Buzz Baum

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Winging it--actin on the fly
    Buzz Baum
    LICR, Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Dev Cell 2:125-6. 2002
  2. ncbi Animal development: crowd control
    Buzz Baum
    Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 7BS, UK
    Curr Biol 14:R716-8. 2004
  3. ncbi Actin nucleation: spire - actin nucleator in a class of its own
    Buzz Baum
    Ludwig Institute for Cancer Research, UCL Branch, London, UK
    Curr Biol 15:R305-8. 2005
  4. doi Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis
    Patricia Kunda
    MRC Laboratory of Molecular Cell Biology, UCL, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 18:91-101. 2008
  5. ncbi Left-right asymmetry: actin-myosin through the looking glass
    Buzz Baum
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Curr Biol 16:R502-4. 2006
  6. ncbi RNAi in a postmodern, postgenomic era
    Buzz Baum
    Ludwig Institute for Cancer Research, UCL Branch, London W1W 7BS, UK
    Oncogene 23:8336-9. 2004
  7. doi Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions
    Marios Georgiou
    MRC Laboratory of Molecular Cell Biology, UCL, London, WC1E 6BT, UK
    J Cell Sci 123:1089-98. 2010
  8. doi Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition
    Michael Cohen
    Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, London, WC1E 6BT, UK
    Dev Cell 19:78-89. 2010
  9. pmc The FLIGHT Drosophila RNAi database: 2010 update
    David Sims
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Fly (Austin) 4:344-8. 2010
  10. pmc Tao-1 is a negative regulator of microtubule plus-end growth
    Tao Liu
    MRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK
    J Cell Sci 123:2708-16. 2010

Collaborators

Detail Information

Publications32

  1. ncbi Winging it--actin on the fly
    Buzz Baum
    LICR, Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Dev Cell 2:125-6. 2002
    ..New insights may be gained from the recent identification of a conserved cofilin phosphatase, Slingshot, which modulates actin dynamics to help control Drosophila wing hair morphogenesis...
  2. ncbi Animal development: crowd control
    Buzz Baum
    Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 7BS, UK
    Curr Biol 14:R716-8. 2004
    ..Two recent studies help show how this is achieved during convergence and extension of the Drosophila germ-band, where polarity within the plane of the embryonic epithelium biases junction remodeling to polarize cell intercalation...
  3. ncbi Actin nucleation: spire - actin nucleator in a class of its own
    Buzz Baum
    Ludwig Institute for Cancer Research, UCL Branch, London, UK
    Curr Biol 15:R305-8. 2005
    ..A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation...
  4. doi Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis
    Patricia Kunda
    MRC Laboratory of Molecular Cell Biology, UCL, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 18:91-101. 2008
    ..Here we identify Moesin as a key player. Moesin is the sole Drosophila member of the ERM proteins, which, once activated via phosphorylation, crosslink actin filaments to the cytoplasmic tails of plasma membrane proteins...
  5. ncbi Left-right asymmetry: actin-myosin through the looking glass
    Buzz Baum
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Curr Biol 16:R502-4. 2006
    ..In several animals, microtubule-based structures are thought to be the source of chiral information used to establish handedness. Now, two new studies in Drosophila identify a role for unconventional myosin motors in this process...
  6. ncbi RNAi in a postmodern, postgenomic era
    Buzz Baum
    Ludwig Institute for Cancer Research, UCL Branch, London W1W 7BS, UK
    Oncogene 23:8336-9. 2004
    ....
  7. doi Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions
    Marios Georgiou
    MRC Laboratory of Molecular Cell Biology, UCL, London, WC1E 6BT, UK
    J Cell Sci 123:1089-98. 2010
    ....
  8. doi Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition
    Michael Cohen
    Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, London, WC1E 6BT, UK
    Dev Cell 19:78-89. 2010
    ..Significantly, the intermittent signaling induced by these filopodial dynamics generates a type of structured noise that is uniquely suited to the generation of well-ordered, tissue-wide epithelial patterns...
  9. pmc The FLIGHT Drosophila RNAi database: 2010 update
    David Sims
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Fly (Austin) 4:344-8. 2010
    ..FLIGHT integrates RNAi screen data with microarray gene expression as well as genomic annotations and genetic/physical interaction datasets to provide a single interface for RNAi screen analysis and data-mining in Drosophila...
  10. pmc Tao-1 is a negative regulator of microtubule plus-end growth
    Tao Liu
    MRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK
    J Cell Sci 123:2708-16. 2010
    ..These data reveal a role for Tao-1 in controlling the dynamic interplay between microtubule plus ends and the actin cortex in the regulation of cell form...
  11. pmc Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology
    Tao Liu
    MRC Laboratory of Molecular Cell Biology, UCL, London, UK
    Genome Biol 10:R26. 2009
    ..However, to date, most RNAi screens have been performed in a single cell line, and results then extrapolated across cell types and systems...
  12. pmc The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling
    Michael Cohen
    CoMPLEX, University College London, London, UK
    J R Soc Interface 8:787-98. 2011
    ..Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling...
  13. ncbi Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis
    Eleonora Jovceva
    Ludwig Institute for Cancer Research, UCL Branch, London, W1W 7BS, UK
    J Cell Sci 120:1888-97. 2007
    ....
  14. pmc PDGF/VEGF signaling controls cell size in Drosophila
    David Sims
    Morphogenesis Group, Ludwig Institute for Cancer Research UCL Branch, Riding House Street, London, W1W 7BS, UK
    Genome Biol 10:R20. 2009
    ..To delineate the pathways controlling this process, we screened a genome-scale, image-based Drosophila RNA interference dataset for double-stranded RNAs that reduce the average size of adherent S2R+ cells...
  15. ncbi Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions
    Patricia Kunda
    Ludwig Institute for Cancer Research University College Branch, London, UK
    Curr Biol 13:1867-75. 2003
    ..SCAR and WASP then activate the Arp2/3 complex to nucleate the formation of new actin filaments, which through polymerization exert a protrusive force on the membrane...
  16. ncbi Drosophila oogenesis: generating an axis of polarity
    Buzz Baum
    Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 7BS, UK
    Curr Biol 12:R835-7. 2002
    ..New studies of moesin function during Drosophila oogenesis show that Dmoesin tethers actin to the oocyte membrane. Interestingly, Dmoesin and an intact cortex are also required to stabilise ooycte polarity...
  17. doi The metastatic cancer cell cortex: an adaptation to enhance robust cell division in novel environments?
    Helen K Matthews
    MRC Laboratory for Molecular Cell Biology, University College London, London, UK
    Bioessays 34:1017-20. 2012
    ..We suggest that mitotic cell rounding, aided by several actin-regulatory oncogenes, may facilitate this process in a robust, context-independent manner...
  18. ncbi Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly
    Jody Rosenblatt
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London SC1E 6BT, United Kingdom
    Cell 117:361-72. 2004
    ..We propose that after NEBD, completion of centrosome separation and positioning around chromosomes depends on astral microtubule connections to a moving cell cortex...
  19. doi The actin cytoskeleton in spindle assembly and positioning
    Patricia Kunda
    Department of Cell and Developmental Biology, University College London, UK
    Trends Cell Biol 19:174-9. 2009
    ..Here, we discuss this recent work and the possible role of crosstalk between the mitotic actin cortex and the plus ends of astral microtubules in this process...
  20. doi Cell shape: taking the heat
    Patricia Kunda
    MRC Laboratory for Molecular Cell Biology, and the Department of Cell and Developmental Biology, UCL, Gower Street, London, UK
    Curr Biol 18:R470-2. 2008
    ..A new study reveals how an extracellular protein--Spam--helps mechanosensory organs in the fruit fly to withstand the effects of the water loss that accompanies heat shock...
  21. doi Transitions between epithelial and mesenchymal states in development and disease
    Buzz Baum
    Department of Cell and Developmental Biology, UCL, London, UK
    Semin Cell Dev Biol 19:294-308. 2008
    ..In this review, we discuss the common molecular and cellular mechanisms involved in EMT in both cases...
  22. pmc FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets
    David Sims
    Morphogenesis Group, Ludwig Institute for Cancer Research UCL Branch, Courtauld Building, 91 Riding House Street, London, W1W 7BS, UK
    Nucleic Acids Res 34:D479-83. 2006
    ....
  23. doi Drosophila cell lines as model systems and as an experimental tool
    Buzz Baum
    University College London Branch of the Ludwig Institute for Cancer Research, London, UK
    Methods Mol Biol 420:391-424. 2008
    ..These include techniques for growing and maintaining cell lines, transient and stable transfection, RNA interference, imaging, immunostaining, fluorescence-activated cell sorting, and for the isolation of RNA and protein from fly cells...
  24. doi Plasma Microcontact Patterning (PμCP): A Technique for the Precise Control of Surface Patterning at Small-Scale
    Remigio Picone
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA Department of Pediatric Oncology, Howard Hughes Medical Institute, Boston, Massachusetts, USA Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA London Centre for Nanotechnology and Department of Medicine, University College London, London, United Kingdom Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom CoMPLEX, University College London, London, United Kingdom
    Methods Cell Biol 119:73-90. 2014
    ..In conclusion, PμCP is a simple way to generate surface patterns that are highly reproducible, stable and uniform, making it a useful method for many applications. ..
  25. pmc A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila
    Jeroen Dobbelaere
    The Gurdon Institute, Cambridge, United Kingdom
    PLoS Biol 6:e224. 2008
    ..Cnn is phosphorylated during mitosis in a Polo-dependent manner, suggesting that the Polo-dependent phosphorylation of Cnn initiates centrosome maturation in flies...
  26. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..These studies identify Capulet as part of an emerging pathway linking guidance signals to regulation of cytoskeletal dynamics and suggest that the Abl pathway mediates signals downstream of multiple Roundabout receptors...
  27. ncbi Cascade pathway of filopodia formation downstream of SCAR
    Assel Biyasheva
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Sci 117:837-48. 2004
    ..We propose a new, cascade pathway model of filopodia regulation in which SCAR signals to lamellipodia and then filopodia arise from lamellipodia in response to additional signal(s)...
  28. ncbi Minimizing the risk of reporting false positives in large-scale RNAi screens
    Christophe J Echeverri
    Cenix BioScience GmbH, Tatzberg 47, Dresden, 10307, Germany
    Nat Methods 3:777-9. 2006
    ....
  29. ncbi Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing
    Ceniz Zihni
    Kings College London, Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, United Kingdom
    J Biol Chem 282:6484-93. 2007
    ....
  30. ncbi Actin in development
    Antonio Jacinto
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, 2780 156 Oeiras, Portugal
    Mech Dev 120:1337-49. 2003
  31. doi Cell shape and tissue morphogenesis
    Jeffrey Settleman
    Semin Cell Dev Biol 19:213-4. 2008
  32. ncbi Regulation of apicomplexan actin-based motility
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Rev Microbiol 4:621-8. 2006
    ....