Research Topics
Species | Rosemary BlandSummaryAffiliation: University of Warwick Country: UK Publications
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Detail Information
Publications
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic isletsRosemary Bland
Department of Biological Sciences, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK
J Steroid Biochem Mol Biol 89:121-5. 2004..Therefore, we would postulate that local production of 1alpha,25(OH)(2)D(3) maybe an important autocrine link between Vitamin D status and pancreatic function...- High glucose up-regulates ENaC and SGK1 expression in HCD-cellsClaire E Hills
Molecular Physiology, Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Coventry, UK
Cell Physiol Biochem 18:337-46. 2006..However, the mechanisms by which glucose alters sodium re-uptake have not been fully characterised... 
Serum and glucocorticoid regulated kinase and disturbed renal sodium transport in diabetesClaire E Hills
Department of Biological Sciences, Biomedical Research Institute, The University of Warwick, Coventry CV4 7AL, UK
J Endocrinol 199:343-9. 2008..This short commentary considers the evidence that supports the involvement of SGK1 in diabetic hypertension, but also discusses how aberrant sodium reabsorption may account for the cellular changes seen in the nephron...- Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosisGuerman Molostvov
The Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
Cell Physiol Biochem 22:413-22. 2008..05). In conclusion, stimulation of CaSR leads to activation of MEK1/ERK1,2 and PLC pathways and up-regulation of cell proliferation. CaSR-mediated PLC activation is important for SMC survival and protection against apoptosis... 
Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammationDaniel Zehnder
Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK mail
Kidney Int 74:1343-53. 2008..Our study indicates that renal inflammation is associated with decreased serum vitamin D metabolites and involves activation of the paracrine/autocrine vitamin D system...- Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathyClaire E Hills
School of Life Sciences, The University of Warwick, Coventry CV4 7AL, UK
Exp Diabetes Res 2012:936518. 2012..In the current study, we examine the functional expression of TRPV4 channels in cell volume regulation in cells of the human collecting duct... - Expression and role of the calcium-sensing receptor in the blood vessel wallGuerman Molostvov
The Clinical Sciences Research Institute, Warwick Medical School and Department of Biological Sciences, The University of Warwick, Coventry, UK
Curr Pharm Biotechnol 10:282-8. 2009..Further detailed analysis will clarify the role the vascular CaSR plays as a therapeutic target for complex disease conditions such as hypertension, tissue hypoperfusion, atherosclerosis and vascular calcification... - Glucose-evoked alterations in connexin43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathyClaire E Hills
Molecular Physiology, Biomedical Research Institute, Dept of Biological Sciences, Univ of Warwick, Coventry, CV4 7AL, UK
Am J Physiol Renal Physiol 291:F1045-51. 2006..Cx43 expression and cell-to-cell communication increased in response to high glucose and may protect the collecting duct from renal damage associated with more established diabetic nephropathy... - Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cellsMartin Hewison
Department of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
J Immunol 170:5382-90. 2003..In conclusion, differential regulation of endogenous 1 alpha 25(OH)(2)D(3) ligand and its nuclear receptor appear to be important regulators of DC biology and represent potential targets for the manipulation of DC function... - Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase CNeil S Holden
Airways Inflammation Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Cell Signal 20:1338-48. 2008.... - Extracellular calcium-sensing receptor is functionally expressed in human arteryGuerman Molostvov
Clinical Sciences Research Institute, University of Warwick, Coventry, UK
Am J Physiol Renal Physiol 293:F946-55. 2007..Expression was significantly lower in arteries from ESRD patients. In conclusion, these data not only demonstrate the presence of a functional CaSR in human artery but show a correlation between CaSR expression and progression of CKD... - Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3)Petra Bareis
Department of Pathophysiology, University of Vienna Medical School, Austria
Exp Cell Res 276:320-7. 2002.... - Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesionDaniel Zehnder
Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
J Am Soc Nephrol 13:621-9. 2002..The rapid induction of endothelial 1alpha-OHase activity by inflammatory cytokines suggests a novel autocrine/paracrine role for the enzyme, possibly as a modulator of endothelial cell adhesion...