David A Bechtold

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi Circadian dysfunction in disease
    David A Bechtold
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester
    Trends Pharmacol Sci 31:191-8. 2010
  2. ncbi The role of RFamide peptides in feeding
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    J Endocrinol 192:3-15. 2007
  3. pmc Induction of the metabolic regulator Txnip in fasting-induced and natural torpor
    Laura E Hand
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 154:2081-91. 2013
  4. doi Hypothalamic clocks and rhythms in feeding behaviour
    David A Bechtold
    University of Manchester, Manchester, UK
    Trends Neurosci 36:74-82. 2013
  5. doi A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor
    David A Bechtold
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 22:70-7. 2012
  6. ncbi Energy-responsive timekeeping
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Genet 87:447-58. 2008
  7. pmc Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
    Qing Jun Meng
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 107:15240-5. 2010
  8. ncbi Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
    Elena A Ivanova
    Faculty of Life Sciences, Univ of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester, UK, M13 9PT
    Am J Physiol Endocrinol Metab 294:E176-82. 2008
  9. pmc GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling
    Jian Li
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e23725. 2011
  10. ncbi PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling
    Zoe Hawke
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 29:14828-35. 2009

Collaborators

Detail Information

Publications18

  1. doi Circadian dysfunction in disease
    David A Bechtold
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester
    Trends Pharmacol Sci 31:191-8. 2010
    ..Here we consider the implications of decentralised and internally responsive clockwork to disease, with a focus on energy metabolism and the immune response...
  2. ncbi The role of RFamide peptides in feeding
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    J Endocrinol 192:3-15. 2007
    ....
  3. pmc Induction of the metabolic regulator Txnip in fasting-induced and natural torpor
    Laura E Hand
    Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 154:2081-91. 2013
    ....
  4. doi Hypothalamic clocks and rhythms in feeding behaviour
    David A Bechtold
    University of Manchester, Manchester, UK
    Trends Neurosci 36:74-82. 2013
    ..Given our 24-h society, it is important that we understand how the circadian clock influences what and when we eat...
  5. doi A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor
    David A Bechtold
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 22:70-7. 2012
    ..Thus, our findings identify hypothalamic circuits involved in torpor and reveal GPR50 to be a novel component of adaptive thermogenesis in mammals...
  6. ncbi Energy-responsive timekeeping
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Genet 87:447-58. 2008
    ..This close interaction is likely to be critical for normal circadian regulation of metabolism, and may also underlie the disruption of proper metabolic rhythms observed in metabolic disorders, such as obesity and type-II diabetes...
  7. pmc Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
    Qing Jun Meng
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 107:15240-5. 2010
    ..Accordingly, selective pharmacological targeting of the endogenous circadian regulator CK1delta offers an avenue for therapeutic modulation of perturbed circadian behavior...
  8. ncbi Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
    Elena A Ivanova
    Faculty of Life Sciences, Univ of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester, UK, M13 9PT
    Am J Physiol Endocrinol Metab 294:E176-82. 2008
    ..GPR50 expression was highly responsive to energy status, showing a significantly reduced expression following both fasting and 5 wk of HED. These data implicate GPR50 as an important regulator of energy metabolism...
  9. pmc GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling
    Jian Li
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e23725. 2011
    ..These results identify a novel role for GPR50 in glucocorticoid receptor signalling through interaction with TIP60...
  10. ncbi PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling
    Zoe Hawke
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 29:14828-35. 2009
    ..Thus, it appears that PACAP is an important mediator of central leptin effects on energy balance...
  11. pmc Appetite-modifying actions of pro-neuromedin U-derived peptides
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Physiol Endocrinol Metab 297:E545-51. 2009
    ..proNMU(104-136) administration also significantly increased metabolic rate. These results suggest that proNMU(104-136) is a novel modulator of energy balance and may contribute to the phenotype exhibited by NMU knockout mice...
  12. pmc Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins
    Qing Jun Meng
    Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neuron 58:78-88. 2008
    ....
  13. pmc Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting
    Clare Guilding
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Physiol 591:1063-80. 2013
    ..Together, these findings reveal unexpected consequences of the Afh mutation on the amplitude and synchrony of individual cellular oscillators in the SCN...
  14. doi Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock
    Mino D C Belle
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and King s College London and MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 34:3607-21. 2014
    ....
  15. ncbi Hypothalamic thyroid hormones: mediators of seasonal physiology
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Endocrinology 148:3605-7. 2007
  16. ncbi Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Am J Physiol Regul Integr Comp Physiol 294:R344-51. 2008
    ..These results demonstrate that altering SCN function not only affects neuronal and wheel-running activity rhythms but also dramatically impairs temporal regulation of metabolism and feeding...
  17. ncbi Prolactin-releasing Peptide mediates cholecystokinin-induced satiety in mice
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Endocrinology 147:4723-9. 2006
    ..These findings suggest that PrRP, acting through GPR10, is involved in regulating food intake and may be a key intermediary in the central satiating actions of CCK...
  18. ncbi A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli
    Violetta Pilorz
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Curr Biol 24:766-73. 2014
    ..These studies therefore reveal a role for CK1ε in stabilizing the circadian clock against phase shift and highlight it as a novel target for minimizing physiological disturbance in shift workers...