Mariann Bienz

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Biochemistry. A lipid linchpin for Wnt-Fz docking
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Science 337:44-5. 2012
  2. ncbi request reprint APC: the plot thickens
    M Bienz
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Genet Dev 9:595-603. 1999
  3. ncbi request reprint Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  4. ncbi request reprint TCF: transcriptional activator or repressor?
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 10:366-72. 1998
  5. ncbi request reprint Endoderm induction in Drosophila: the nuclear targets of the inducing signals
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Genet Dev 7:683-8. 1997
  6. ncbi request reprint The PHD finger, a nuclear protein-interaction domain
    Mariann Bienz
    LMB Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Trends Biochem Sci 31:35-40. 2006
  7. ncbi request reprint The subcellular destinations of APC proteins
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Mol Cell Biol 3:328-38. 2002
  8. ncbi request reprint beta-Catenin: a pivot between cell adhesion and Wnt signalling
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK
    Curr Biol 15:R64-7. 2005
  9. ncbi request reprint Adenomatous polyposis coli proteins and cell adhesion
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Cell Biol 16:528-35. 2004
  10. ncbi request reprint APC
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 13:R215-6. 2003

Research Grants

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Biochemistry. A lipid linchpin for Wnt-Fz docking
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Science 337:44-5. 2012
  2. ncbi request reprint APC: the plot thickens
    M Bienz
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Genet Dev 9:595-603. 1999
    ..Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive...
  3. ncbi request reprint Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  4. ncbi request reprint TCF: transcriptional activator or repressor?
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 10:366-72. 1998
    ..Its deregulation in the colonic epithelium, and in other cells, leads to cancer. This raises the question of how TCF is kept inactive in unstimulated cells...
  5. ncbi request reprint Endoderm induction in Drosophila: the nuclear targets of the inducing signals
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Genet Dev 7:683-8. 1997
  6. ncbi request reprint The PHD finger, a nuclear protein-interaction domain
    Mariann Bienz
    LMB Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Trends Biochem Sci 31:35-40. 2006
    ..New evidence also suggests that some PHD fingers bind to nucleosomes, raising the possibility that chromatin might be a common nuclear ligand of PHD fingers...
  7. ncbi request reprint The subcellular destinations of APC proteins
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Mol Cell Biol 3:328-38. 2002
    ..These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer...
  8. ncbi request reprint beta-Catenin: a pivot between cell adhesion and Wnt signalling
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK
    Curr Biol 15:R64-7. 2005
    ..Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer...
  9. ncbi request reprint Adenomatous polyposis coli proteins and cell adhesion
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Cell Biol 16:528-35. 2004
    ..Thus, APC--like beta-catenin/Armadillo--may have a dual role in Wnt signal transduction and in cellular adhesion, which could be relevant to its activity as a tumour suppressor...
  10. ncbi request reprint APC
    Mariann Bienz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 13:R215-6. 2003
  11. ncbi request reprint Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?
    Mariann Bienz
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 5:179-82. 2003
    ..Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin...
  12. pmc Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    Hoanh Tran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Genes Dev 22:528-42. 2008
    ..Our results indicate a role of K63-linked ubiquitin chains during Wnt-induced transcription...
  13. pmc A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription
    Juliusz Mieszczanek
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 105:19324-9. 2008
    ..This indicates an anti-repressor function of Pygo: we propose that Pygo predisposes Drosophila TCF target genes for rapid Wingless-induced transcription, or that it protects them against premature shut-down...
  14. pmc Intracellular shuttling of a Drosophila APC tumour suppressor homolog
    Adam Cliffe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Cell Biol 5:37. 2004
    ..Here, we ask whether the junctional association of E-APC is stable, or whether E-APC shuttles between the plasma membrane and the cytoplasm...
  15. ncbi request reprint The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
    Fumihiko Hamada
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 7:677-85. 2004
    ..Our evidence indicates that APC is an adaptor between beta-catenin and CtBP and that CtBP lowers the availability of free nuclear beta-catenin for binding to TCF by sequestering APC/beta-catenin complexes...
  16. ncbi request reprint Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function
    Fiona M Townsley
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Cell Biol 6:626-33. 2004
    ..This indicates that Pygo and Lgs function in targeting Armadillo/beta-catenin to the nucleus, thus ensuring its availability to TCF during Wnt signalling...
  17. ncbi request reprint A new nuclear component of the Wnt signalling pathway
    Barry Thompson
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Cell Biol 4:367-73. 2002
    ..The presence of a PHD domain implicates Pygo proteins in a chromatin-related function, and we propose that they mediate chromatin access to TCF or Arm/beta-catenin...
  18. pmc Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
    Marc Fiedler
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 30:507-18. 2008
    ..The specificity of this process provided by the Pygo-BCL9/Legless complex suggests that this complex facilitates an early step in the transition from gene silence to Wnt-induced transcription...
  19. ncbi request reprint Pygopus residues required for its binding to Legless are critical for transcription and development
    Fiona M Townsley
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 279:5177-83. 2004
    ..These residues at the Legless>Pygopus interface thus define a specific molecular target for blocking Wnt signaling during development and cancer...
  20. pmc Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
    Marc Fiedler
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 108:1937-42. 2011
    ..This result implies that Dishevelled has the potential to act as a "natural" dominant-negative, binding to the polymerization interface of Axin's DIX domain to interfere with its self-assembly, thereby blocking its effector function...
  21. pmc Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization
    Ciara Metcalfe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Cell Sci 123:1588-99. 2010
    ..Thus, stable polymerization emerges as a key principle underlying the function of Dishevelled-dependent signalosomes...
  22. ncbi request reprint A Drosophila APC tumour suppressor homologue functions in cellular adhesion
    Fumihiko Hamada
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Cell Biol 4:208-13. 2002
    ..These results indicate that Drosophila APC functions in cellular adhesion; these results could have implications for colorectal adenoma formation and tumour progression in humans...
  23. pmc The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
    Carolina Mendoza-Topaz
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Open Biol 1:110013. 2011
    ..APC thus empowers Axin to function in two ways-by enabling its DIX-dependent self-assembly, and by opposing its DIX-dependent copolymerization with Dishevelled and consequent inactivation...
  24. ncbi request reprint A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling
    Adam Cliffe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    Curr Biol 13:960-6. 2003
    ..This relocation depends on Dsh. It may permit the subsequent inactivation of the Axin complex by Wingless signaling...
  25. pmc Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer
    Ciara Metcalfe
    Medical Research Council Laboratory of Molecular Biology, Li Ka Shing Centre, Cambridge, United Kingdom
    Cancer Res 70:6629-38. 2010
    ..Our results implicate Dvl2 and mTOR in the progression of colorectal neoplasia and highlight their potential as therapeutic targets in colorectal cancer...
  26. ncbi request reprint Wingless-independent association of Pygopus with dTCF target genes
    Marc de la Roche
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom
    Curr Biol 17:556-61. 2007
    ....
  27. pmc Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor
    Thomas C R Miller
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 401:969-84. 2010
    ....
  28. doi request reprint An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains
    Julien D F Licchesi
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nat Struct Mol Biol 19:62-71. 2012
    ..Our data are consistent with AnkUBD functioning as an enzymatic S1' ubiquitin-binding site, which orients a ubiquitin chain so that Lys29 and Lys33 linkages are cleaved preferentially...
  29. pmc The transcriptional repressor Brinker antagonizes Wingless signaling
    Elisabeth Saller
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
    Genes Dev 16:1828-38. 2002
    ..Finally, brinker and tsh produce similar mutant phenotypes in the ventral epidermis, and double mutants mimic overactive Wg signaling in this tissue. This suggests that Brinker may have a widespread function in antagonizing Wg signaling...
  30. ncbi request reprint decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 122:849-58. 1996
    ..As decapentaplegic itself is required for wingless expression in the midgut, this represents a positive feed-back loop between two cell groups signalling to each other to stimulate each other's signal production...
  31. ncbi request reprint Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
    L Waltzer
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 395:521-5. 1998
    ..Although CBP is a coactivator of other transcription factors, our data show that CBP represses TCF...
  32. pmc Transcriptional repression due to high levels of Wingless signalling
    X Yu
    Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 17:7021-32. 1998
    ..Finally, we show that Wingless can repress its own expression via an autorepressive feedback loop that results in a change of the Wingless signalling profile during development...
  33. ncbi request reprint A new Drosophila APC homologue associated with adhesive zones of epithelial cells
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Cell Biol 1:144-51. 1999
    ....
  34. pmc A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
    S Eresh
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:2014-22. 1997
    ..Therefore, a CREB protein may act as a nuclear target, or as a partner of a nuclear target, for Dpp signalling in the embryonic midgut...
  35. ncbi request reprint Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development
    Kirsten K Hanson
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Development 132:4777-87. 2005
    ..Unexpectedly, during late larval development, cells survive loss of borr and develop giant bristles that may reflect their high degree of ploidy...
  36. ncbi request reprint LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
    J Riese
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 88:777-87. 1997
    ..Thus, LEF-1 coordinates inputs from multiple positional signals, consistent with its architectural role in regulating the assembly of multiprotein enhancer complexes...
  37. pmc Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction
    D Szuts
    Medical Research Council MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genes Dev 12:2022-35. 1998
    ..We discuss the potential significance of why an inductive process might use a secondary signal whose function is intertwined with that of the primary signal...
  38. pmc The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells
    Marc de la Roche
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    BMC Cancer 8:199. 2008
    ..No loss-of-function data are available for BCL9...
  39. ncbi request reprint Dynamic recruitment of axin by Dishevelled protein assemblies
    Thomas Schwarz-Romond
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Cell Sci 120:2402-12. 2007
    ..We discuss how the recruitment of casein kinase Iepsilon by Dvl2 assemblies might impact on the recruitment of axin to the plasma membrane during Wnt signalling...
  40. ncbi request reprint Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 84:69-73. 1999
    ..However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved...
  41. ncbi request reprint Homeotic genes and positional signalling in the Drosophila viscera
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Trends Genet 10:22-6. 1994
    ..The homeotic genes that are expressed in the viscera control morphogenesis and differentiation of the larval midgut...
  42. ncbi request reprint The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
    Thomas Schwarz-Romond
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Cell Sci 118:5269-77. 2005
    ..Our evidence indicates that Dvl2 and Axin puncta are dynamic protein assemblies rather than cytoplasmic vesicles...
  43. pmc Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    Rina Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:1101-13. 2003
    ..Our evidence indicates that the rate of nuclear export of APC, rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin...
  44. ncbi request reprint The APC tumour suppressor has a nuclear export function
    R Rosin-Arbesfeld
    Laboratory of Molecular Biology, Cambridge, UK
    Nature 406:1009-12. 2000
    ..Thus, the ability of APC to exit from the nucleus appears to be critical for its tumour suppressor function...
  45. ncbi request reprint D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction
    J Riese
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:3353-61. 1997
    ....
  46. pmc An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
    Marc de la Roche
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Commun 3:680. 2012
    ....
  47. ncbi request reprint Bre1 is required for Notch signaling and histone modification
    Sarah Bray
    Department of Anatomy, University of Cambridge, Cambridge, CB, UK
    Dev Cell 8:279-86. 2005
    ..Our results indicate that histone modification is critical for the transcription of Notch target genes...
  48. ncbi request reprint The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
    Thomas Schwarz-Romond
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Struct Mol Biol 14:484-92. 2007
    ....
  49. pmc Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription
    E Saller
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    EMBO Rep 2:298-305. 2001
    ..These results indicate how Brinker acts as a dominant repressor of Dpp target genes, and explain why Brinker is a potent antagonist of Dpp...
  50. ncbi request reprint Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila
    D Szuts
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:3209-19. 1997
    ..Finally, we show that the segmental zones of high EGFR signalling activity depend on bithorax gene function and that they account for the main difference in shape between abdominal and thoracic denticle belts...
  51. ncbi request reprint Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo
    F M Townsley
    Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Curr Biol 10:1339-48. 2000
    ..In Drosophila epithelial cells, the ubiquitous form of APC, known as E-APC, is associated with adherens junctions. This association appears to be necessary for E-APC to function in destabilising Armadillo...
  52. pmc A function of CBP as a transcriptional co-activator during Dpp signalling
    L Waltzer
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 18:1630-41. 1999
    ..Our results provide evidence that CBP functions as a co-activator during Dpp signalling, and they suggest that Mad may recruit CBP to effect the transcriptional activation of Dpp-responsive genes during development...
  53. doi request reprint Inhibition of GSK3 by Wnt signalling--two contrasting models
    Ciara Metcalfe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Cell Sci 124:3537-44. 2011
    ..We shall consider whether the two models apply to different modes of Wnt signaling: acute versus chronic...
  54. ncbi request reprint Transcriptional silencing of homeotic genes in Drosophila
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, England
    Bioessays 17:775-84. 1995
    ..We propose that this complex consists of specific non-histone proteins, the so-called Polycomb group proteins, and that it is anchored at SIL-M elements and at the promoter...
  55. pmc Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut
    S Hoppler
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 14:5016-26. 1995
    ..Thus, midgut cells respond differentially to distinct wingless thresholds in terms of both gene control and cellular differentiation...
  56. pmc LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator
    D Szuts
    Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 97:5351-6. 2000
    ..Because Dfos behaves as an autonomous transcriptional activator in more artificial assays systems, our data suggest that context-dependence of transcription factors may be more prevalent than previously thought...
  57. ncbi request reprint An autoregulatory function of Dfos during Drosophila endoderm induction
    D Szuts
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Mech Dev 98:71-6. 2000
    ..We show that Dfos expression is stimulated by Egfr signalling. Finally, we find that Dfos function is required for its own upregulation. Thus, endoderm induction is based on at least four tiers of positive autoregulatory feedback loops...
  58. ncbi request reprint A test for cell autonomy, based on di-cistronic messenger translation
    K Hart
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 122:747-51. 1996
    ..Consequently, wing cells are transformed into cells that appear to be intermediates between wing and haltere cells, contesting the view that homeotic genes act as binary switches...
  59. ncbi request reprint Molecular mechanisms of determination in Drosophila
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 4:955-61. 1992
    ..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved...
  60. pmc EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO Rep 2:157-62. 2001
    ..Thus, our results show that activated Armadillo is subject to a specific negative control by EGFR/Rolled MAP kinase signalling...
  61. ncbi request reprint Imaginal disc silencers from Ultrabithorax: evidence for Polycomb response elements
    B Christen
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 48:255-66. 1994
    ..Since silencing by BXD also requires Pc function, this suggests that BXD contains target sites for Pc or for Pc-like proteins. We propose that stable silencing of Ubx is achieved through cooperation between hb and Pc target sites...
  62. pmc Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells
    R Rosin-Arbesfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
    EMBO J 20:5929-39. 2001
    ..The ability of APC to reach the cell periphery may thus contribute to its tumour suppressor function in the intestinal epithelium...
  63. ncbi request reprint Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    Josipa Bilic
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 316:1619-22. 2007
    ..We propose that Wnts induce coclustering of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization...
  64. ncbi request reprint Bio-sketch for oncogene review issue on Wnt signalling
    M Bienz
    Oncogene 25:7441. 2006

Research Grants1

  1. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. ..