- The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508Sonja Baumli
Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U K
ACS Chem Biol 7:811-6. 2012..By comparison with a previously published structure of CDK9/cyclin T/human immunodeficiency virus TAT we find that the CDK9 αC-helix has a degree of conformational variability that has the potential to be exploited for inhibitor design...
- The CDK9 tail determines the reaction pathway of positive transcription elongation factor bSonja Baumli
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Structure 20:1788-95. 2012..We propose that this mechanism is critical for the pattern of CTD Ser2 phosphorylation on actively transcribed genes...