Affiliation: University of Nottingham
- Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitroRoger Bayston
Biomaterials Related Infection Group, School of Clinical Sciences, University of Nottingham School of Medicine and Health Sciences, Nottingham, United Kingdom
Antimicrob Agents Chemother 56:2842-5. 2012..It is hoped that these in vitro results will stimulate further clinical trials with linezolid, avoiding surgical shunt removal...
- An experimental in-vivo canine model for adult shunt infectionRoger Bayston
Department of Neurosurgery S80, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
Cerebrospinal Fluid Res 5:17. 2008..The intention of this pilot study was to show that the canine hydrocephalus model could be shunted using conventional "human" shunts, and that a shunt infection could be established so that further studies could then be planned...
- Use of antibiotics in penetrating craniocerebral injuries. "Infection in Neurosurgery" Working Party of British Society for Antimicrobial ChemotherapyR Bayston
Division of Microbiology and Infectious Diseases, University of Nottingham Faculty of Medicine and Health Sciences, UK
Lancet 355:1813-7. 2000..Broad-spectrum antibiotic prophylaxis is recommended for both military and civilian PCCI, Including those due to sports or recreational injuries...
- Prevention of infection in neurosurgery: role of "antimicrobial" cathetersRoger Bayston
Biomaterials-Related Infection Group, School of Medical and Surgical Sciences, University of Nottingham, UK
J Hosp Infect 65:39-42. 2007
- Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: a novel mode of evasion of susceptibility to antisepticsRoger Bayston
Biomaterials Related Infection Group, Division of Orthopaedic and Accident Surgery, School of Medical and Surgical Sciences, University Hospitals Nottingham, Nottingham NG7 2UH, UK
J Antimicrob Chemother 59:848-53. 2007..Triclosan resistance is uncommon, usually being due to mutation in fabI or overexpression of efflux pumps. This study investigated the ability of triclosan-containing silicone elastomer to kill MRSA adherent to its surface...
- Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: impact on diagnosis and treatmentRoger Bayston
Biomaterials Related Infection Group, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, England
J Biomed Mater Res A 81:705-9. 2007..Biofilm development by P. acnes explains the difficulties encountered in clinical management of such infections...
- Hydromer-coated catheters to prevent shunt infection?Roger Bayston
Biomaterials Related Infection Group, Orthopaedic and Accident Surgery, University Hospital, Nottingham, United Kingdom
J Neurosurg 102:207-12. 2005....
- Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infectionRoger Bayston
Biomaterials Related Infection Group, School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK
J Antimicrob Chemother 60:1298-301. 2007..acnes biofilms in vitro. Outcomes were eradication or regrowth after withdrawal of antibiotics, simulating successful treatment and relapse...
- An antimicrobial modified silicone peritoneal catheter with activity against both Gram-positive and Gram-negative bacteriaRoger Bayston
Biomaterials Related Infection Group, Division of Orthopaedic and Accident Surgery, School of Clinical Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
Biomaterials 30:3167-73. 2009..The antimicrobial catheter material showed prolonged activity against common CAPD pathogens and promises to reduce clinical CAPD infection...
- Mode of action of an antimicrobial biomaterial for use in hydrocephalus shuntsRoger Bayston
Biomaterials Related Infection Group, Division of Orthopaedic and Accident Surgery, C Floor West Block, University Hospital, Nottingham NG7 2UH, UK
J Antimicrob Chemother 53:778-82. 2004..As there is no clear evidence to support antibiotic prophylaxis, we have developed an impregnated antimicrobial shunt material. This study aimed to elucidate its mode of action in terms of bacterial adherence and killing kinetics...
- In vitro antimicrobial activity of silver-processed catheters for neurosurgeryRoger Bayston
Biomaterials Related Infection Group, Division of Orthopaedic and Accident Surgery, C Floor West Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
J Antimicrob Chemother 65:258-65. 2010..To investigate the in vitro antibacterial activity of silver-processed catheters for use in neurosurgery using clinically predictive tests...
- Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnesRoger Bayston
BRIG Division of Orthopaedic and Accident Surgery, C Floor West Block, Nottingham University Hospitals QMC, Nottingham NG7 2UH, United Kingdom
Antimicrob Agents Chemother 54:5082-5. 2010..acnes for 56 days. Using tests that were designed to be clinically predictive when done together, the results suggest that the antimicrobial catheters will be able to prevent colonization of hydrocephalus shunts by P. acnes...
- Epidemiology, diagnosis, treatment, and prevention of cerebrospinal fluid shunt infectionsR Bayston
Biomaterials Related Infection Group, Division of Microbiology and Infectious Diseases, University of Nottingham, City Hospital, Nottingham NG5 1PB, England
Neurosurg Clin N Am 12:703-8, viii. 2001..Subsequent research has since revealed their etiology and provided data that have improved the understanding of aspects of diagnosis, treatment, and prevention...
- Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection?Franck Furno
Biomaterials Related Infection Group, School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
J Antimicrob Chemother 54:1019-24. 2004..We have developed a completely new approach using supercritical carbon dioxide to impregnate silicone with nanoparticulate silver metal. This study aimed to evaluate the impregnated polymer for antimicrobial activity...
- Combinatorial discovery of polymers resistant to bacterial attachmentAndrew L Hook
Laboratory of Biophysics and Surface Analysis, University of Nottingham, Nottingham, UK
Nat Biotechnol 30:868-75. 2012..These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions...
- Electromagnetic augmentation of antibiotic efficacy in infection of orthopaedic implantsS A W Pickering
Academic Department of Orthopaedic and Fracture Surgery, Queen's Medical Centre, Nottingham, England, UK
J Bone Joint Surg Br 85:588-93. 2003..Analysis of variance (ANOVA) confirmed an effect by a PEMF on the efficacy of gentamicin which was significant at p < 0.05. There was no significant effect with vancomycin...
- Comment on: the increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?Roger Bayston
J Antimicrob Chemother 60:447; author reply 447-8. 2007
- Spine update: prevention of postoperative infection in patients undergoing spinal surgeryErwin M Brown
Department of Medical Microbiology, Frenchay Hospital, Bristol, UK
Spine 29:938-45. 2004
- Use of elemental iodine for shunt infection prophylaxisSooHo Choi
Division of Neurosurgery, Childrens Hospital of Los Angeles, CA 90027, USA
Neurosurgery 52:908-12; discussion 912-3. 2003..CONCLUSION: I(2) can be added to irrigation solutions in sufficient concentrations to be bactericidal without causing any central nervous system injury...
- Stimulation of Staphylococcus epidermidis growth and biofilm formation by catecholamine inotropesMark Lyte
Department of Surgery, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis 55404, USA
Lancet 361:130-5. 2003..We postulated that administration of inotropic agents via indwelling intravenous catheters may stimulate growth and formation of biofilms by Staphylococcus epidermidis...
- Duration of in vivo antimicrobial activity of antibiotic-impregnated cerebrospinal fluid cathetersRoger Bayston
Neurosurgery 60:E208; author reply E208. 2007