Margaret F Bassendine

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Lipids and HCV
    M F Bassendine
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Semin Immunopathol 35:87-100. 2013
  2. doi request reprint HCV and the hepatic lipid pathway as a potential treatment target
    Margaret F Bassendine
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 55:1428-40. 2011
  3. doi request reprint Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection
    Simon H Bridge
    Institute of Cellular Medicine, William Leech Building, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Gut 60:680-7. 2011
  4. doi request reprint Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity
    David A Sheridan
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Hepatol 57:32-8. 2012
  5. doi request reprint Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles
    Daniel J Felmlee
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Gastroenterology 139:1774-83, 1783.e1-6. 2010
  6. pmc Characterization of hepatitis C RNA-containing particles from human liver by density and size
    Søren U Nielsen
    Liver Research Group, Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Gen Virol 89:2507-17. 2008
  7. pmc Characterization of the genome and structural proteins of hepatitis C virus resolved from infected human liver
    Søren U Nielsen
    School of Clinical Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Gen Virol 85:1497-507. 2004
  8. ncbi request reprint HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study
    Peter T Donaldson
    School of Clinical Medical Sciences Hepatology, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, and Institute of Liver Studies, Kings College Hospital, London, UK
    Hepatology 44:667-74. 2006
  9. pmc Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients
    Søren U Nielsen
    Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, England
    J Virol 80:2418-28. 2006
  10. ncbi request reprint Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002

Detail Information

Publications12

  1. doi request reprint Lipids and HCV
    M F Bassendine
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Semin Immunopathol 35:87-100. 2013
    ..In summary, HCV utilises triglyceride-rich lipoprotein pathways within the liver and the circulation to its advantage...
  2. doi request reprint HCV and the hepatic lipid pathway as a potential treatment target
    Margaret F Bassendine
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 55:1428-40. 2011
    ..This review aims to: • update the hepatologist on lipid metabolism • review the evidence that HCV exploits hepatic lipid pathways to its advantage • discuss approaches to targeting host lipid pathways as adjunctive therapy...
  3. doi request reprint Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection
    Simon H Bridge
    Institute of Cellular Medicine, William Leech Building, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Gut 60:680-7. 2011
    ..Objective To measure LVP in patients with chronic hepatitis C genotype 1 (CHC-G1) and examine metabolic determinants of LVP load. Patients 51 patients with CHC-G1 infection...
  4. doi request reprint Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity
    David A Sheridan
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Hepatol 57:32-8. 2012
    ..LDL cholesterol (LDL-C) also predicts interferon response, therefore we hypothesised that LVP may also be associated with interferon sensitivity...
  5. doi request reprint Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles
    Daniel J Felmlee
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Gastroenterology 139:1774-83, 1783.e1-6. 2010
    ..We sought to determine if factors that affect triglyceride-rich lipoprotein (TRL) metabolism alter the density and dynamics of HCV particles in the plasma of patients with chronic HCV infection...
  6. pmc Characterization of hepatitis C RNA-containing particles from human liver by density and size
    Søren U Nielsen
    Liver Research Group, Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    J Gen Virol 89:2507-17. 2008
    ..This HCV was associated with ApoB, ApoE and viral glycoprotein E2, similar to viral particles circulating in serum. Our results indicate that the association between HCV and VLDL occurs in the liver...
  7. pmc Characterization of the genome and structural proteins of hepatitis C virus resolved from infected human liver
    Søren U Nielsen
    School of Clinical Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Gen Virol 85:1497-507. 2004
    ..Glycoprotein E2 was 62 kDa before and 36 kDa after deglycosylation, but E2-P7 was not detected. This was in contrast to recombinant sources of E2 which contain E2-P7...
  8. ncbi request reprint HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study
    Peter T Donaldson
    School of Clinical Medical Sciences Hepatology, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, and Institute of Liver Studies, Kings College Hospital, London, UK
    Hepatology 44:667-74. 2006
    ..042, OR=0.65 in the UK patients; and 10% versus 31%, P=.00092, OR=0.25 in the Italian patients). In conclusion, a complex relationship exists between HLA and PBC, and some genetic associations may be population specific...
  9. pmc Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients
    Søren U Nielsen
    Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, England
    J Virol 80:2418-28. 2006
    ..Immunoprecipitation analysis showed that ApoB remained associated with HCV after treatment of serum with deoxycholic acid or NP-40, whereas ApoE was removed from HCV with these detergents...
  10. ncbi request reprint Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002
    ..This model may provide a useful system for investigating the etiology and treatment of PBC...
  11. doi request reprint Hepatitis C virus and lipids in the era of direct acting antivirals (DAAs)
    David A Sheridan
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Res Hepatol Gastroenterol 37:10-6. 2013
    ..We consider how understanding the interactions of HCV and host lipid metabolism remains relevant in the era of DAAs for genotype 1 infection and for treatment of non-genotype 1 chronic hepatitis C...
  12. pmc Binding of liver derived, low density hepatitis C virus to human hepatoma cells
    Caroline Martin
    The Liver Research Group, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    J Med Virol 80:816-23. 2008
    ..These data indicate that whilst liver derived HCV RNA containing particles are taken up by HepG2 cells by a virus glycoprotein independent mechanism, the mechanism differs from that of LDL uptake...