Research Topics
| Lynne BingleSummaryAffiliation: University of Sheffield Country: UK Publications
| Collaborators
|
Detail Information
Publications
SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotypeLynne Bingle
Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK
J Pathol 205:491-7. 2005..This expression pattern is consistent with the presumed phenotypic origin of these tumours and suggests that SPLUNC1 may be a useful marker for lung cancer...
Distribution of human PLUNC/BPI fold-containing (BPIF) proteinsLynne Bingle
Oral and Maxillofacial Pathology, The School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK
Biochem Soc Trans 39:1023-7. 2011..We suggest that this differential expression may be reflected in the function of individual PLUNC proteins...- Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory proteinLynne Bingle
Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK
Histochem Cell Biol 132:339-49. 2009..Thus, our study shows that multiple SPLUNC2 isoforms are found in the oral cavity and suggest that these proteins may be differentially regulated in distinct tissues where they may function in the innate immune response... 
WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lungLynne Bingle
Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
Respir Res 7:61. 2006..The precise location of WFDC2 protein in these sites has not been described...- Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosisLynne Bingle
Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
Respir Res 8:79. 2007.... 
Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tractsColin D Bingle
Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, S10 2JF, UK
Histochem Cell Biol 133:505-15. 2010....- The role of α9β1 integrin in modulating epithelial cell behaviourSushmita Roy
Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, UK
J Oral Pathol Med 40:755-61. 2011.... - The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoformsLynne Bingle
Respiratory Medicine Unit, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
Oncogene 21:2768-73. 2002..These results cast doubt on the potential role of HE4 as a serum tumour marker specific for ovarian cancer and open the door to understanding the function of multiple WAP domain containing protein isoforms arising from a single gene... - BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung diseaseLynne Bingle
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
Histochem Cell Biol 138:749-58. 2012..It is unclear if this elevation of protein production, which results from phenotypic alteration of the cells within the diseased epithelium, plays a role in the pathogenesis of the disease... - Phylogenetic and evolutionary analysis of the PLUNC gene familyColin D Bingle
Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, S10 2JF, UK
Protein Sci 13:422-30. 2004..Our data provide a basis for future functional studies of this novel protein family... - Distant cousins: genomic and sequence diversity within the BPI fold-containing (BPIF)/PLUNC protein familyColin D Bingle
Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield S10 2JF, UK
Biochem Soc Trans 39:961-5. 2011..This suggests that evolutionary forces have continued to act on the structure of this conserved domain in what are likely to be functionally important ways... - Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of miceMaslinda Musa
Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, S10 2JF, UK
Cell Tissue Res 350:455-64. 2012..Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function... - Pulmonary Genomics, Proteomics, and PLUNCsFrances A Barnes
Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK
Am J Respir Cell Mol Biol 38:377-9. 2008 - Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high-grade mucoepidermoid carcinoma of the salivary glandWilfredo A González-Arriagada
Oral Diagnosis Department, Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas UNICAMP, Piracicaba, Sao Paulo, Brazil
J Oral Pathol Med 41:589-97. 2012..Recently, expression of the PLUNC proteins has been described in mucin-producing salivary gland tumors, with the suggestion that they could provide a powerful tool for the diagnosis of difficult cases... - Functional expression of the chemokine receptor XCR1 on oral epithelial cellsSyed A Khurram
Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, S10 2TA, UK
J Pathol 221:153-63. 2010..These findings show that XCR1 and its ligand, lymphotactin, are expressed by oral epithelial cells and suggest that they play a role in regulating the behaviour of these cells...