Affiliation: University of Sussex
Baxter J. "Breaking up is hard to do": the formation and resolution of sister chromatid intertwines. J Mol Biol. 2015;427:590-607 pubmed publisher
Baxter J, Sen N, Martínez V, De Carandini M, Schvartzman J, Diffley J, et al
. Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science. 2011;331:1328-32 pubmed publisher
..Thus, a topological change on DNA drives topoisomerase II to decatenate molecules during mitosis, potentially driving the full decatenation of the genome. ..
Baxter J, Aragon L. A model for chromosome condensation based on the interplay between condensin and topoisomerase II. Trends Genet. 2012;28:110-7 pubmed publisher
Schalbetter S, Mansoubi S, Chambers A, Downs J, Baxter J. Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proc Natl Acad Sci U S A. 2015;112:E4565-70 pubmed publisher
..We conclude that although fork rotation and precatenation facilitate unwinding in hard-to-replicate contexts, they intrinsically disrupt normal chromosome duplication and are therefore restricted by Timeless/Tipin. ..
Keszthelyi A, Minchell N, Baxter J. The Causes and Consequences of Topological Stress during DNA Replication. Genes (Basel). 2016;7: pubmed publisher
..Finally, we describe how topological stress, and the ways forks respond to it, may contribute to genomic instability in cells. ..