. 2004
    ....
  79. pmc Localisation of members of the vascular endothelial growth factor (VEGF) family and their receptors in human atherosclerotic arteries
    F Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Clin Pathol 57:266-72. 2004
    ..The existence of single or multiple VEGF isoforms and receptors suggests that these proteins may have overlapping but distinct functions, which may be reflected in their cell expression and distribution...
  80. ncbi Platelet activation in pregnancy-induced hypertension
    Ioannis Karalis
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Thromb Res 116:377-83. 2005
    ....
  81. ncbi Thrombogenesis, atherogenesis and angiogenesis in vascular disease: a new 'vascular triad'
    Gregory Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England
    Ann Med 36:119-25. 2004
    ..Indeed, we suggest that angiogenesis is an important aspect of the pathophysiology of cardiovascular disease, impacting with both thrombogenesis and atherogenesis, in a new vascular triad (the 'Birmingham vascular triad')...
  82. doi Circulating endothelial cells and rheumatoid arthritis: relationship with plasma markers of endothelial damage/dysfunction
    Will Foster
    University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Rheumatology (Oxford) 48:285-8. 2009
    ..We hypothesized altered CECs in patients with RA compared with community controls (CCs) and hospital controls (HCs, with diabetes and hypertension) correlate with established plasma markers of inflammation and of ECD...
  83. ncbi Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure
    Bernard S P Chin
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 90:1258-60. 2002
  84. ncbi Interleukin-6, tissue factor and von Willebrand factor in acute decompensated heart failure: relationship to treatment and prognosis
    Bernard S P Chin
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 14:515-21. 2003
    ..Improvement of symptoms and plasma markers after treatment of acute CHF and prediction of prognosis by the markers may be useful in the clinical setting...
  85. ncbi Interleukin-6, endothelial activation and thrombogenesis in chronic atrial fibrillation
    Vanessa Roldan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 24:1373-80. 2003
    ....
  86. ncbi Effects of "newer" and "older" antihypertensive drugs on hemorrheological, platelet, and endothelial factors. A substudy of the Anglo-Scandinavian Cardiac Outcomes Trial
    Charles G C Spencer
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Am J Hypertens 20:699-704. 2007
    ..Different antihypertensive therapies may exert benefits via not only a reduction in blood pressure but also in improving the risk of thrombosis...
  87. ncbi Plasma markers of endothelial damage/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes
    Kaeng W Lee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 94:1077-83. 2005
    ..These indices may further refine global risk stratification for short-term adverse cardiac events in these patients...
  88. ncbi Markers of inflammation in acute coronary syndromes: association with increased heart rate and reductions in heart rate variability
    Ali Hamaad
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine City Hospital, Birmingham, United Kingdom
    Clin Cardiol 28:570-6. 2005
    ..Systemic and vascular inflammation is at the heart of the thrombotic occlusion of coronary arteries...
  89. ncbi A reliable plasma marker of platelet activation: does it exist?
    David Gurney
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Am J Hematol 70:139-44. 2002
    ..Nevertheless, if our goal is to improve our ability to recognize and treat subjects with thrombotic disorders, then additional studies on these molecules may prove to be a sound investment...
  90. ncbi Plasma levels of tissue factor and soluble E-selectin in sickle cell disease: relationship to genotype and to inflammation
    Junette S Mohan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 1QH, UK
    Blood Coagul Fibrinolysis 16:209-14. 2005
    ..However, lack of correlation of sE-sel with inflammatory markers implies that other mechanisms are responsible for increased levels of this marker of endothelial activation...
  91. ncbi Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison
    Patrick K Y Goon
    Haemostasis Thrombosis and Vascular Biology Unit, City Hospital, Dudley Road, Birmingham, B18 7QH, United Kingdom
    Thromb Haemost 96:45-52. 2006
    ..The agreement between the two methods appears to weaken in healthy controls, and at lower and higher absolute CEC counts...
  92. ncbi A prospective randomized trial of aspirin-clopidogrel combination therapy and dose-adjusted warfarin on indices of thrombogenesis and platelet activation in atrial fibrillation
    Sridhar Kamath
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    J Am Coll Cardiol 40:484-90. 2002
    ..This study was designed to investigate whether or not combination aspirin-clopidogrel therapy would reduce markers of thrombogenesis and platelet activation in atrial fibrillation (AF), in a manner similar to warfarin...
  93. ncbi Platelet adhesion in breast cancer: development and application of a novel assay
    Graham J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 15:513-8. 2004
    ..This increase in platelet adhesiveness may be related to an increased risk of thromboembolism in these patients...
  94. ncbi Cancer and the prothrombotic state
    Gregory Y H Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    Lancet Oncol 3:27-34. 2002
    ..Further work is needed to examine the mechanisms leading to the prothrombotic state in cancer, the potential prognostic and treatment implications, and the possible value of quantifying indices of hypercoagulability in clinical practice...
  95. ncbi Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units
    S S Marwah
    The City Hospital NHS Trust, Birmingham, UK
    Vox Sang 82:122-6. 2002
    ..We hypothesized that this may be related to excess NTBI present in plasma-depleted red blood cell units that are free of clear haemolysis...
  96. ncbi Neither carvedilol nor bisoprolol in maximally tolerated doses has any specific advantage in lowering chronic heart failure oxidant stress: implications for beta-blocker selection
    Bernard S P Chin
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Clin Sci (Lond) 105:507-12. 2003
    ..Contrary to the proposed antioxidative effects of carvedilol, initiating and titrating such therapy did not result in a reduction in levels of LHP in CHF...
  97. doi Inflammation and microvascular and macrovascular endothelial dysfunction in rheumatoid arthritis: effect of treatment
    Will Foster
    University of Birmingham Centre for Cardiovascular Sciences, Department of Medicine, City Hospital, Birmingham, England
    J Rheumatol 37:711-6. 2010
    ..Although endothelial dysfunction in RA has been demonstrated by altered plasma markers, the relationships with macrovascular and microvascular function are relatively unexplored...
  98. ncbi Circulating endothelial cells in cardiovascular disease
    Christopher J Boos
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    J Am Coll Cardiol 48:1538-47. 2006
    ..This article presents an overview of the pathophysiology of CECs in the setting of cardiovascular disease and a brief comparison with EPCs...
  99. ncbi Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    J Am Coll Cardiol 44:415-22. 2004
    ..g., mass, volume and granularity, soluble P-selectin [sP-sel], and beta-thromboglobulin [beta-TG])...
  100. doi Prevalence of urinary and faecal incontinence among female members of the Hypermobility Syndrome Association (HMSA)
    A S Arunkalaivanan
    Department of Urogynaecology, City Hospital, Birmingham, UK
    J Obstet Gynaecol 29:126-8. 2009
    ..Increasing BMI but not age is associated with the higher ICIQ scores with reference to urinary incontinence, whereas both increasing age and BMI increases the risk of faecal incontinence in this group of women...
  101. ncbi Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study
    Martin J Landray
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Am J Kidney Dis 43:244-53. 2004
    ..Studies in the general population suggest that low-grade inflammation, endothelial dysfunction, and platelet activation are associated with an increased risk of cardiovascular events...