D Timothy Bishop

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
  2. pmc An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study
    Benjamin D Brown
    Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, UK
    BMC Med 8:5. 2010
  3. pmc Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data
    Juliette A Randerson-Moor
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Eur J Cancer 45:3271-81. 2009
  4. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
  5. pmc Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
  6. pmc A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes
    Yu Mei Chang
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, United Kingdom
    Int J Cancer 124:420-8. 2009
  7. pmc The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James s Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Cancer Causes Control 22:1471-82. 2011
  8. pmc Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Cancer 47:732-41. 2011
  9. ncbi request reprint No Evidence for BRAF as a melanoma/nevus susceptibility gene
    Sharon Jackson
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:913-8. 2005
  10. pmc Patterns of expression of DNA repair genes and relapse from melanoma
    Rosalyn Jewell
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 16:5211-21. 2010

Detail Information

Publications41

  1. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  2. pmc An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study
    Benjamin D Brown
    Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, UK
    BMC Med 8:5. 2010
    ....
  3. pmc Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data
    Juliette A Randerson-Moor
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Eur J Cancer 45:3271-81. 2009
    ..03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression...
  4. pmc Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett Street, Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2043-54. 2010
    ..Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk...
  5. pmc Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
    ..6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series...
  6. pmc A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes
    Yu Mei Chang
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, United Kingdom
    Int J Cancer 124:420-8. 2009
    ..The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes...
  7. pmc The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, St James s Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Cancer Causes Control 22:1471-82. 2011
    ..We report the determinants of serum levels of vitamin D in a U.K. melanoma case-control study benefitting from detailed exposure and genotyping data...
  8. pmc Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Cancer 47:732-41. 2011
    ..A melanoma case-control study was conducted to elucidate the complex relationship between sun exposure and risk...
  9. ncbi request reprint No Evidence for BRAF as a melanoma/nevus susceptibility gene
    Sharon Jackson
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:913-8. 2005
    ..In addition, we found that there was no association between the BRAF genotype and mean total number of banal or atypical nevi in either the cases or controls...
  10. pmc Patterns of expression of DNA repair genes and relapse from melanoma
    Rosalyn Jewell
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 16:5211-21. 2010
    ..To use gene expression profiling of formalin-fixed primary melanoma samples to detect expression patterns that are predictive of relapse and response to chemotherapy...
  11. pmc Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 49:425-38. 2010
    ..There was no association between reduced gene dosage at 9p21.3 and subtype or site of tumor. This study presents supportive evidence that CDKN2B, P14ARF, and CDKN2A may all play a tumor suppressor role in melanoma progression...
  12. pmc A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)
    Mark Harland
    Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
    Eur J Cancer 44:1269-74. 2008
    ..The relatively low rate of CDKN2A mutation detection is not due to failure to detect mutations and implies the existence of other high penetrance melanoma susceptibility genes...
  13. pmc Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Pigment Cell Melanoma Res 25:384-94. 2012
    ..78; 95% CI, 0.65-0.94) with some support from the nine smaller data sets considered together (HR, 0.83; 95% CI, 0.67-1.04). The data are suggestive of a survival benefit for inherited MC1R variants in melanoma patients...
  14. pmc Analysis of variants in DNA damage signalling genes in bladder cancer
    Ananya Choudhury
    Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, Leeds, LS9 7TF, UK
    BMC Med Genet 9:69. 2008
    ..We hypothesized that SNPs in DSB signalling genes may modulate predisposition to bladder cancer and influence the effects of environmental exposures...
  15. ncbi request reprint Prevalence of 9p21 deletions in UK melanoma families
    Sushila H Mistry
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre in Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Genes Chromosomes Cancer 44:292-300. 2005
    ..Deletions at 9p21 are rare and explain only a small proportion of melanoma susceptibility. This study is the first to comprehensively exclude deletions in melanoma-prone families with no previously identified CDKN2A mutations...
  16. pmc Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls
    Yu Mei Chang
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK
    Int J Epidemiol 38:814-30. 2009
    ..Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude...
  17. ncbi request reprint An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype
    Chandra Gooptu Bertram
    Genetic Epidemiology Division, Cancer Research UK, Cancer Genetics Building, St James s University Hospital, Leeds, UK
    J Invest Dermatol 122:429-32. 2004
    ..The previous association between XRCC3 and melanoma may be a result of the choice of control group and we emphasize the need for appropriate choice of controls...
  18. pmc MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer
    Ananya Choudhury
    Sections of Experimental Oncology and Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Genome Variation Laboratory Service, Leeds, United Kingdom
    Cancer Res 70:7017-26. 2010
    ..MRE11 expression may ultimately allow patient selection for radiotherapy or cystectomy, thus improving overall cure rates...
  19. pmc The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes
    Mark T W Teo
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
    Carcinogenesis 33:581-6. 2012
    ..If validated, these findings may give further insight into the biology of bladder carcinogenesis, allow testing of the RAD51 SNP as a potential predictive biomarker and also reveal potential targets for new cancer treatments...
  20. pmc Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett St, Leeds LS9 7TF, United Kingdom
    J Clin Oncol 27:5439-44. 2009
    ..A cohort study was carried out to test the hypothesis that higher vitamin D levels reduce the risk of relapse from melanoma...
  21. pmc DNA repair gene XRCC1 polymorphisms and bladder cancer risk
    Sei Chung Sak
    Molecular Radiobiology Group, Section of Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Genet 8:13. 2007
    ..To clarify the situation, we conducted a comprehensive analysis of 14 XRCC1 polymorphisms in a case-control study involving more than 1100 subjects...
  22. doi request reprint An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study
    John R Davies
    Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK
    Pigment Cell Melanoma Res 27:234-43. 2014
    ..The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing Mendelian randomization. ..
  23. pmc A variant in FTO shows association with melanoma risk not due to BMI
    Mark M Iles
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 45:428-32, 432e1. 2013
    ..This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity...
  24. ncbi request reprint Sun-protective behaviors in families at increased risk of melanoma
    Julia A Newton Bishop
    Genetic Epidemiology Division, Cancer Research UK, St James s University Hospital, Leeds, UK
    J Invest Dermatol 127:1343-50. 2007
    ....
  25. ncbi request reprint Management of familial melanoma
    Julia Newton Bishop
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Lancet Oncol 8:46-54. 2007
    ..Prevention advice to families relates to moderation of sun exposure and self-examination of naevi, although there are few supportive data...
  26. doi request reprint Do vitamin A serum levels moderate outcome or the protective effect of vitamin D on outcome from malignant melanoma?
    Sinead Field
    Section of Epidemiology and Biostatistics, Leeds Institute of Cancer Studies and Pathology, University of Leeds, Cancer Genetics Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom Electronic address
    Clin Nutr 32:1012-6. 2013
    ..Vitamin A metabolites and vitamin D bind to the same heterodimeric receptor. We report a study testing the hypothesis that high vitamin A levels may reduce the protective effect of vitamin D on outcome...
  27. pmc Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression
    Nils Schoof
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    PLoS ONE 6:e29451. 2011
    ..As one of the first attempts to replicate a pathway-level association, our results suggest that low power and heterogeneity may present challenges...
  28. pmc Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival
    Caroline Conway
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 15:6939-46. 2009
    ..The purpose of this study was to evaluate the Illumina DASL Array Human Cancer Panel for gene expression studies in formalin-fixed melanoma primary tumors and to identify prognostic biomarkers...
  29. pmc Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations
    Nicola Ingram
    Section of Molecular Gastroenterology, Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, LS9 7TF, UK
    Carcinogenesis 34:2341-9. 2013
    ..These results should prompt evaluation of the effect of pharmacological manipulation of IL-4R signalling on future CRC risk and for CRC treatment. ..
  30. pmc Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients
    Boling Qiao
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, Leeds LS9 7TF, UK
    BMC Med Genet 12:84. 2011
    ..618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if these two 3'UTR variants can affect mRNA stability and assessed the impact of all three variants on mRNA and protein expression...
  31. ncbi request reprint Intronic sequence variants of the CDKN2A gene in melanoma pedigrees
    Mark Harland
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, England
    Genes Chromosomes Cancer 43:128-36. 2005
    ..IVS1 + 1104 was shown to result in the aberrant splicing of both p16(INK4a) and p14(ARF) mRNA. Overall, however, the proportion of English melanoma families with these variants is small...
  32. ncbi request reprint An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele
    Chandra G Bertram
    Division of Genetic Epidemiology, Cancer Research UK Clinical Center in Leeds, St James s University Hospital, Leeds, U K
    J Invest Dermatol 119:961-5. 2002
    ..5 nevi in those without, p = 0.02). After allowing for potential confounders this was not evident in the population-based sample...
  33. ncbi request reprint The genetics of susceptibility to cutaneous melanoma
    Julia A Newton Bishop
    Division of Genetic Epidemiology, Cancer Research UK, St James s Hospital, Leeds, UK
    Drugs Today (Barc) 41:193-203. 2005
    ..There is evidence of one at 1p22. The Melanoma Genetics Consortium (www.genomel.org) continues to explore this and the genetic epidemiology of the CDKN2A locus...
  34. ncbi request reprint Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer
    Faye Turner
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Int J Cancer 112:259-64. 2004
    ..06), GSTP1 (p=0.16, with p=0.02 after adjustment for potential confounders) and NQO1 predicted phenotype (p=0.01). Because of the multiple hypotheses tested in our study, these findings require independent confirmation...
  35. ncbi request reprint The effect of sun exposure in determining nevus density in UK adolescent twins
    Rachel C Wachsmuth
    Genetic Epidemiology Division, Cancer Research UK, St James s University Hospital, Leeds, UK
    J Invest Dermatol 124:56-62. 2005
    ..Of the 25% of variation attributable to environmental influences, one-third is estimated to be because of sun exposure on hot holidays...
  36. ncbi request reprint Geographical variation in the penetrance of CDKN2A mutations for melanoma
    D Timothy Bishop
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    J Natl Cancer Inst 94:894-903. 2002
    ..We examined the penetrance of such mutations using data from eight groups from Europe, Australia and the United States that are part of The Melanoma Genetics Consortium...
  37. pmc Strategies for selecting subsets of single-nucleotide polymorphisms to genotype in association studies
    Joe M Butler
    Cancer Research UK Genetic Epidemiology Division, University of Leeds, Cancer Genetics Building, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    BMC Genet 6:S72. 2005
    ..An initial sample size of 50 individuals is sufficient in most situations investigated, which involved selection from a set of 7 SNPs, although to select a larger number of SNPs, a larger initial sample size may be required...
  38. pmc Environmental risk factors for relapse of melanoma
    Samantha Beswick
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, United Kingdom
    Eur J Cancer 44:1717-25. 2008
    ..To identify lifestyle factors affecting risk of relapse...
  39. doi request reprint Design considerations for genetic linkage and association studies
    Jeremie Nsengimana
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Cancer Genetics Building, Leeds, UK
    Methods Mol Biol 850:237-62. 2012
    ..Differential bias could be a more serious threat and must be minimised by strictly controlling all the aspects of DNA acquisition, storage, and processing...
  40. ncbi request reprint Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
    Gillian P Crockford
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Hum Mol Genet 15:443-51. 2006
    ..Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease...
  41. ncbi request reprint Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia
    Jeremie Nsengimana
    Genetic Epidemiology Division, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Hum Genet 15:313-9. 2007
    ..Candidate genes include the interleukin 1 cluster and two potential regulators of high-density lipoprotein cholesterol level, PLA2R1 and OSBPL6...