Johanne Bentley

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
    Johanne Bentley
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, LS9 7TF, UK
    Nucleic Acids Res 32:5249-59. 2004
  2. doi request reprint Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities
    Johanne Bentley
    Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 48:310-21. 2009
  3. ncbi request reprint Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation
    Kay Barnes
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Oncogene 24:3257-67. 2005
  4. pmc Development of a rapid, small-scale DNA repair assay for use on clinical samples
    Christine P Diggle
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS9 7TF, UK
    Nucleic Acids Res 31:e83. 2003
  5. pmc In vitro functional effects of XPC gene rare variants from bladder cancer patients
    Boling Qiao
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Beckett St, Leeds LS9 7TF, UK
    Carcinogenesis 32:516-21. 2011
  6. ncbi request reprint 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2
    Veronique Mesguiche
    Northern Institute of Cancer Research and Department of Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 13:217-22. 2003
  7. ncbi request reprint Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
    Johanne Bentley
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 278:39337-48. 2003
  8. ncbi request reprint Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2
    Francesco Marchetti
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, UKNE1 7RU
    Org Biomol Chem 5:1577-85. 2007
  9. ncbi request reprint Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
    Kerry L Sayle
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 13:3079-82. 2003
  10. ncbi request reprint Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
    Thomas G Davies
    Laboratory of Molecular Biophysics and Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK
    Nat Struct Biol 9:745-9. 2002

Collaborators

Detail Information

Publications11

  1. pmc DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
    Johanne Bentley
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, LS9 7TF, UK
    Nucleic Acids Res 32:5249-59. 2004
    ..Therefore, in high-grade tumours mismatched DSBs are repaired by a highly mutagenic, microhomology-mediated, alternative end-joining pathway, a process that may contribute to genomic instability observed in bladder cancer...
  2. doi request reprint Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities
    Johanne Bentley
    Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 48:310-21. 2009
    ..End-joining fidelity correlated with stage and was increasingly error-prone as tumors became more invasive and KU binding activity reduced; these changes may underlie the different genomic profiles of these tumors...
  3. ncbi request reprint Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation
    Kay Barnes
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Oncogene 24:3257-67. 2005
    ....
  4. pmc Development of a rapid, small-scale DNA repair assay for use on clinical samples
    Christine P Diggle
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS9 7TF, UK
    Nucleic Acids Res 31:e83. 2003
    ..The application of this method will allow investigation of the role of DSB DNA repair pathways in human tumours...
  5. pmc In vitro functional effects of XPC gene rare variants from bladder cancer patients
    Boling Qiao
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Beckett St, Leeds LS9 7TF, UK
    Carcinogenesis 32:516-21. 2011
    ..These assays may be useful in determining which rare variants are functional, prior to large genotyping efforts...
  6. ncbi request reprint 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2
    Veronique Mesguiche
    Northern Institute of Cancer Research and Department of Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 13:217-22. 2003
    ..Thus the parent compound, 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine (NU6027), remains the optimal basis for future structure-activity studies for cyclin-dependent kinase inhibitors in this series...
  7. ncbi request reprint Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
    Johanne Bentley
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 278:39337-48. 2003
    ..We conclude that one component of the survival mechanisms elicited by IL-3 involves the subcellular redistribution of glucose transporters, thus ensuring the supply of a key metabolic substrate...
  8. ncbi request reprint Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2
    Francesco Marchetti
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, UKNE1 7RU
    Org Biomol Chem 5:1577-85. 2007
    ..The SARs determined in this study are discussed with reference to the crystal structure of 4-(6-amino-4-cyclohexylmethoxy-5-nitrosopyrimidin-2-ylamino)-N-(2,3-dihydroxypropyl)benzenesulfonamide (7j) bound to phosphorylated CDK2/cyclin A...
  9. ncbi request reprint Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
    Kerry L Sayle
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 13:3079-82. 2003
    ....
  10. ncbi request reprint Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
    Thomas G Davies
    Laboratory of Molecular Biophysics and Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK
    Nat Struct Biol 9:745-9. 2002
    ..Furthermore, the potency of O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino)purine was both predicted and fully rationalized on the basis of protein-ligand interactions...
  11. ncbi request reprint Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives
    Ashleigh E Gibson
    Department of Chemistry and Cancer Research Unit, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Med Chem 45:3381-93. 2002
    ..Thus, the parent compound O(6)-cyclohexylmethylguanine (NU2058, 25) is the preferred starting point for exploring other areas of the kinase active site...