F Beck

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi request reprint The role of Cdx genes in the gut and in axial development
    Felix Beck
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE17RH, UK
    Biochem Soc Trans 38:353-7. 2010
  2. pmc The role of Cdx genes in the mammalian gut
    F Beck
    Department of Biochemistry, University of Leicester, Adrian Building, University Rd, Leicester LE 1 7RH, UK
    Gut 53:1394-6. 2004
  3. ncbi request reprint A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice
    Felix Beck
    Department of Biochemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Dev Biol 255:399-406. 2003
  4. ncbi request reprint Homeobox genes and gut development
    F Beck
    Department of Biochemistry, University of Leicester, United Kingdom
    Bioessays 22:431-41. 2000
  5. pmc Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne 3052, Australia
    Proc Natl Acad Sci U S A 96:7318-23. 1999
  6. ncbi request reprint Collagen studies in late pregnant relaxin null mice
    L Zhao
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biol Reprod 63:697-703. 2000
  7. ncbi request reprint Expression of IGF-II and H19 mRNA in the neonatal rat during normal maturation and after dexamethasone administration
    P V Senior
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Mol Endocrinol 17:217-23. 1996
  8. ncbi request reprint Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
  9. ncbi request reprint Mice without a functional relaxin gene are unable to deliver milk to their pups
    L Zhao
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Endocrinology 140:445-53. 1999
  10. ncbi request reprint A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2
    H G Mack
    Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Vic, Australia
    Gene 185:11-7. 1997

Collaborators

  • E M Wintour
  • Nicholas A Wright
  • P Waring
  • R J Playford
  • D D Bowtell
  • J B Furness
  • Jacqueline Deschamps
  • Janet Rossant
  • Stephen J Gaunt
  • R Poulsom
  • N Suda
  • A Russell
  • C S Samuel
  • Kallayanee Chawengsaksophak
  • Wim de Graaff
  • L Zhao
  • Fairouz Benahmed
  • Emma J Stringer
  • Claire Domon-Dell
  • Jean Noel Freund
  • Philippe Choquet
  • Johan van Nes
  • Dan Strumpf
  • K Chawengsaksophak
  • Eric van den Akker
  • Kongkwan Mekaapiruk
  • P V Senior
  • G W Tregear
  • Isabelle Duluc
  • Elisabeth Martin
  • J Tucci
  • N L Blythe
  • Frederic Jehan
  • Isabelle Gross
  • Michele Kedinger
  • Catrin A Pritchard
  • AndrĂ© Constantinesco
  • Alexandre Calon
  • Elodie Breton
  • Markus Gerhard
  • Franck Lebrin
  • V E Hammond
  • Yojiro Yamanaka
  • Amy Ralston
  • Chai An Mao
  • H Valcanis
  • H G Mack
  • Tatsuo Terashima
  • Sylvie Forlani
  • Barbara I Meyer
  • Vicki E Hammond
  • Takayuki Kuroda
  • Yoshiro Takano
  • N G Della
  • P J Roche
  • J M Gunnersen
  • E Kachab
  • J Haralambidis
  • F Kontgen
  • R James
  • V Hammond
  • A Gibson

Detail Information

Publications26

  1. doi request reprint The role of Cdx genes in the gut and in axial development
    Felix Beck
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE17RH, UK
    Biochem Soc Trans 38:353-7. 2010
    ..A significant degree of redundancy is apparent between the Cdx genes with respect to caudal extension and possibly also during gut development...
  2. pmc The role of Cdx genes in the mammalian gut
    F Beck
    Department of Biochemistry, University of Leicester, Adrian Building, University Rd, Leicester LE 1 7RH, UK
    Gut 53:1394-6. 2004
  3. ncbi request reprint A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice
    Felix Beck
    Department of Biochemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Dev Biol 255:399-406. 2003
    ..Our results indicate a difference in potency between forestomach and midgut precursor endodermal cells...
  4. ncbi request reprint Homeobox genes and gut development
    F Beck
    Department of Biochemistry, University of Leicester, United Kingdom
    Bioessays 22:431-41. 2000
    ..This results in the anatomical and physiological specialization of the adult gut...
  5. pmc Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne 3052, Australia
    Proc Natl Acad Sci U S A 96:7318-23. 1999
    ..This intercalary growth in a restricted space results in the formation of the polypoid lesions observed...
  6. ncbi request reprint Collagen studies in late pregnant relaxin null mice
    L Zhao
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biol Reprod 63:697-703. 2000
    ..As proliferation and differentiation of uterine and vaginal epithelia are thought to be induced by a paracrine stromal factor that acts upon estrogen stimulation, our results indicate that relaxin may be this paracrine factor...
  7. ncbi request reprint Expression of IGF-II and H19 mRNA in the neonatal rat during normal maturation and after dexamethasone administration
    P V Senior
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Mol Endocrinol 17:217-23. 1996
    ..In skeletal muscle, H19 continues to be expressed in the adult after IGF-II is switched off suggesting that IGF-II can also be regulated independently of H19...
  8. ncbi request reprint Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
    ..In contrast to the surrounding intestinal epithelium, the neoplastic cells do not express Cdx2 from the remaining allele. These results suggest that Cdx2 mutation is the primary event in the genesis of some intestinal tumours...
  9. ncbi request reprint Mice without a functional relaxin gene are unable to deliver milk to their pups
    L Zhao
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Endocrinology 140:445-53. 1999
    ..The interpubic ligament does not relax during pregnancy in rlx-/- mice. Plasma osmolality during late gestation was significantly higher (P < 0.001) in rlx-/- mice than in wild-type controls...
  10. ncbi request reprint A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2
    H G Mack
    Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Vic, Australia
    Gene 185:11-7. 1997
    ..Sequence analysis shows that Zfp64 has multiple potential phosphorylation sites for casein kinase II (CK II), protein kinase C (PKC), tyrosine kinase (TK) and c-AMP- and c-GMP-dependent protein kinase (cA/GMPDPK)...
  11. ncbi request reprint Chromosomal localization of cdx2, a murine homologue of the Drosophila gene caudal, to mouse chromosome 5
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, 3052, Australia
    Genomics 34:270-1. 1996
  12. pmc Homeobox genes in gut development
    F Beck
    Biochemistry Department, University of Leicester, UK
    Gut 51:450-4. 2002
    ..In this review, evidence is considered for their role, with particular regard to the acquisition of positional information...
  13. pmc Expression of insulin-like growth factor II (IGF)-II) and H19 in murine teratocarcinomas derived from embryonic stem (ES) cells
    N L Blythe
    Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Victoria, Australia
    J Anat 188:65-74. 1996
    ..However, there were some areas in which H19 was expressed strongly in comparison with IGF-II and vice versa suggesting the existence of further control elements other than the H19 enhancers...
  14. ncbi request reprint The effect of antisense oligonucleotides to Cdx2 on the development of mouse embryos in vitro
    H Valcanis
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    Int J Dev Biol 41:375-8. 1997
    ..In our view, this does not necessarily imply that Cdx2 has a direct role in brain morphogenesis...
  15. doi request reprint Cdx2 initiates histodifferentiation of the midgut endoderm
    Emma J Stringer
    Department of Biochemistry, University of Leicester, Leicester, UK
    FEBS Lett 582:2555-60. 2008
    ....
  16. ncbi request reprint Developmental biology at the Howard Florey Institute
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol Suppl 25:S12-5. 1998
    ..Homozygous embryos did not implant in the uterus. Heterozygotes exhibited homeosis involving the gut and skeleton. Animals developed intestinal tumours within a few weeks of birth...
  17. ncbi request reprint Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Dev Dyn 204:219-27. 1995
    ....
  18. ncbi request reprint The role of fetal parathyroid hormone-related protein in transplacental calcium transport
    J Tucci
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Mol Endocrinol 17:159-64. 1996
    ..Alternatively, the increased avidity of the bones for calcium may in itself have produced a lower equilibrium level of available ionised calcium...
  19. ncbi request reprint Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis
    N G Della
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Cell Tissue Res 279:411-9. 1995
    ..abstract truncated at 250 words)..
  20. pmc Cdx2 is essential for axial elongation in mouse development
    Kallayanee Chawengsaksophak
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Proc Natl Acad Sci U S A 101:7641-5. 2004
    ..The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning...
  21. ncbi request reprint Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE...
  22. ncbi request reprint The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice
    Johan van Nes
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Development 133:419-28. 2006
    ..Cdx genes thus operate in a redundant way during placentogenesis, as they do during embryonic axial elongation and patterning, and independently from the previously reported early Cdx2-specific role in the trophectoderm at implantation...
  23. ncbi request reprint Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice
    Philippe Choquet
    Service de Biophysique et de Medecine Nucleaire, Hopitaux Universitaires de Strasbourg, Hopital de Hautepierre, 1, Avenue Moliere, 67098 Strasbourg, France
    C R Biol 330:821-7. 2007
    ..As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice...
  24. ncbi request reprint Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
    Eric van den Akker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 129:2181-93. 2002
    ..The function of Cdx genes in morphogenetic processes during gastrulation and tail bud extension, and their relationship with the Hox genes are discussed in the light of available data in Amphioxus, C. elegans, Drosophila and mice...
  25. doi request reprint Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene
    Fairouz Benahmed
    INSERM, U682, Strasbourg, France
    Gastroenterology 135:1238-1247, 1247.e1-3. 2008
    ..The aim of this study was to map genomic regions that regulate the transcription of Cdx2, with a particular interest in the gut...
  26. ncbi request reprint The influence of parathyroid hormone-related protein (PTHrP) on tooth-germ development and osteoclastogenesis in alveolar bone of PTHrP-knock out and wild-type mice in vitro
    Kongkwan Mekaapiruk
    Maxillofacial Orthognathics, Division of Maxillofacial Neck Reconstruction, Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549, Tokyo, Japan
    Arch Oral Biol 47:665-72. 2002
    ..These data suggest that PTHrP is not required for the development of the tooth germ proper but is indispensable in promoting the osteoclast formation required to accommodate that development...