K P Bhatia

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Sensory tricks in primary cervical dystonia depend on visuotactile temporal discrimination
    Georg Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:356-61. 2013
  2. pmc Limb amputations in fixed dystonia: a form of body integrity identity disorder?
    Mark J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK
    Mov Disord 26:1410-4. 2011
  3. pmc The non-motor syndrome of primary dystonia: clinical and pathophysiological implications
    Maria Stamelou
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology Queen Square, London, WC1N 3BG UK
    Brain 135:1668-81. 2012
  4. pmc Functional reorganization of sensorimotor cortex in early Parkinson disease
    M Kojovic
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    Neurology 78:1441-8. 2012
  5. doi request reprint Paroxysmal dyskinesias
    Kailash P Bhatia
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Mov Disord 26:1157-65. 2011
  6. ncbi request reprint Spontaneously changing muscular activation pattern in patients with cervical dystonia
    A Munchau
    MRC Human Movement and Balance Unit, University College London, United Kingdom
    Mov Disord 16:1091-7. 2001
  7. pmc The blink reflex recovery cycle differs between essential and presumed psychogenic blepharospasm
    P Schwingenschuh
    UCL Institute of Neurology, London WC1N 3BG, UK
    Neurology 76:610-4. 2011
  8. pmc THAP1 mutations (DYT6) are an additional cause of early-onset dystonia
    H Houlden
    University College London Institute of Neurology, Queen Square, London WC1N 3BG, England
    Neurology 74:846-50. 2010
  9. doi request reprint Neurophysiological evidence for cerebellar dysfunction in primary focal dystonia
    J T H Teo
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 80:80-3. 2009
  10. doi request reprint Neuropathology of primary adult-onset dystonia
    J L Holton
    Queen Square Brain Bank, Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 70:695-9. 2008

Collaborators

Detail Information

Publications41

  1. pmc Sensory tricks in primary cervical dystonia depend on visuotactile temporal discrimination
    Georg Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:356-61. 2013
    ....
  2. pmc Limb amputations in fixed dystonia: a form of body integrity identity disorder?
    Mark J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK
    Mov Disord 26:1410-4. 2011
    ..The outcome of amputation in fixed dystonia is invariably unfavorable...
  3. pmc The non-motor syndrome of primary dystonia: clinical and pathophysiological implications
    Maria Stamelou
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology Queen Square, London, WC1N 3BG UK
    Brain 135:1668-81. 2012
    ..Here, we review this evidence and discuss its clinical and pathophysiological implications...
  4. pmc Functional reorganization of sensorimotor cortex in early Parkinson disease
    M Kojovic
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    Neurology 78:1441-8. 2012
    ..Here we sought evidence that compensation may be a part of a more widespread functional reorganization in sensorimotor networks, including primary motor cortex...
  5. doi request reprint Paroxysmal dyskinesias
    Kailash P Bhatia
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Mov Disord 26:1157-65. 2011
    ..Potassium and calcium channel mutations underlie the 2 main forms of episodic ataxia (EA1 and EA2), whereas benign torticollis of infancy may also be a calcium channel disorder...
  6. ncbi request reprint Spontaneously changing muscular activation pattern in patients with cervical dystonia
    A Munchau
    MRC Human Movement and Balance Unit, University College London, United Kingdom
    Mov Disord 16:1091-7. 2001
    ..This should be considered when BT treatment response is unsatisfactory, and should also be taken into account when interpreting results of EMG recordings of neck muscles in these patients...
  7. pmc The blink reflex recovery cycle differs between essential and presumed psychogenic blepharospasm
    P Schwingenschuh
    UCL Institute of Neurology, London WC1N 3BG, UK
    Neurology 76:610-4. 2011
    ..The blink reflex recovery cycle measures the excitability of human brainstem interneurons and is abnormal in BEB. We wished to study the blink reflex recovery cycle in patients with atypical (presumed psychogenic) blepharospasm (AB)...
  8. pmc THAP1 mutations (DYT6) are an additional cause of early-onset dystonia
    H Houlden
    University College London Institute of Neurology, Queen Square, London WC1N 3BG, England
    Neurology 74:846-50. 2010
    ..The clinical phenotype of DYT6 consists mainly of primary craniocervical dystonia. Recently, the THAP1 gene was identified as the cause of DYT6, where a total of 13 mutations have been identified in Amish-Mennonite and European families...
  9. doi request reprint Neurophysiological evidence for cerebellar dysfunction in primary focal dystonia
    J T H Teo
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 80:80-3. 2009
    ..Further work needs to be done to determine if these changes are primary, secondary or epiphenomenal to the disease...
  10. doi request reprint Neuropathology of primary adult-onset dystonia
    J L Holton
    Queen Square Brain Bank, Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 70:695-9. 2008
    ..However, it was unclear whether these changes are characteristic of these particular disorders or an epiphenomenon of dystonic conditions in general...
  11. pmc Effect of electrode contact location on clinical efficacy of pallidal deep brain stimulation in primary generalised dystonia
    S Tisch
    Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, University College London, Box 146, 8 11 Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 78:1314-9. 2007
    ..To determine the effect of electrode contact location on efficacy of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for primary generalised dystonia (PGD). Subjects and..
  12. doi request reprint BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease
    T Foltynie
    Cambridge Centre for Brain Repair, Cambridge, UK
    J Neurol Neurosurg Psychiatry 80:141-4. 2009
    ..There is accumulating evidence that LID develop due to abnormal synaptic plasticity, which is in turn influenced by the release of brain derived neurotrophic factor (BDNF)...
  13. ncbi request reprint Patterns of EMG-EMG coherence in limb dystonia
    Pascal Grosse
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 19:758-69. 2004
    ..We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology...
  14. ncbi request reprint Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystonia
    A Munchau
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Brain 124:769-83. 2001
    ..Reinnervation is not infrequent and can compromise outcome. Postoperative morbidity is low, but there is a risk of dysphagia...
  15. ncbi request reprint Polymyography combined with time-locked video recording (video EMG) for presurgical assessment of patients with cervical dystonia
    A Munchau
    University Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Eur Neurol 45:222-8. 2001
    ..Video EMG allows an integrated approach to identify overactive neck muscles in patients with cervical dystonia taking into account both relevant clinical findings and EMG data...
  16. pmc Prospective study of swallowing function in patients with cervical dystonia undergoing selective peripheral denervation
    A Munchau
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:67-72. 2001
    ..To characterise swallowing function in patients with cervical dystonia with botulinum toxin treatment failure, before and after selective peripheral denervation surgery...
  17. pmc Genotype-phenotype interactions in primary dystonias revealed by differential changes in brain structure
    B Draganski
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, UK
    Neuroimage 47:1141-7. 2009
    ..Alternatively, a DYT1 gene dependent primary defect of motor circuit development may lead to stress-induced remodelling of the basal ganglia and hence dystonia...
  18. doi request reprint Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients
    I Trender-Gerhard
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 80:839-45. 2009
    ..However, a number of clinical issues remain unresolved including phenotypic variability, long-term response to levodopa and associated non-motor symptoms, and there are limited data on long-term follow-up of genetically proven cases...
  19. ncbi request reprint Changes in forearm reciprocal inhibition following pallidal stimulation for dystonia
    S Tisch
    obell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square London, United Kingdom
    Neurology 66:1091-3. 2006
    ..The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition...
  20. ncbi request reprint Arm tremor in cervical dystonia differs from essential tremor and can be classified by onset age and spread of symptoms
    A Munchau
    Sobell Department of Neurophysiology, University College London, London, UK
    Brain 124:1765-76. 2001
    ..These groups do not correspond to the currently proposed clinical subdivision of 'dystonic tremor' and 'tremor associated with dystonia'...
  21. ncbi request reprint Physiological studies in carriers of the DYT1 gene mutation
    J C Rothwell
    Sobell Department, Institute of Neurology, London, UK
    Rev Neurol (Paris) 159:880-4. 2003
    ..Non-manifesting cases had some but not all of these defects, suggesting that additional genetic or environmental factors may be needed to produce the full range of physiological deficiencies needed to give rise to clinical symptoms...
  22. ncbi request reprint Phenotypic homogeneity of the Huntington disease-like presentation in a SCA17 family
    S A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Neurology 67:1701-3. 2006
    ..However, SCA17 HDL presentation has been observed only sporadically or in solitary individuals within a family. HDL phenotypic homogeneity in SCA17 has not been described. SCA17 can present with a HDL syndrome in multiple family members...
  23. ncbi request reprint Severe tongue protrusion dystonia: clinical syndromes and possible treatment
    S A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neurology 67:940-3. 2006
    ..Tongue protrusion dystonia is often unresponsive to oral drugs but may benefit from botulinum toxin injections into the genioglossus muscle. Bilateral deep brain pallidal stimulation was beneficial in two cases...
  24. pmc Autosomal dominant cerebellar ataxia: SCA2 is the most frequent mutation in eastern India
    K K Sinha
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 75:448-52. 2004
    ..The purpose of this study was to determine the prevalence of different SCA mutations in a relatively homogeneous population from eastern India...
  25. ncbi request reprint Familial dopa-responsive cervical dystonia
    S A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK
    Neurology 66:599-601. 2006
    ..These cases may represent new forms of dopa-responsive dystonia. Levodopa is advisable in all patients with young-onset cervical dystonia...
  26. ncbi request reprint Late-onset episodic ataxia type 2 due to an in-frame insertion in CACNA1A
    P Imbrici
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, United Kingdom
    Neurology 65:944-6. 2005
    ..Molecular expression revealed evidence of impaired calcium channel function, suggesting that genetically induced reduction in calcium channel function may associate with cases of late-onset EA2...
  27. doi request reprint Extragenetic factors and clinical penetrance of DYT1 dystonia: an exploratory study
    D Martino
    Neuroscience and Trauma Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurol 260:1081-6. 2013
    ..Perinatal adversities might modulate the clinical penetrance of DYT1 dystonia; their interaction with known genetic factors modifying penetrance of this condition should be investigated in new, larger collaborative studies...
  28. ncbi request reprint Familial (idiopathic) paroxysmal dyskinesias: an update
    K P Bhatia
    Department of Clinical Neurology, Institute of Neurology, University College London, United Kingdom
    Semin Neurol 21:69-74. 2001
    ..However, another family with ADNFLE has been linked to chromosome 15 in the area of another nicotinic acetylcholine receptor gene. Thus the familial paroxysmal dyskinesias appear to be clinically and genetically heterogeneous...
  29. pmc A dystonic syndrome associated with anti-basal ganglia antibodies
    M J Edwards
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 75:914-6. 2004
    ..It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA...
  30. doi request reprint The prognosis of fixed dystonia: a follow-up study
    N M Ibrahim
    Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, University College London, UK
    Parkinsonism Relat Disord 15:592-7. 2009
    ..The syndrome of fixed dystonia includes both CRPS-dystonia and psychogenic dystonia. The underlying mechanisms are unclear, but a high prevalence of neuropsychiatric illness has previously been reported...
  31. ncbi request reprint Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease
    N L Khan
    Department of Molecular Neurosciences, Institute of Neurology, London School of Hygiene and Tropical Medicine, University College London, UK
    Neurology 62:1224-6. 2004
    ..3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease...
  32. doi request reprint Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs)
    L Silveira-Moriyama
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London WC1N 1PJ, UK
    J Neurol Neurosurg Psychiatry 80:744-8. 2009
    ..More than 10% of patients diagnosed as early PD can have scans without evidence of dopaminergic deficiency (SWEDDs). This study investigated whether smell tests can help identify possible cases with SWEDDs...
  33. ncbi request reprint A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm
    A Misbahuddin
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Neurology 58:124-6. 2002
    ..Allele 2 of a DRD5 dinucleotide repeat was significantly associated with blepharospasm. This may indicate a pathogenic role for this receptor...
  34. ncbi request reprint Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype
    H Houlden
    Neurogenetics, Clinical Neurology and Dementia Research Group, Institute of Neurology, London
    Neurology 56:1702-6. 2001
    ..05 > CI 95% > 1.85]). CONCLUSIONS: The CBD tau association described here suggests that PSP and CBD share a similar cause, although the pathogenic mechanism behind the two diseases leads to a different clinical and pathologic phenotype...
  35. doi request reprint Secondary dystonia--clinical clues and syndromic associations
    S A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Eur J Neurol 17:52-7. 2010
    ..In this article, we point out some clinical clues and syndromic associations which may be helpful in the approach to a patient with dystonia...
  36. doi request reprint The role of DAT-SPECT in movement disorders
    G Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 81:5-12. 2010
    ..This review addresses the value of DAT-SPECT and its impact on diagnostic accuracy in movement disorders presenting with tremor and/or parkinsonism...
  37. ncbi request reprint Young onset limb spasticity with PSP-like brain and spinal cord NFT-tau pathology
    S Papapetropoulos
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Neurology 64:731-3. 2005
    ..Eight years later, postmortem revealed a tauopathy similar to progressive supranuclear palsy. Unusual aspects were early age at onset, neurofibrillary tangle, and tau involvement of the cord...
  38. ncbi request reprint Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study
    M J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
    Neurology 63:156-8. 2004
    ..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders...
  39. ncbi request reprint Quality of life in patients with orthostatic tremor
    W Gerschlager
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 250:212-5. 2003
    ..The BDI score correlated significantly with several SF-36 subscores. We conclude that OT strongly impacts on QoL. The results highlight the importance of recognizing and treating depression in patients with OT...
  40. pmc Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging
    N P S Bajaj
    Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1, UK
    J Neurol Neurosurg Psychiatry 72:635-8. 2002
    ..A neurological phenotype is present in heterozygotes and the family shows the extent of homozygotic phenotypic diversity that can be seen in this disorder...
  41. ncbi request reprint Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation
    N L Khan
    MRC Clinical Sciences Centre, and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Neurology 64:134-6. 2005
    ..Four had subtle extrapyramidal signs. Parkin heterozygosity is a risk factor for nigrostriatal dysfunction and in some may contribute to late-onset Parkinson disease...