Esther B E Becker
Affiliation: University of Oxford
- Candidate screening of the TRPC3 gene in cerebellar ataxiaEsther B E Becker
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
Cerebellum 10:296-9. 2011..We identified a number of variants but no causative mutations in TRPC3. Our findings suggest that mutations in TRPC3 do not significantly contribute to the cause of late-onset and episodic human cerebellar ataxias...
- Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxiaEsther B E Becker
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford, UK
J Neurol Neurosurg Psychiatry 83:437-40. 2012..Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia...
- Oxr1 is essential for protection against oxidative stress-induced neurodegenerationPeter L Oliver
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 7:e1002338. 2011..Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease...
- A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker miceEsther B E Becker
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
Proc Natl Acad Sci U S A 106:6706-11. 2009..Our findings define a previously unknown role for TRPC3 in both dendritic development and survival of Purkinje cells, and provide a unique mechanism underlying cerebellar ataxia...