Research Topics
Genomes and GenesSpecies | Sheila BinghamSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]Charlotte Atkinson
MRC Dunn Human Nutrition Unit, Cambridge, UK
Breast Cancer Res 6:R170-9. 2004..Furthermore, there were no effects on oestradiol, gonadotrophins, lymphocyte tyrosine kinase activity, or menopausal symptoms...- Mammographic breast density as a biomarker of effects of isoflavones on the female breastCharlotte Atkinson
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Breast Cancer Res 4:1-4. 2002..Breast density may therefore serve as a biomarker of estrogenic or anti-estrogenic effects of a treatment on breast tissue. The effect of isoflavones on breast density is under investigation... 
Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and womenLisa R Purslow
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
BMC Public Health 8:112. 2008..The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK...- Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and womenEmily McFadden
Institute of Public Health, University of Cambridge, UK
BMC Public Health 8:230. 2008..We investigate the association between occupational social class and self-rated health (SRH) at different ages in men and women... - Self-reported parkinsonian symptoms in the EPIC-Norfolk cohortLianna S Ishihara
Department of Public Health and Primary Care, University of Cambridge, Forvie Site, Cambridge CB2 2SR, UK
BMC Neurol 5:15. 2005..The objective of the study was to determine the self-reported prevalence of parkinsonian symptoms from a questionnaire, and to examine their association with age and self-reported Parkinson's disease in a large cohort... - Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)Federico Canzian
German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Cancer 9:257. 2009..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)... 
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactionsYen Ling Low
Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:213-20. 2005..We conclude that higher isoflavone exposure is associated with lower plasma estradiol in postmenopausal women and that this preliminary study is suggestive of the involvement of diet-gene interactions...- Are imprecise methods obscuring a relation between fat and breast cancer?Sheila A Bingham
MRC Dunn Human Nutrition Unit, Welcome Trust MRC Building, Hills Road, CB2 2XY, Cambridge, UK
Lancet 362:212-4. 2003..10 [0.94-1.29], p=0.23). Dietary measurement error might explain the absence of a significant association between dietary fat and breast-cancer risk in cohort studies... - Measurement error in the assessment of interaction between dietary and genetic factors in cohort studies of cancerSheila A Bingham
Medical Research Council, Dunn Human Nutrition Unit, Welcome Trust/MRC Building, Cambridge, UK
World Rev Nutr Diet 94:144-51. 2005 
Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort StudySheila Bingham
Medical Research Council, Dunn Human Nutrition Unit, Welcome Trust MRC Building, Cambridge, UK
Int J Epidemiol 37:978-87. 2008..Methods for assessing diet are prone to measurement error, which may be substantial in large cohort investigations. Biomarkers can be used as objective measures with which to compare estimates of nutritional exposure using different methods..- Biomarkers in nutritional epidemiologySheila A Bingham
Medical Research Council, Dunn Human Nutrition Unit, Welcome Trust MRC Building, Cambridge, UK
Public Health Nutr 5:821-7. 2002..To illustrate biomarkers of diet that can be used to validate estimates of dietary intake in the study of gene-environment interactions in complex diseases... - Urine nitrogen as a biomarker for the validation of dietary protein intakeSheila A Bingham
Medical Research Council, Cambridge, UK
J Nutr 133:921S-924S. 2003..Other markers of dietary intake and intermediate risk markers may also be measured in the 24-h urine that is obtained... - The fibre-folate debate in colo-rectal cancerSheila Bingham
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Cambridge, UK
Proc Nutr Soc 65:19-23. 2006..001)... - Diet and cancer--the European Prospective Investigation into Cancer and NutritionSheila Bingham
MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK
Nat Rev Cancer 4:206-15. 2004 - Plasma ascorbic acid concentrations and fat distribution in 19,068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort studyDexter Canoy
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Am J Clin Nutr 82:1203-9. 2005..Excess fat may promote fatty acid oxidation and increase free radical concentrations, which could result in increased antioxidant use. Whether plasma ascorbic acid concentrations are associated with fat distribution remains unclear... - Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population studyKay Tee Khaw
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
PLoS Med 5:e12. 2008..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community... - Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population studyTeresa Norat
MRC Dunn Human Nutrition Unit, Cambridge, United Kingdom
Am J Clin Nutr 88:392-7. 2008..Intervention studies have indicated an interaction between the blood pressure response to a low-sodium or a low-fat and high-fruit and -vegetable diet and the angiotensinogen gene (AGT) polymorphisms G-6A and M235T... - Past oral contraceptive and hormone therapy use and endogenous hormone concentrations in postmenopausal womenMei Fen Chan
Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Menopause 15:332-9. 2008..The aim of this study was to examine the relationship between past hormone use and current endogenous hormone status... - Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective studyDexter Canoy
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Circulation 116:2933-43. 2007..Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain... - Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort studyAlireza Moayyeri
Department of Public Health and Primary Care, Institute of Public Health, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, UK
Eur J Epidemiol 24:259-66. 2009..The interaction observed between sex and age points to the need for further prospective studies among men... - Physical activity and mammographic breast density in the EPIC-Norfolk cohort studyTricia M Peters
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
Am J Epidemiol 167:579-85. 2008..The lack of an association between physical activity and percentage breast density suggests that an association between physical activity and breast cancer risk is unlikely to be mediated through an effect on mammographic breast density... - Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population studyMei Fen Chan
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:900-5. 2007..However, the relationship between usual daily physical activity and endogenous hormones in postmenopausal women in the general population is still uncertain... - Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohortEmily McFadden
Institute of Public Health, University of Cambridge, Cambridge, UK
Eur J Epidemiol 23:449-58. 2008.... - Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolkPhilip B Grace
MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:698-708. 2004..024) for serum equol, and 1.22 (1.01-1.48; P = 0.044) for serum daidzein]. These estimates of risk are similar to those established for estrogens and androgens in postmenopausal breast cancer but need confirmation in larger studies... - Relationship between subdomains of total physical activity and mortalityHerve Besson
Epidemiology Unit, Medical Research Council, Cambridge, United Kingdom
Med Sci Sports Exerc 40:1909-15. 2008..However, it is unclear how this association varies according to the domain of life in which the activity takes place... - Social class, risk factors, and stroke incidence in men and women: a prospective study in the European prospective investigation into cancer in Norfolk cohortEmily McFadden
MSc, Room 311, Strangeways Research Laboratory, Wort s Causeway, Cambridge, UK
Stroke 40:1070-7. 2009..The purpose of this study was to investigate the association between occupational social class and stroke incidence and the extent to which classical, lifestyle, and psychosocial risk factors may explain such relationships... - Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) studyDexter Canoy
Department of Public Health and Primary Care, University of Cambridge, Cambridge, MRC Dunn Human Nutrition Unit, Cambridge and MRC Epidemiology Unit, Cambridge, UK
J Hypertens 22:2067-74. 2004..To determine the relation between fat distribution and blood pressure, independent of body mass index... - Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort studyHeather Ward
MRC Centre for Nutrition and Cancer, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
Breast Cancer Res 10:R32. 2008..Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies... - Is QUS or DXA better for predicting the 10-year absolute risk of fracture?Alireza Moayyeri
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
J Bone Miner Res 24:1319-25. 2009..Given the feasibility and lower cost of ultrasound measurement in primary care, further studies to develop and validate models for prediction of 10-yr risk of fracture using clinical risk factors and QUS are recommended... - Occupational social class, educational level, smoking and body mass index, and cause-specific mortality in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohortEmily McFadden
Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Wort s Causeway, Cambridge, UK
Eur J Epidemiol 23:511-22. 2008.... - Blood pressure and urinary sodium in men and women: the Norfolk Cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)Kay Tee Khaw
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Am J Clin Nutr 80:1397-403. 2004..A key issue is whether differences in usual sodium intake within the range feasible in free-living populations have clinical or public health relevance... - Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) populationShubhada Sinha
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Eur J Cardiovasc Prev Rehabil 12:144-50. 2005..In men who stop smoking plasma fibrinogen may remain elevated for several years after cessation... - Modifiable lifestyle behaviors and functional health in the European Prospective Investigation into Cancer (EPIC)-Norfolk population studyPhyo K Myint
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Prev Med 44:109-16. 2007..To examine the association between modifiable lifestyle behaviors and functional health... - Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in menYen Ling Low
MRC Dunn Human Nutrition Unit, Cambridge, UK
J Nutr 135:2680-6. 2005..In this first study on phytoestrogen-gene associations in men, we conclude that enterolactone and equol are positively associated with plasma androgen concentrations, and interactions with CYP19 gene may be involved... - Dietary energy density predicts the risk of incident type 2 diabetes: the European Prospective Investigation of Cancer (EPIC)-Norfolk StudyJing Wang
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Diabetes Care 31:2120-5. 2008..Our aim was to investigate whether there is an independent association between dietary energy density and incidence of diabetes... - Cross-sectional association between fish consumption and albuminuria: the European Prospective Investigation of Cancer-Norfolk StudyChee Tin Christine Lee
Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
Am J Kidney Dis 52:876-86. 2008..The aim of this study is to examine the association between fish consumption and albuminuria in individuals with and without diabetes... - Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variantsYen Ling Low
Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Dunn Human Nutrition Unit Building, Hills Road, Cambridge CB2 2XY, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1009-16. 2007..Such phytoestrogen-gene interactions may explain the conflicting literature on the hormonal effects of phytoestrogens... - Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer riskYen Ling Low
MRC Dunn Human Nutrition Unit, Cambridge CB2 2XY, UK
Nutr Cancer 56:31-9. 2006..005]. Our results utilizing a combined prospective exposure provide no evidence that phytoestrogens alter prostate cancer risk in British men, whereas the C allele for the PvuII polymorphism may be associated with increased risk... - Is bowel habit linked to colorectal cancer? - Results from the EPIC-Norfolk studyJin Young Park
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Eur J Cancer 45:139-45. 2009..Frequency of bowel movement, stool quantity, feeling discomfort and laxative use was not overall associated with CRC risk. These findings suggest that having loose stools may be an indicator of colorectal cancer risk... - Effect of age on the relationship of occupational social class with prevalence of modifiable cardiovascular risk factors and cardiovascular diseases. A population-based cross-sectional study from European Prospective Investigation into Cancer - Norfolk (EPhyo K Myint
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Gerontology 52:51-8. 2006..Previous studies on cardiovascular risk profile in different socioeconomic status were focused on younger populations and many of them have not been able to take into account age and sex differences... - Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in NorfolkKay Tee Khaw
University of Cambridge, School of Clinical Medicine, Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
Ann Intern Med 141:413-20. 2004..Increasing evidence suggests a continuous relationship between blood glucose concentrations and cardiovascular risk, even below diagnostic threshold levels for diabetes... - Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population studyKay Tee Khaw
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK
Lancet 363:197-202. 2004..We aimed to assess quantitative ultrasound of the calcaneum and fracture incidence in a prospective observational population study... - Calcaneum broadband ultrasound attenuation relates to vegetarian and omnivorous diets differently in men and women: an observation from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population studyAilsa Welch
Department of Public Health and Primary Care, Strangeway s Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK
Osteoporos Int 16:590-6. 2005..Our findings emphasize the need for further research and investigation into dietary inter-relationships and bone health and the effects of vegetarian status, including consumption of soya-based foods, in men as well as women... - A prospective study of microalbuminuria and incident coronary heart disease and its prognostic significance in a British population: the EPIC-Norfolk studyMatthew F Yuyun
Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Am J Epidemiol 159:284-93. 2004..61 (95% CI: 1.19, 2.07). Microalbuminuria may be useful in identifying persons at increased risk of CHD and subsequent death in the general population... - Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk studyKelvin Wu
MRC Dunn Human Nutrition Unit, Diet and Cancer Group, Hills Road, Cambridge CB2 2XY, UK
Eur Heart J 28:2930-6. 2007..To investigate whether blood lipid response to dietary fat and fibre vary according to the apolipoprotein E (APOE) gene locus... - Dietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk studyAnne-Helen Harding
Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
Am J Epidemiol 159:73-82. 2004..81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors... - The effect of including quantitative heel ultrasound in models for estimation of 10-year absolute risk of fractureAlireza Moayyeri
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
Bone 45:180-4. 2009..Adding a QUS measurement to models based on clinical risk factors and BMD improves the predictive power of models and suggests that further attention should be paid to QUS as a clinical tool for fracture risk assessment... - Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS StudyPanagiota N Mitrou
Dunn Human Nutrition Unit, MRC Wellcome Trust Building, Hills Road, Cambridge CB2 2XY, UK
Carcinogenesis 28:875-82. 2007..Alcohol increases risk of colorectal adenoma in carriers of the high-activity genotype possibly through enhanced activation of alcohol-related procarcinogens... - Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old womenCharlotte Atkinson
MRC Biostatistics Unit, Institute of Public Health, Cambridge, CB2 2SR, UK
J Nutr 134:1759-64. 2004..A larger study is required to confirm the effect modification by apoE genotype... - Evaluation and comparison of food records, recalls, and frequencies for energy and protein assessment by using recovery biomarkersRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109 1024, USA
Am J Epidemiol 174:591-603. 2011..1% for energy; 20.3%, 32.7%, and 28.4% for protein; and 8.7%, 14.4%, and 10.4% for protein density. Calibration equations using any of the assessment procedures may yield suitable consumption estimates for epidemiologic study purposes... - Association of ESR1 gene tagging SNPs with breast cancer riskAlison M Dunning
Department of Oncology, University of Cambridge, Cambridge, UK
Hum Mol Genet 18:1131-9. 2009..The region tagged by SNP rs3020314 contains sequence that is more highly conserved across mammalian species than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms... - Adjusting for energy intake--what measure to use in nutritional epidemiological studies?Rupert W Jakes
MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
Int J Epidemiol 33:1382-6. 2004.... - Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin geneYen Ling Low
Medical Research Council Dunn Human Nutrition Unit, Department of Oncology, Cancer Research UK, London, United Kingdom
Cancer Res 66:8980-3. 2006.... - Obesity indices and self-reported functional health in men and women in the EPIC-NorfolkPhyo K Myint
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Obesity (Silver Spring) 14:884-93. 2006..To investigate the association between two indices of obesity, BMI and waist-to-hip ratio (WHR), and self-reported physical and mental functional health... - Combined work and leisure physical activity and risk of stroke in men and women in the European prospective investigation into Cancer-Norfolk Prospective Population StudyPhyo K Myint
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Neuroepidemiology 27:122-9. 2006..70, 95% CI: 0.49-0.99, p = 0.024) compared to those who were inactive. This highlights the fact that efforts to increase physical activity in both the work place and in leisure time should be encouraged... - Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studiesNadeem Sarwar
Department of Public Health and Primary Care, University of Cambridge, Cambridge, England, UK
Circulation 115:450-8. 2007..In the present study, we report 2 separate nested case-control comparisons in 2 different prospective, population-based cohorts, plus an updated meta-analysis of 27 additional prospective studies in general Western populations... - Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship?Phyo K Myint
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Stroke 38:271-5. 2007..The relationship between blood glucose concentration and stroke in people without established diabetes has been studied less extensively... - The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trialCharlotte Atkinson
MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom
Am J Clin Nutr 79:326-33. 2004..CONCLUSION: These data suggest that, through attenuation of bone loss, isoflavones have a potentially protective effect on the lumbar spine in women... - No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening TrialMarc J Gunter
Dunn Human Nutrition Unit, Medical Research Council, MRC/Wellcome Trust Building, Hills Road, Cambridge CB2 2XY, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:1028-30. 2005 - EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countriesJohn Danesh
EPIC Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
Eur J Epidemiol 22:129-41. 2007..Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors... - Smoking status and differential white cell count in men and women in the EPIC-Norfolk populationMegan R Smith
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, Cambridge CB2 2SR, UK
Atherosclerosis 169:331-7. 2003..The apparent almost immediate reversibility of effects of smoking on inflammation, as indicated by the WBC count, may help motivate efforts to stop smoking... - What determines Self-Rated Health (SRH)? A cross-sectional study of SF-36 health domains in the EPIC-Norfolk cohortNahal Mavaddat
General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK
J Epidemiol Community Health 65:800-6. 2011..This study aimed to determine the extent to which dimensions of physical, mental and social functioning are associated with SRH... - Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk studyKay Tee Khaw
Depqartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:915-9. 2004..Increasing evidence suggests that abnormal glucose metabolism may be associated with increased risk of colorectal cancer... - APOE genotype, lipids, and coronary heart disease risk: a prospective population studyHeather Ward
Medical Research Council MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Institute of Public Health, University of Cambridge, Cambridge, England
Arch Intern Med 169:1424-9. 2009..The risk of coronary heart disease (CHD) may be related to genetic mutations in the production of apolipoprotein E via alterations to the metabolism of CHD-related blood lipids such as low-density lipoprotein cholesterol and triglycerides... - Physical activity and breast cancer risk: the European Prospective Investigation into Cancer and NutritionPetra H Lahmann
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
Cancer Epidemiol Biomarkers Prev 16:36-42. 2007..This study provides additional evidence for a protective effect of physical activity on breast cancer risk... - Cigarette smoking and fat distribution in 21,828 British men and women: a population-based studyDexter Canoy
Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Obes Res 13:1466-75. 2005..To examine the relationship between cigarette smoking habits and fat distribution in a population-based cohort of men and women... - Epidemiologic assessment of sugars consumption using biomarkers: comparisons of obese and nonobese individuals in the European prospective investigation of cancer NorfolkSheila Bingham
Medical Research Council Dunn Human Nutrition Unit University of Cambridge, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1651-4. 2007..001) despite an inverse association for plasma vitamin C. Nutritional biomarkers of consumption can complement existing methods for assessing cancer risk from diet in epidemiologic studies... - Lack of prospective associations between plasma and urinary phytoestrogens and risk of prostate or colorectal cancer in the European Prospective into Cancer-Norfolk studyHeather Ward
MRC Centre for Nutrition and Cancer, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:2891-4. 2008..In conclusion, we have found no evidence to support an inverse association between phytoestrogen exposure and prostate or colorectal cancer risk... - How far can we explain the social class differential in respiratory function? A cross-sectional population study of 21,991 men and women from EPIC-NorfolkEmily McFadden
Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB20SR, UK
Eur J Epidemiol 24:193-201. 2009..This suggests that socioeconomic inequalities in respiratory function may be preventable or modifiable and highlights factors for further exploration... - Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: results from the EPIC-Norfolk population-based cohort studyDexter Canoy
Department of Public Health and Primary Care, University of Cambridge, Strangeway s Site, Worts Causeway, Cambridge CB1 8RN, United Kingdom
Atherosclerosis 189:420-7. 2006..We examine whether lipid levels vary between central and peripheral fat distribution in the general population... - Work and leisure time physical activity assessed using a simple, pragmatic, validated questionnaire and incident cardiovascular disease and all-cause mortality in men and women: The European Prospective Investigation into Cancer in Norfolk prospective popKay Tee Khaw
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK
Int J Epidemiol 35:1034-43. 2006..This may be partly related to different methods for assessing physical activity. Most studies have focused on leisure time physical activity... - Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort studyPaul G Surtees
Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
Am J Psychiatry 165:515-23. 2008..The authors investigated the association between major depressive disorder, including its clinical course, and mortality from ischemic heart disease... - Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and womenLisa R Purslow
MRC Epidemiology Unit, Institute of Medical Science, Addenbrooke s Hospital, Cambridge, United Kingdom
Am J Epidemiol 167:188-92. 2008..Redistribution of daily energy intake, so that more energy is consumed at breakfast and less energy is consumed later in the day, may help to reduce weight gain in middle-aged adults... - Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population studyAilsa A Welch
Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
Br J Nutr 99:1335-43. 2008..As urine pH relates to dietary acid-base load its use to monitor change in consumption of fruit and vegetables, in individuals, warrants further investigation... - LDL-cholesterol concentrations: a genome-wide association studyManjinder S Sandhu
Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
Lancet 371:483-91. 2008..We therefore did a genome-wide association study of LDL-cholesterol concentrations... - Phytoestrogen content of beverages, nuts, seeds, and oilsGunter G C Kuhnle
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
J Agric Food Chem 56:7311-5. 2008..The results published here will contribute to databases of dietary phytoestrogen content and allow a more accurate determination of phytoestrogen exposure in free-living individuals... - Telomere length in prospective and retrospective cancer case-control studiesKaren A Pooley
Cancer Research UK Genetic Epidemiology Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Li Ka Shing Centre, Cambridge, United Kingdom
Cancer Res 70:3170-6. 2010..This suggests that telomere shortening largely occurs after diagnosis, and therefore, might not be of value in cancer prediction... - Early age at menarche associated with cardiovascular disease and mortalityRajalakshmi Lakshman
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
J Clin Endocrinol Metab 94:4953-60. 2009..The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality... - Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk studyTuomas O Kilpeläinen
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
Hum Mol Genet 18:3496-501. 2009..68 for BMI and obesity, respectively). In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population. However, the effect of rs6232 may be age-dependent... - Genetic variation in LIN28B is associated with the timing of pubertyKen K Ong
Medical Research Council MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
Nat Genet 41:729-33. 2009..These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development... - Phytoestrogen content of cereals and cereal-based foods consumed in the UKGunter G C Kuhnle
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
Nutr Cancer 61:302-9. 2009..These results will allow a more accurate estimation of exposure to dietary phytoestrogens... - Mammographic density using two computer-based methods in an isoflavone trialMasako Kataoka
Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Maturitas 59:350-7. 2008.... - No association between APOE and major depressive disorder in a community sample of 17,507 adultsPaul G Surtees
Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
J Psychiatr Res 43:843-7. 2009..These findings suggest that the association between APOE and MDD risk is more modest than has been previously reported... - No evidence that social stress is associated with breast cancer incidencePaul G Surtees
Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
Breast Cancer Res Treat 120:169-74. 2010.... - Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafoodGunter G C Kuhnle
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
J Agric Food Chem 56:10099-104. 2008..This is the first comprehensive study of phytoestrogen content of foods of animal origin and will allow for a more accurate estimation of exposure to dietary phytoestrogens... - Mastery is associated with cardiovascular disease mortality in men and women at apparently low riskPaul G Surtees
Strangeways Research Laboratory, Cambridge, UK
Health Psychol 29:412-20. 2010.... - Adaptation to social adversity is associated with stroke incidence: evidence from the EPIC-Norfolk prospective cohort studyPaul G Surtees
Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
Stroke 38:1447-53. 2007..We test the hypothesis that sense of coherence (SOC), a marker of social stress adaptive capacity, is associated with incident stroke in a population-based prospective cohort study... - Optimization of conditions for the enzymatic hydrolysis of phytoestrogen conjugates in urine and plasmaJames I Taylor
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
Anal Biochem 341:220-9. 2005..Therefore, the use of beta-glucuronidase from H. pomatia combined with an enzyme "blank" to correct for phytoestrogen contamination was shown to be a suitable method for hydrolysis of phytoestrogens... - Dietary fish intake and plasma phospholipid n-3 polyunsaturated fatty acid concentrations in men and women in the European Prospective Investigation into Cancer-Norfolk United Kingdom cohortAilsa A Welch
Department of Public Health and Primary Care and the Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom
Am J Clin Nutr 84:1330-9. 2006.... - Measured height loss predicts fractures in middle-aged and older men and women: the EPIC-Norfolk prospective population studyAlireza Moayyeri
Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
J Bone Miner Res 23:425-32. 2008..Serial measurement of height is, therefore, recommended among the elderly people... - Commentary: fat and breast cancer: time to re-evaluate both methods and results?Sheila A Bingham
MRC Centre for Nutrition and Cancer, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK
Int J Epidemiol 35:1022-4. 2006 - More acidic dietary acid-base load is associated with reduced calcaneal broadband ultrasound attenuation in women but not in men: results from the EPIC-Norfolk cohort studyAilsa A Welch
Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom
Am J Clin Nutr 85:1134-41. 2007..Dietary patterns that promote mild metabolic acidosis may have a negative effect on bone density... - Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometryPhilip B Grace
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Cambridgeshire, UK
Anal Biochem 315:114-21. 2003..Results show a large range in both the amount and the type of phytoestrogens excreted... - Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometryPhilip B Grace
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
Rapid Commun Mass Spectrom 17:1350-7. 2003..The results of the analysis of serum samples from 300 men and women living in the UK are reported... - Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational studySheila A Bingham
MRC Dunn Human Nutrition Unit, Cambridge, UK
Lancet 361:1496-501. 2003..INTERPRETATION: In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%... - Healthy lifestyle choices: could sense of coherence aid health promotion?Nicholas W J Wainwright
Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
J Epidemiol Community Health 61:871-6. 2007..A research framework based on the personal characteristic defined by a sense of coherence (SOC) focuses on the effective use of resources to maintain good health... - Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer preventionAlexandre Loktionov
Dunn Human Nutrition Unit, MRC Wellcome Trust, Cambridge, UK
Cancer Detect Prev 26:15-22. 2002.... - Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosisAlexandre Loktionov
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
Cancer Lett 189:189-96. 2003..02, 95% confidence interval, 1.15-31.54). Our results suggest that PAI-1 genotype may be a useful prognostic marker for colorectal cancer, however further specifically designed studies are needed to assess its value in this respect... - Susceptibility of human metabolic phenotypes to dietary modulationCinzia Stella
Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA, Faculty of Medicine, Imperial College London, and MRC Dunn Human Nutrition Unit, Addenbrookes Hospital, Cambridge, United Kingdom
J Proteome Res 5:2780-8. 2006..This work shows the potential for the routine use of metabonomics in nutritional and epidemiological studies, in characterizing and predicting the metabolic effects and the influence of diet on human metabotypes... - Urinary potassium is as reliable as urinary nitrogen for use as a recovery biomarker in dietary studies of free living individualsNatasa Tasevska
Medical Research Council Dunn Human Nutrition Unit, Cambridge CB2 2XY, UK
J Nutr 136:1334-40. 2006..92; P < 0.001). The high correlations between UK and K in the diet show that UK is a reliable recovery biomarker for use in studies of dietary measurement error. Factors for use of urinary N as a recovery biomarker are also confirmed... - Association between type of dietary fish and seafood intake and the risk of incident type 2 diabetes: the European prospective investigation of cancer (EPIC)-Norfolk cohort studyPinal S Patel
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Diabetes Care 32:1857-63. 2009..To investigate the association between fish and seafood intake and new-onset type 2 diabetes...