Christine Beedham

Summary

Affiliation: University of Bradford
Country: UK

Publications

  1. ncbi request reprint Human liver aldehyde oxidase: inhibition by 239 drugs
    R Scott Obach
    Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA
    J Clin Pharmacol 44:7-19. 2004
  2. ncbi request reprint Ziprasidone metabolism, aldehyde oxidase, and clinical implications
    Christine Beedham
    Department of Clinical Sciences, School of Life Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    J Clin Psychopharmacol 23:229-32. 2003
  3. ncbi request reprint Metabolism of 2-phenylethylamine and phenylacetaldehyde by precision-cut guinea pig fresh liver slices
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK
    Eur J Drug Metab Pharmacokinet 29:111-8. 2004
  4. ncbi request reprint Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, UK
    Acta Biochim Pol 51:649-63. 2004
  5. ncbi request reprint Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    Chem Res Toxicol 17:1368-76. 2004
  6. ncbi request reprint Enzymatic oxidation of 2-phenylethylamine to phenylacetic acid and 2-phenylethanol with special reference to the metabolism of its intermediate phenylacetaldehyde
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Basic Clin Pharmacol Toxicol 95:273-9. 2004
  7. ncbi request reprint Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, UK
    Pharmacology 73:199-208. 2005
  8. ncbi request reprint Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
    Georgios I Panoutsopoulos
    School of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
    Acta Biochim Pol 51:943-51. 2004
  9. ncbi request reprint In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase
    Mohammad Reza Rashidi
    Drug Applied Research Center, Research and Development Complex, Tabriz University of Medical Sciences, Iran
    Drug Metab Pharmacokinet 22:299-306. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Human liver aldehyde oxidase: inhibition by 239 drugs
    R Scott Obach
    Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA
    J Clin Pharmacol 44:7-19. 2004
    ....
  2. ncbi request reprint Ziprasidone metabolism, aldehyde oxidase, and clinical implications
    Christine Beedham
    Department of Clinical Sciences, School of Life Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    J Clin Psychopharmacol 23:229-32. 2003
    ..Consequently, it is unlikely that there would be any pharmacokinetic interaction between ethanol and ziprasidone...
  3. ncbi request reprint Metabolism of 2-phenylethylamine and phenylacetaldehyde by precision-cut guinea pig fresh liver slices
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK
    Eur J Drug Metab Pharmacokinet 29:111-8. 2004
    ..Therefore, in liver slices, phenylacetaldehyde is rapidly oxidized by aldehyde dehydrogenase and aldehyde oxidase with little or no contribution from xanthine oxidase...
  4. ncbi request reprint Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, UK
    Acta Biochim Pol 51:649-63. 2004
    ..It is therefore possible that aldehyde oxidase may be critical in the oxidation of the analogous phenylacetaldehydes derived from dopamine and noradrenaline...
  5. ncbi request reprint Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    Chem Res Toxicol 17:1368-76. 2004
    ..In addition, this enzyme may also have a role in the catabolism of biogenic amines such as dopamine and noradrenaline where 3-methoxyphenylacetic acids are major metabolites...
  6. ncbi request reprint Enzymatic oxidation of 2-phenylethylamine to phenylacetic acid and 2-phenylethanol with special reference to the metabolism of its intermediate phenylacetaldehyde
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Basic Clin Pharmacol Toxicol 95:273-9. 2004
    ..Thus aldehyde dehydrogenase is not the only enzyme oxidising xenobiotic and endobiotic aldehydes and the role of aldehyde oxidase in such reactions should not be ignored...
  7. ncbi request reprint Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices
    Georgios I Panoutsopoulos
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford, UK
    Pharmacology 73:199-208. 2005
    ..It is therefore concluded that isovanillin is predominantly metabolized by aldehyde dehydrogenase activity, with minimal contribution from either aldehyde oxidase or xanthine oxidase...
  8. ncbi request reprint Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
    Georgios I Panoutsopoulos
    School of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
    Acta Biochim Pol 51:943-51. 2004
    ....
  9. ncbi request reprint In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase
    Mohammad Reza Rashidi
    Drug Applied Research Center, Research and Development Complex, Tabriz University of Medical Sciences, Iran
    Drug Metab Pharmacokinet 22:299-306. 2007
    ..The first step which is the rate limiting step is catalyzed solely by XO, whereas both XO and AO are involved in the oxidation of 6-thioxanthine to 6-thiouric acid...