Alex Best

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. doi request reprint Evolution, the loss of diversity and the role of trade-offs
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Hicks Building, Hounsfield Road, S3 7RH, Sheffield, UK Electronic address
    Math Biosci 264:86-93. 2015
  2. doi request reprint The coevolutionary implications of host tolerance
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, United Kingdom Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, TR10 9EZ, United Kingdom
    Evolution 68:1426-35. 2014
  3. doi request reprint The effects of seasonal forcing on invertebrate-disease interactions with immune priming
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK
    Bull Math Biol 75:2241-56. 2013
  4. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
  5. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
  6. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
  7. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
  8. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
  9. doi request reprint The importance of who infects whom: the evolution of diversity in host resistance to infectious disease
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, UK
    Ecol Lett 15:1104-11. 2012
  10. pmc How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, Cornwall, TR10 9EZ, United Kingdom
    Evolution 68:1594-606. 2014

Collaborators

Detail Information

Publications15

  1. doi request reprint Evolution, the loss of diversity and the role of trade-offs
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Hicks Building, Hounsfield Road, S3 7RH, Sheffield, UK Electronic address
    Math Biosci 264:86-93. 2015
    ..We also show similar results for a non-polynomial but complex trade-off, and for a different eco-evolutionary model. Our work further highlights the importance of trade-offs to evolutionary behaviour. ..
  2. doi request reprint The coevolutionary implications of host tolerance
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, United Kingdom Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, TR10 9EZ, United Kingdom
    Evolution 68:1426-35. 2014
    ..More broadly, we emphasize that tolerance may change host-parasite interactions from antagonistic to a form of "apparent commensalism," but may also lead to the evolution of parasites that are highly virulent in nontolerant hosts. ..
  3. doi request reprint The effects of seasonal forcing on invertebrate-disease interactions with immune priming
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK
    Bull Math Biol 75:2241-56. 2013
    ....
  4. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
    ..Importantly, we find that conclusions on disease severity are highly dependent on how severity is measured. Finally, we discuss the effect of treatments used to combat disease symptoms caused by immunopathology...
  5. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
    ..Our findings stress that it is important to measure the effects of different mechanisms on characteristics that affect the epidemiology of the parasite to completely understand the evolutionary dynamics of defense...
  6. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
    ..Overall, our model shows that significant diversity in infectivity and resistance range can evolve and be maintained from initially monomorphic populations...
  7. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
    ..Resistance is therefore a waste of resources, but tolerance can explain why parasites do not castrate their hosts. Our results further emphasize the importance of tolerance as opposed to resistance to parasites...
  8. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
    ..Our work emphasizes the importance of considering coevolutionary dynamics and shows that certain highly virulent parasites may result from responses to host evolution...
  9. doi request reprint The importance of who infects whom: the evolution of diversity in host resistance to infectious disease
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, UK
    Ecol Lett 15:1104-11. 2012
    ..Only dimorphisms can evolve when infection is determined only by an individuals' susceptibility or when transmissibility and susceptibility are simply positively or negatively correlated...
  10. pmc How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, Cornwall, TR10 9EZ, United Kingdom
    Evolution 68:1594-606. 2014
    ..We emphasize that although the high specificity is well known to promote temporal "Red Queen" diversity, it is costs and combinations of hosts and parasites that cannot infect that will promote static trait diversity. ..
  11. pmc The evolutionary dynamics of within-generation immune priming in invertebrate hosts
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    J R Soc Interface 10:20120887. 2013
    ..Finally, we show when the evolution of priming leads to the exclusion of the pathogens or hosts experiencing population cycles. Overall the model acts as a baseline for understanding the evolution of priming in host-pathogen systems...
  12. pmc Host resistance and coevolution in spatially structured populations
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Proc Biol Sci 278:2216-22. 2011
    ..Crucially, this means that more population mixing may lead to the evolution of both fast-transmitting highly virulent parasites and reduced resistance in the host...
  13. pmc The epidemiological consequences of immune priming
    Hannah J Tidbury
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Proc Biol Sci 279:4505-12. 2012
    ..We discuss the implications of our model both in the context of invertebrate immunity and more widely...
  14. doi request reprint Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense
    Edze R Westra
    Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn TR10 9FE, UK Electronic address
    Curr Biol 25:1043-9. 2015
    ..Using a general theoretical model and experimental evolution, we tease apart the mechanism that drives their evolution and show that infection risk determines the relative investment in the two arms of defense...