J I Bell

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc New hope for haplotype mapping
    John I Bell
    John Radcliffe Hospital, Oxford, UK
    Arthritis Res Ther 5:51-3. 2003
  2. ncbi request reprint Human TCR-binding affinity is governed by MHC class restriction
    David K Cole
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Immunol 178:5727-34. 2007
  3. ncbi request reprint Association study designs for complex diseases
    L R Cardon
    University of Oxford, Nuffield Department of Clinical Medicine, Headington, Oxford OX3 9DU, UK
    Nat Rev Genet 2:91-9. 2001
  4. pmc Single nucleotide polymorphisms and disease gene mapping
    John I Bell
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    Arthritis Res 4:S273-8. 2002
  5. ncbi request reprint Medical implications of understanding complex disease traits
    J Bell
    University of Oxford Level 7 John Radcliffe Hospital Headington Oxford OX3 9DU UK
    Curr Opin Biotechnol 9:573-7. 1998
  6. pmc Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Protein Sci 7:1264-6. 1998
  7. ncbi request reprint Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Mol Cell 1:531-41. 1998
  8. ncbi request reprint BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Anal Biochem 266:9-15. 1999
  9. ncbi request reprint Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL
    J Mongkolsapaya
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 160:3-6. 1998
  10. ncbi request reprint Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load
    A Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, Great Britain
    Eur J Immunol 31:1115-21. 2001

Collaborators

Detail Information

Publications40

  1. pmc New hope for haplotype mapping
    John I Bell
    John Radcliffe Hospital, Oxford, UK
    Arthritis Res Ther 5:51-3. 2003
    ..These data suggest that significant regions of the genome show highly conserved haplotypes, potentially enhancing the ability to detect disease associations...
  2. ncbi request reprint Human TCR-binding affinity is governed by MHC class restriction
    David K Cole
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Immunol 178:5727-34. 2007
    ....
  3. ncbi request reprint Association study designs for complex diseases
    L R Cardon
    University of Oxford, Nuffield Department of Clinical Medicine, Headington, Oxford OX3 9DU, UK
    Nat Rev Genet 2:91-9. 2001
    ..Now is the time to consider critically the design of such studies, to avoid the mistakes of the past and to maximize their potential to identify new components of disease...
  4. pmc Single nucleotide polymorphisms and disease gene mapping
    John I Bell
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    Arthritis Res 4:S273-8. 2002
    ..Only the careful use of these strategies and a clear understanding of their statistical limits will allow novel genetic determinants for many of the common autoimmune diseases to be determined...
  5. ncbi request reprint Medical implications of understanding complex disease traits
    J Bell
    University of Oxford Level 7 John Radcliffe Hospital Headington Oxford OX3 9DU UK
    Curr Opin Biotechnol 9:573-7. 1998
    ..Its application has also increased to include aspects of pharmacogenetics relating to pharmacokinetics and pharmacodynamics...
  6. pmc Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Protein Sci 7:1264-6. 1998
    ..Crystals of this complex formed slowly over four to six months in the presence of ammonium sulphate. The crystals diffract to 2.85 A with space group P3(1)21 and unit cell dimensions a = 182.2 A, b = 182.2 A, c = 88.4 A...
  7. ncbi request reprint Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Mol Cell 1:531-41. 1998
    ..These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells...
  8. ncbi request reprint BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom
    Anal Biochem 266:9-15. 1999
    ..These tetrameric proteins can be used to study protein receptor-ligand interactions at the cell surface, and site-specific biotinylation can be used to study proteins in vitro using a defined orientation...
  9. ncbi request reprint Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL
    J Mongkolsapaya
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 160:3-6. 1998
    ..LIT is expressed predominantly on PBL, where it can competitively inhibit TRAIL-induced apoptosis through DR4/TRICK2, and may function to modulate lymphocyte sensitivity to TRAIL...
  10. ncbi request reprint Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load
    A Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, Great Britain
    Eur J Immunol 31:1115-21. 2001
    ....
  11. ncbi request reprint Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
    G F Gao
    Molecular Immunology Group, Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 387:630-4. 1997
    ..Although these shifts in alpha3 may provide a synergistic modulation of affinity, the binding of CD8 to MHC is clearly consistent with an avidity-based contribution from CD8 to TCR-peptide-MHC interactions...
  12. ncbi request reprint Reconstitution of antigen presentation in HLA class I-negative cancer cells with peptide-beta2m fusion molecules
    S Tafuro
    MRC Human Immunology Unit, Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 31:440-9. 2001
    ..Specific peptides covalently linked to beta2m and delivered via retroviral vectors may be useful reagents for in vivo priming of CTL against epitopes of clinical relevance...
  13. ncbi request reprint The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain
    M A Purbhoo
    University of Oxford, Nuffield Department of Clinical Medicine, Level 7, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    J Biol Chem 276:32786-92. 2001
    ..These reagents may prove useful in circumventing undesirable activation-related perturbation of intracellular processes when pMHC multimers are used to phenotype antigen-specific CD8+ lymphocytes...
  14. ncbi request reprint HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    V M Braud
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 391:795-9. 1998
    ....
  15. ncbi request reprint Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G
    C A O'Callaghan
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK
    Immunol Rev 163:129-38. 1998
    ..Expression of HLA-G inhibits NK cells expressing the CD94/NKG2 class of receptors, though an interaction with these receptors has not been directly demonstrated...
  16. ncbi request reprint Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease
    P J Hunt
    Department of Endocrinology, Radcliffe Infirmary, Oxford, Oxford Transplant Centre, Churchill Hospital, Oxford, UK
    Clin Endocrinol (Oxf) 55:491-9. 2001
    ..This study examines genetic variation across the MHC in UK Caucasoid subjects with autoimmune thyroid disease...
  17. ncbi request reprint Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
    J Satsangi
    Gastroenterology Unit, Nuffield Department of Medicine, Radcliffe Infirmary, Oxford, UK
    Nat Genet 14:199-202. 1996
    ..08 and 2.69 for D7S669 and D3S1573, respectively. Our data suggest that CD and UC are closely related, but distinct, polygenic disorders that share some, but not all, susceptibility genes...
  18. pmc Antagonist HIV-1 Gag peptides induce structural changes in HLA B8
    S W Reid
    Laboratory of Molecular Biophysics, Oxford, United Kingdom
    J Exp Med 184:2279-86. 1996
    ..While the first two mechanisms frequently lead to antagonism, the third has more profound effects on TCR recognition...
  19. ncbi request reprint Work stress: an exploratory study of the practices and perceptions of female junior healthcare managers
    K Rodham
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    J Nurs Manag 10:5-11. 2002
    ..This exploratory study set out to investigate the perceptions and practices of junior healthcare managers with regard to stress at work...
  20. ncbi request reprint Genetics of inflammatory bowel disease. A personal view on progress and prospects
    J Satsangi
    Gastroenterology Unit, Radcliffe Infirmary, John Radcliffe Hospital, Headington, Oxford, UK
    Dig Dis 16:370-4. 1998
    ..Once this has been achieved, there are likely to be immediate clinical benefits, both in understanding disease pathophysiology, and in disease management...
  21. pmc Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors
    G M Gillespie
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Virol 74:8140-50. 2000
    ..These observations should improve our understanding of the immunobiology of persistent viral infection...
  22. ncbi request reprint An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501
    K J Smith
    Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Immunity 4:203-13. 1996
    ....
  23. ncbi request reprint Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation
    D G Jackson
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England
    J Immunol 144:2811-5. 1990
    ..PvuII digests of human genomic DNA revealed a polymorphism linked to the CD38 gene...
  24. ncbi request reprint Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor
    D G Jackson
    Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Great Britain
    Eur J Immunol 22:1157-63. 1992
    ..The likelihood that the CMRF35 antigen shares a common evolutionary ancestor with the poly Ig Fc receptor is discussed...
  25. pmc LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing
    G R Screaton
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 94:4615-9. 1997
    ..Upon T cell activation, a programmed change in alternative splicing occurs so that the full-length, membrane-bound LARD-1 predominates. This may have implications for the control of lymphocyte proliferation following activation...
  26. ncbi request reprint Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53
    K J Smith
    Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Immunity 4:215-28. 1996
    ....
  27. ncbi request reprint Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
    A M Lucassen
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Genet 4:305-10. 1993
    ..These represent a set of candidate disease polymorphisms one or more of which may account for the susceptibility to IDDM...
  28. pmc Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
    G R Screaton
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    EMBO J 14:4336-49. 1995
    ....
  29. ncbi request reprint Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain
    D G Jackson
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Biol Chem 267:4732-9. 1992
    ....
  30. pmc Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
    G R Screaton
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 89:12160-4. 1992
    ..The genomic structure of CD44 reveals a remarkable degree of complexity, and we confirm the role of alternative splicing as the basis of the structural and functional diversity seen in the CD44 molecule...
  31. pmc Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence
    Angela J Frodsham
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 103:9148-53. 2006
    ..0003), and in vitro assays support functional roles for these variants in receptor signaling...
  32. ncbi request reprint The double helix in clinical practice
    John I Bell
    The Office of the Regius Professor of Medicine, University of Oxford, Oxford OX3 9DU, UK
    Nature 421:414-6. 2003
    ..Changes to the way medicine is practised and new doctors are trained will be required before potential benefits are realized...
  33. ncbi request reprint Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands
    George F Gao
    Nuffield Dept of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    Trends Immunol 23:408-13. 2002
    ..Here we discuss the interactions of pMHC with the TCR and coreceptor CD8 or CD4 on the surfaces of alphabeta T cells and antigen presenting cells, and the implications for TCR signalling and the T-cell repertoire...
  34. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
  35. pmc Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide
    Fuliang Chu
    Laboratory of Molecular Immunology and Molecular Virology, Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:614-6. 2005
    ..8 A resolution. The structure is being solved by molecular replacement and this is the first attempt to determined the crystal structure of a peptide-nonhuman primate MHC complex...
  36. ncbi request reprint Novel CD8+ T cell antagonists based on beta 2-microglobulin
    Meir Glick
    Department of Chemistry, Central Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 277:20840-6. 2002
    ..This mutation also significantly reduces CD8alphaalpha binding and is a potent antagonist of CTL activation. These results suggest a novel approach to CTL-specific therapeutic immunosuppression...
  37. ncbi request reprint Functional epistasis on a common MHC haplotype associated with multiple sclerosis
    Jon W Gregersen
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, 8200 N, Aarhus, Denmark
    Nature 443:574-7. 2006
    ....
  38. ncbi request reprint The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome p450 peptide: steric hindrance influences TCR allo-recognition
    Christopher S Hourigan
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 36:3288-93. 2006
    ..These findings are relevant to understanding the basis of T cell cross-reactivity in allo-recognition, optimal transplant donor-recipient matching and developing specific molecular inhibitors of allo-recognition...
  39. ncbi request reprint First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape
    Fuliang Chu
    Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, 13 Beiyitiao, Zhongguancun, Beijing 100080, People s Republic of China
    J Immunol 178:944-52. 2007
    ..The results we present in this study are most relevant for the rational design of Mamu-A*01-restricted CTL epitopes with improved binding, as a step toward development of AIDS vaccines...
  40. ncbi request reprint Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
    David K Cole
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom
    Proteins 67:65-74. 2007
    ..The analysis of this structure suggests that the higher affinity is achieved by providing a larger side chain that allows for an optimal contact to be made between the HLA alpha3 loop and the mutated CDR-like loops of CD8...