Affiliation: University of Birmingham
- Steroid hormone receptor expression and action in boneR Bland
Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
Clin Sci (Lond) 98:217-40. 2000..Finally, the role that future developments, such as steroid hormone receptor knockout mice, will play in our understanding of steroid hormone action in bone is considered...
- Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activationM S Cooper
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, United Kingdom
J Bone Miner Res 16:1037-44. 2001..Therefore, it can be postulated that some of the effects of proinflammatory cytokines within bone (e.g., periarticular erosions in inflammatory arthritis) are mediated by this mechanism...
- Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylaseD Zehnder
Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom B15 2TH
J Clin Endocrinol Metab 86:888-94. 2001..However, the discrete patterns of staining in these tissues emphasizes a possible role for 1 alpha-hydroxylase as an intracrine modulator of vitamin D function in peripheral tissues...
- Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human boneM S Cooper
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
Bone 27:375-81. 2000..In particular, variation in 11beta-HSD isozyme expression and activity may explain individual variation in susceptibility to glucocorticoid-induced osteoporosis...