Research Topics
| J F BelchSummaryAffiliation: University of Dundee Country: UK Publications
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Detail Information
Publications
Longitudinal assessment of endothelial function in the microvasculature of mice in-vivoJill J F Belch
Vascular and Inflammatory Diseases Research Unit, Dundee, DD1 9SY, Scotland
Microvasc Res 85:86-92. 2013..Longitudinal assessments of skin microvascular function in mice could provide a useful translatable model for assessing early endothelial dysfunction...
Study protocol for BeWEL: the impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomasAngela M Craigie
Centre for Research into Cancer Prevention and Screening, University of Dundee, UK
BMC Public Health 11:184. 2011..These diseases share risk factors related to the metabolic syndrome including large body size, abnormal lipids and markers of insulin resistance indicating common aetiological pathways...- Macrovascular disease in systemic sclerosis: the tip of an iceberg?J J F Belch
Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital, Tayside, Scotland, UK
Rheumatology (Oxford) 47:v16-7. 2008..Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population... - The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial diseaseJill Belch
Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY
BMJ 337:a1840. 2008..To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease... 
Evening primrose oil and borage oil in rheumatologic conditionsJ J Belch
Department of Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom
Am J Clin Nutr 71:352S-6S. 2000..The results of most of these studies suggest some clinical benefit to these treatments; these data are reviewed here...- Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trialJill J F Belch
Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
J Vasc Surg 52:825-33, 833.e1-2. 2010..We sought to determine whether clopidogrel plus ASA conferred benefit on limb outcomes over ASA alone in patients undergoing below-knee bypass grafting... - Critical issues in peripheral arterial disease detection and management: a call to actionJill J F Belch
Department of Medicine, Ninewells Hospitals and Medical School, Scotland
Arch Intern Med 163:884-92. 2003 - The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemiaJ J F Belch
C1Peripheral Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital, Dundee, UK
Int Angiol 30:150-5. 2011..The aim of this study was to determine whether Taprostene sodium, a PGI2 analogue, was a safe and effective treatment for CLI... - Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemiaJill Belch
The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
Lancet 377:1929-37. 2011..Patients with critical limb ischaemia have a high rate of amputation and mortality. We tested the hypothesis that non-viral 1 fibroblast growth factor (NV1FGF) would improve amputation-free survival... - Metabolic, endocrine and haemodynamic risk factors in the patient with peripheral arterial diseaseJill J F Belch
University Department of Medicine, Ninewells Hospital, Dundee, DD1 9SY, UK
Diabetes Obes Metab 4:S7-13. 2002..It is therefore important to improve detection rates so that these patients can receive appropriate risk factor management... - Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresisJamie Turner
University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
Trends Cardiovasc Med 18:109-16. 2008..With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease... - Allopurinol improves endothelial dysfunction in chronic heart failureColin A J Farquharson
Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Circulation 106:221-6. 2002..This raises the distinct possibility that allopurinol might reduce cardiovascular events and even improve exercise capacity in chronic heart failure... - Circadian variation in vascular tone and endothelial cell function in normal malesKhalid Elherik
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
Clin Sci (Lond) 102:547-52. 2002..These circadian variations in endothelial activity might play an important role in the occurrence of acute cardiovascular events at this time, which are precipitated through the interplay between ET-1, NO and vascular function... - Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndromeVance A Spence
Vascular and Inflammatory Diseases Research Unit, Institute for Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Clin Sci (Lond) 114:561-6. 2008..Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group... - The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old childrenFaisel Khan
Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
Vasc Med 14:137-42. 2009..30, p = 0.006). The risk of later cardiovascular disease may be reduced by exclusively breastfeeding during infancy. These findings have potential public health implications, and support policies aimed at promoting breastfeeding... - Is chronic fatigue syndrome associated with platelet activation?Gwen Kennedy
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Blood Coagul Fibrinolysis 17:89-92. 2006..Nevertheless, we certainly found no evidence of increased platelet activation or of a hypercoagulable state in patients with CFS and, on the basis of these results, anti-platelet or anti-coagulant therapy is not warranted... - The association between serum urate levels and arterial stiffness/endothelial function in stroke survivorsFaisel Khan
The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Atherosclerosis 200:374-9. 2008..A therapeutic intervention trial of lowering of serum urate is required to see whether this will impact positively on mortality and morbidity in patients with high-risk of strokes... - Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiographyFaisel Khan
Institute of Cardiovascular Research, University Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Clin Sci (Lond) 115:295-300. 2008..446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects... - Relationship between maternal arterial wave reflection, microvascular function and fetal growth in normal pregnancyFaisel Khan
Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Microcirculation 17:608-14. 2010..In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum... - The role of endothelial function and its assessment in rheumatoid arthritisFaisel Khan
The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
Nat Rev Rheumatol 6:253-61. 2010..Given the increase in cardiovascular mortality associated with RA, effective management must involve prevention of cardiovascular risk, in addition to control of disease activity and inflammation... - Allopurinol treatment reduces arterial wave reflection in stroke survivorsFaisel Khan
The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
Cardiovasc Ther 26:247-52. 2008..A further larger study is warranted to look at whether a therapeutic intervention with allopurinol will impact positively on mortality and morbidity in stroke survivors... - Changes in endothelial function precede the clinical disease in women in whom preeclampsia developsFaisel Khan
The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Hypertension 46:1123-8. 2005..These changes precede the onset of clinical disease and might be related to a compensatory increased sensitivity of the microcirculation to nitric oxide... - Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptomsGwen Kennedy
Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
Free Radic Biol Med 39:584-9. 2005..002; postexertional malaise P=0.027, Pearson). This is the first time that raised levels of the gold standard measure of in vivo oxidative stress (isoprostanes) and their association with CFS symptoms have been reported... - Vasoactive properties of lignocaine administered by iontophoresis in human skinDavid J Newton
Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Clin Sci (Lond) 104:87-92. 2003..It might be worth considering the use of alternative, non-vasoactive preservatives in local anaesthetic preparations, or avoiding the use of additives altogether, when this is feasible... - Biochemical and vascular aspects of pediatric chronic fatigue syndromeGwen Kennedy
Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Arch Pediatr Adolesc Med 164:817-23. 2010..To evaluate the biochemical and vascular aspects of pediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)... - The use of Ginkgo biloba in Raynaud's disease: a double-blind placebo-controlled trialAndrew H Muir
Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Vasc Med 7:265-7. 2002..00001). There were no significant differences in haamorrheology between the two groups. Ginkgo biloba phytosome may be effective in reducing the number of Raynaud's attacks per week in patients suffering from Raynaud's disease... - Impaired microvascular function in normal children: effects of adiposity and poor glucose handlingFaisel Khan
Vascular Diseases Research Unit, Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
J Physiol 551:705-11. 2003..These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life... - Chemical synthesis and microvascular effects of new nitric oxide donors in humansFaisel Khan
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Clin Sci (Lond) 105:577-84. 2003..Since such compounds release NO in a non-enzymic manner following topical application, they might produce an attractive therapeutic source of localized NO delivery without inducing systemic side effects... - Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndromeFaisel Khan
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Clin Physiol Funct Imaging 23:282-5. 2003.... - Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposureFaisel Khan
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
Clin Sci (Lond) 106:183-9. 2004.... - The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjectsFaisel Khan
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Cardiovasc Res 59:955-62. 2003..Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years... - Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humansFaisel Khan
Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
J Appl Physiol 97:883-7. 2004..Deionized water is a better iontophoresis vehicle for the assessment of microvascular function in skin when using ACh and SNP... - The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteriaGwen Kennedy
Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Ann Epidemiol 14:95-100. 2004..To test this, we have compared three groups of patients, all of whom fulfill the criteria but self-report different etiologies... - The effect of adjuvant epinephrine concentration on the vasoactivity of the local anesthetics bupivacaine and levobupivacaine in human skinDavid J Newton
Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Dundee, United Kingdom
Reg Anesth Pain Med 29:307-11. 2004..The aim of our study was to determine the lowest effective vasoconstrictor concentration of epinephrine in human skin for a range of doses of bupivacaine and its less-vasodilatory S(-) isomer, levobupivacaine... - Therapeutic development in cardiac syndrome X: a need to target the underlying pathophysiologyTiong K Lim
Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
Cardiovasc Ther 27:49-58. 2009.... - Left ventricular hypertrophy is present in one-half of newly-diagnosed peripheral arterial disease patientsGary A Wright
Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
J Hypertens 25:463-9. 2007..Peripheral arterial disease (PAD) patients are at high risk of cardiac death. Coincidental but silent coronary disease is obviously a major contributor but left ventricular hypertrophy (LVH) could be a second major contributor... - Clinical improvement in rheumatoid arthritis is associated with healthier microvascular function in patients who respond to antirheumatic therapyBernat Galarraga
Vascular and Inflammatory Diseases Research Unit, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland
J Rheumatol 37:521-8. 2010..We assessed the effect of antirheumatic treatment on microvascular endothelial function in patients with RA, particularly to examine responders versus nonresponders to therapy... - Two-dimensional flow quantitative MRI of aortic arch blood flow patterns: Effect of age, sex, and presence of carotid atheromatous disease on prevalence of spiral blood flowJ Graeme Houston
Department of Clinical Radiology, Ninewells Hospital and Medical School, Tayside University Hospitals NHS Trust, Dundee, Scotland, UK
J Magn Reson Imaging 18:169-74. 2003..To determine the effect of age, sex, and presence of carotid atheromatous disease on the presence of aortic spiral blood flow pattern using two-dimensional flow quantitative magnetic resonance imaging (MRI)... - Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritisBernat Galarraga
The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Rheumatology (Oxford) 48:1418-23. 2009..The second objective was to establish any effect anti-rheumatic treatment may have on augmentation index... - Dark chocolate inhibits platelet aggregation in healthy volunteersAndrew J Innes
University Department of Medicine, Ninewells Hospital and Medical School, Dundee
Platelets 14:325-7. 2003..However dark chocolate inhibited collagen-induced platelet aggregation in platelet rich plasma. In the future dark chocolate may have a role in prevention of cardiovascular and thromboembolic diseases... - Association of common variation in glutathione S-transferase genes with premature development of cardiovascular disease in patients with systemic sclerosisColin N A Palmer
Ninewells Hospital and Medical School, Dundee, Scotland, UK
Arthritis Rheum 48:854-5. 2003 - Spiral laminar flow in the abdominal aorta: a predictor of renal impairment deterioration in patients with renal artery stenosis?J Graeme Houston
Tayside University Hospitals, Clinical Radiology, Dundee, UK
Nephrol Dial Transplant 19:1786-91. 2004.... - Optimization of the contrast dose and injection rates in whole-body MR angiography at 3.0TShelley A Waugh
Department of Medical Physics, Ninewells Hospital, NHS Tayside, Dundee, UK
J Magn Reson Imaging 30:1059-67. 2009..To optimize the contrast agent dose and delivery rate used in a novel whole-body magnetic resonance angiography (MRA) protocol using a 3.0T MR scanner... - A focus on risk factor managementJill J F Belch
Vasc Med 9:169-70. 2004 - Dietary lipids and vascular function: UK Food Standards Agency workshop reportPeter Sanderson
Nutrition Division, Food Standards Agency, London, UK
Br J Nutr 91:491-500. 2004....