Elena V Bichenkova

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi DNA-mounted self-assembly: new approaches for genomic analysis and SNP detection
    Elena V Bichenkova
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Biochim Biophys Acta 1809:1-23. 2011
  2. ncbi Target-assembled exciplexes based on Scorpion oligonucleotides
    Abdul Gbaj
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, UK
    Biosci Rep 28:1-5. 2008
  3. ncbi Detection of nucleic acids in situ: novel oligonucleotide analogues for target-assembled DNA-mounted exciplexes
    Elena V Bichenkova
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Org Biomol Chem 5:1039-51. 2007
  4. ncbi SNP detection for cytochrome P450 alleles by target-assembled tandem oligonucleotide systems based on exciplexes
    Lindsey Walsh
    Wolfson Center for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, U K
    J Biomol Struct Dyn 25:629-40. 2008
  5. ncbi Molecular basis of action of HyBeacon fluorogenic probes: a spectroscopic and molecular dynamics study
    Abigail H R Marks
    Wolfson Centre for Structure-Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    J Biomol Struct Dyn 23:49-62. 2005
  6. ncbi Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors
    Elena V Bichenkova
    Wolfson Centre for Structure Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UKM13 9PL
    Org Biomol Chem 4:367-78. 2006
  7. ncbi Target-assembled ExciProbes: application to DNA detection at the level of PCR product and plasmid DNA
    Lindsey Walsh
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, UK
    J Biomol Struct Dyn 25:219-30. 2007
  8. ncbi Molecular probes: insights into design and analysis from computational and physical chemistry
    Felicity L Mitchell
    Wolfson Centre for Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, U K
    Biochem Soc Trans 36:46-50. 2008
  9. ncbi Target-assembled tandem oligonucleotide systems based on exciplexes for detecting DNA mismatches and single nucleotide polymorphisms
    Elena V Bichenkova
    Wolfson Centre for Rational Structure-Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    Biochem Biophys Res Commun 332:956-64. 2005
  10. ncbi DNA mismatch detection by resonance energy transfer between ruthenium(II) and osmium(II) tris(2,2'-bipyridyl) chromophores
    Elena V Bichenkova
    Wolfson Centre for Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, and School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Inorg Chem 44:4112-4. 2005

Collaborators

  • Alexander J Blake
  • Benjamin J Coe
  • David J French
  • Pascal Bonnet
  • João Neres
  • Lindsey Walsh
  • Kenneth T Douglas
  • Felicity L Mitchell
  • Abdul Gbaj
  • Laura L Etchells
  • Richard A Bryce
  • David Mansell
  • Sally Freeman
  • Manikandan Kadirvel
  • Abigail H R Marks
  • Carl H Schwalbe
  • Christopher J Barker
  • Steven M Miles
  • Nicholas Rattray
  • Julia Torres
  • Carlos Kremer
  • Maria Candelaria Rogert
  • Alireza Sardarian
  • Gabriel E Marks
  • Biljana Arsic
  • David Whitcombe
  • M Candelaria Rogert Bacigalupo
  • Hannah E Savage
  • Pranab K Bhadra
  • David G McDowell

Detail Information

Publications14

  1. ncbi DNA-mounted self-assembly: new approaches for genomic analysis and SNP detection
    Elena V Bichenkova
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Biochim Biophys Acta 1809:1-23. 2011
    ..One approach to improving the sensitivity of an assay to confidently discriminate between single point mutations is based on the use of target assembled, split-probe systems, which constitutes the main focus of this review...
  2. ncbi Target-assembled exciplexes based on Scorpion oligonucleotides
    Abdul Gbaj
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, UK
    Biosci Rep 28:1-5. 2008
    ..Hybridization of the probe to a complementary target in a buffer containing trifluoroethanol produced an obvious fluorescence change from blue (pyrene locally excited state emission) to green (exciplex emission)...
  3. ncbi Detection of nucleic acids in situ: novel oligonucleotide analogues for target-assembled DNA-mounted exciplexes
    Elena V Bichenkova
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Org Biomol Chem 5:1039-51. 2007
    ..The exciplexes formed emitted at approximately 480 nm with large Stokes shifts ( approximately 130-140 nm). Comparative studies with pyrene excimer systems were also carried out...
  4. ncbi SNP detection for cytochrome P450 alleles by target-assembled tandem oligonucleotide systems based on exciplexes
    Lindsey Walsh
    Wolfson Center for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, U K
    J Biomol Struct Dyn 25:629-40. 2008
    ....
  5. ncbi Molecular basis of action of HyBeacon fluorogenic probes: a spectroscopic and molecular dynamics study
    Abigail H R Marks
    Wolfson Centre for Structure-Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    J Biomol Struct Dyn 23:49-62. 2005
    ..Hybridization leads to an extended linker conformation, removing the fluorophore from the immediate vicinity of the DNA bases...
  6. ncbi Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors
    Elena V Bichenkova
    Wolfson Centre for Structure Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UKM13 9PL
    Org Biomol Chem 4:367-78. 2006
    ..This research provides the initial background for design of self-assembled, DNA-mounted exciplexes and underpins further development of exciplex-based hybridisation bioassays...
  7. ncbi Target-assembled ExciProbes: application to DNA detection at the level of PCR product and plasmid DNA
    Lindsey Walsh
    Wolfson Centre for Rational Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, UK
    J Biomol Struct Dyn 25:219-30. 2007
    ..The effect of counter cations (Na(+), K(+), and Mg(2+)) and PCR additives on exciplex emission has been also examined...
  8. ncbi Molecular probes: insights into design and analysis from computational and physical chemistry
    Felicity L Mitchell
    Wolfson Centre for Structure Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, U K
    Biochem Soc Trans 36:46-50. 2008
    ..Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield...
  9. ncbi Target-assembled tandem oligonucleotide systems based on exciplexes for detecting DNA mismatches and single nucleotide polymorphisms
    Elena V Bichenkova
    Wolfson Centre for Rational Structure-Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    Biochem Biophys Res Commun 332:956-64. 2005
    ..Inserts and mismatches can be effectively detected by this exciplex construct giving potential for single nucleotide polymorphism detection...
  10. ncbi DNA mismatch detection by resonance energy transfer between ruthenium(II) and osmium(II) tris(2,2'-bipyridyl) chromophores
    Elena V Bichenkova
    Wolfson Centre for Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, and School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Inorg Chem 44:4112-4. 2005
    ....
  11. ncbi Exciplex and excimer molecular probes: detection of conformational flip in a myo-inositol chair
    Manikandan Kadirvel
    School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester M139PT, UK
    Org Biomol Chem 6:1966-72. 2008
    ..This study provides proof of principle for the development of novel fluorescent molecular probes...
  12. ncbi Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic
    David Mansell
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, UK M13 9PT
    Org Biomol Chem 8:2850-8. 2010
    ..The data presented confirms that Fe(3+) binds tightly to the unstable penta-axial conformation of myo-inositol phosphates possessing the 1,2,3-trisphosphate motif...
  13. ncbi Tryptophan as a molecular shovel in the glycosyl transfer activity of Trypanosoma cruzi trans-sialidase
    Felicity L Mitchell
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
    Biophys J 98:L38-40. 2010
    ..These computational simulations provide detailed structural insights into sialyl transfer by the trans-sialidase and may aid the design of inhibitors effective against this neglected tropical disease...
  14. ncbi An exciplex-based, target-assembled fluorescence system with inherently low background to probe for specific nucleic acid sequences
    Elena V Bichenkova
    Wolfson Centre for Structure Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Assay Drug Dev Technol 3:39-46. 2005
    ..Compared to other fluorophore systems that have large backgrounds (typically >60%), ExciProbes show backgrounds of <1% under comparable conditions, and can be used with DNA, RNA, or synthetic nucleic acids such as locked nucleic acid...