J Baxter


Affiliation: University of Sussex
Country: UK


  1. Baxter J. "Breaking up is hard to do": the formation and resolution of sister chromatid intertwines. J Mol Biol. 2015;427:590-607 pubmed publisher
  2. Baxter J, Sen N, Martínez V, De Carandini M, Schvartzman J, Diffley J, et al. Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science. 2011;331:1328-32 pubmed publisher
    ..Thus, a topological change on DNA drives topoisomerase II to decatenate molecules during mitosis, potentially driving the full decatenation of the genome. ..
  3. Baxter J, Aragon L. A model for chromosome condensation based on the interplay between condensin and topoisomerase II. Trends Genet. 2012;28:110-7 pubmed publisher
  4. Schalbetter S, Mansoubi S, Chambers A, Downs J, Baxter J. Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proc Natl Acad Sci U S A. 2015;112:E4565-70 pubmed publisher
    ..We conclude that although fork rotation and precatenation facilitate unwinding in hard-to-replicate contexts, they intrinsically disrupt normal chromosome duplication and are therefore restricted by Timeless/Tipin. ..
  5. Keszthelyi A, Minchell N, Baxter J. The Causes and Consequences of Topological Stress during DNA Replication. Genes (Basel). 2016;7: pubmed publisher
    ..Finally, we describe how topological stress, and the ways forks respond to it, may contribute to genomic instability in cells. ..