Adrian Bird

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells
    Rodoniki Athanasiadou
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e9937. 2010
  2. pmc Orphan CpG islands identify numerous conserved promoters in the mammalian genome
    Robert S Illingworth
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 6:e1001134. 2010
  3. pmc Engineering a high-affinity methyl-CpG-binding protein
    Helle F Jørgensen
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Nucleic Acids Res 34:e96. 2006
  4. ncbi request reprint DNA methylation patterns and epigenetic memory
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Genes Dev 16:6-21. 2002
  5. doi request reprint The methyl-CpG-binding protein MeCP2 and neurological disease
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King s Buildings, Edinburgh, Scotland, UK
    Biochem Soc Trans 36:575-83. 2008
  6. ncbi request reprint Adrian Bird
    Adrian Bird
    The Welcome Trust Centre for Cell Biology, School of Biological Sciences, Edenburgh University, Edinburgh, UK
    Curr Biol 17:R393-4. 2007
  7. doi request reprint DNA methylation landscapes: provocative insights from epigenomics
    Miho M Suzuki
    The Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Rev Genet 9:465-76. 2008
  8. doi request reprint The dinucleotide CG as a genomic signalling module
    Adrian Bird
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    J Mol Biol 409:47-53. 2011
  9. ncbi request reprint Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR Scotland, UK
    Mamm Genome 10:906-12. 1999
  10. pmc Cell type-specific DNA methylation at intragenic CpG islands in the immune system
    Aimée M Deaton
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    Genome Res 21:1074-86. 2011

Collaborators

Detail Information

Publications64

  1. pmc Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells
    Rodoniki Athanasiadou
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e9937. 2010
    ..Analysis of the Oct-4 regulatory domain as a whole has allowed us to detect targeted de novo methylation and to refine our understanding the roles of key protein components in this process...
  2. pmc Orphan CpG islands identify numerous conserved promoters in the mammalian genome
    Robert S Illingworth
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 6:e1001134. 2010
    ..The data indicate that orphan CGIs correspond to previously undetected promoters whose transcriptional activity may play a functional role during development...
  3. pmc Engineering a high-affinity methyl-CpG-binding protein
    Helle F Jørgensen
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Nucleic Acids Res 34:e96. 2006
    ..We propose that poly-MBD proteins are sensitive reagents for the detection of DNA methylation levels in isolated native DNA and for cytological detection of chromosomal CpG methylation...
  4. ncbi request reprint DNA methylation patterns and epigenetic memory
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Genes Dev 16:6-21. 2002
  5. doi request reprint The methyl-CpG-binding protein MeCP2 and neurological disease
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King s Buildings, Edinburgh, Scotland, UK
    Biochem Soc Trans 36:575-83. 2008
    ..Future studies of MeCP2 promise to shed light upon brain function, neurological disease and the biology of DNA methylation...
  6. ncbi request reprint Adrian Bird
    Adrian Bird
    The Welcome Trust Centre for Cell Biology, School of Biological Sciences, Edenburgh University, Edinburgh, UK
    Curr Biol 17:R393-4. 2007
  7. doi request reprint DNA methylation landscapes: provocative insights from epigenomics
    Miho M Suzuki
    The Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Rev Genet 9:465-76. 2008
    ..Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes...
  8. doi request reprint The dinucleotide CG as a genomic signalling module
    Adrian Bird
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    J Mol Biol 409:47-53. 2011
    ..Thus, CG, despite its simplicity, has the properties of a genome-wide signalling module that adds a layer of positive or negative control over gene expression...
  9. ncbi request reprint Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King s Buildings, Edinburgh EH9 3JR Scotland, UK
    Mamm Genome 10:906-12. 1999
    ..The Mbd1 and Mbd2 genes, in contrast, map together to murine and human Chromosomes (Chrs)18. The Mbd3 and Mbd4 genes map to murine Chrs 10 and 6, respectively, while the human MBD3 and MBD4 genes map to Chrs 19 and 3, respectively...
  10. pmc Cell type-specific DNA methylation at intragenic CpG islands in the immune system
    Aimée M Deaton
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    Genome Res 21:1074-86. 2011
    ....
  11. pmc Active repression of methylated genes by the chromosomal protein MBD1
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 20:1394-406. 2000
    ..Thus, the deacetylase-dependent pathway by which MBD1 actively silences methylated genes is likely to be different from that utilized by the methylation-dependent repressors MeCP1 and MeCP2...
  12. pmc Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells
    Thomas Clouaire
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, United Kingdom
    Genes Dev 26:1714-28. 2012
    ..Our results demonstrate that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3...
  13. pmc CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    John P Thomson
    Wellcome Trust Centre for Cell Biology, Michael Swann Building, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
    Nature 464:1082-6. 2010
    ..The data indicate that a primary function of non-methylated CGIs is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins...
  14. ncbi request reprint Reversal of neurological defects in a mouse model of Rett syndrome
    Jacky Guy
    Wellcome Trust Centre for Cell Biology, Edinburgh University, King s Buildings, Edinburgh EH9 3JR, UK
    Science 315:1143-7. 2007
    ....
  15. ncbi request reprint Molecular biology. MeCP2 repression goes nonglobal
    Robert Klose
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Science 302:793-5. 2003
  16. pmc Mbd2 contributes to DNA methylation-directed repression of the Xist gene
    Helen Barr
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh, United Kingdom
    Mol Cell Biol 27:3750-7. 2007
    ..The presence of redundant mechanisms to enforce repression at Xist and other loci is compatible with the hypothesis that "stacking" of imperfect repressive tendencies may be an evolutionary strategy to ensure leakproof gene silencing...
  17. pmc Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows
    Hélène Cheval
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Hum Mol Genet 21:3806-14. 2012
    ..Unexpectedly, we identified a later age threshold (30-45 weeks) beyond which an 80% reduction in MeCP2 is incompatible with life. This finding suggests an enhanced role for MeCP2 in the aging brain...
  18. ncbi request reprint Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    X Nan
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nature 393:386-9. 1998
    ..The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2...
  19. ncbi request reprint MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    X Nan
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Cell 88:471-81. 1997
    ..These properties, together with the abundance of MeCP2 and the high frequency of its 2 bp binding site, suggest a role as a global transcriptional repressor in vertebrate genomes...
  20. ncbi request reprint MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Nat Genet 23:58-61. 1999
    ..12). In our hands, MBD2 does not demethylate DNA. Our data suggest that HeLa cells, which lack the known methylation-dependent repressor MeCP2, use an alternative pathway involving MBD2 to silence methylated genes...
  21. pmc CpG methylation is targeted to transcription units in an invertebrate genome
    Miho M Suzuki
    The Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    Genome Res 17:625-31. 2007
    ..The results lend support to the hypothesis that CpG methylation functions to suppress spurious transcriptional initiation within infrequently transcribed genes...
  22. ncbi request reprint Nonmethylated transposable elements and methylated genes in a chordate genome
    M W Simmen
    Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, UK
    Science 283:1164-7. 1999
    ..Cytosine methylation in this urochordate may be preferentially directed to genes...
  23. pmc MBD2 is required for correct spatial gene expression in the gut
    Jennifer Berger
    Wellcome Trust Centre for Cell Biology, Edinburgh University, The King s Buildings, Mayfield Road, Edinburgh, United Kingdom
    Mol Cell Biol 27:4049-57. 2007
    ..The results suggest that modulation of MBD2 during gut development establishes a region-specific gene expression pattern that is essential for establishing correct segmental character...
  24. pmc Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome
    Skirmantas Kriaucionis
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 26:5033-42. 2006
    ..Our findings raise the possibility that mitochondrial dysfunction contributes to pathology of the Mecp2-null mouse and may contribute to the long-known resemblance between Rett syndrome and certain mitochondrial disorders...
  25. doi request reprint The role of MeCP2 in the brain
    Jacky Guy
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Annu Rev Cell Dev Biol 27:631-52. 2011
    ..Finally, we consider two alternative views of MeCP2 in the brain: as a regulator of brain development or as a factor that helps maintain neuronal/glial function...
  26. ncbi request reprint A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
    ....
  27. ncbi request reprint DNA methylation and Rett syndrome
    Skirmantas Kriaucionis
    Welcome Trust Centre for Biology, University of Edingburgh, The King s Buildings, Edingburgh, Scotland, UK
    Hum Mol Genet 12:R221-7. 2003
    ..This review will focus on experiments addressing the basic properties of MeCP2 and on mouse models of Rett syndrome that are starting to yield insights into this condition...
  28. pmc Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor
    Matthew J Lyst
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    Nat Neurosci 16:898-902. 2013
    ..Our data are compatible with the hypothesis that brain dysfunction in RTT is caused by a loss of the MeCP2 'bridge' between the NCoR/SMRT co-repressors and chromatin. ..
  29. pmc Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation
    Xinsheng Nan
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, United Kingdom
    Proc Natl Acad Sci U S A 104:2709-14. 2007
    ..We propose that disruption of the MeCP2-ATRX interaction leads to pathological changes that contribute to mental retardation...
  30. pmc CpG islands and the regulation of transcription
    Aimée M Deaton
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    Genes Dev 25:1010-22. 2011
    ..CGIs are therefore generically equipped to influence local chromatin structure and simplify regulation of gene activity...
  31. ncbi request reprint The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nature 401:301-4. 1999
    ..The combined specificities of binding and catalysis indicate that this enzyme may function to minimize mutation at methyl-CpG...
  32. pmc Kaiso-deficient mice show resistance to intestinal cancer
    Anna Prokhortchouk
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, United Kingdom
    Mol Cell Biol 26:199-208. 2006
    ..Our data suggest that Kaiso plays a role in intestinal cancer and may therefore represent a potential target for therapeutic intervention...
  33. pmc The major form of MeCP2 has a novel N-terminus generated by alternative splicing
    Skirmantas Kriaucionis
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JR, Scotland, UK
    Nucleic Acids Res 32:1818-23. 2004
    ..The presence of a previously unknown MeCP2 isoform has implications for the genetic screening of Rett syndrome patients and for studies of the functional significance of MeCP2...
  34. ncbi request reprint A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins
    S H Cross
    Institute of Cell and Molecular Biology, Edinburgh University U K and
    Nat Genet 16:256-9. 1997
    ..A polyclonal antibody raised against the protein was able to 'supershift' the native MeCP11 complex from HeLa cells, indicating that PCM1 is a component of mammalian MeCP1...
  35. ncbi request reprint Role of MBD2 in gene regulation and tumorigenesis
    J Berger
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Biochem Soc Trans 33:1537-40. 2005
    ..These findings validate MBD2 as a potential target for therapeutic intervention in colorectal cancer...
  36. ncbi request reprint Reading the DNA methylation signal
    A Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, United Kingdom
    Cold Spring Harb Symp Quant Biol 69:113-8. 2004
  37. ncbi request reprint The biological functions of the methyl-CpG-binding protein MeCP2 and its implication in Rett syndrome
    X Nan
    MRC Human Genetics Unit and Medical Genetics Section, Molecular Medicine Centre, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
    Brain Dev 23:S32-7. 2001
    ..We propose a genetic therapeutic approach based on activation of the wild type copy of the MeCP2 gene located in the inactive X chromosome...
  38. pmc Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
    B Hendrich
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, Scotland
    Genes Dev 15:710-23. 2001
    ..Genetic and biochemical data together favor the view that MBD3 is a key component of the Mi-2/NuRD corepressor complex, whereas MBD2 may be one of several factors that can recruit this complex to DNA...
  39. ncbi request reprint DNA methylation and chromatin modification
    H H Ng
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Curr Opin Genet Dev 9:158-63. 1999
    ..Taken together, the data strongly suggest that DNA methylation can pattern chromatin modification...
  40. pmc Identification and characterization of a family of mammalian methyl-CpG binding proteins
    B Hendrich
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
    Mol Cell Biol 18:6538-47. 1998
    ..The data demonstrate that MBD2 and MBD4 bind specifically to methyl-CpG in vitro and in vivo and are therefore likely to be mediators of the biological consequences of the methylation signal...
  41. pmc Gene number in an invertebrate chordate, Ciona intestinalis
    M W Simmen
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, United Kingdom
    Proc Natl Acad Sci U S A 95:4437-40. 1998
    ..The data indicate that evolution of vertebrates was accompanied by a dramatic increase in protein-coding capacity of the genome...
  42. pmc Methylation of genomes and genes at the invertebrate-vertebrate boundary
    S Tweedie
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Mol Cell Biol 17:1469-75. 1997
    ....
  43. pmc An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands
    D Macleod
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland
    Mol Cell Biol 18:4433-43. 1998
    ..These and other results support the idea that all CpG islands arise at promoters that are active in early embryonic cells...
  44. ncbi request reprint The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse
    P Tate
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nat Genet 12:205-8. 1996
    ..The results demonstrate that MeCP2, like DNA methyltransferase, is dispensable in stem cells, but essential for embryonic development...
  45. ncbi request reprint Sequence analysis of transposable elements in the sea squirt, Ciona intestinalis
    M W Simmen
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, Scotland
    Mol Biol Evol 17:1685-94. 2000
    ..This study provides the first systematic characterization of the families of transposable elements in a lower chordate...
  46. pmc A novel CpG island set identifies tissue-specific methylation at developmental gene loci
    Robert Illingworth
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 6:e22. 2008
    ..The findings enable a comprehensive analysis of the roles played by CGI methylation in normal and diseased human tissues...
  47. ncbi request reprint Genomic approaches reveal unexpected genetic divergence within Ciona intestinalis
    Miho M Suzuki
    The Wellcome Trust Centre for Cell, Biology The University of Edinburgh, Michael Swann Building, The King s Buildings, Edinburgh EH9 3JR, UK
    J Mol Evol 61:627-35. 2005
    ..This analysis revealed that specimens from Naples, Italy, have the Pacific-type genome, perhaps due to human-mediated marine transport of species. Despite major genomic divergence, the two forms could be hybridized in the laboratory...
  48. ncbi request reprint Perceptions of epigenetics
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, Edinburgh University, The King s Buildings, Edinburgh EH9 3JR, UK
    Nature 447:396-8. 2007
    ..It encompasses some of the most exciting contemporary biology and is portrayed by the popular press as a revolutionary new science--an antidote to the idea that we are hard-wired by our genes. So what is epigenetics?..
  49. pmc Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse
    P Lavia
    MRC Mammalian Genome Unit, Edinburgh, Scotland, UK
    EMBO J 6:2773-9. 1987
    ..The results support the view that HTF islands often mark genes, and they suggest that bidirectional transcription may be a common feature of island promoters...
  50. ncbi request reprint Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
    J D Lewis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland
    Cell 69:905-14. 1992
    ..In mouse, for example, MeCP2 is concentrated in pericentromeric heterochromatin, which contains a large fraction (about 40%) of all genomic 5-methylcytosine...
  51. ncbi request reprint A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection
    Aimée M Deaton
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 44:1835-41. 2014
    ..These data provide important insight into the molecular mechanisms behind the co-existence of Th1 and Th2 characteristics. ..
  52. ncbi request reprint Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice
    Catherine B Millar
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, UK
    Science 297:403-5. 2002
    ..On a cancer-susceptible Apc(Min/+) background, Mbd4-/- mice showed accelerated tumor formation with CpG --> TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo...
  53. pmc MMDiff: quantitative testing for shape changes in ChIP-Seq data sets
    Gabriele Schweikert
    School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH89AB, UK
    BMC Genomics 14:826. 2013
    ....
  54. pmc A temporal threshold for formaldehyde crosslinking and fixation
    Lars Schmiedeberg
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 4:e4636. 2009
    ..An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length of time required for an interaction to become fixed has not been determined...
  55. ncbi request reprint MeCP2 and other methyl-CpG binding proteins
    Helle Faerk Jørgensen
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Ment Retard Dev Disabil Res Rev 8:87-93. 2002
    ..Furthermore, MeCP2 represses transcription in a methylation-dependent manner, and it is the founding member of the family of methyl-CpG binding domain (MBD) proteins...
  56. ncbi request reprint Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    Rudolf Jaenisch
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Nat Genet 33:245-54. 2003
    ..The extent to which environmental effects can provoke epigenetic responses represents an exciting area of future research...
  57. ncbi request reprint Deficiency of Mbd2 suppresses intestinal tumorigenesis
    Owen J Sansom
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Nat Genet 34:145-7. 2003
    ..As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance...
  58. pmc The effect of interspecific oocytes on demethylation of sperm DNA
    Nathalie Beaujean
    Division of Gene Expression and Development, Roslin Institute, Roslin EH25 9PS, United Kingdom
    Proc Natl Acad Sci U S A 101:7636-40. 2004
    ..Our results suggest that the murine demethylation process is facilitated either by a sperm-derived factor or by male pronuclear chromatin composition...
  59. ncbi request reprint Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome
    Ulrike A Nuber
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Hum Mol Genet 14:2247-56. 2005
    ..Given the known deleterious effect of glucocorticoid exposure on brain development, our data raise the possibility that disruption of MeCP2-dependent regulation of stress-responsive genes contributes to the symptoms of RTT...
  60. ncbi request reprint MBD2 deficiency does not accelerate p53 mediated lymphomagenesis
    Owen James Sansom
    Mammalian Genetics, Cardiff School of Biosciences, University of Cardiff, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Oncogene 24:2430-2. 2005
    ..Unlike DNMT1, loss of Mbd2 does not accelerate lymphomagenesis, arguing that MBD2 may represent a better potential therapeutic target than DNMT1...
  61. pmc Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
    Victoria Valinluck
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Nucleic Acids Res 32:4100-8. 2004
    ..Oxidative damage to DNA could therefore result in heritable, epigenetic changes in chromatin organization...
  62. ncbi request reprint MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR
    Owen J Sansom
    School of Biosciences, University of Cardiff, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
    Oncogene 23:5693-6. 2004
    ..Taken together, these findings show that nullizygosity or heterozygosity for Mbd4 does not affect MMR-dependent tumorigenesis...
  63. ncbi request reprint Il2 transcription unleashed by active DNA demethylation
    Adrian Bird
    Nat Immunol 4:208-9. 2003
  64. pmc Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis
    Robert A Screaton
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:5211-6. 2003
    ..The nuclear localization of FADD and its interaction with a genome surveillance/DNA repair protein that can regulate apoptosis suggests a novel function of FADD distinct from direct participation in death receptor signaling complexes...