Ardeshir Bayat

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Genetic susceptibility to Dupuytren's disease: transforming growth factor beta receptor (TGFbetaR) gene polymorphisms and Dupuytren's disease
    A Bayat
    Hand Surgery Units, Wythenshawe Hospital, South Moor Road, Wythenshawe, Manchester M23 9LT, UK
    Br J Plast Surg 56:328-33. 2003
  2. ncbi request reprint Clinical management of skin scarring
    Ardeshir Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Manchester, England
    Skinmed 4:165-73. 2005
  3. ncbi request reprint Keloid disease: clinical relevance of single versus multiple site scars
    A Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Southmoor Road, Wythenshawe, Manchester, UK
    Br J Plast Surg 58:28-37. 2005
  4. ncbi request reprint Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population
    A Bayat
    Department of Plastic and Reconstructive Surgery, University of West Indies, Mona, Kingston, Jamaica
    Br J Plast Surg 57:122-33. 2004
  5. ncbi request reprint Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease
    Ardeshir Bayat
    The Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    Exp Dermatol 13:120-4. 2004
  6. ncbi request reprint Rapid denaturing high-performance liquid chromatography (DHPLC) for mutation scanning of the transforming growth factor beta3 gene using a novel proof-reading polymerase
    A Bayat
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    Eur J Immunogenet 30:335-40. 2003
  7. pmc "Aggressive keloid": a severe variant of familial keloid scarring
    Ardeshir Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Manchester, UK
    J R Soc Med 96:554-5. 2003
  8. ncbi request reprint Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene
    Ardeshir Bayat
    Center for Integrated Genomic Research and Division of Cell Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
    Plast Reconstr Surg 111:2133-9. 2003
  9. ncbi request reprint Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology, and Development, School of Biological Sciences, University of Manchester, England
    Plast Reconstr Surg 111:535-43; discussion 544-6. 2003
  10. pmc Skin scarring
    A Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Wythenshawe Hospital, Wythenshawe, Manchester M23 9LT, UK
    BMJ 326:88-92. 2003

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Genetic susceptibility to Dupuytren's disease: transforming growth factor beta receptor (TGFbetaR) gene polymorphisms and Dupuytren's disease
    A Bayat
    Hand Surgery Units, Wythenshawe Hospital, South Moor Road, Wythenshawe, Manchester M23 9LT, UK
    Br J Plast Surg 56:328-33. 2003
    ..However, there were no significant difference in genotype or allele frequency distributions between cases and controls for the TGFbetaRII and TGFbetaRIII SNPs...
  2. ncbi request reprint Clinical management of skin scarring
    Ardeshir Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Manchester, England
    Skinmed 4:165-73. 2005
    ..This article reviews the spectrum of abnormal scar types and problems associated with scarring...
  3. ncbi request reprint Keloid disease: clinical relevance of single versus multiple site scars
    A Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Southmoor Road, Wythenshawe, Manchester, UK
    Br J Plast Surg 58:28-37. 2005
    ..This knowledge further emphasizes the need for genetic studies in KD, which may lead to better diagnostic and therapeutic regimes...
  4. ncbi request reprint Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population
    A Bayat
    Department of Plastic and Reconstructive Surgery, University of West Indies, Mona, Kingston, Jamaica
    Br J Plast Surg 57:122-33. 2004
    ..Three plantar and eight pubic keloids were rare findings. Recognition of different morphological phenotypes is necessary in understanding genotypic predisposition and aiding diagnosis, treatment and prognosis of keloid scars...
  5. ncbi request reprint Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease
    Ardeshir Bayat
    The Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    Exp Dermatol 13:120-4. 2004
    ..It is possible that other SNPs in other TGF-beta family members are associated with KD. To our knowledge, this is the first report of a case-control association study with KD and TGF-beta receptor gene polymorphisms...
  6. ncbi request reprint Rapid denaturing high-performance liquid chromatography (DHPLC) for mutation scanning of the transforming growth factor beta3 gene using a novel proof-reading polymerase
    A Bayat
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    Eur J Immunogenet 30:335-40. 2003
    ..Understanding the genetic variations affecting the TGFbeta3 gene is important as this molecule has multiple regulatory functions on a variety of cell types...
  7. pmc "Aggressive keloid": a severe variant of familial keloid scarring
    Ardeshir Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Manchester, UK
    J R Soc Med 96:554-5. 2003
  8. ncbi request reprint Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene
    Ardeshir Bayat
    Center for Integrated Genomic Research and Division of Cell Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
    Plast Reconstr Surg 111:2133-9. 2003
    ..9; 95 percent confidence interval, 1.2 to 2.9). The authors believe this to be the first report of a positive genetic association study in Dupuytren disease using single nucleotide polymorphisms...
  9. ncbi request reprint Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology, and Development, School of Biological Sciences, University of Manchester, England
    Plast Reconstr Surg 111:535-43; discussion 544-6. 2003
    ..To the authors' knowledge, this is the first report of a case-control association study in keloid disease and hypertrophic scars using any single nucleotide polymorphisms...
  10. pmc Skin scarring
    A Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Wythenshawe Hospital, Wythenshawe, Manchester M23 9LT, UK
    BMJ 326:88-92. 2003
  11. ncbi request reprint Novel single nucleotide polymorphisms in the 3'-UTR of the TGFbetaRI and TGFbetaRIII genes
    A Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, UK
    Eur J Immunogenet 29:445-6. 2002
    ..The observed heterozygosities of TGFbetaRI and TGFbetaRIII gene polymorphisms in the control population were 43 and 33%, respectively, suggesting these SNPs could be useful markers in disease association studies...
  12. ncbi request reprint Genetic susceptibility in Dupuytren's disease: lack of association of a novel transforming growth factor beta(2) polymorphism in Dupuytren's disease
    A Bayat
    Hand Surgery Unit, Wrightington Hospital, Manchester, UK
    J Hand Surg Br 27:47-9. 2002
    ..There was no statistically significant difference in TGFbeta(2) allele frequency distributions between cases and controls for the TGFbeta(2) polymorphism...
  13. pmc Science, medicine, and the future: Bioinformatics
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester M13 9PT
    BMJ 324:1018-22. 2002
  14. ncbi request reprint Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans
    Jason J Brown
    Department of Plastic and Reconstructive Surgery, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, UK
    Exp Dermatol 17:610-3. 2008
    ..Identification of genetic markers in candidate genes such as the SMAD family may be of significant importance in diagnosis, prognosis and development of new therapies in the management of keloid scarring...
  15. ncbi request reprint Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome
    Daniel J T Kyle
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 21:762-9. 2013
    ..IL8 and TIMP4 may serve as potential key diagnostic, therapeutic, and prognostic biomarkers in capsular contracture formation...
  16. pmc Enhancement of differentiation and mineralisation of osteoblast-like cells by degenerate electrical waveform in an in vitro electrical stimulation model compared to capacitive coupling
    Michelle Griffin
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom
    PLoS ONE 8:e72978. 2013
    ..In summary, we have demonstrated for the first time that DW stimulation in an in vitro ES chamber has a significant effect on maturation of osteoblast-like cells compared to CC stimulation of the same magnitude. ..
  17. doi request reprint Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, United Kingdom
    Am J Pathol 181:1642-58. 2012
    ....
  18. doi request reprint Identification of biomarkers in sequential biopsies of patients with chronic wounds receiving simultaneous acute wounds: a genetic, histological, and noninvasive imaging study
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Wound Repair Regen 20:757-69. 2012
    ..05). This unique study has showed aberrant expression of INHBA in chronic wounds using a sequential biopsy model of chronic vs. acute wounds in the same individual...
  19. doi request reprint Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    J Hand Surg Am 34:124-36. 2009
    ..This study aims to identify potential biomarkers in Dupuytren's disease (DD), a fibroproliferative benign tumor with an unknown etiology and high recurrence after surgery...
  20. ncbi request reprint Superior effect of combination vs. single steroid therapy in keloid disease: a comparative in vitro analysis of glucocorticoids
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 21:88-102. 2013
    ..05) induced apoptosis. In conclusion, this is the first study to report the efficacy of three well-known steroids on KF and suggest that combination may be superior than using a single steroid in treating KD...
  21. doi request reprint Ex vivo evaluation of antifibrotic compounds in skin scarring: EGCG and silencing of PAI-1 independently inhibit growth and induce keloid shrinkage
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology MIB, University of Manchester, Manchester, UK
    Lab Invest 93:946-60. 2013
    ..Therefore, the application of EGCG, PAI-1 silencing, and other emerging compounds tested using this model may provide effective treatment and potentially aid in the prevention of recurrence of KD following surgery. ..
  22. doi request reprint Acceleration of cutaneous healing by electrical stimulation: degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study
    Anil Sebastian
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 19:693-708. 2011
    ..In summary, cutaneous wounds receiving DW electrical stimulation display accelerated healing seen by reduced inflammation, enhanced angiogenesis and advanced remodeling phase...
  23. doi request reprint A double-blind controlled clinical trial assessing the effect of topical gels on striae distensae (stretch marks): a non-invasive imaging, morphological and immunohistochemical study
    Sara Ud-Din
    Plastic and Reconstructive Surgery Research PRSR, Manchester Institute of Biotechnology MIB, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    Arch Dermatol Res 305:603-17. 2013
    ..Furthermore, vascularity significantly decreased with placebo gel. These findings provide preliminary evidence of the utility of topical gels in the clinical management of SD...
  24. doi request reprint Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools
    Sara Ud-Din
    Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, University of Manchester, Manchester, UK
    Arch Dermatol Res 305:205-14. 2013
    ..In conclusion, PDT reduces scar formation in KD evidenced by decreased blood flow, increased pliability, decreased collagen and haemoglobin levels. These findings indicate potential utility of PDT in the treatment of KD...
  25. ncbi request reprint Dupuytren's diathesis revisited: Evaluation of prognostic indicators for risk of disease recurrence
    Sandip Hindocha
    Plastic and Reconstructive Surgery Research, The Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    J Hand Surg Am 31:1626-34. 2006
    ..Prognostic indicators of risks associated with surgery are important. We aimed to evaluate these 4 factors and known associated risk factors to formulate a statistical predictive value for DD diathesis...
  26. doi request reprint Electrical stimulation increases blood flow and haemoglobin levels in acute cutaneous wounds without affecting wound closure time: evidenced by non-invasive assessment of temporal biopsy wounds in human volunteers
    Sara Ud-Din
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK
    Exp Dermatol 21:758-64. 2012
    ..This study, for the first time, shows that DW increases blood flow and haemoglobin levels in acute healing wounds without affecting wound closure time and may have potential application in enhancing acute cutaneous healing...
  27. doi request reprint Notch signaling pathway in keloid disease: enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Wound Repair Regen 20:688-706. 2012
    ..In conclusion, this is the first study to demonstrate a potential role for the Notch signaling pathway in KD progression and that targeting this pathway may provide a novel strategy for treatment of KD...
  28. pmc In vitro study of novel collagenase (XIAFLEX®) on Dupuytren's disease fibroblasts displays unique drug related properties
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    PLoS ONE 7:e31430. 2012
    ..05) inhibited. This is the first report elucidating potential mechanisms of action of Xiaflex® on Dupuytren fibroblasts, offering a greater insight and a better understanding of its effect in DD...
  29. doi request reprint Genome-wide high-resolution screening in Dupuytren's disease reveals common regions of DNA copy number alterations
    Barbara B Shih
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester M17ND, UK
    J Hand Surg Am 35:1172-1183.e7. 2010
    ..The objective was to detect cryptic chromosomal imbalances in DD...
  30. doi request reprint Differential cytotoxic response in keloid fibroblasts exposed to photodynamic therapy is dependent on photosensitiser precursor, fluence and location of fibroblasts within the lesion
    Jenifer Mendoza
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Institute of Biotechnology MIB, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    Arch Dermatol Res 304:549-62. 2012
    ..We conclude that cytotoxicity post-PDT in KD fibroblasts is dependent on the lesional site, precursor of intracellular photosensitiser and fluence. Thus, PDT may be used for site-targeted therapy of KD...
  31. doi request reprint Long-term organ culture of keloid disease tissue
    Rania Bagabir
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Exp Dermatol 21:376-81. 2012
    ..Therefore, this novel assay provides a quantitative, clinically relevant model system for studying KD pathobiology and response to treatment...
  32. doi request reprint Comparative genomic hybridisation analysis of keloid tissue in Caucasians suggests possible involvement of HLA-DRB5 in disease pathogenesis
    Barbara Shih
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, The Manchester Interdisciplinary Biocentre MIB, University of Manchester, Manchester, UK
    Arch Dermatol Res 304:241-9. 2012
    ..In conclusion, these preliminary findings further support the possible contribution of the HLA genes in KD pathogenesis...
  33. pmc Degenerate wave and capacitive coupling increase human MSC invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model
    Michelle Griffin
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e23404. 2011
    ..Application of DW or CC to the fracture site may help in the recruitment of BMMSCs to the wound that may enhance rate of bone healing at the fracture site...
  34. ncbi request reprint Genetics of keloid scarring
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Epithelial Sciences, School of Translational Medicine, The Manchester Interdisciplinary Biocentre MIB, University of Manchester, 131 Princess Street, Manchester M17ND, UK
    Arch Dermatol Res 302:319-39. 2010
    ..A better understanding of the genes involved in KD may potentially lead to the development of more effective diagnostic, therapeutic and prognostic measures...
  35. ncbi request reprint Identification of a novel mitochondrial mutation in Dupuytren's disease using multiplex DHPLC
    Ardeshir Bayat
    Center for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 115:134-41. 2005
    ..001; chi2 = 16.1). This mutation may be important in the pathogenesis of Dupuytren's disease...
  36. ncbi request reprint Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing
    Nicholas S Greaves
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, UK The University of Manchester, Manchester Academic Health Science Centre, University Hospital South Manchester Foundation Trust, Wythenshawe Hospital, Manchester, UK
    J Dermatol Sci 72:206-17. 2013
    ....
  37. doi request reprint Identification of steroid sensitive responders versus non-responders in the treatment of keloid disease
    Sara Ud-Din
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Arch Dermatol Res 305:423-32. 2013
    ..Selection of KD non-responders to steroid treatment can avoid potentially painful injection, its subsequent side effects and unnecessary continuation of redundant therapy and follow-up...
  38. doi request reprint Up-regulation of tension-related proteins in keloids: knockdown of Hsp27, α2β1-integrin, and PAI-2 shows convincing reduction of extracellular matrix production
    Edna Suárez
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 131:158e-173e. 2013
    ..The aim of this study was to investigate the effect of tension-related proteins on extracellular matrix steady-state synthesis in primary keloid fibroblasts...
  39. ncbi request reprint Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing
    Samrina Rehman
    Doctoral Training Centre ISBML, The Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK
    Mol Biosyst 8:2274-88. 2012
    ..Experimental conditions have been identified in which these DD data are reproducible. The experimental reproducibility will be useful in DD diagnostics and for DD systems biology...
  40. pmc Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy
    Syed Amir Iqbal
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    Stem Cells Dev 21:609-22. 2012
    ..These findings provide preliminary support for a potential alternative source of disease myofibroblasts originating from sites such as SON and PNF as opposed to palmar fascia alone...
  41. doi request reprint Influence of the human leukocyte antigen complex on the development of cutaneous fibrosis: an immunogenetic perspective
    Sara M McCarty
    Manchester Interdisciplinary Biocentre, University of Manchester, United Kingdom
    Acta Derm Venereol 90:563-74. 2010
    ..However, the exact mechanisms remain to be elucidated, since the pathogenesis of cutaneous fibrosis and abnormal wound healing are not fully understood...
  42. doi request reprint A novel in vitro assay for electrophysiological research on human skin fibroblasts: degenerate electrical waves downregulate collagen I expression in keloid fibroblasts
    Anil Sebastian
    Plastic and Reconstructive Surgery Research, Epithelial Sciences, School of Translational Medicine, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, UK
    Exp Dermatol 20:64-8. 2011
    ....
  43. ncbi request reprint Genetic susceptibility to total hip arthroplasty failure--positive association with mannose-binding lectin
    Mohammad H A Malik
    Center for Hip Surgery, Wrightington Hospital, Wigan, United Kingdom
    J Arthroplasty 22:265-70. 2007
    ..In the septic group, the frequency of the C allele (P = .01) and that of the genotype C/C (P = .05) for the -550 SNP were significant. Failure of THAs may be under genetic influence to candidate susceptibility genes such as MBL...
  44. ncbi request reprint The heritability of Dupuytren's disease: familial aggregation and its clinical significance
    Sandip Hindocha
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom
    J Hand Surg Am 31:204-10. 2006
    ..Our aims in this study were (1) to provide evidence for familial aggregation of DD by estimating the sibling recurrence-risk ratio and (2) to link previously associated environmental risk factors with family history of DD...
  45. ncbi request reprint Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene
    A Bayat
    Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Br J Plast Surg 58:914-21. 2005
    ..These data demonstrate that there is no association between the exonic and promoter regions of TGFbeta(3) gene and keloid scarring in our cohort of Caucasian patients...
  46. pmc Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity
    Farhatullah Syed
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK
    J Invest Dermatol 133:1340-50. 2013
    ..In contrast, Rapamycin induced minimal antitumor activity. In conclusion, potent dual mTORC1 and mTORC2 inhibitors display therapeutic potential for the treatment of KD...
  47. doi request reprint Molecular dissection of abnormal wound healing processes resulting in keloid disease
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 18:139-53. 2010
    ....
  48. pmc Hyaluronan, TSG-6, and inter-α-inhibitor in periprosthetic breast capsules: reduced levels of free hyaluronan and TSG-6 expression in contracted capsules
    Kian T Tan
    National Institute for Health Research and Plastic and Reconstructive Surgery Research, University of Manchester, 131 Princess Street, Manchester, UK
    Aesthet Surg J 31:47-55. 2011
    ....
  49. doi request reprint A clinical characterization of familial keloid disease in unique African tribes reveals distinct keloid phenotypes
    Husam Bella
    Plastic and Reconstructive Surgery Research, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 127:689-702. 2011
    ..Site distribution, morphologic features, and other characteristics of the scars were studied to assess whether each tribe had a specific scar phenotype...
  50. pmc Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor
    M H A Malik
    Centre for Integrated Genomic Medical Research, University of Manchester, Oxford Road, Manchester M13 9TP, UK
    Ann Rheum Dis 66:1116-20. 2007
    ..The individual responses to such stimuli may be dictated by genetic variation...
  51. ncbi request reprint Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms
    A Bayat
    Centre for Integrated Genomic Medical Research, School of Biological Sciences, University of Manchester, Manchester, UK
    Br J Plast Surg 55:283-6. 2002
    ..We believe this to be the first report of a case-control association study in KD and TGF beta 2 polymorphisms...
  52. pmc Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway
    M H A Malik
    Centre for Hip Surgery, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, WN6 9EP, UK
    Int Orthop 30:177-81. 2006
    ..001) for the OPG-163 SNP were statistically significant. Aseptic loosening and deep infection of THA may be under the influence of susceptibility genes. SNP markers may serve as predictors of implant survival...
  53. doi request reprint The role of skin substitutes in the management of chronic cutaneous wounds
    Nicholas S Greaves
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology MIB, The University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 21:194-210. 2013
    ..This review discusses chronic wound biology, the influence that skin substitutes can exert on this environment, the products currently available, and examines the evidence for their use in chronic wound management...
  54. pmc Dupuytren's: a systems biology disease
    Samrina Rehman
    Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, M1 7DN, UK
    Arthritis Res Ther 13:238. 2011
    ..We outline how DD may be investigated more effectively by employing a systems biology approach that considers the disease network as a whole rather than focusing on any specific single molecule...
  55. ncbi request reprint Use of a non-contact 3D digitiser to measure the volume of keloid scars: a useful tool for scar assessment
    Ben Taylor
    Plastic and Reconstructive Surgery Research, The University of Manchester, Stopford Building, Room 3 102, Oxford Road, Manchester, M13 9PT, UK
    J Plast Reconstr Aesthet Surg 60:87-94. 2007
    ..This technique could allow monitoring of a patient on treatment, or comparison of treatments in a research setting. It overcomes previous problems with the measurement of scar volume as it is quantitatively objective and well-tolerated...
  56. doi request reprint The influence of surgical excision margins on keloid prognosis
    Kian Tjon Tan
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Ann Plast Surg 64:55-8. 2010
    ..This study has given evidence that incomplete surgical excision are associated with higher recurrence and this may justify the practice of routine histopathologic reporting of keloid excision margins...
  57. doi request reprint Current tools for noninvasive objective assessment of skin scars
    Donna M Perry
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocenter, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 126:912-23. 2010
    ..This review aims to explore the current range of noninvasive objective assessment tools available for cutaneous skin scarring, with specific emphasis on their application to research trials and clinical practice...
  58. doi request reprint Molecular phenotypic descriptors of Dupuytren's disease defined using informatics analysis of the transcriptome
    Samrina Rehman
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    J Hand Surg Am 33:359-72. 2008
    ....
  59. doi request reprint Scientific understanding and clinical management of Dupuytren disease
    Barbara Shih
    Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Academic Health Science Centre, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Nat Rev Rheumatol 6:715-26. 2010
    ..Nonsurgical correction of DD contractures can be achieved by Clostridium histolyticum collagenase injection, although the long-term safety and recurrence rate of this procedure requires further assessment...
  60. ncbi request reprint Genetic susceptibility in Dupuytren's disease. TGF-beta1 polymorphisms and Dupuytren's disease
    A Bayat
    Wrightington Hospital, Wigan, Withington Hospital, Manchester, England
    J Bone Joint Surg Br 84:211-5. 2002
    ..To our knowledge, this is the first report of a case-control association study in Dupuytren's disease using single nucleotide polymorphisms in TGF-beta1...
  61. doi request reprint Single-stage application of a novel decellularized dermis for treatment-resistant lower limb ulcers: positive outcomes assessed by SIAscopy, laser perfusion, and 3D imaging, with sequential timed histological analysis
    Nicholas S Greaves
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom Wythenshawe Hospital, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Wound Repair Regen 21:813-22. 2013
    ..DCD safely produced significant improvement in treatment-resistant leg ulcers. With no requirement for hospital admission, anesthetic, or autogenic skin grafting, this treatment could be administered in hospital and community settings...
  62. pmc First Identification of Resident and Circulating Fibrocytes in Dupuytren's Disease Shown to Be Inhibited by Serum Amyloid P and Xiapex
    Syed Amir Iqbal
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom
    PLoS ONE 9:e99967. 2014
    ..Our results show for the first time the increased presence of fibrocytes in DD patient's blood and disease tissue compared to control tissue. Additionally, we evaluate the response of these fibrocytes to SAP and Xiapex therapy. ..
  63. pmc Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling
    Kevin J Ashcroft
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, United Kingdom Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
    PLoS ONE 8:e75600. 2013
    ....
  64. doi request reprint Designing implant surface topography for improved biocompatibility
    Alison G Harvey
    Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK
    Expert Rev Med Devices 10:257-67. 2013
    ..In doing this, it should be possible to control the signals that are relayed to the nucleus and thus gain a degree of control over the cell behavior and ultimately the tissue response...
  65. doi request reprint DNA copy number variations at chromosome 7p14.1 and chromosome 14q11.2 are associated with dupuytren's disease: potential role for MMP and Wnt signaling pathway
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    Plast Reconstr Surg 129:921-32. 2012
    ..Emerging evidence suggests a strong genetic component involved in the manifestation of the disease. This study aims to investigate the potential involvement of copy number variations in Dupuytren's disease pathogenesis...
  66. ncbi request reprint Transforming growth factor beta (TGFbeta) and keloid disease
    Jagajeevan Jagadeesan
    Department of Plastic and Reconstructive Surgery, Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston PR2 9HT, UK
    Int J Surg 5:278-85. 2007
    ..Understanding the role of TGFbeta in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of this condition...
  67. pmc Epidemiological Evaluation of Dupuytren's Disease Incidence and Prevalence Rates in Relation to Etiology
    Sandip Hindocha
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocenter, University of Manchester, 131 Princess St, Manchester, M1 7DN, England, UK
    Hand (N Y) 4:256-69. 2009
    ....
  68. ncbi request reprint Two novel polymorphisms in the human transforming growth factor beta 2 gene
    A Alansari
    ARC Epidemiology Unit, Manchester University Medical School, Oxford Road, Manchester M13 9PT, UK
    Genes Immun 2:295-6. 2001
    ..Exon 1 polymorphism is rare and results in an R to H amino acid substitution in codon 91. Both polymorphisms may prove useful for investigating possible associations of TGFbeta2 with disease...
  69. doi request reprint Breast implant surface development: perspectives on development and manufacture
    Simon Barr
    Manchester Interdisciplinary Biocentre, School of Translational Medicine, University of Manchester, 131 Princess Street, Manchester, UK
    Aesthet Surg J 31:56-67. 2011
    ..The literature suggests that development of new implant surfaces designed to reduce a patient's foreign body response will improve the safety profile of implant devices and increase patient satisfaction in the long-term...
  70. ncbi request reprint Novel noninvasive identification of biomarkers by analytical profiling of chronic wounds using volatile organic compounds
    Alexis N Thomas
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, and Department of Vascular Surgery, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Wound Repair Regen 18:391-400. 2010
    ..This study showcases a reproducible, robust, noninvasive methodology that is applicable in a clinical setting and may offer a new, hitherto unexplored, class of biochemical markers underpinning the metabolism of chronic wounds...
  71. pmc Role of the HLA System in the Pathogenesis of Dupuytren's Disease
    Sara McCarty
    University of Manchester, Manchester, UK
    Hand (N Y) 5:241-50. 2010
    ..This paper presents a detailed account of the immunogenetic component of DD and explores the possible mechanisms of association between specific HLA molecules and susceptibility to DD...
  72. ncbi request reprint A technique for accurate and safe injection of steroid in trigger digits using ultrasound guidance
    Shashi Kanth Godey
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospitals, United Kingdom
    Acta Orthop Belg 72:633-4. 2006
    ..We describe a technique using ultrasound for accurate injection of steroid to maximise its beneficial effects in treatment of trigger digits...
  73. pmc Differential Gene Expression Analysis of Subcutaneous Fat, Fascia, and Skin Overlying a Dupuytren's Disease Nodule in Comparison to Control Tissue
    Barbara Shih
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Hand (N Y) 4:294-301. 2009
    ..In conclusion, this study demonstrates potential roles for subcutaneous fat in DD pathogenesis as well as supports the use of transverse palmar fascia as appropriate control tissues in DD research...
  74. doi request reprint The patient-reported impact of scars measure: development and validation
    Benjamin C Brown
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocenter, The University of Manchester, Manchester, UK
    Plast Reconstr Surg 125:1439-49. 2010
    ..Quantification with disease-specific patient-reported outcome measures is essential for assessing disease severity. This study aimed to develop and validate the first scar-specific patient-reported outcome measure...
  75. doi request reprint Positive association of HLA-DRB1*15 with keloid disease in Caucasians
    J J Brown
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Bio centre, University of Manchester, Manchester, UK
    Int J Immunogenet 35:303-7. 2008
    ..Our data suggest the possible involvement of an immunogenic component to KD although the exact mechanisms involved in MHC-driven abnormal fibrosis will require further investigation...
  76. ncbi request reprint Mitochondrial mutation detection using enhanced multiplex denaturing high-performance liquid chromatography
    A Bayat
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    Int J Immunogenet 32:199-205. 2005
    ..Using this complete mitochondrial genome-screening approach, we confirmed a number of previously reported mutations and additionally identified a large number of novel mutations using an enhanced DHPLC technique...
  77. doi request reprint Genetic susceptibility to raised dermal scarring
    J J Brown
    Plastic and Reconstructive Surgery Research, Dermatological Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Br J Dermatol 161:8-18. 2009
    ..The ability to assess accurately an individual's potential genetic susceptibility to raised scarring may lead to a more personalized approach to their management in the future...
  78. ncbi request reprint Positive association of HLA-DRB1*15 with Dupuytren's disease in Caucasians
    J J Brown
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Foundation Trust, Manchester, UK
    Tissue Antigens 72:166-70. 2008
    ..3%) when compared with control data (20.9%) (corrected P=0.029): we conclude that in Caucasoids of European origin, HLA-DRB1*15 is associated with risk of developing DD...
  79. ncbi request reprint Treatment of symptomatic abnormal skin scars with electrical stimulation
    D Perry
    School of Translational Medicine, University of Manchester, UK
    J Wound Care 19:447-53. 2010
    ..To evaluate the effect of non-invasive biofeedback electrical stimulation on symptomatic abnormal skin scars...
  80. ncbi request reprint Spectrum of abnormal skin scars and their clinical management
    A Bayat
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester
    Br J Hosp Med (Lond) 67:527-32. 2006
  81. doi request reprint Keloid scar harbouring malignant blue naevus emphasises the need for excision biopsy and routine histology
    C Theopold
    Department of Plastic and Reconstructive Surgery, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    J Plast Reconstr Aesthet Surg 62:93-5. 2009
    ..Excision should be complete, rather than intralesional, in order to avoid leaving behind areas of potential neoplasia...
  82. ncbi request reprint Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars
    Oliver Bock
    Primary Health Care Center, Fabriksgatan 17, SE 552 85 Jönköping, Sweden
    Acta Derm Venereol 85:216-20. 2005
    ..Therefore our data support a possible role of TGFssRI and TGFssRII in combination with a certain TGFss expression pattern as fibrosis-inducing factors in keloids...
  83. ncbi request reprint Transforming growth factor-12 polymorphism and systemic lupus erythematosus
    Aliya Alansari
    ARC Epidemiology Unit, Manchester University Medical School, UK
    J Rheumatol 29:1189-91. 2002
    ..Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-beta2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-beta2 gene has been mapped...
  84. ncbi request reprint Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring
    Haiyan Yu
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Plast Reconstr Aesthet Surg 59:221-9. 2006
    ..This could explain why TGFbeta signaling is not terminated in keloids leading to overexpression of extracellularmatrix in keloids. These data support a possible role of SMAD6 and 7 in the pathogenesis of keloids...
  85. ncbi request reprint Modernising medical careers and factors influencing career choices of medical students
    Yusur Al-Nuaimi
    Manchester Interdisciplinary Biocentre, University ofManchester, Manchester M1 7DN
    Br J Hosp Med (Lond) 69:163-6. 2008
    ..The role of gender in career choice and the importance of structured career advice and management is highlighted and discussed...
  86. doi request reprint Identification of unique gene expression patterns within different lesional sites of keloids
    Oliver Seifert
    Department of Clinical and Experimental Medicine, Linkopings University, Linkoping, Sweden
    Wound Repair Regen 16:254-65. 2008
    ..Activating proapoptotic genes or inhibiting ECM-inducing genes as INHBA or monocyte chemoattractant protein-1 might be possible target genes for new treatment strategies for keloid disease...