Stephen A Beers
Affiliation: University of Southampton
Dahal L, Dou L, Hussain K, Liu R, Earley A, Cox K, et al
. STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy. Cancer Res. 2017;77:3619-3631 pubmed publisher
..i>Cancer Res; 77(13); 3619-31. Â©2017 AACR. ..
Buchan S, Dou L, Remer M, Booth S, Dunn S, Lai C, et al
. Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity. 2018;: pubmed publisher
..These insights into the effector mechanisms of anti-4-1BB mAbs lay the groundwork for translation into the clinic. ..
Dahal L, Huang C, Stopforth R, Mead A, Chan K, Bowater J, et al
. Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy. J Immunol. 2018;201:1211-1221 pubmed publisher
..Therefore, shaving may represent an important mechanism of resistance when modulation is curtailed, and glycoengineering mAb to increase affinity for Fc?R may enhance resistance because of shaving. ..
Vaughan A, Cragg M, Beers S. Antibody modulation: Limiting the efficacy of therapeutic antibodies. Pharmacol Res. 2015;99:269-75 pubmed publisher
..The evidence for each of these processes will be discussed, in addition to possible therapeutic strategies that might be employed to inhibit or reverse them. ..