Alex Best

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint The coevolutionary implications of host tolerance
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, United Kingdom Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, TR10 9EZ, United Kingdom
    Evolution 68:1426-35. 2014
  2. doi request reprint The effects of seasonal forcing on invertebrate-disease interactions with immune priming
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK
    Bull Math Biol 75:2241-56. 2013
  3. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
  4. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
  5. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
  6. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
  7. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
  8. ncbi request reprint How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, Cornwall, TR10 9EZ, United Kingdom
    Evolution 68:1594-606. 2014
  9. pmc The evolutionary dynamics of within-generation immune priming in invertebrate hosts
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    J R Soc Interface 10:20120887. 2013
  10. pmc Host resistance and coevolution in spatially structured populations
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Proc Biol Sci 278:2216-22. 2011

Detail Information

Publications13

  1. ncbi request reprint The coevolutionary implications of host tolerance
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, United Kingdom Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, TR10 9EZ, United Kingdom
    Evolution 68:1426-35. 2014
    ..More broadly, we emphasize that tolerance may change host-parasite interactions from antagonistic to a form of "apparent commensalism," but may also lead to the evolution of parasites that are highly virulent in nontolerant hosts. ..
  2. doi request reprint The effects of seasonal forcing on invertebrate-disease interactions with immune priming
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK
    Bull Math Biol 75:2241-56. 2013
    ....
  3. pmc The implications of immunopathology for parasite evolution
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    Proc Biol Sci 279:3234-40. 2012
    ..Importantly, we find that conclusions on disease severity are highly dependent on how severity is measured. Finally, we discuss the effect of treatments used to combat disease symptoms caused by immunopathology...
  4. pmc Maintenance of host variation in tolerance to pathogens and parasites
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:20786-91. 2008
    ..Our findings stress that it is important to measure the effects of different mechanisms on characteristics that affect the epidemiology of the parasite to completely understand the evolutionary dynamics of defense...
  5. doi request reprint The implications of coevolutionary dynamics to host-parasite interactions
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 173:779-91. 2009
    ..Our work emphasizes the importance of considering coevolutionary dynamics and shows that certain highly virulent parasites may result from responses to host evolution...
  6. doi request reprint Resistance is futile but tolerance can explain why parasites do not always castrate their hosts
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
    Evolution 64:348-57. 2010
    ..Resistance is therefore a waste of resources, but tolerance can explain why parasites do not castrate their hosts. Our results further emphasize the importance of tolerance as opposed to resistance to parasites...
  7. doi request reprint The evolution of host-parasite range
    A Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, England, United Kingdom
    Am Nat 176:63-71. 2010
    ..Overall, our model shows that significant diversity in infectivity and resistance range can evolve and be maintained from initially monomorphic populations...
  8. ncbi request reprint How specificity and epidemiology drive the coevolution of static trait diversity in hosts and parasites
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Cornwall Campus, Penryn, Cornwall, TR10 9EZ, United Kingdom
    Evolution 68:1594-606. 2014
    ..We emphasize that although the high specificity is well known to promote temporal "Red Queen" diversity, it is costs and combinations of hosts and parasites that cannot infect that will promote static trait diversity. ..
  9. pmc The evolutionary dynamics of within-generation immune priming in invertebrate hosts
    Alex Best
    School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, UK
    J R Soc Interface 10:20120887. 2013
    ..Finally, we show when the evolution of priming leads to the exclusion of the pathogens or hosts experiencing population cycles. Overall the model acts as a baseline for understanding the evolution of priming in host-pathogen systems...
  10. pmc Host resistance and coevolution in spatially structured populations
    Alex Best
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Proc Biol Sci 278:2216-22. 2011
    ..Crucially, this means that more population mixing may lead to the evolution of both fast-transmitting highly virulent parasites and reduced resistance in the host...
  11. doi request reprint The importance of who infects whom: the evolution of diversity in host resistance to infectious disease
    Mike Boots
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, UK
    Ecol Lett 15:1104-11. 2012
    ..Only dimorphisms can evolve when infection is determined only by an individuals' susceptibility or when transmissibility and susceptibility are simply positively or negatively correlated...
  12. pmc The epidemiological consequences of immune priming
    Hannah J Tidbury
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Proc Biol Sci 279:4505-12. 2012
    ..We discuss the implications of our model both in the context of invertebrate immunity and more widely...