Rachel L Batterham

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
  2. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
  3. ncbi request reprint PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Nature 450:106-9. 2007
  4. doi request reprint Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery
    William R Scott
    Centre for Obesity Research, Dept of Medicine, Rayne Institute, University College London, WC1E 6JJ, UK
    Am J Physiol Regul Integr Comp Physiol 301:R15-27. 2011
  5. pmc Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice
    C Gelegen
    Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Am J Physiol Endocrinol Metab 303:E659-68. 2012
  6. ncbi request reprint Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
  7. pmc Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice
    William R Scott
    Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
    PLoS ONE 8:e59407. 2013
  8. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
  9. pmc Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    Hind Al-Qassab
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
    Cell Metab 10:343-54. 2009
  10. pmc Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY
    Keval Chandarana
    Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, London, UK
    Diabetes 60:810-8. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  2. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
    ..To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents...
  3. ncbi request reprint PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Nature 450:106-9. 2007
    ..An increased understanding of how such homeostatic and higher brain functions are integrated may pave the way for the development of new treatment strategies for obesity...
  4. doi request reprint Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery
    William R Scott
    Centre for Obesity Research, Dept of Medicine, Rayne Institute, University College London, WC1E 6JJ, UK
    Am J Physiol Regul Integr Comp Physiol 301:R15-27. 2011
    ..Here we review mechanisms of weight loss and T2D resolution after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy bariatric surgery, two markedly different procedures with robust clinical outcomes...
  5. pmc Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice
    C Gelegen
    Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Am J Physiol Endocrinol Metab 303:E659-68. 2012
    ....
  6. ncbi request reprint Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
    ..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
  7. pmc Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice
    William R Scott
    Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London, United Kingdom
    PLoS ONE 8:e59407. 2013
    ..Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variation of NNAT is associated with severe obesity. Currently, little is known about the long-term regulation of Nnat...
  8. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  9. pmc Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    Hind Al-Qassab
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
    Cell Metab 10:343-54. 2009
    ..These results demonstrate distinct metabolic roles for the p110alpha and p110beta isoforms of PI3K in hypothalamic energy regulation...
  10. pmc Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY
    Keval Chandarana
    Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, London, UK
    Diabetes 60:810-8. 2011
    ..To evaluate PYY's role in mediating weight loss post-GIBP, we undertook GIBP surgery in PyyKO mice...
  11. pmc A link between FTO, ghrelin, and impaired brain food-cue responsivity
    Efthimia Karra
    Centre for Obesity Research, University College London, London, United Kingdom
    J Clin Invest 123:3539-51. 2013
    ..Our findings show that FTO regulates ghrelin, a key mediator of ingestive behavior, and offer insight into how FTO obesity-risk alleles predispose to increased energy intake and obesity in humans. ..
  12. doi request reprint The role of gut hormones in the regulation of body weight and energy homeostasis
    Efthimia Karra
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London, United Kingdom
    Mol Cell Endocrinol 316:120-8. 2010
    ....
  13. ncbi request reprint Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
    FASEB J 22:807-18. 2008
    ..Our results therefore suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age-related processes...
  14. pmc Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice
    James Cantley
    Centre for Diabetes and Endocrinology, Faculty of Medicine, Rayne Institute, University College London, London, UK
    J Clin Invest 119:125-35. 2009
    ..These data suggest that VHL/HIF oxygen-sensing mechanisms play a critical role in glucose homeostasis and that activation of this pathway in response to decreased islet oxygenation may contribute to beta cell dysfunction...
  15. pmc The role of peptide YY in appetite regulation and obesity
    Efthimia Karra
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    J Physiol 587:19-25. 2009
    ..Taken together these findings, coupled with the retained responsiveness of obese subjects to the effects of PYY3-36, suggest that targeting the PYY system may offer a therapeutic strategy to help treat obesity...
  16. doi request reprint Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males
    David R Broom
    Department of Medicine, School of Sport and Exercise Sciences, Loughborough Univ, Leicestershire, LE11 3TU, UK
    Am J Physiol Regul Integr Comp Physiol 296:R29-35. 2009
    ..These findings suggest ghrelin and PYY may regulate appetite during and after exercise, but further research is required to establish whether exercise-induced changes in ghrelin and PYY influence subsequent food intake...
  17. doi request reprint Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
    ..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging...
  18. doi request reprint Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans
    Keval Chandarana
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Gastroenterology 136:2115-26. 2009
    ..However, controversy surrounds the effects that adiposity, dietary manipulations, and bariatric surgery have on their circulating concentrations. We sought to determine whether these discrepancies are due to methodologic differences...
  19. doi request reprint Gaining new insights into food reward with functional neuroimaging
    Marianne T Neary
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London, UK
    Forum Nutr 63:152-63. 2010
    ..Finally, we discuss the potential to use such information to guide development of pharmaceuticals, functional foods and life-style modifications...
  20. doi request reprint Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery
    Efthimia Karra
    Department of Medicine, University College London, Centre for Obesity Research, 5 University Street, London WC1E 6JJ, United Kingdom
    Trends Endocrinol Metab 21:337-44. 2010
    ..Understanding the mechanisms mediating these beneficial outcomes of bariatric surgery could result in new non-surgical treatment strategies for obesity and T2DM...
  21. doi request reprint Shedding pounds after going under the knife: metabolic insights from cutting the gut
    Keval Chandarana
    Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, UK
    Nat Med 18:668-9. 2012
    ..These insights may open new avenues to bypass the surgery and obtain the same results with targeted drugs...
  22. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  23. doi request reprint Peptide YY: food for thought
    Marianne T Neary
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Building, London, United Kingdom
    Physiol Behav 97:616-9. 2009
    ..Taken in concert, these findings suggest that the PYY system may hold significant potential in the treatment and prevention of obesity...
  24. doi request reprint Gut hormones: implications for the treatment of obesity
    Marianne T Neary
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Pharmacol Ther 124:44-56. 2009
    ..Up-to-date outcomes of clinical trials are evaluated and directions for the future suggested...
  25. doi request reprint Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans
    Ahmed Yousseif
    Centre for Obesity Research Department of Medicine, University College London, Rayne Institute, 5, University Street, WC1E 6JJ, London, UK
    Obes Surg 24:241-52. 2014
    ..A similar increase in post-prandial fullness was observed post-surgery following both procedures. LRYGBP and LSG produced comparable enhanced satiety and weight loss. However, LSG and LRYGBP differentially altered gut hormone profiles. ..
  26. doi request reprint The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On
    Sean Manning
    Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, United Kingdom email
    Annu Rev Physiol 76:585-608. 2014
    ....
  27. ncbi request reprint Can glucose make you faint?
    Suehana Rahman
    Bariatric Unit, Division of Surgery, University College London Hospitals, London, UK
    Lancet 372:1358. 2008
  28. pmc Metabolic state alters economic decision making under risk in humans
    Mkael Symmonds
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    PLoS ONE 5:e11090. 2010
    ..We hypothesised that baseline metabolic reserves and alterations in metabolic state would systematically modulate decision-making and financial risk-taking in humans...
  29. ncbi request reprint Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  30. ncbi request reprint Oxyntomodulin suppresses appetite and reduces food intake in humans
    Mark A Cohen
    Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom W12 0NN
    J Clin Endocrinol Metab 88:4696-701. 2003
    ..0001). Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia...