Esther B E Becker
Affiliation: University of Oxford
- Autism spectrum disorder and the cerebellumEsther B E Becker
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom Electronic address
Int Rev Neurobiol 113:1-34. 2013....
- Candidate screening of the TRPC3 gene in cerebellar ataxiaEsther B E Becker
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
Cerebellum 10:296-9. 2011..We identified a number of variants but no causative mutations in TRPC3. Our findings suggest that mutations in TRPC3 do not significantly contribute to the cause of late-onset and episodic human cerebellar ataxias...
- Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunctionGabriella Sekerkova
Departments of Physiology and Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, Department of Physiology, Anatomy, and Genetics, MRC Functional Genomics Unit, Oxford OX1 3PT, United Kingdom, Institute of Neuroscience, Technical University Munich, 80802 Munich, Germany, and Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina 27709
J Neurosci 33:19689-94. 2013....
- Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxiaEsther B E Becker
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford, UK
J Neurol Neurosurg Psychiatry 83:437-40. 2012..Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia...
- Oxr1 is essential for protection against oxidative stress-induced neurodegenerationPeter L Oliver
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 7:e1002338. 2011..Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease...
- A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker miceEsther B E Becker
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
Proc Natl Acad Sci U S A 106:6706-11. 2009..Our findings define a previously unknown role for TRPC3 in both dendritic development and survival of Purkinje cells, and provide a unique mechanism underlying cerebellar ataxia...