J F Belch

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo
    Jill J F Belch
    Vascular and Inflammatory Diseases Research Unit, Dundee, DD1 9SY, Scotland
    Microvasc Res 85:86-92. 2013
  2. pmc Study protocol for BeWEL: the impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas
    Angela M Craigie
    Centre for Research into Cancer Prevention and Screening, University of Dundee, UK
    BMC Public Health 11:184. 2011
  3. doi request reprint Macrovascular disease in systemic sclerosis: the tip of an iceberg?
    J J F Belch
    Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital, Tayside, Scotland, UK
    Rheumatology (Oxford) 47:v16-7. 2008
  4. pmc The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
    Jill Belch
    Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY
    BMJ 337:a1840. 2008
  5. ncbi request reprint Evening primrose oil and borage oil in rheumatologic conditions
    J J Belch
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Am J Clin Nutr 71:352S-6S. 2000
  6. doi request reprint Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial
    Jill J F Belch
    Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
    J Vasc Surg 52:825-33, 833.e1-2. 2010
  7. ncbi request reprint Critical issues in peripheral arterial disease detection and management: a call to action
    Jill J F Belch
    Department of Medicine, Ninewells Hospitals and Medical School, Scotland
    Arch Intern Med 163:884-92. 2003
  8. ncbi request reprint The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemia
    J J F Belch
    C1Peripheral Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
    Int Angiol 30:150-5. 2011
  9. doi request reprint Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    Jill Belch
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 377:1929-37. 2011
  10. ncbi request reprint Metabolic, endocrine and haemodynamic risk factors in the patient with peripheral arterial disease
    Jill J F Belch
    University Department of Medicine, Ninewells Hospital, Dundee, DD1 9SY, UK
    Diabetes Obes Metab 4:S7-13. 2002

Collaborators

Detail Information

Publications45

  1. doi request reprint Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo
    Jill J F Belch
    Vascular and Inflammatory Diseases Research Unit, Dundee, DD1 9SY, Scotland
    Microvasc Res 85:86-92. 2013
    ..Longitudinal assessments of skin microvascular function in mice could provide a useful translatable model for assessing early endothelial dysfunction...
  2. pmc Study protocol for BeWEL: the impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas
    Angela M Craigie
    Centre for Research into Cancer Prevention and Screening, University of Dundee, UK
    BMC Public Health 11:184. 2011
    ..These diseases share risk factors related to the metabolic syndrome including large body size, abnormal lipids and markers of insulin resistance indicating common aetiological pathways...
  3. doi request reprint Macrovascular disease in systemic sclerosis: the tip of an iceberg?
    J J F Belch
    Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital, Tayside, Scotland, UK
    Rheumatology (Oxford) 47:v16-7. 2008
    ..Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population...
  4. pmc The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
    Jill Belch
    Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY
    BMJ 337:a1840. 2008
    ..To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease...
  5. ncbi request reprint Evening primrose oil and borage oil in rheumatologic conditions
    J J Belch
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Am J Clin Nutr 71:352S-6S. 2000
    ..The results of most of these studies suggest some clinical benefit to these treatments; these data are reviewed here...
  6. doi request reprint Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial
    Jill J F Belch
    Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
    J Vasc Surg 52:825-33, 833.e1-2. 2010
    ..We sought to determine whether clopidogrel plus ASA conferred benefit on limb outcomes over ASA alone in patients undergoing below-knee bypass grafting...
  7. ncbi request reprint Critical issues in peripheral arterial disease detection and management: a call to action
    Jill J F Belch
    Department of Medicine, Ninewells Hospitals and Medical School, Scotland
    Arch Intern Med 163:884-92. 2003
  8. ncbi request reprint The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemia
    J J F Belch
    C1Peripheral Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
    Int Angiol 30:150-5. 2011
    ..The aim of this study was to determine whether Taprostene sodium, a PGI2 analogue, was a safe and effective treatment for CLI...
  9. doi request reprint Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    Jill Belch
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 377:1929-37. 2011
    ..Patients with critical limb ischaemia have a high rate of amputation and mortality. We tested the hypothesis that non-viral 1 fibroblast growth factor (NV1FGF) would improve amputation-free survival...
  10. ncbi request reprint Metabolic, endocrine and haemodynamic risk factors in the patient with peripheral arterial disease
    Jill J F Belch
    University Department of Medicine, Ninewells Hospital, Dundee, DD1 9SY, UK
    Diabetes Obes Metab 4:S7-13. 2002
    ..It is therefore important to improve detection rates so that these patients can receive appropriate risk factor management...
  11. doi request reprint Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
    ..With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease...
  12. ncbi request reprint Allopurinol improves endothelial dysfunction in chronic heart failure
    Colin A J Farquharson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Circulation 106:221-6. 2002
    ..Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure...
  13. ncbi request reprint Circadian variation in vascular tone and endothelial cell function in normal males
    Khalid Elherik
    University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
    Clin Sci (Lond) 102:547-52. 2002
    ..These circadian variations in endothelial activity might play an important role in the occurrence of acute cardiovascular events at this time, which are precipitated through the interplay between ET-1, NO and vascular function...
  14. ncbi request reprint Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome
    Vance A Spence
    Vascular and Inflammatory Diseases Research Unit, Institute for Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 114:561-6. 2008
    ..Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group...
  15. doi request reprint The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Med 14:137-42. 2009
    ..30, p = 0.006). The risk of later cardiovascular disease may be reduced by exclusively breastfeeding during infancy. These findings have potential public health implications, and support policies aimed at promoting breastfeeding...
  16. ncbi request reprint Is chronic fatigue syndrome associated with platelet activation?
    Gwen Kennedy
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Blood Coagul Fibrinolysis 17:89-92. 2006
    ..Nevertheless, we certainly found no evidence of increased platelet activation or of a hypercoagulable state in patients with CFS and, on the basis of these results, anti-platelet or anti-coagulant therapy is not warranted...
  17. doi request reprint The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Atherosclerosis 200:374-9. 2008
    ..A therapeutic intervention trial of lowering of serum urate is required to see whether this will impact positively on mortality and morbidity in patients with high-risk of strokes...
  18. doi request reprint Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography
    Faisel Khan
    Institute of Cardiovascular Research, University Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 115:295-300. 2008
    ..446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects...
  19. doi request reprint Relationship between maternal arterial wave reflection, microvascular function and fetal growth in normal pregnancy
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Microcirculation 17:608-14. 2010
    ..In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum...
  20. doi request reprint The role of endothelial function and its assessment in rheumatoid arthritis
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Nat Rev Rheumatol 6:253-61. 2010
    ..Given the increase in cardiovascular mortality associated with RA, effective management must involve prevention of cardiovascular risk, in addition to control of disease activity and inflammation...
  21. doi request reprint Allopurinol treatment reduces arterial wave reflection in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Cardiovasc Ther 26:247-52. 2008
    ..A further larger study is warranted to look at whether a therapeutic intervention with allopurinol will impact positively on mortality and morbidity in stroke survivors...
  22. ncbi request reprint Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Hypertension 46:1123-8. 2005
    ..These changes precede the onset of clinical disease and might be related to a compensatory increased sensitivity of the microcirculation to nitric oxide...
  23. ncbi request reprint Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
    Gwen Kennedy
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
    Free Radic Biol Med 39:584-9. 2005
    ..002; postexertional malaise P=0.027, Pearson). This is the first time that raised levels of the gold standard measure of in vivo oxidative stress (isoprostanes) and their association with CFS symptoms have been reported...
  24. ncbi request reprint Vasoactive properties of lignocaine administered by iontophoresis in human skin
    David J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 104:87-92. 2003
    ..It might be worth considering the use of alternative, non-vasoactive preservatives in local anaesthetic preparations, or avoiding the use of additives altogether, when this is feasible...
  25. doi request reprint Biochemical and vascular aspects of pediatric chronic fatigue syndrome
    Gwen Kennedy
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Arch Pediatr Adolesc Med 164:817-23. 2010
    ..To evaluate the biochemical and vascular aspects of pediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)...
  26. ncbi request reprint The use of Ginkgo biloba in Raynaud's disease: a double-blind placebo-controlled trial
    Andrew H Muir
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Med 7:265-7. 2002
    ..00001). There were no significant differences in haamorrheology between the two groups. Ginkgo biloba phytosome may be effective in reducing the number of Raynaud's attacks per week in patients suffering from Raynaud's disease...
  27. pmc Impaired microvascular function in normal children: effects of adiposity and poor glucose handling
    Faisel Khan
    Vascular Diseases Research Unit, Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    J Physiol 551:705-11. 2003
    ..These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life...
  28. ncbi request reprint Chemical synthesis and microvascular effects of new nitric oxide donors in humans
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Clin Sci (Lond) 105:577-84. 2003
    ..Since such compounds release NO in a non-enzymic manner following topical application, they might produce an attractive therapeutic source of localized NO delivery without inducing systemic side effects...
  29. ncbi request reprint Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Clin Physiol Funct Imaging 23:282-5. 2003
    ....
  30. ncbi request reprint Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Clin Sci (Lond) 106:183-9. 2004
    ....
  31. ncbi request reprint The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Cardiovasc Res 59:955-62. 2003
    ..Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years...
  32. ncbi request reprint Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans
    Faisel Khan
    Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Appl Physiol 97:883-7. 2004
    ..Deionized water is a better iontophoresis vehicle for the assessment of microvascular function in skin when using ACh and SNP...
  33. ncbi request reprint The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria
    Gwen Kennedy
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Ann Epidemiol 14:95-100. 2004
    ..To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies...
  34. ncbi request reprint The effect of adjuvant epinephrine concentration on the vasoactivity of the local anesthetics bupivacaine and levobupivacaine in human skin
    David J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Dundee, United Kingdom
    Reg Anesth Pain Med 29:307-11. 2004
    ..The aim of our study was to determine the lowest effective vasoconstrictor concentration of epinephrine in human skin for a range of doses of bupivacaine and its less-vasodilatory S(-) isomer, levobupivacaine...
  35. doi request reprint Therapeutic development in cardiac syndrome X: a need to target the underlying pathophysiology
    Tiong K Lim
    Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
    Cardiovasc Ther 27:49-58. 2009
    ....
  36. ncbi request reprint Left ventricular hypertrophy is present in one-half of newly-diagnosed peripheral arterial disease patients
    Gary A Wright
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Hypertens 25:463-9. 2007
    ..Peripheral arterial disease (PAD) patients are at high risk of cardiac death. Coincidental but silent coronary disease is obviously a major contributor but left ventricular hypertrophy (LVH) could be a second major contributor...
  37. doi request reprint Clinical improvement in rheumatoid arthritis is associated with healthier microvascular function in patients who respond to antirheumatic therapy
    Bernat Galarraga
    Vascular and Inflammatory Diseases Research Unit, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland
    J Rheumatol 37:521-8. 2010
    ..We assessed the effect of antirheumatic treatment on microvascular endothelial function in patients with RA, particularly to examine responders versus nonresponders to therapy...
  38. ncbi request reprint Two-dimensional flow quantitative MRI of aortic arch blood flow patterns: Effect of age, sex, and presence of carotid atheromatous disease on prevalence of spiral blood flow
    J Graeme Houston
    Department of Clinical Radiology, Ninewells Hospital and Medical School, Tayside University Hospitals NHS Trust, Dundee, Scotland, UK
    J Magn Reson Imaging 18:169-74. 2003
    ..To determine the effect of age, sex, and presence of carotid atheromatous disease on the presence of aortic spiral blood flow pattern using two-dimensional flow quantitative magnetic resonance imaging (MRI)...
  39. doi request reprint Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis
    Bernat Galarraga
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Rheumatology (Oxford) 48:1418-23. 2009
    ..The second objective was to establish any effect anti-rheumatic treatment may have on augmentation index...
  40. ncbi request reprint Dark chocolate inhibits platelet aggregation in healthy volunteers
    Andrew J Innes
    University Department of Medicine, Ninewells Hospital and Medical School, Dundee
    Platelets 14:325-7. 2003
    ..However dark chocolate inhibited collagen-induced platelet aggregation in platelet rich plasma. In the future dark chocolate may have a role in prevention of cardiovascular and thromboembolic diseases...
  41. ncbi request reprint Association of common variation in glutathione S-transferase genes with premature development of cardiovascular disease in patients with systemic sclerosis
    Colin N A Palmer
    Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Arthritis Rheum 48:854-5. 2003
  42. ncbi request reprint Spiral laminar flow in the abdominal aorta: a predictor of renal impairment deterioration in patients with renal artery stenosis?
    J Graeme Houston
    Tayside University Hospitals, Clinical Radiology, Dundee, UK
    Nephrol Dial Transplant 19:1786-91. 2004
    ....
  43. doi request reprint Optimization of the contrast dose and injection rates in whole-body MR angiography at 3.0T
    Shelley A Waugh
    Department of Medical Physics, Ninewells Hospital, NHS Tayside, Dundee, UK
    J Magn Reson Imaging 30:1059-67. 2009
    ..To optimize the contrast agent dose and delivery rate used in a novel whole-body magnetic resonance angiography (MRA) protocol using a 3.0T MR scanner...
  44. ncbi request reprint A focus on risk factor management
    Jill J F Belch
    Vasc Med 9:169-70. 2004
  45. ncbi request reprint Dietary lipids and vascular function: UK Food Standards Agency workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, London, UK
    Br J Nutr 91:491-500. 2004
    ....