P M Bath

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 25:431-9. 2005
  2. ncbi request reprint Early recovery and functional outcome are related with causal stroke subtype: data from the tinzaparin in acute ischemic stroke trial
    Nikola Sprigg
    Institute of Neuroscience, University of Nottingham, United Kingdom
    J Stroke Cerebrovasc Dis 16:180-4. 2007
  3. pmc A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility
    Nikola Sprigg
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottinghamshire, United Kingdom
    PLoS ONE 3:e2852. 2008
  4. pmc Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Eur Heart J 29:2031-41. 2008
  5. pmc The cog-4 subset of the national institutes of health stroke scale as a measure of cognition: relationship with baseline factors and functional outcome after stroke using data from the virtual international stroke trials archive
    Sandeep Ankolekar
    Stroke Trials Unit, Division of Stroke, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Stroke Res Treat 2013:562506. 2013
  6. pmc Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in Patients with Ultra-Acute Stroke: Study Protocol for the "Rapid Intervention with GTN in Hypertensive Stroke Trial" (RIGHT, ISRCTN66434824)
    Sandeep Ankolekar
    Stroke Trials Unit, Division of Stroke, University of Nottingham, City Hospital Campus, Hucknall Road, Nottingham NG5 1PB, UK
    Stroke Res Treat 2012:385753. 2012
  7. doi request reprint Prevention of Decline in Cognition after Stroke Trial (PODCAST): a study protocol for a factorial randomised controlled trial of intensive versus guideline lowering of blood pressure and lipids
    Daniel J Blackburn
    Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Trials 14:401. 2013
  8. doi request reprint Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke
    Philip M W Bath
    Division of Stroke Medicine, University of Nottingham, Nottingham, UK
    Cochrane Database Syst Rev 6:CD005207. 2013
  9. ncbi request reprint Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial
    Sandeep Ankolekar
    Stroke Trials Unit, University of Nottingham, Nottingham, UK
    J Neurol Neurosurg Psychiatry 84:342-7. 2013
  10. doi request reprint Statistical analysis of the primary outcome in acute stroke trials
    Philip M W Bath
    University of Glasgow, Western Infirmary, 44 Church Street, Glasgow, UK G11 6NT
    Stroke 43:1171-8. 2012

Detail Information

Publications71

  1. ncbi request reprint G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 25:431-9. 2005
    ..These results indicate long-term beneficial effects of a single dose of G-CSF administered on reperfusion, and illustrate the need to further investigate the mechanisms of G-CSF action...
  2. ncbi request reprint Early recovery and functional outcome are related with causal stroke subtype: data from the tinzaparin in acute ischemic stroke trial
    Nikola Sprigg
    Institute of Neuroscience, University of Nottingham, United Kingdom
    J Stroke Cerebrovasc Dis 16:180-4. 2007
    ..Baseline severity and causal subtype are predictors of outcome in ischemic stroke. We used data from the Tinzaparin in Acute Ischemic Stroke Trial (TAIST) to further assess the relationship among stroke subtype, early recovery, and outcome...
  3. pmc A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility
    Nikola Sprigg
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottinghamshire, United Kingdom
    PLoS ONE 3:e2852. 2008
    ..Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet treatment in the secondary prevention of ischaemic stroke...
  4. pmc Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Eur Heart J 29:2031-41. 2008
    ..Randomized controlled trials (RCTs) have shown that the risk of stroke and venous thromboembolism (VTE) is increased with hormone replacement therapy (HRT); the effect on coronary heart disease (CHD) remains unclear...
  5. pmc The cog-4 subset of the national institutes of health stroke scale as a measure of cognition: relationship with baseline factors and functional outcome after stroke using data from the virtual international stroke trials archive
    Sandeep Ankolekar
    Stroke Trials Unit, Division of Stroke, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Stroke Res Treat 2013:562506. 2013
    ..Specific and validated measures are more appropriate for the assessment of poststroke cognition than Cog-4...
  6. pmc Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in Patients with Ultra-Acute Stroke: Study Protocol for the "Rapid Intervention with GTN in Hypertensive Stroke Trial" (RIGHT, ISRCTN66434824)
    Sandeep Ankolekar
    Stroke Trials Unit, Division of Stroke, University of Nottingham, City Hospital Campus, Hucknall Road, Nottingham NG5 1PB, UK
    Stroke Res Treat 2012:385753. 2012
    ..The trial stopped recruitment in December 2011 after 41 patients were recruited. Trial Registration. The trial registration number is ISRCTN66434824 and EudraCT number is 2007-004766-40...
  7. doi request reprint Prevention of Decline in Cognition after Stroke Trial (PODCAST): a study protocol for a factorial randomised controlled trial of intensive versus guideline lowering of blood pressure and lipids
    Daniel J Blackburn
    Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Trials 14:401. 2013
    ..Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids...
  8. doi request reprint Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke
    Philip M W Bath
    Division of Stroke Medicine, University of Nottingham, Nottingham, UK
    Cochrane Database Syst Rev 6:CD005207. 2013
    ..Some CSFs also mobilise the release of bone marrow stem cells into the circulation. CSFs have been shown to be neuroprotective in experimental stroke...
  9. ncbi request reprint Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial
    Sandeep Ankolekar
    Stroke Trials Unit, University of Nottingham, Nottingham, UK
    J Neurol Neurosurg Psychiatry 84:342-7. 2013
    ..However, the effect of results of clinical trials of devices and non-pharmacological interventions on clinical practice is less clear...
  10. doi request reprint Statistical analysis of the primary outcome in acute stroke trials
    Philip M W Bath
    University of Glasgow, Western Infirmary, 44 Church Street, Glasgow, UK G11 6NT
    Stroke 43:1171-8. 2012
    ..If these approaches are followed, then the risk of missing useful treatment effects for acute stroke will diminish...
  11. pmc Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis
    Chamila Geeganage
    Stroke Trials Unit, Institute of Neuroscience, Division of Stroke, University of Nottingham, City Hospital Campus, Nottingham, UK
    BMC Med 8:36. 2010
    ..This systematic review assesses the safety and efficacy of triple antiplatelet therapy in comparison with dual therapy in reducing recurrent vascular events...
  12. doi request reprint Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis
    Philip M W Bath
    Stroke Trials Unit, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Stroke 40:3541-6. 2009
    ..High blood pressure (BP) is common in acute ischemic stroke and associated independently with a poor functional outcome. However, the management of BP acutely remains unclear because no large trials have been completed...
  13. pmc Effects of NXY-059 in experimental stroke: an individual animal meta-analysis
    P M W Bath
    Stroke Trials Unit, University of Nottingham, Clinical Sciences Building, City Hospital Campus, Hucknall Road, Nottingham, UK
    Br J Pharmacol 157:1157-71. 2009
    ..This first-ever individual animal meta-analysis was used to assess the preclinical studies...
  14. doi request reprint Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial
    Timothy J England
    Stroke Trials Unit, University of Nottingham, Nottingham, United Kingdom
    Stroke 43:405-11. 2012
    ..We assessed the safety of G-CSF in recent stroke in a phase IIb single-center randomized, controlled trial...
  15. doi request reprint Calculation of numbers-needed-to-treat in parallel group trials assessing ordinal outcomes: case examples from acute stroke and stroke prevention
    Philip Bath
    Division of Stroke Medicine, University of Nottingham, Hospital Campus, Nottingham NG5 1PB, UK
    Int J Stroke 6:472-9. 2011
    ..Aims Numbers-needed-to-treat may be calculated for ordinal data from parallel group trials by using an unmatched comparison of all subjects or by generating matched pairs of patients nested within the study...
  16. ncbi request reprint Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease
    Philip Bath
    Division of Stroke Medicine, Institute of Neuroscience, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Stroke 35:622-6. 2004
    ..Mean platelet volume (MPV) is positively associated with measures of platelet activity and may be a useful indicator of the risk of vascular events in a variety of patient groups...
  17. doi request reprint Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis
    Philip M W Bath
    Stroke Trials Unit, Division of Stroke Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK
    Stroke 41:732-8. 2010
    ..Long-term antiplatelet therapy is effective at reducing recurrence after ischemic stroke. However, the relative safety and efficacy of combined aspirin-dipyridamole or clopidogrel are not known in patients with acute ischemic stroke...
  18. ncbi request reprint Systematic reviews as a tool for planning and interpreting trials
    Philip M W Bath
    Stroke Trials Unit, University of Nottingham, Nottingham, UK
    Int J Stroke 4:23-7. 2009
    ....
  19. ncbi request reprint Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke
    P M W Bath
    University of Nottingham, Division of Stroke Medicine, South Block D Floor, Queens Medical Centre, Nottingham, Nottinghamshire, UK NG7 2UH
    Cochrane Database Syst Rev 3:CD005207. 2006
    ..They have been shown to be neuroprotective in experimental stroke. Some CSFs also mobilise the release of bone marrow stem cells into the circulation...
  20. doi request reprint Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke
    P M W Bath
    Stroke Trials Unit, Division of Stroke Medicine, City Hospital Campus, University of Nottingham, Nottingham, UK
    Int J Stroke 4:471-9. 2009
    ..The additional costs involved should be seen as reasonable when compared with the resources that would have been expended in running a clinical trial that subsequently proved negative...
  21. doi request reprint Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials
    Philip M W Bath
    Division of Stroke Medicine, Stroke Trials Unit, University of Nottingham, Clinical Sciences Block, City Hospital Campus, Nottingham, UK
    Stroke 39:2817-23. 2008
    ..Although this is not a novel idea in the statistical community, ordinal outcomes have not been applied to stroke prevention trials in the past...
  22. pmc Association between hormone replacement therapy and subsequent stroke: a meta-analysis
    Philip M W Bath
    Division of Stroke Medicine, Institute of Neuroscience, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH
    BMJ 330:342. 2005
    ..To review completed trials assessing effect of hormone replacement therapy on subsequent risk of stroke, assessing stroke by pathological type, severity, and outcome...
  23. ncbi request reprint The effect of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure and platelet function in acute stroke
    P M Bath
    Stroke Group, Department of Medicine, King s College School of Medicine and Dentistry, London, UK
    Cerebrovasc Dis 11:265-72. 2001
    ..We assessed, in a double-blind randomised controlled trial, whether the nitric oxide (NO) donor glyceryl trinitrate (GTN, a known systemic and cerebral vasodilator), would lower BP and alter platelet function...
  24. ncbi request reprint Tinzaparin in acute ischaemic stroke (TAIST): a randomised aspirin-controlled trial
    P M Bath
    Centre for Vascular Research, University of Nottingham, Nottingham, UK
    Lancet 358:702-10. 2001
    ..Low-molecular-weight heparins and heparinoids are superior to unfractionated heparin in the prevention and treatment of venous thromboembolism, but their safety and efficacy in acute ischaemic stroke are inadequately defined...
  25. ncbi request reprint Should data monitoring committees assess efficacy when considering safety in trials in acute stroke?
    P M W Bath
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Int J Clin Pract 61:1749-55. 2007
    ..We hypothesised that functional outcome at the end of follow-up, a measure of efficacy, is also a powerful measure of safety and tested this in a systematic review...
  26. ncbi request reprint Blood pressure-lowering for secondary prevention of stroke: ACE inhibition is not the key
    Philip Bath
    University of Nottingham, Division of Stroke Medicine, City Hospital Campus, Nottingham, NG5 1PB, UK
    Stroke 34:1334-5. 2003
  27. ncbi request reprint Anticoagulants and antiplatelet agents in acute ischaemic stroke
    Philip Bath
    Centre for Vascular Research, University of Nottingham, Nottingham, UK
    Lancet Neurol 1:405. 2002
  28. ncbi request reprint High blood pressure as risk factor and prognostic predictor in acute ischaemic stroke: when and how to treat it?
    Philip Bath
    Centre for Vascular Research, University of Nottingham, Nottingham, UK
    Cerebrovasc Dis 17:51-7. 2004
    ....
  29. ncbi request reprint The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions
    Lian Zhao
    Centre for Vascular Research, University of Nottingham, UK
    Curr Med Res Opin 19:178-86. 2003
    ..The Asp/Dip/AR-C was superior to abciximab and MK-852 in inhibiting platelet and leukocyte function...
  30. ncbi request reprint Dipyridamole for preventing recurrent ischemic stroke and other vascular events: a meta-analysis of individual patient data from randomized controlled trials
    Jo Leonardi-Bee
    University of Nottingham, Nottingham, UK
    Stroke 36:162-8. 2005
    ..We performed a meta-analysis using individual patient data from relevant randomized controlled trials...
  31. ncbi request reprint Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke
    Lian Zhao
    Clinical Research, University of Nottingham, Nottingham, UK
    Platelets 17:100-4. 2006
    ..In particular, dipyridamole reduces plasma vWf and clopidogrel lowers plasma PAI-1 levels. These effects may explain, in part, their roles in preventing atherothrombogenesis...
  32. ncbi request reprint Blood pressure and clinical outcomes in the International Stroke Trial
    Jo Leonardi-Bee
    Centre for Vascular Research, University of Nottingham, Nottingham, UK
    Stroke 33:1315-20. 2002
    ....
  33. ncbi request reprint Further characterisation of a thromboembolic model of stroke in the rat
    J S Beech
    Department of Medicine, Division of Anaesthesia, University of Cambridge, Box 93, Level 4, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain Res 895:18-24. 2001
    ..21%). These data underline the relative variability of this embolic model and provide important preliminary information regarding the value of early changes in T2* in predicting eventual infarct size...
  34. ncbi request reprint Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study
    R Pathansali
    Department of Medicine, King's College London, Denmark Hill, London, UK
    Platelets 12:144-9. 2001
    ..Since antihypertensive therapy reduces the risk of stroke and myocardial infarction, MKs are a novel therapeutic target for the prevention of vascular events...
  35. ncbi request reprint High blood pressure in acute stroke and subsequent outcome: a systematic review
    Mark Willmot
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Hypertension 43:18-24. 2004
    ..Moderate lowering of BP might improve outcome. Acute BP lowering needs to be tested in 1 or more large, randomized trials...
  36. doi request reprint The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the tinzaparin in acute ischaemic stroke trial (TAIST)
    Gillian M Sare
    Stroke Trials Unit, University of Nottingham, Clinical Sciences Building, City Hospital Campus, Nottingham NG7 2UH UK
    Stroke 40:41-6. 2009
    ..High blood pressure (BP) is present in approximately 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings...
  37. ncbi request reprint P-selectin, tissue factor and CD40 ligand expression on platelet-leucocyte conjugates in the presence of a GPIIb/IIIa antagonist
    Lian Zhao
    Centre for Integrated Systems Biology and Medicine and Institute of Neuroscience, University of Nottingham, UK
    Platelets 14:473-80. 2003
    ..Pro-inflammatory and pro-thrombotic effects of CD40L and tissue factor may be an explanation of the negative clinical effects using GPIIb/IIIa antagonists...
  38. ncbi request reprint Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke: data from the TAIST trial
    Nikola Sprigg
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    J Hypertens 24:1413-7. 2006
    ....
  39. ncbi request reprint Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST)
    Nikola Sprigg
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    J Neurol Sci 254:54-9. 2007
    ..We used data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST) to assess the relationship between stroke severity, early recovery, outcome and OCSP syndrome...
  40. ncbi request reprint Quality of full and final publications reporting acute stroke trials: a systematic review
    F J Bath
    Stroke Group, Department of Medicine, King s College School of Medicine and Dentistry, London, UK
    Stroke 29:2203-10. 1998
    ..We report on the quality of the final reports of randomized controlled trials (RCTs) of drug therapies assessed in acute stroke...
  41. ncbi request reprint Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain
    D Cash
    Institute of Psychiatry, King s College, University of London, London, UK
    Brain Res 905:91-103. 2001
    ..Although this does not rule out a role for AG as a neuroprotective agent via its ability to inhibit iNOS, these findings indicate that neuroprotective actions of AG may also be mediated via other cellular targets...
  42. ncbi request reprint Sex differences in quality of life in stroke survivors: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
    Laura J Gray
    Institute of Neuroscience, University of Nottingham, Clinical Sciences Building, City Hospital Campus, Nottingham NG7 2UH, UK
    Stroke 38:2960-4. 2007
    ..We used data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) to assess the relationship between sex and QoL after ischemic stroke...
  43. ncbi request reprint Sample size calculations in acute stroke trials: a systematic review of their reporting, characteristics, and relationship with outcome
    Chris S Weaver
    Institute of Neuroscience, University of Nottingham, UK
    Stroke 35:1216-24. 2004
    ..Inadequate trial design, especially low sample size, may partly explain this failure. We investigated sample size calculations (SSCs) in a systematic review of acute stroke trials...
  44. doi request reprint High blood pressure in acute ischaemic stroke--broadening therapeutic horizons
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Cerebrovasc Dis 27:156-61. 2009
    ..There are four large ongoing trials examining whether to continue or stop pre-stroke antihypertensive therapy (COSSACS, ENOS) or lower BP in acute stroke (ENOS, SCAST) or haemorrhage (INTERACT 2)...
  45. doi request reprint Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA collaboration
    Gillian M Sare
    Stroke Trials Unit, University of Nottingham, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB UK
    Stroke 40:2098-103. 2009
    ..High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses "baseline" BP was measured 24 hours or more postictus, and not during the hyperacute period...
  46. doi request reprint Asymptomatic hemorrhagic transformation of infarction and its relationship with functional outcome and stroke subtype: assessment from the Tinzaparin in Acute Ischaemic Stroke Trial
    Timothy J England
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Clinical Sciences Building, City Hospital Campus, Nottingham NG7 2UH, UK
    Stroke 41:2834-9. 2010
    ..Asymptomatic hemorrhagic transformation of infarction (AHTI) is common, but its risk factors and relationship with functional outcome are poorly defined...
  47. ncbi request reprint Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke
    Mark Willmot
    Institute of Neuroscience, University of Nottingham, Nottingham, United Kingdom
    Hypertension 47:1209-15. 2006
    ..Trials need to assess the effect of lowering BP on functional outcome...
  48. ncbi request reprint Altered megakaryocyte-platelet-haemostatic axis in patients with acute stroke
    Nicholas M Smith
    Department of Medicine, King s College School of Medicine and Dentistry, Bessemer Road, London SE5 9PJ, UK
    Platelets 13:113-20. 2002
    ..Although megakaryocyte changes are likely, in part, to be secondary to the stroke, they could also precede the stroke and therefore explain some of the increased platelet function observed in acute stroke...
  49. ncbi request reprint Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials
    Philip M W Bath
    Division of Stroke Medicine, University of Nottingham, Nottingham, UK
    Stroke 38:1911-5. 2007
    ..Functional outcome is usually analyzed using a yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are most efficient in analyzing outcomes from stroke trials...
  50. ncbi request reprint Platelet size: measurement, physiology and vascular disease
    P M Bath
    Department of Medicine, King s College School of Medicine and Dentistry, London, UK
    Blood Coagul Fibrinolysis 7:157-61. 1996
    ..Similarly, the physiological mechanisms which regulate MPV within the megakaryocyte need to be elucidated. Whether MPV ever becomes a routinely requested test remains to be seen but changes in methodology will be required first...
  51. doi request reprint Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression
    Chamila M Geeganage
    Division of Stroke Medicine, University of Nottingham, Nottingham City Campus, Nottingham, United Kingdom
    Hypertension 54:775-81. 2009
    ..72), 14.6 mm Hg. Although large falls or increases in BP are associated with a worse outcome, modest reductions may reduce death and combine death or dependency, although the CIs are wide and compatible with an overall benefit or hazard...
  52. ncbi request reprint Should stroke trials adjust functional outcome for baseline prognostic factors?
    Laura J Gray
    Stroke Trials Unit, University of Nottingham, UK
    Stroke 40:888-94. 2009
    ..Suboptimal statistical analyses may be failing to detect effective interventions. Adjusting outcomes for baseline prognostic factors in the analysis may improve the efficiency of analysis of outcomes...
  53. ncbi request reprint Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Blood Press Monit 14:20-5. 2009
    ..Particular uncertainty exists in patients with carotid stenosis in whom lowering BP might reduce cerebral perfusion and worsen outcome...
  54. ncbi request reprint Estrogens and experimental ischemic stroke: a systematic review
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 26:1103-13. 2006
    ..On the basis of these data, estrogens are a candidate treatment for ischemic stroke, although further preclinical studies are also warranted...
  55. doi request reprint Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: A systematic review
    Timothy J England
    University of Nottingham, City Hospital Campus, UK
    Brain Res Rev 62:71-82. 2009
    ..Motor impairment and death were also reduced. Further studies assessing dose response, administration time, length of ischaemia and long-term functional recovery are needed...
  56. doi request reprint Relationship between baseline blood pressure parameters (including mean pressure, pulse pressure, and variability) and early outcome after stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
    Chamila Geeganage
    Division of Stroke, University of Nottingham, City Hospital Campus, Nottingham NG5 1PB, UK
    Stroke 42:491-3. 2011
    ..High blood pressure (BP) in acute stroke is associated independently with a poor outcome. Recent evidence suggests that other hemodynamic parameters may also be associated with outcomes following stroke...
  57. ncbi request reprint G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice
    Claire L Gibson
    Institute of Cell Signalling, University of Nottingham, UK
    J Neuropathol Exp Neurol 64:763-9. 2005
    ..This suggests that part of the neuroprotection may be attributed to the ability of G-CSF to reduce the inflammatory response...
  58. ncbi request reprint Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    Claire L Gibson
    Institute of Cell Signalling, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Exp Neurol 193:522-30. 2005
    ..Thus, progesterone is neuroprotective in both permanent and transient ischemia, and this effect is related to the suppression of specific aspects of the inflammatory response...
  59. ncbi request reprint High blood pressure in acute stroke: to treat or not to treat?
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Int J Stroke 2:172-3. 2007
  60. doi request reprint Speeding stroke recovery? A systematic review of amphetamine after stroke
    Nikola Sprigg
    Division of Stroke Medicine, University of Nottingham, Nottingham University Hospitals NHS Trust, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, UK
    J Neurol Sci 285:3-9. 2009
    ..The use of drugs to enhance recovery ("rehabilitation pharmacology") has been assessed. Amphetamine can improve outcome in experimental models of stroke, and several small clinical trials have assessed its use in stroke...
  61. doi request reprint Ordinal reanalysis of the SHEP trial
    Philip M W Bath
    Stroke 39:e145; author reply e146. 2008
  62. ncbi request reprint Control of blood pressure after stroke
    Philip M W Bath
    Hypertension 48:203-4. 2006
  63. doi request reprint Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach
    Nicolas A Crossley
    Center for Stroke Research, Department of Experimental Neurology, Charite Universitatsmedizin Berlin, 10098 Berlin, Germany
    Stroke 39:929-34. 2008
    ..Using a metaepidemiologic approach, we addressed the effect of randomization, blinding, and use of comorbid animals on the estimate of how effectively therapeutic interventions reduce infarct size...
  64. doi request reprint Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials
    Inke R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Stroke 39:1821-6. 2008
    ..Herein we demonstrate the applicability of our models in an independent sample of patients from controlled clinical trials...
  65. ncbi request reprint How to manage blood pressure in acute stroke
    Philip M W Bath
    J Hypertens 23:1135-6. 2005
  66. ncbi request reprint The Virtual International Stroke Trials Archive
    Myzoon Ali
    University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK
    Stroke 38:1905-10. 2007
    ..The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses...
  67. doi request reprint Pulse pressure as a predictor of stroke
    Chamila Geeganage
    Expert Rev Neurother 8:165-7. 2008
  68. ncbi request reprint Progesterone for the treatment of experimental brain injury; a systematic review
    Claire L Gibson
    School of Psychology, Henry Wellcome Building, Lancaster Road, Leicester, LE1 9HN, UK
    Brain 131:318-28. 2008
    ..Although this systematic review provides some supporting evidence for a neuroprotective role of progesterone following either cerebral ischaemia or TBI importantly it highlights areas which need further pre-clinical investigation...
  69. ncbi request reprint Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke
    Martin Horan
    Institute of Medical Genetics, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK
    Hum Genet 119:527-40. 2006
    ..Although the underlying mechanisms are still unclear, our findings are consistent with a complex relationship between height, hypertension, GH1 promoter haplotype, GHR polymorphism and the risk of stroke...
  70. ncbi request reprint Efficacy of Nitric Oxide in Stroke - a randomized trial. Characteristics of patients recruited in Poland
    Adam Kobayashi
    II Klinika Neurologii, Instytut Psychiatrii i Neurologii, w Warszawie
    Neurol Neurochir Pol 42:99-104. 2008
    ..The rationale for the study is presented and characteristics of patients recruited in Poland and elsewhere compared...