Clive Bate

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Manipulation of PrPres production in scrapie-infected neuroblastoma cells
    Clive Bate
    Department of Veterinary Pathology, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Neurosci Methods 138:217-23. 2004
  2. ncbi request reprint Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro
    Clive Bate
    Institute of Comparative Medicine, Glasglow University Veterinary School, Glasgow, UK
    Neuroreport 13:1933-8. 2002
  3. ncbi request reprint Neurones treated with cyclo-oxygenase-1 inhibitors are resistant to amyloid-beta1-42
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 14:2099-103. 2003
  4. ncbi request reprint Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Biol Chem 279:14983-90. 2004
  5. ncbi request reprint The role of platelet activating factor in prion and amyloid-beta neurotoxicity
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:509-13. 2004
  6. ncbi request reprint Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:1427-30. 2004
  7. ncbi request reprint Detoxified lipopolysaccharide reduces microglial cell killing of prion-infected neurons
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:2765-8. 2004
  8. ncbi request reprint Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 85:3797-804. 2004
  9. ncbi request reprint Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Univeristy of Glasgow Veterinary School, Bearsden Road, Glasgow G61 IQH, UK
    Neuroreport 13:1695-700. 2002
  10. ncbi request reprint Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom
    J Biol Chem 279:36405-11. 2004

Detail Information

Publications23

  1. ncbi request reprint Manipulation of PrPres production in scrapie-infected neuroblastoma cells
    Clive Bate
    Department of Veterinary Pathology, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Neurosci Methods 138:217-23. 2004
    ..The production of interleukin-6 by microglia cultured with retinoic acid-treated ScN2a cells was significantly higher than that of microglia cultured with untreated ScN2a cells...
  2. ncbi request reprint Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro
    Clive Bate
    Institute of Comparative Medicine, Glasglow University Veterinary School, Glasgow, UK
    Neuroreport 13:1933-8. 2002
    ..The cox-1 inhibitors also inhibited neuronal PGE production and protected both neuroblastoma cells and primary cortical neurones against prions. They also reduced microglia-mediated killing of prion-treated neurones...
  3. ncbi request reprint Neurones treated with cyclo-oxygenase-1 inhibitors are resistant to amyloid-beta1-42
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 14:2099-103. 2003
    ..Although the production of neuronal prostaglandin E2 in response to amyloid-beta1-42 was reduced by the presence of COX-1 inhibitors, no neurotoxic effects of prostaglandin E2, or any other prostaglandin, were observed...
  4. ncbi request reprint Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Biol Chem 279:14983-90. 2004
    ..These studies indicate a pivotal role for cholesterol-sensitive processes in controlling PrP(Sc) formation, and in the activation of signaling pathways associated with PrP-induced neuronal death...
  5. ncbi request reprint The role of platelet activating factor in prion and amyloid-beta neurotoxicity
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:509-13. 2004
    ....
  6. ncbi request reprint Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:1427-30. 2004
    ..These results indicate an important role for CD14 in the recognition and subsequent killing of amyloid-beta damaged neurons by microglia...
  7. ncbi request reprint Detoxified lipopolysaccharide reduces microglial cell killing of prion-infected neurons
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:2765-8. 2004
    ..These results suggest that some compounds that bind to CD14 might reduce microglial cell activation and increase neuronal survival in prion and Alzheimer's diseases...
  8. ncbi request reprint Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 85:3797-804. 2004
    ..These results implicate phospholipase A(2) activation by PrP-GPIs as an early event in prion-induced neurodegeneration...
  9. ncbi request reprint Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Univeristy of Glasgow Veterinary School, Bearsden Road, Glasgow G61 IQH, UK
    Neuroreport 13:1695-700. 2002
    ..Activation of microglia and microglia-mediated killing of PrP-treated neurones or scrapie-infected neuroblastoma cells were maximal only when microglia were in direct contact with neurones...
  10. ncbi request reprint Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication
    Clive Bate
    Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom
    J Biol Chem 279:36405-11. 2004
    ..These data indicate a pivotal role for PLA(2) and PAF in controlling PrP(res) formation and identify them as potential therapeutic agents...
  11. pmc Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide
    Rona Wilson
    1Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, G11 6NT, Glasgow
    BMC Neurosci 8:99. 2007
    ....
  12. doi request reprint Cholesterol esterification reduces the neurotoxicity of prions
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 54:1247-53. 2008
    ..These results indicate that cholesterol esterification is an important cellular response that reduces PrP(Sc)-induced activation of PLA(2) and protects against cell death in ScGT1 cells...
  13. doi request reprint Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Abeta 1-42
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, AL9 7TA North Mymms, Herts, UK
    Neuropharmacology 54:934-43. 2008
    ..Such observations raise the possibility that some PUFA supplements may accelerate neuronal loss in the terminal stages of prion or Alzheimer's diseases...
  14. pmc Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    BMC Biol 6:8. 2008
    ....
  15. ncbi request reprint Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Abeta(1-42)
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    Neuropharmacology 53:222-31. 2007
    ..This process is dependent on the amounts of cholesterol in neuronal membranes and is susceptible to treatment with squalestatin or simvastatin...
  16. ncbi request reprint Simvastatin treatment prolongs the survival of scrapie-infected mice
    Sarah Kempster
    Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Hospital, Robinson Way, Cambridge, UK
    Neuroreport 18:479-82. 2007
    ..183 days). These results indicate that low-dosage simvastatin treatment affects the progression of experimental scrapie, and supports the concept that statin treatment may influence the prion pathogenesis...
  17. pmc Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, UK
    J Neuroinflammation 4:5. 2007
    ..Since some epidemiological studies demonstrate that statins, drugs that reduce cholesterol synthesis, have a beneficial effect on mild AD, we examined the effects of two cholesterol synthesis inhibitors on neuronal responses to PAF...
  18. ncbi request reprint Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Neuropharmacology 51:173-81. 2006
    ..At nanomolar concentrations PAF induces a change in neuronal phenotype that activates microglia via the CD14 molecule, these activated microglia then kill the amyloid-beta1-42 damaged neurons...
  19. ncbi request reprint Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Neuropharmacology 50:229-37. 2006
    ....
  20. ncbi request reprint Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
    J Neuroimmunol 170:62-70. 2005
    ..None of the mabs affected the survival of HuPrP106-126-damaged neurons in the absence of monocytes...
  21. pmc Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
    Clive Bate
    Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, UK, AL9 7TA
    BMC Biol 6:39. 2008
    ..Since polyunsaturated fatty acids also reduced cellular cholesterol levels we tested their effects on PrPSc formation in three prion-infected neuronal cell lines (ScGT1, ScN2a and SMB cells)...
  22. ncbi request reprint A role for B lymphocytes in anti-infective prion therapies?
    Mourad Tayebi
    Department of Pathology and Infectious Diseases, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, UK
    Expert Rev Anti Infect Ther 5:631-8. 2007
    ..Furthermore, in vivo stimulation of immune-competent cells to specifically recognize and neutralize the abnormally folded isoform should also be pursued...