Polly J Bingley

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Cerebellar ataxia, peripheral neuropathy, "gluten sensitivity" and anti-neuronal autoantibodies
    Robert J Lock
    Immunology and Immunogenetics, North Bristol NHS Trust, Southmead Hospital, Bristol, UK
    Clin Lab 52:589-92. 2006
  2. ncbi request reprint Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials
    P J Bingley
    Division of Medicine, University of Bristol, U K
    Diabetes Care 22:1796-801. 1999
  3. ncbi request reprint Diabetes Antibody Standardization Program: first assay proficiency evaluation
    Polly J Bingley
    Division of Medicine, Medical School Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, U K
    Diabetes 52:1128-36. 2003
  4. ncbi request reprint Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk
    P J Bingley
    Diabetes and Metabolism, Department of Clinical Science at North Bristol, University of Bristol, Southmead Hospital, UK
    Diabetologia 49:881-90. 2006
  5. ncbi request reprint Validation of autoantibody assays in type 1 diabetes: workshop programme
    Polly J Bingley
    Department of Clinical Science at North Bristol, University of Bristol, UK
    Autoimmunity 37:257-60. 2004
  6. pmc Undiagnosed coeliac disease at age seven: population based prospective birth cohort study
    Polly J Bingley
    Division of Medicine, University of Bristol, Southmead Hospital, Bristol BS10 5NB
    BMJ 328:322-3. 2004
  7. ncbi request reprint Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    Polly J Bingley
    Clinical Science at North Bristol, University of Bristol, UK
    Diabetes Care 31:146-50. 2008
  8. pmc Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2β
    Michael Schlosser
    Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University ofGreifswald, Karlsburg, Germany
    Diabetes Care 34:2410-2. 2011
  9. doi request reprint Clinical applications of diabetes antibody testing
    Polly J Bingley
    Department of Clinical Science at North Bristol, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:25-33. 2010
  10. ncbi request reprint Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom
    A Paul Lambert
    Division of Medicine, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 89:4037-43. 2004

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Cerebellar ataxia, peripheral neuropathy, "gluten sensitivity" and anti-neuronal autoantibodies
    Robert J Lock
    Immunology and Immunogenetics, North Bristol NHS Trust, Southmead Hospital, Bristol, UK
    Clin Lab 52:589-92. 2006
    ..Second, our idiopathic cases, whether they be gliadin antibody seropositive or not (i.e. "gluten sensitive" or not) were rarely neuronal autoantibody positive...
  2. ncbi request reprint Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials
    P J Bingley
    Division of Medicine, University of Bristol, U K
    Diabetes Care 22:1796-801. 1999
    ..To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy...
  3. ncbi request reprint Diabetes Antibody Standardization Program: first assay proficiency evaluation
    Polly J Bingley
    Division of Medicine, Medical School Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, U K
    Diabetes 52:1128-36. 2003
    ..Differences in assay protocols between laboratories must be addressed so that all centers and kit manufacturers can perform to the same high standard...
  4. ncbi request reprint Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk
    P J Bingley
    Diabetes and Metabolism, Department of Clinical Science at North Bristol, University of Bristol, Southmead Hospital, UK
    Diabetologia 49:881-90. 2006
    ....
  5. ncbi request reprint Validation of autoantibody assays in type 1 diabetes: workshop programme
    Polly J Bingley
    Department of Clinical Science at North Bristol, University of Bristol, UK
    Autoimmunity 37:257-60. 2004
  6. pmc Undiagnosed coeliac disease at age seven: population based prospective birth cohort study
    Polly J Bingley
    Division of Medicine, University of Bristol, Southmead Hospital, Bristol BS10 5NB
    BMJ 328:322-3. 2004
  7. ncbi request reprint Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    Polly J Bingley
    Clinical Science at North Bristol, University of Bristol, UK
    Diabetes Care 31:146-50. 2008
    ..We wanted to see whether measures of insulin resistance improved risk assessment in islet cell antibody (ICA)-positive relatives when added to other immune and metabolic markers...
  8. pmc Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2β
    Michael Schlosser
    Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University ofGreifswald, Karlsburg, Germany
    Diabetes Care 34:2410-2. 2011
    ..Autoantibodies to IA-2β (IA-2βA) are important risk markers of type 1 diabetes. We report the first Diabetes Antibody Standardization Program (DASP) evaluation of IA-2βA assays...
  9. doi request reprint Clinical applications of diabetes antibody testing
    Polly J Bingley
    Department of Clinical Science at North Bristol, Medical School Unit, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:25-33. 2010
    ..Autoantibody assays are increasingly available to clinicians. This article reviews the prognostic significance of autoantibodies and considers the utility of diabetes antibody testing in routine clinical practice...
  10. ncbi request reprint Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom
    A Paul Lambert
    Division of Medicine, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 89:4037-43. 2004
    ..4%), whereas inclusion of 11 genotypes achieved the same sensitivity for diagnosis for ages 10-14 yr. Analysis of genotype-specific risk should form the basis for design of future primary prevention trials in the general population...
  11. ncbi request reprint The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
    Kathleen M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Lancet 364:1699-700. 2004
    ..003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect...
  12. pmc Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 62:2067-71. 2013
    ..Association of an HLA class I susceptibility allele with altered islet autoantibody phenotype at diagnosis suggests CD8 T-cell and/or natural killer cell-mediated killing modulates humoral autoimmune responses...
  13. ncbi request reprint Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
    Kathleen M Gillespie
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetes 54:1245-8. 2005
    ..012). These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter...
  14. ncbi request reprint Islet autoimmunity in children with Down's syndrome
    Kathleen M Gillespie
    Medical School Unit, Southmead Hospital, Bristol BS10 5NB, UK
    Diabetes 55:3185-8. 2006
    ..Other factors, possibly including genes on chromosome 21, may increase the penetrance of type 1 diabetes in Down's syndrome...
  15. doi request reprint The role of autoantibodies to zinc transporter 8 in prediction of type 1 diabetes in relatives: lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) cohort
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK
    J Clin Endocrinol Metab 97:632-7. 2012
    ..Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen...
  16. pmc Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
    Anna E Long
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Diabetes 61:683-6. 2012
    ..Understanding how changes in environment or lifestyle alter the humoral autoimmune response to islet antigens should help explain why the incidence of type 1 diabetes is increasing and may suggest new strategies for preventing disease...
  17. doi request reprint Anti-BSA antibodies are a major cause of non-specific binding in insulin autoantibody radiobinding assays
    Alistair J K Williams
    School of Clinical Sciences, University of Bristol, Bristol, UK
    J Immunol Methods 362:199-203. 2010
    ..High titre BSA antibodies interfere with IAA measurement because of (125)I-BSA present in some insulin labels. Improved purification of insulin labels should obviate the need for competitive displacement...
  18. pmc Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
    Polly J Bingley
    Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK
    Clin Trials 7:S56-64. 2010
    ..and..
  19. pmc Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility
    Alistair J K Williams
    Clinical Science at North Bristol, Southmead Hospital, Bristol, UK
    J Immunol Methods 351:75-9. 2009
    ..We conclude that common assay reagents such as azide and Tween-20 can strongly influence IA-2A binding in an epitope-related manner, and their use may explain some of the differences between laboratories in IA-2A measurement...
  20. ncbi request reprint High familial risk and genetic susceptibility in early onset childhood diabetes
    Kathleen M Gillespie
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetes 51:210-4. 2002
    ..001). Diabetes with onset before age 5 years is therefore a marker of high familial risk...
  21. ncbi request reprint Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes
    A Paul Lambert
    Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetes Care 26:333-7. 2003
    ..We examined the prevalence of HNF-1alpha mutations in families with three generations of diabetes identified in a population-based study of childhood diabetes, representing a subpopulation in which misclassification was likely...
  22. ncbi request reprint Non-specific binding to protein A Sepharose and protein G Sepharose in insulin autoantibody assays may be reduced by pre-treatment with glycine or ethanolamine
    Alistair J K Williams
    Clinical Science at North Bristol, University of Bristol, UK
    J Immunol Methods 314:170-3. 2006
    ..6. Pre-treatment with glycine or ethanolamine allows "poor" batches of PAS or PGS to be used in sensitive IAA assays, improving both consistency and performance...
  23. ncbi request reprint HLA class II typing of whole genome amplified mouth swab DNA
    K M Gillespie
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Tissue Antigens 56:530-8. 2000
    ..We have optimised conditions for HLA class II typing on whole genome amplified DNA collected by mouth swab, but this method could potentially be applied to low concentrations of DNA from other sources...
  24. ncbi request reprint The high prevalence of autoantibodies to tissue transglutaminase in first-degree relatives of patients with type 1 diabetes is not associated with islet autoimmunity
    A J Williams
    Diabetes and Metabolism Division of Medicine, University of Bristol, UK
    Diabetes Care 24:504-9. 2001
    ..The high prevalence of celiac autoimmunity may be explained by shared genetic susceptibility and identifies a population within which screening for the disease may be justified...
  25. pmc The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes
    Karen T Elvers
    School of Clinical Sciences, Learning and Research, University of Bristol, Southmead Hospital, Bristol, UK
    Diabetes 62:214-22. 2013
    ..In most patients, at disease onset, >90% of antibodies binding to the PTP domain of IA-2 recognize just two epitope regions...
  26. ncbi request reprint Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with Type I diabetes
    A J K Williams
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 45:217-23. 2002
    ..Our aim was to evaluate the influence of age, gender, proband characteristics and nationality on the prevalence of ICA and co-existence of autoantibodies to GAD, IA-2 and insulin...
  27. doi request reprint Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2
    A J K Williams
    Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 51:1444-8. 2008
    ..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)...
  28. ncbi request reprint Three generations of autoimmune diabetes: an extended family study
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetologia 46:1313-8. 2003
    ..We set out to study the clinical and immune features of diabetes in the grandparents' generation, and to examine sharing of HLA class II susceptibility haplotypes between grandparent and grandchild...
  29. ncbi request reprint The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
    A J K Williams
    Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
    Diabetologia 46:1354-6. 2003
    ..Humoral responses to the beta cell antigen insulin could help to reveal the mechanism underlying this difference. We therefore determined the influence of sex on the prevalence of insulin autoantibodies (IAA) at diagnosis...
  30. ncbi request reprint Diabetes in the parents of children with Type I diabetes
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabetologia 45:495-501. 2002
    ..We set out to characterise the clinical and immunogenetic features of diabetes in parents of affected children, and to test the hypothesis that there is no excess of Type II diabetes within this population...
  31. ncbi request reprint European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
    E A M Gale
    University of Bristol, UK
    Lancet 363:925-31. 2004
    ..We aimed to assess whether high dose nicotinamide prevents or delays clinical onset of diabetes in people with a first-degree family history of type 1 diabetes...
  32. pmc Early-Onset, Coexisting Autoimmunity and Decreased HLA-Mediated Susceptibility Are the Characteristics of Diabetes in Down Syndrome
    Rachel J Aitken
    Corresponding author Kathleen M Gillespie
    Diabetes Care 36:1181-5. 2013
    ..Overall, these studies demonstrate more extreme autoimmunity in DSD typified by early-onset diabetes with multiple autoimmunity, persistent islet autoantibodies, and decreased HLA-mediated susceptibility...
  33. doi request reprint Strategies to prevent type 1 diabetes
    S L Thrower
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Diabetes Obes Metab 11:931-8. 2009
    ..Some interventions have shown promising results in early trials, but effective disease prevention remains elusive. This article reviews current progress in the field...
  34. doi request reprint Prevention of type 1 diabetes
    S L Thrower
    School of Clinical Sciences, University of Bristol, and Second Floor, Learning and Research, Southmead Hospital, Bristol BS10 5NB, UK
    Br Med Bull 99:73-88. 2011
    ..Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide...
  35. ncbi request reprint Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial
    I F Douek
    Diabetes and Metabolism, Division of Medicine, University of Bristol, Bristol, UK
    Diabet Med 22:634-40. 2005
    ..To test the effect of continuing metformin on weight gain and glycaemic control in patients with poorly controlled Type 2 diabetes who need to start insulin...
  36. ncbi request reprint Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department, Hospital München Schwabing, Munich, Germany
    Diabetes 53:384-92. 2004
    ..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years...
  37. ncbi request reprint Association of intercellular adhesion molecule-1 gene with type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
    Lancet 362:1723-4. 2003
    ..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments...
  38. ncbi request reprint Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens
    Massimo Bearzatto
    Department of Medicine 1 and Medicine Laboratory, Istituto Scientifico San Raffaele, Milan, Italy
    J Immunol 168:4202-8. 2002
    ..This is a unique demonstration of HLA-associated B cell responses to epitopes within a single autoantigen in humans and is consistent with modification of Ag processing by specific Ab-influencing peptide presentation by HLA molecules...
  39. ncbi request reprint Predicting type 1 diabetes using autoantibodies: the latest results from the diabetes autoantibody standardization program
    Patricia W Mueller
    Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Diabetes Technol Ther 4:397-400. 2002
  40. ncbi request reprint HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months
    Emma L Edghill
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 55:1895-8. 2006
    ..0001). We conclude that infants diagnosed with diabetes before 6 months of age are unlikely to have autoimmune type 1 diabetes and are most likely to have a monogenic etiology...
  41. ncbi request reprint Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Clin Immunol 122:85-90. 2007
    ..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays...
  42. ncbi request reprint Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 8:87-93. 2008
    ....
  43. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
    ..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...