Research Topics
| J BirksSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Donepezil for mild cognitive impairmentJ Birks
University of Oxford, Department of Clinical Geratology, Radcliffe Infirmary, Woodstock Road, Oxford, UK OX2 6HE
Cochrane Database Syst Rev 3:CD006104. 2006..Donepezil (Aricept, E2020), a cholinesterase inhibitor, has been shown to benefit all severities of AD including mild and it would be reasonable to investigate its efficacy for those with MCI...- Investigational treatment for vascular cognitive impairmentJacqueline Birks
University of Oxford, Cochrane Dementia and Cognitive Improvement Group, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
Expert Opin Investig Drugs 16:647-58. 2007..For the purposes of this review, the authors focus on interventions that have been evaluated by randomised controlled trials... - Vitamin B12 and folate deficiency in later lifeRobert Clarke
Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
Age Ageing 33:34-41. 2004..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom... - Screening for vitamin B-12 and folate deficiency in older personsRobert Clarke
Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 77:1241-7. 2003..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency... - Low vitamin B-12 status and risk of cognitive decline in older adultsRobert Clarke
Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 86:1384-91. 2007..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline... - Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalaminRobert Clarke
Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
Clin Chem 53:963-70. 2007..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)... - Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 studyHarold Hin
Hightown Surgery, Hightown Gardens, Banbury, UK
Age Ageing 35:416-22. 2006..Large-scale trials of vitamin B12 supplementation are required to assess the clinical significance of these associations... - Does donepezil improve well-being for dementia due to Alzheimer's disease?Jacqueline Birks
Cochrane Neurological Network
Neuroepidemiology 24:168-9. 2005 - Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trialsAnne Whitehead
The University of Reading, Medical and Pharmaceutical Statistics Research Unit, Reading, UK
Int J Geriatr Psychiatry 19:624-33. 2004..The objective was to evaluate the efficacy and tolerability of donepezil (5 and 10 mg/day) compared with placebo in alleviating manifestations of mild to moderate Alzheimer's disease (AD)... - Evidence-based pharmacotherapy of Alzheimer's diseaseJohn Grimley Evans
Cochrane Dementia and Cognitive Improvement Group, University of Oxford, UK
Int J Neuropsychopharmacol 7:351-69. 2004..Memantine has been licensed in Europe for treatment of patients with moderately severe to severe Alzheimer's disease... - For debate: is the evidence for the efficacy of cholinesterase inhibitors in the symptomatic treatment of Alzheimer's disease convincing or not?David Ames
Department of Psychiatry, University of Melbourne, Australia
Int Psychogeriatr 20:259-92. 2008 - Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly populationAngela M Devlin
Department of Internal Medicine, University of California, Davis, Davis, CA, USA
Am J Clin Nutr 83:708-13. 2006..Homocysteine concentrations are influenced by vitamin status and genetics, especially several polymorphisms in folate-metabolizing genes...