Martin Berry

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Gene therapy for central nervous system repair
    M Berry
    Department of Medicine, University of Birmingham, Edgbaston, UK
    Curr Opin Mol Ther 3:338-49. 2001
  2. ncbi request reprint Regeneration of axons in the visual system
    Martin Berry
    Molecular Neuroscience Group, School of Experimental and Clinical Medicine, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Restor Neurol Neurosci 26:147-74. 2008
  3. doi request reprint Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth
    Michael R Douglas
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Brain 132:3102-21. 2009
  4. ncbi request reprint Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Brain 129:1517-33. 2006
  5. doi request reprint Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Neurobiol Dis 37:441-54. 2010
  6. ncbi request reprint Optimisation of siRNA-mediated RhoA silencing in neuronal cultures
    Ellen L Suggate
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B152TT, UK
    Mol Cell Neurosci 40:451-62. 2009
  7. doi request reprint In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Gene Med 11:335-44. 2009
  8. doi request reprint Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E
    Barbara Lorber
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Neurosci Res 87:2645-52. 2009
  9. doi request reprint Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Institute of Biomedical Research West, Edgbaston, Birmingham B15 2TT, UK
    Neurobiol Dis 36:142-50. 2009
  10. doi request reprint Targeting adenoviral transgene expression to neurons
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, Institute of Biomedical Research West, University of Birmingham, Edgbaston, Birmingham, UK
    Mol Cell Neurosci 39:411-7. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Gene therapy for central nervous system repair
    M Berry
    Department of Medicine, University of Birmingham, Edgbaston, UK
    Curr Opin Mol Ther 3:338-49. 2001
    ..Subsequent retrograde axonal transport delivers the therapeutic genes to all axotomized neurons throughout the CNS...
  2. ncbi request reprint Regeneration of axons in the visual system
    Martin Berry
    Molecular Neuroscience Group, School of Experimental and Clinical Medicine, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Restor Neurol Neurosci 26:147-74. 2008
    ....
  3. doi request reprint Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth
    Michael R Douglas
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Brain 132:3102-21. 2009
    ..These off-target effects of epidermal growth factor receptor kinase inhibition suggest a novel therapeutic approach for designing treatments to promote central nervous system axon regeneration...
  4. ncbi request reprint Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Brain 129:1517-33. 2006
    ..In all the above experimental paradigms, Schwann cell-derived factor/NTF-induced attenuation of NgR/p75NTR signalling suppresses EGFR activation, thereby potentiating axon growth disinhibition...
  5. doi request reprint Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Neurobiol Dis 37:441-54. 2010
    ....
  6. ncbi request reprint Optimisation of siRNA-mediated RhoA silencing in neuronal cultures
    Ellen L Suggate
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B152TT, UK
    Mol Cell Neurosci 40:451-62. 2009
    ....
  7. doi request reprint In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Gene Med 11:335-44. 2009
    ..Polymer coating of adenovirus type 5 (Ad5) particles produces a 'stealth' Ad5 (sAd5) that confers protection from immune recognition, blocks receptor-mediated uptake, and favours uptake into pinocytic cells...
  8. doi request reprint Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E
    Barbara Lorber
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Neurosci Res 87:2645-52. 2009
    ..These observations suggest that ApoE, expressed by activated retinal glia, stimulates RGC neurite outgrowth after intravitreal Zymosan injection...
  9. doi request reprint Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Institute of Biomedical Research West, Edgbaston, Birmingham B15 2TT, UK
    Neurobiol Dis 36:142-50. 2009
    ..Accordingly, we suggest that chemical EGFR inhibitors act independently of EGFR, inducing glia and neurons to secrete NT and raising cAMP levels in DRG cultures, leading to Trk-dependent disinhibited DRGN neurite outgrowth...
  10. doi request reprint Targeting adenoviral transgene expression to neurons
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, Institute of Biomedical Research West, University of Birmingham, Edgbaston, Birmingham, UK
    Mol Cell Neurosci 39:411-7. 2008
    ..Moreover, since the effective titres of delivered Ad5 are reduced with this neuron specific promoter/WPRE expression cassette, the viral immune challenge should be attenuated when used in vivo...
  11. doi request reprint Profiling RNA interference (RNAi)-mediated toxicity in neural cultures for effective short interfering RNA design
    Martin L Read
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Gene Med 11:523-34. 2009
    ..However, it is important to profile the biological impact of siRNA on cell homeostasis in order to develop safe and effective therapies...
  12. ncbi request reprint The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies
    Ana Maria Gonzalez
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Gene Med 11:679-88. 2009
    ..Lyophilized GAMs containing collagen and adenoviral vectors were assessed in vitro and in vivo...
  13. ncbi request reprint Satellite glia not DRG neurons constitutively activate EGFR but EGFR inactivation is not correlated with axon regeneration
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Neurobiol Dis 39:292-300. 2010
    ..Together, these data argue against a direct intra-axonal involvement of pEGFR in axon regeneration...
  14. ncbi request reprint Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury
    Barbara Lorber
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Eur J Neurosci 21:2375-83. 2005
    ....
  15. ncbi request reprint Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting
    Barbara Lorber
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    J Neurosci Res 86:894-903. 2008
    ..This suggests that in vivo RGC axon regeneration induced by lens injury and peripheral nerve grafting may be limited, in part, by factors derived from activated retinal glia...
  16. ncbi request reprint TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FASEB J 20:1939-41. 2006
    ..Thus, TACE-induced cleavage of NgR and RIP of p75(NTR) abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth...
  17. ncbi request reprint Lens injury stimulates adult mouse retinal ganglion cell axon regeneration via both macrophage- and lens-derived factors
    Barbara Lorber
    Molecular Neuroscience Group, Department of Medicine, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Neurosci 21:2029-34. 2005
    ..Together, these results show that lens injury promotes retinal ganglion cell axon regeneration/neurite outgrowth in adult mice, an observation with important implications for axon regeneration studies in transgenic mouse models...
  18. ncbi request reprint Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR
    Barbara Lorber
    Molecular Neuroscience, Department of Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Mol Cell Neurosci 27:404-16. 2004
    ..Interestingly, neither RPTPalpha, STEP, nor LAR localized to intact or regenerating axons. One explanation of these findings is that RPTPalpha and LAR may modulate RGC survival, and that RPTPalpha, STEP, and LAR may modulate axon growth...
  19. doi request reprint Epidermal growth factor receptor antagonists and CNS axon regeneration: mechanisms and controversies
    Martin Berry
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
    Brain Res Bull 84:289-99. 2011
    ..This review discusses the current evidences for and against the involvement of EGFR in signalling myelin inhibition...
  20. doi request reprint AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection
    Steven J Jacques
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 49:464-74. 2012
    ..These results open up opportunities for targeted delivery of therapeutics such as neurotrophic factors to the injured spinal cord...
  21. ncbi request reprint Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, 3rd Floor Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH, UK
    Mol Cell Neurosci 28:509-23. 2005
    ..Together, these results suggest that Rho-A knockdown might be the most effective target for a disinhibition strategy to promote CNS axon regeneration in vivo...
  22. ncbi request reprint Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury
    Ann Logan
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Brain 129:490-502. 2006
    ..Thus, combinatorial NTF administration synergistically enhanced neuronal survival, disinhibited axon growth and promoted axon regeneration through the hostile CNS environment without the intervention of scar tissue at the lesion site...
  23. ncbi request reprint Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 28:64-78. 2005
    ..These results suggest that activation of MMP and coincident down-regulation of TIMP may act to attenuate the inhibitory scarring in the regenerating ON, thus transforming the ON into a noninhibitory pathway for axon regrowth...
  24. doi request reprint Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA
    Zubair Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Neurobiol Dis 41:421-9. 2011
    ..We conclude that Citron-K regulates actin polymerisation downstream of RhoA and may offer a potentially novel therapeutic approach for promoting CNS axon regeneration...
  25. ncbi request reprint Matrix-mediated gene transfer to brain cortex and dorsal root ganglion neurones by retrograde axonal transport after dorsal column lesion
    Ana Maria Gonzalez
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    J Gene Med 8:901-9. 2006
    ....
  26. doi request reprint ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Room WX2 17 Institute of Biomedical Research West, Edgbaston, Birmingham, B15 2TT, UK
    Mol Cell Neurosci 42:128-33. 2009
    ..Our results suggest that Y27632-induced ROCK inhibition promotes robust disinhibited axon regeneration of adult neurons only when growth promoting factors are added and/or cAMP levels are raised...
  27. doi request reprint Decorin prevents the development of juvenile communicating hydrocephalus
    Hannah Botfield
    Neurotrauma and Neurodegeneration, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, B15 2TT, UK
    Brain 136:2842-58. 2013
    ..The results suggest that decorin is a potential clinical therapeutic for the treatment of juvenile post-haemorrhagic communicating hydrocephalus. ..
  28. pmc A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids
    Martin L Read
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham Birmingham, B15 2TT, UK
    Nucleic Acids Res 33:e86. 2005
    ..This should enable different or a combination of therapeutic strategies to be evaluated using a single type of polycation-based vector...
  29. ncbi request reprint Cellular and molecular determinants of glial scar formation
    Ann Logan
    Molecular Neuroscience, Department of Medicine, Wolfson Research Laboratories, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Adv Exp Med Biol 513:115-58. 2002
  30. doi request reprint Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds
    Zubair Ahmed
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Electronic address
    Neurobiol Dis 64:163-76. 2014
    ..Accordingly, intrathecal delivery of Decorin offers a potential translatable treatment for scar tissue attenuation in patients with spinal cord injury. ..
  31. pmc Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling
    Vasanthy Vigneswara
    1 Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Brain 137:1656-75. 2014
    ..This study offers insights for the development of effective therapeutics for promoting retinal ganglion cell survival and axon regeneration...
  32. pmc Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e57861. 2013
    ..Accordingly, inhibiting CASP2 expression is a potential therapy for improving both the SN regeneration response and peripheral sensory recovery...
  33. ncbi request reprint Effect of lens lesion on neurite outgrowth of retinal ganglion cells in vitro
    Barbara Lorber
    Department of Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Mol Cell Neurosci 21:301-11. 2002
    ..Together, these results suggest the existence of a neuritogenic factor(s) associated with the lesioned lens that belongs to neither the neurotrophin nor the gp130 cytokine family...
  34. ncbi request reprint Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex
    W E Leadbeater
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    J Neurochem 96:1189-200. 2006
    ..The spatiotemporal dynamics of FGF-2-FGFR1-HSPG complex formation implies a role for individual HSPGs in regulating FGF-2 storage, nuclear trafficking and cell-specific injury responses in CNS wounds...
  35. ncbi request reprint CTb targeted non-viral cDNA delivery enhances transgene expression in neurons
    L B Barrett
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Birmingham B15 2TH, UK
    J Gene Med 6:429-38. 2004
    ..Here, we illustrate the potential for this strategy by demonstrating enhanced transfection of a differentiated neuronal cell type, PC12...
  36. ncbi request reprint Cytology and lineage of NG2-positive glia
    M Berry
    Neural Damage and Repair, Centre for Neuroscience Research, Hodgkin Building, GKT School of Biomedical Sciences, Guy s Campus, London Bridge, London SE1 1UL, UK
    J Neurocytol 31:457-67. 2002
    ..The definitive functions of synantocytes remain undefined...
  37. ncbi request reprint Age-dependent changes in Fibroblast growth factor 2 (FGF-2) expression in mouse cerebellar neurons
    J Reynolds
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    J Cell Mol Med 9:398-406. 2005
    ..3+/-0.91%) compared to young (48.5+/-1.67%) mice, whereas no statistically significant age-dependent difference occurred in the number of FGF-2 positive PC. These results indicate a possible role of FGF-2 in cerebellar ageing...
  38. ncbi request reprint Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo
    D R Goddard
    Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, United Kingdom
    Mol Cell Neurosci 18:557-69. 2001
    ....
  39. pmc Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme
    D Salvatore
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 96:2421-30. 1995
    ..The conservation of this enzyme from Xenopus laevis tadpoles to humans implies an essential role for regulation of thyroid hormone inactivation during embryological development...
  40. ncbi request reprint Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats
    W E Clarke
    Department of Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Mol Cell Neurosci 17:17-30. 2001
    ..However, the precise contribution of nuclear FGF-2/FGFR1 to the pathophysiological response of astrocytes after injury is undetermined...
  41. ncbi request reprint Sustained effects of gene-activated matrices after CNS injury
    M Berry
    Centre for Neuroscience, Neural Damage and Repair, GKT (Guy's Campus, Hodgkin Building, London Bridge, London, SE1 1UL, United Kingdom
    Mol Cell Neurosci 17:706-16. 2001
    ..Whether further optimization of the matrices, plasmids, promoters, and genes present in the GAM will promote even more survival or, alternatively, axon regeneration remains to be determined...
  42. ncbi request reprint A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
    M Berry
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
    Nature 358:499-502. 1992
    ..We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults...
  43. ncbi request reprint Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord
    C Lagord
    Department of Medicine, Wolfson Research Laboratories, Queen Elizabeth Medical Centre, University of Birmingham, Edgbaston, United Kingdom
    Mol Cell Neurosci 20:69-92. 2002
    ..The cellular localization and temporal pattern of expression of TGFbeta after spinal cord injury suggest that TGFbeta1 modulates the inflammatory and neuronal responses, while TGFbeta2 regulates glial/collagen scarring...