B M Biccard

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Relationship between the inability to climb two flights of stairs and outcome after major non-cardiac surgery: implications for the pre-operative assessment of functional capacity
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella 4013, South Africa
    Anaesthesia 60:588-93. 2005
  2. ncbi Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials
    B M Biccard
    Nelson R Mandela School of Medicine, KwaZulu Natal, South Africa
    Anaesthesia 63:4-14. 2008
  3. ncbi Meta-analysis of the effect of heart rate achieved by perioperative beta-adrenergic blockade on cardiovascular outcomes
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella, Kwazulu Natal 4013, South Africa
    Br J Anaesth 100:23-8. 2008
  4. ncbi A peri-operative statin update for non-cardiac surgery. Part I: The effects of statin therapy on atherosclerotic disease and lessons learnt from statin therapy in medical (non-surgical) patients
    B M Biccard
    Nelson R Mandela School of Medicine, Private Bag 7, Congella, 4013, South Africa
    Anaesthesia 63:52-64. 2008
  5. doi A peri-operative statin update for non-cardiac surgery. Part II: Statin therapy for vascular surgery and peri-operative statin trial design
    B M Biccard
    Nelson R Mandela School of Medicine, Private Bag 7, Congella, 4013, South Africa
    Anaesthesia 63:162-71. 2008
  6. ncbi Acute peri-operative beta blockade in intermediate-risk patients
    B M Biccard
    Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Anaesthesia 61:924-31. 2006
  7. ncbi The pharmacoeconomics of peri-operative beta-blocker therapy
    B M Biccard
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Anaesthesia 61:4-8. 2006
  8. ncbi Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease
    B M Biccard
    Clinical Research Fellow, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
    Anaesthesia 60:1106-14. 2005
  9. ncbi The pharmaco-economics of peri-operative statin therapy
    B M Biccard
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
    Anaesthesia 60:1059-63. 2005
  10. pmc Investigation of predictors of increased creatine kinase levels following vascular surgery and the association with peri-operative statin therapy
    B M Biccard
    Nelson R Mandela School of Medicine, Durban, South Africa
    Cardiovasc J Afr 20:187-91. 2009

Collaborators

Detail Information

Publications33

  1. ncbi Relationship between the inability to climb two flights of stairs and outcome after major non-cardiac surgery: implications for the pre-operative assessment of functional capacity
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella 4013, South Africa
    Anaesthesia 60:588-93. 2005
    ..Principles for the selection of an appropriate screening test of aerobic function are put forward...
  2. ncbi Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials
    B M Biccard
    Nelson R Mandela School of Medicine, KwaZulu Natal, South Africa
    Anaesthesia 63:4-14. 2008
    ..45, 95% CI 2.98-9.95, p < 0.00001) were significantly increased. An anticholinergic did not reduce the incidence of bradycardia (p = 0.43). A randomised placebo-controlled trial of dexmedetomidine is warranted...
  3. ncbi Meta-analysis of the effect of heart rate achieved by perioperative beta-adrenergic blockade on cardiovascular outcomes
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella, Kwazulu Natal 4013, South Africa
    Br J Anaesth 100:23-8. 2008
    ..We have investigated the association between the heart rate achieved with perioperative beta-blockade and the incidence of perioperative cardiac complications...
  4. ncbi A peri-operative statin update for non-cardiac surgery. Part I: The effects of statin therapy on atherosclerotic disease and lessons learnt from statin therapy in medical (non-surgical) patients
    B M Biccard
    Nelson R Mandela School of Medicine, Private Bag 7, Congella, 4013, South Africa
    Anaesthesia 63:52-64. 2008
    ..Withdrawal of statin therapy results in a rapid return to endothelial dysfunction and amplification of the inflammatory process, which may increase cardiovascular risk...
  5. doi A peri-operative statin update for non-cardiac surgery. Part II: Statin therapy for vascular surgery and peri-operative statin trial design
    B M Biccard
    Nelson R Mandela School of Medicine, Private Bag 7, Congella, 4013, South Africa
    Anaesthesia 63:162-71. 2008
    ..Recommendations are made regarding retrospective reporting of statin studies to minimise the bias inherent in a number of the current retrospective studies on this subject...
  6. ncbi Acute peri-operative beta blockade in intermediate-risk patients
    B M Biccard
    Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Anaesthesia 61:924-31. 2006
    ....
  7. ncbi The pharmacoeconomics of peri-operative beta-blocker therapy
    B M Biccard
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Anaesthesia 61:4-8. 2006
    ..However, there is evidence that in patients at lower cardiovascular risk, beta-blockers may be potentially harmful, since their adverse effects (hypotension, bradycardia) may outweigh their potential cardioprotective effects...
  8. ncbi Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease
    B M Biccard
    Clinical Research Fellow, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
    Anaesthesia 60:1106-14. 2005
    ..These include indications for peri-operative statin therapy, timing of administration, therapeutic targets, duration of administration, the adverse implications of peri-operative statin withdrawal, safety and cost-effectiveness...
  9. ncbi The pharmaco-economics of peri-operative statin therapy
    B M Biccard
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
    Anaesthesia 60:1059-63. 2005
    ....
  10. pmc Investigation of predictors of increased creatine kinase levels following vascular surgery and the association with peri-operative statin therapy
    B M Biccard
    Nelson R Mandela School of Medicine, Durban, South Africa
    Cardiovasc J Afr 20:187-91. 2009
    ..The aim of this study was to determine independent predictors of creatine kinase (CK) elevation following vascular surgery...
  11. ncbi Validation of a model to predict all-cause in-hospital mortality in vascular surgical patients
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine and Inkosi Albert Luthuli Central Hospital, Durban, South Africa
    Cardiovasc J Afr 19:303-8. 2008
    ..To develop and validate a pre- and postoperative model of all-cause in-hospital mortality in South African vascular surgical patients...
  12. doi What is the best pre-operative risk stratification tool for major adverse cardiac events following elective vascular surgery? A prospective observational cohort study evaluating pre-operative myocardial ischaemia monitoring and biomarker analysis
    B M Biccard
    Perioperative Research Unit, Department of Anaesthesia, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa
    Anaesthesia 67:389-95. 2012
    ..001). Pre-operative brain natriuretic peptide evaluation was the only clinically useful predictor of postoperative cardiac complications...
  13. ncbi HIV, vascular surgery and cardiovascular outcomes: a South African cohort study
    L A Redman
    Entabeni Hospital, Durban, KwaZulu Natal, South Africa
    Anaesthesia 69:208-13. 2014
    ..Research should focus on why this is the case, and if alternative clinical risk predictors can be developed for HIV patients. ..
  14. doi The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients
    B M Biccard
    Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Anaesthesia 67:55-9. 2012
    ..1, 95% CI 1.8-15 for the intermediate class, and OR 25, 95% CI 8.7-70 for the high-risk class). The clinical risk factors in the revised cardiac risk index cannot improve a risk stratification model based on B-type natriuretic peptides...
  15. ncbi Cardiac biomarkers in the prediction of risk in the non-cardiac surgery setting
    B M Biccard
    Perioperative Research Group, Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Anaesthesia 69:484-93. 2014
    ....
  16. ncbi Heart rate and outcome in patients with cardiovascular disease undergoing major noncardiac surgery
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Congella, South Africa
    Anaesth Intensive Care 36:489-501. 2008
    ..Therefore, any bradycardic manipulation of heart rate in the perioperative period must be accompanied by simultaneous attention to other physiological variables associated with increased morbidity and mortality...
  17. doi A meta-analysis of the utility of pre-operative brain natriuretic peptide in predicting early and intermediate-term mortality and major adverse cardiac events in vascular surgical patients
    R N Rodseth
    Nelson R Mandela School of Medicine, KwaZulu Natal, South Africa
    Anaesthesia 63:1226-33. 2008
    ..02) and major adverse cardiac events (OR 3.31, 95% CI 2.1-5.24, p < 0.00001). B-type natriuretic peptide and N-terminal-pro B-type natriuretic peptide are potentially useful pre-operative prognostic tests in vascular surgical patients...
  18. ncbi The pathophysiology of peri-operative myocardial infarction
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Inkosi Albert Luthuli Central Hospital, South Africa
    Anaesthesia 65:733-41. 2010
    ..Research and therapeutic interventions should be focused on the prediction and therapy of flow stagnation and thrombus formation. Plaque rupture appears to be a more random event, distributed over the entire peri-operative admission...
  19. ncbi The pharmaco-economics of peri-operative beta-blocker and statin therapy in South Africa
    B M Biccard
    Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
    S Afr Med J 96:1199-202. 2006
    ..The validity of these findings is dependent on whether the incidence of cardiovascular complications following major noncardiac surgery reported in the international literature is found to be similar in South Africa...
  20. doi Outcomes in vascular surgical patients with isolated postoperative troponin leak: a meta-analysis
    G Redfern
    Perioperative Research Unit, Department of Anaesthetics, Nelson R Mandela School of Medicine, KwaZulu Natal, South Africa
    Anaesthesia 66:604-10. 2011
    ..3%, 11.6% and 21.6%, respectively (p = 0.000001). Insufficient data were available to analyse intermediate-term outcomes. An isolated troponin leak following vascular surgery is strongly associated with short-term mortality...
  21. pmc Factors associated with mortality when chronic betablocker therapy is withdrawn in the peri-operative period in vascular surgical patients: a matched case-control study
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine and Inkosi Albert Luthuli Central Hospital, Durban, South Africa
    Cardiovasc J Afr 21:97-102. 2010
    ..787. Conclusion: Use of a postoperative heart rate threshold may be clinically useful as an 'early warning system' in patients withdrawn from chronic beta-blockade in the peri-operative period...
  22. doi The role of brain natriuretic peptide in prognostication and reclassification of risk in patients undergoing vascular surgery
    B M Biccard
    Inkosi Albert Luthuli Central Hospital, Durban, Natal, South Africa
    Anaesthesia 66:379-85. 2011
    ..0% (95% CI 16.7-83.3%), p = 0.01). We have shown that measurement of pre-operative brain natriuretic peptide is relevant in the context of risk assessment in this cohort of patients...
  23. doi A meta-analysis of the utility of C-reactive protein in predicting early, intermediate-term and long term mortality and major adverse cardiac events in vascular surgical patients
    L Padayachee
    Nelson R Mandela School of Medicine, KwaZulu Natal, South Africa
    Anaesthesia 64:416-24. 2009
    ..78-5.18, p = 0.15 respectively). Long term all cause mortality (OR 2.40, 95% CI 1.15-5.02, p = 0.02), cardiac death (OR 5.66, 95% CI 1.71-18.73, p = 0.005) and MACE (OR 2.76, 95% CI 1.38-5.55, p = 0.004) were significantly increased...
  24. doi Utility of clinical risk predictors for preoperative cardiovascular risk prediction
    B M Biccard
    Perioperative Research Unit, Department of Anaesthetics, Inkosi Albert Luthuli Central Hospital, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Private Bag 7, Congella 4013, South Africa
    Br J Anaesth 107:133-43. 2011
    ..Risk assignment should occur throughout the perioperative period and the risk factors chosen for model inclusion should vary depending on when the assignment occurs (before operation, intraoperatively, or after operation)...
  25. ncbi When is the risk acceptable to proceed to noncardiac surgery following an acute myocardial infarction?
    A Semark
    Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu Natal, South Africa
    Minerva Anestesiol 77:64-73. 2011
    ....
  26. ncbi The efficacy of peri-operative interventions to decrease postoperative delirium in non-cardiac surgery: a systematic review and meta-analysis
    Z Moyce
    Peri operative Research Group, Department of Anaesthesia, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa
    Anaesthesia 69:259-69. 2014
    ..76, 95% CI 0.47-1.23). This meta-analysis has shown that peri-operative geriatric consultations with multicomponent interventions and lighter anaesthesia are potentially effective in decreasing the incidence of postoperative delirium. ..
  27. ncbi Clinical risk predictors associated with cardiac mortality following vascular surgery in South African patients
    B M Biccard
    Nelson R Mandela School of Medicine, Durban Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Cardiovasc J Afr 18:216-20. 2007
    ..In conclusion, an elevated serum creatinine and a positive history for smoking are important clinical predictors of cardiac mortality in South African patients following elective or urgent vascular surgery...
  28. doi A meta-analysis of the prospective randomised trials of coronary revascularisation before noncardiac vascular surgery with attention to the type of coronary revascularisation performed
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella 4013, South Africa
    Anaesthesia 64:1105-13. 2009
    ..CABG may improve long term outcomes in vascular surgical patients. The indications for and timing of CABG in vascular surgical patients needs further research...
  29. ncbi Peri-operative beta-blockade and haemodynamic optimisation in patients with coronary artery disease and decreasing exercise capacity presenting for major noncardiac surgery
    B M Biccard
    Consultant Anaesthetist, Department of Anaesthetics, Nelson R Mandela School of Medicine, Private Bag 7, Congella, 4013, South Africa
    Anaesthesia 59:60-8. 2004
    ....
  30. pmc Risk factors associated with intermediate and long-term mortality following vascular surgery in South African patients
    B M Biccard
    Department of Anaesthetics, Nelson R Mandela School of Medicine, South Africa
    Cardiovasc J Afr 21:263-7. 2010
    ..The aim of this study was therefore to determine risk factors associated with intermediate and long-term mortality in South African vascular surgical patients...
  31. ncbi Phaeochromocytoma and acute myocardial infarction
    B M Biccard
    Department of Anaesthetics, University of Natal, Congella, South Africa
    Anaesth Intensive Care 30:74-6. 2002
    ..Factors contributing to the myocardial infarction, the role of beta adrenoceptor blockade, the timing of adrenalectomy and the place of coronary revascularization are discussed...
  32. pmc Carotid artery stump pressure and associated neurological changes in predominantly symptomatic carotid artery disease patients undergoing awake carotid endarterectomy
    T V Mulaudzi
    Durban Metropolitan Vascular Service, Durban, South Africa
    Cardiovasc J Afr 20:116-8. 2009
    ..To determine the mean carotid artery stump pressure (SP) at which patients develop neurological changes while undergoing awake carotid artery endarterectomy (CEA) under cervical block anaesthesia (CBA)...
  33. doi Calcium channel blockers, beta-blockers, and perioperative cardiovascular stability
    B M Biccard
    Br J Anaesth 101:439-41. 2008