Alex Best

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
  2. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
  3. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
  4. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
  5. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
  6. pmc The evolutionary dynamics of within-generation immune priming in invertebrate hosts
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    J R Soc Interface 10:20120887. 2013
  7. pmc Host resistance and coevolution in spatially structured populations
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Proc Biol Sci 278:2216-22. 2011
  8. pmc The epidemiological consequences of immune priming
    Hannah J Tidbury
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Proc Biol Sci 279:4505-12. 2012

Detail Information

Publications8

  1. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
    ..Importantly, we find that conclusions on disease severity are highly dependent on how severity is measured. Finally, we discuss the effect of treatments used to combat disease symptoms caused by immunopathology...
  2. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
    ..Our findings stress that it is important to measure the effects of different mechanisms on characteristics that affect the epidemiology of the parasite to completely understand the evolutionary dynamics of defense...
  3. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
    ..Our work emphasizes the importance of considering coevolutionary dynamics and shows that certain highly virulent parasites may result from responses to host evolution...
  4. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
    ..Resistance is therefore a waste of resources, but tolerance can explain why parasites do not castrate their hosts. Our results further emphasize the importance of tolerance as opposed to resistance to parasites...
  5. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
    ..Overall, our model shows that significant diversity in infectivity and resistance range can evolve and be maintained from initially monomorphic populations...
  6. pmc The evolutionary dynamics of within-generation immune priming in invertebrate hosts
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    J R Soc Interface 10:20120887. 2013
    ..Finally, we show when the evolution of priming leads to the exclusion of the pathogens or hosts experiencing population cycles. Overall the model acts as a baseline for understanding the evolution of priming in host-pathogen systems...
  7. pmc Host resistance and coevolution in spatially structured populations
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Proc Biol Sci 278:2216-22. 2011
    ..Crucially, this means that more population mixing may lead to the evolution of both fast-transmitting highly virulent parasites and reduced resistance in the host...
  8. pmc The epidemiological consequences of immune priming
    Hannah J Tidbury
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Proc Biol Sci 279:4505-12. 2012
    ..We discuss the implications of our model both in the context of invertebrate immunity and more widely...