Research Topics
| R J BlairSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Selective impairment in the recognition of anger induced by diazepamR J Blair
Institute of Cognitive Neuroscience, London, UK
Psychopharmacology (Berl) 147:335-8. 1999..Given this functional specialization of expression processing, it is plausible that these neurocognitive systems may also be dissociable pharmacologically...- Impaired social response reversal. A case of 'acquired sociopathy'R J Blair
Institute of Cognitive Neuroscience and Department of Psychology, University College London, UK
Brain 123:1122-41. 2000..Moreover, it is proposed that the orbitofrontal cortex may be implicated specifically either in the generation of these expectations or the use of these expectations to suppress inappropriate behaviour... - Fractionation of visual memory: agency detection and its impairment in autismR J R Blair
Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, WC1H 3AR, London, UK
Neuropsychologia 40:108-18. 2002..The data is interpreted in terms of reduced sensitivity to agency cues in individuals with autism and general information processing capacity... 
Neurocognitive models of aggression, the antisocial personality disorders, and psychopathyR J Blair
Institute of Cognitive Neuroscience and Department of Psychology, University College London, UK
J Neurol Neurosurg Psychiatry 71:727-31. 2001....- A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendenciesR J Blair
Institute of Cognitive Neuroscience, University College London, England
J Abnorm Child Psychol 29:491-8. 2001..These results are interpreted with reference to an amygdala and empathy impairment explanation of psychopathy... - Somatic markers and response reversal: is there orbitofrontal cortex dysfunction in boys with psychopathic tendencies?R J Blair
Institute of Cognitive Neuroscience, University College London, England
J Abnorm Child Psychol 29:499-511. 2001..However, there were no group differences on the ID/ED task either for response reversal or extradimensional set shifting. The implications of these results for models of psychopathy are discussed... - Recognition of emotion in facial expressions and vocal tones in children with psychopathic tendenciesD Stevens
Department of Psychology, University College London, England
J Genet Psychol 162:201-11. 2001..The results are interpreted with reference to the suggestion that the development of psychopathic tendencies may reflect early amygdala dysfunction (R. J. R. Blair, J. S. Morris, C. D. Frith, D. I. Perrett, & R. Dolan, 1999)... - Instrumental learning and relearning in individuals with psychopathy and in patients with lesions involving the amygdala or orbitofrontal cortexD G V Mitchell
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Neuropsychology 20:280-9. 2006..The results are interpreted with reference to current neurocognitive models of stimulus-reinforcement learning, relearning, and developmental psychopathy... - Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletionAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 189:387-94. 2006..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed... - The impact of processing load on emotionD G V Mitchell
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Neuroimage 34:1299-309. 2007..Together, the data suggest that the processing of task-irrelevant emotional information, like neutral information, is subject to the effects of processing load and is under top-down control... - Dysfunctions of medial and lateral orbitofrontal cortex in psychopathyR J R Blair
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1121:461-79. 2007..It is suggested that the impairment in the role of medial OFC in prediction error signaling and the detection of contingency change may underlie the impairments in flexible behavioral change seen in psychopathy... - Deficits in facial affect recognition among antisocial populations: a meta-analysisAbigail A Marsh
National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neurosci Biobehav Rev 32:454-65. 2008..This impairment cannot be attributed solely to task difficulty. These results suggest dysfunction among antisocial individuals in specified neural substrates, namely the amygdala, involved in processing fearful facial affect... - The role of 5-HTTLPR in choosing the lesser of two evils, the better of two goods: examining the impact of 5-HTTLPR genotype and tryptophan depletion in object choiceK S Blair
Department of Health and Human Services, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 300A, MSC 2670, Bethesda, MD 20892 2670, USA
Psychopharmacology (Berl) 196:29-38. 2008..The serotonin (5-HT) system is considered important for decision-making. However, its role in reward- and punishment-based processing has not yet been clearly determined... - Fine cuts of empathy and the amygdala: dissociable deficits in psychopathy and autismR J R Blair
Anxiety Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Q J Exp Psychol (Hove) 61:157-70. 2008..It is concluded that while both conditions can be considered disorders of social cognition, fine cuts can be made dissociating the impairments associated with each... - The interference of operant task performance by emotional distracters: an antagonistic relationship between the amygdala and frontoparietal corticesD G V Mitchell
Department of Psychiatry and Department of Anatomy and Cell Biology, The University of Western Ontario, London, Canada
Neuroimage 40:859-68. 2008.... 
Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disordersAbigail A Marsh
Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:712-20. 2008..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...- Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disordersKarina Blair
Mood and Anxiety Program, NIMH, NIH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:1193-202. 2008..Functional magnetic resonance imaging assessed the neural response to facial expressions in generalized social phobia and generalized anxiety disorder... - The emergence of psychopathy: implications for the neuropsychological approach to developmental disordersR J R Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, USA
Cognition 101:414-42. 2006..However, caveats to the neuropsychological approach with reference to this disorder are noted... - Divergent patterns of aggressive and neurocognitive characteristics in acquired versus developmental psychopathyD G V Mitchell
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neurocase 12:164-78. 2006.... - Theory of mind and psychopathy: can psychopathic individuals read the 'language of the eyes'?R A Richell
Institute of Cognitive Neuroscience, Department of Psychology, University College, London, UK
Neuropsychologia 41:523-6. 2003..Results indicated that the psychopathic individuals did not present with any generalised impairment in ToM. The data are discussed with reference to the putative neural system mediating performance on this task and models of psychopathy... - Facial expressions, their communicatory functions and neuro-cognitive substratesR J R Blair
Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
Philos Trans R Soc Lond B Biol Sci 358:561-72. 2003..In acquired sociopathy, the response to angry expressions in particular is attenuated resulting in reduced regulation of social behaviour... - The roles of orbital frontal cortex in the modulation of antisocial behaviorR J R Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 206, MSC 2670, Bethesda, MD 20892 2670, USA
Brain Cogn 55:198-208. 2004..Impairments in response reversal are also seen in psychopathic individuals. However, it remains unclear whether impairment in response reversal per se is associated with antisocial behavior... - Response reversal and children with psychopathic tendencies: success is a function of salience of contingency changeS Budhani
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Heath, Department of Health and Human Services, Bethesda, Maryland 20892-2670, USA
J Child Psychol Psychiatry 46:972-81. 2005..CONCLUSIONS: We suggest that this data is consistent with suggestions of subtle orbital frontal cortex impairment in children with psychopathic tendencies... - Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populationsR J R Blair
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Room 206, MSC 2670, Bethesda, MD 20892 2670, USA
Conscious Cogn 14:698-718. 2005..In contrast, individuals with psychopathy show clear difficulties with a specific form of emotional empathy but no indications of impairment with cognitive and motor empathy... - Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorderTristan Gorrindo
Mood and Anxiety Program, National Institute of Mental Health, Bldg. 10, Rm. 4N-208, 10 Center Dr.-MSC 1255, Bethesda, MD 20892-1255, USA
Am J Psychiatry 162:1975-7. 2005..CONCLUSIONS: Children with bipolar disorder may have a reversal learning deficit... - Applying a cognitive neuroscience perspective to the disorder of psychopathyR J R Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Dev Psychopathol 17:865-91. 2005..Some directions for future work are considered... - The development of psychopathyR J R Blair
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Heath, Department of Health and Human Services, Bethesda, MD, USA
J Child Psychol Psychiatry 47:262-76. 2006..These impairments disrupt the impact of standard socialization techniques and increase the risk for frustration-induced reactive aggression respectively... - Differentiating among prefrontal substrates in psychopathy: neuropsychological test findingsK S Blair
National Institute of Mental Health and University College, London, UK
Neuropsychology 20:153-65. 2006..In contrast, the 2 groups did not show impairment on the measures preferentially sensitive to the functioning of the DLPFC or ACC. These results are interpreted with reference to executive dysfunction accounts of the disorder... - Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxietyAmanda E Guyer
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 65:1303-12. 2008..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening...