N Barton

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The relation between reproductive value and genetic contribution
    Nicholas H Barton
    Institute of Science and Technology, A 3400 Klosterneuberg, Austria
    Genetics 188:953-73. 2011
  2. pmc Mutation and the evolution of recombination
    N H Barton
    Institute of Science and Technology, Am Campus 1, A 3400 Klosterneuburg, Austria
    Philos Trans R Soc Lond B Biol Sci 365:1281-94. 2010
  3. doi request reprint The effect of a barrier to gene flow on patterns of geographic variation
    N H Barton
    Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, Scotland, UK
    Genet Res (Camb) 90:139-49. 2008
  4. ncbi request reprint The limitations of adaptive dynamics as a model of evolution
    N H Barton
    School of Biological Science, University of Edinburgh, Edinburgh, UK
    J Evol Biol 18:1186-90. 2005
  5. ncbi request reprint Effects of genetic drift on variance components under a general model of epistasis
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, EH9 3JT, United Kingdom
    Evolution 58:2111-32. 2004
  6. pmc The effect of selection on genealogies
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genetics 166:1115-31. 2004
  7. ncbi request reprint Understanding quantitative genetic variation
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 3:11-21. 2002
  8. ncbi request reprint The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
  9. ncbi request reprint Ecology. The rapid origin of reproductive isolation
    N Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Science 290:462-3. 2000
  10. pmc Genetic hitchhiking
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Philos Trans R Soc Lond B Biol Sci 355:1553-62. 2000

Detail Information

Publications33

  1. pmc The relation between reproductive value and genetic contribution
    Nicholas H Barton
    Institute of Science and Technology, A 3400 Klosterneuberg, Austria
    Genetics 188:953-73. 2011
    ..Thus, the influence of the complex pedigree of descendants on an individual's genetic contribution to the population can be summarized through a single number: its reproductive value...
  2. pmc Mutation and the evolution of recombination
    N H Barton
    Institute of Science and Technology, Am Campus 1, A 3400 Klosterneuburg, Austria
    Philos Trans R Soc Lond B Biol Sci 365:1281-94. 2010
    ..These arguments are illustrated by comparing the interaction between good and bad mutations at unlinked loci under the infinitesimal model...
  3. doi request reprint The effect of a barrier to gene flow on patterns of geographic variation
    N H Barton
    Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, Scotland, UK
    Genet Res (Camb) 90:139-49. 2008
    ..Thus, in a two-dimensional population, barriers to gene flow can be detected through their effect on the spatial pattern of genetic marker alleles...
  4. ncbi request reprint The limitations of adaptive dynamics as a model of evolution
    N H Barton
    School of Biological Science, University of Edinburgh, Edinburgh, UK
    J Evol Biol 18:1186-90. 2005
  5. ncbi request reprint Effects of genetic drift on variance components under a general model of epistasis
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, EH9 3JT, United Kingdom
    Evolution 58:2111-32. 2004
    ..Although our analyses clarify the conditions under which drift is expected to increase V(A), we question the evolutionary importance of such increases...
  6. pmc The effect of selection on genealogies
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genetics 166:1115-31. 2004
    ..Moreover, small fluctuations in allele frequency due to random drift can greatly reduce any such effects. This will make it difficult to detect the action of selection from neutral variation alone...
  7. ncbi request reprint Understanding quantitative genetic variation
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 3:11-21. 2002
    ....
  8. ncbi request reprint The role of hybridization in evolution
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 10:551-68. 2001
    ..Moreover, because adaptation is via substitutions of small effect, Fisher's model does not generate the strong effects of single chromosome regions often observed in species crosses...
  9. ncbi request reprint Ecology. The rapid origin of reproductive isolation
    N Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Science 290:462-3. 2000
    ..In an elegant Perspective, Barton discusses two reports (Higgie et al. and Hendry et al.) showing that selection can cause reproductive isolation between two populations within a dozen or so generations...
  10. pmc Genetic hitchhiking
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Philos Trans R Soc Lond B Biol Sci 355:1553-62. 2000
    ..However, it seems unlikely that such sweeps can be sufficiently frequent to increase significantly the drift of neutral alleles...
  11. ncbi request reprint Measuring fitness by means of balancer chromosomes
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 75:297-313. 2000
    ..A full age-structured model can also be applied to the data from both types of experiment. For the invasion method, this gives fitness estimates close to those from the discrete generation model...
  12. ncbi request reprint Estimating multilocus linkage disequilibria
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3 JT, Scotland
    Heredity (Edinb) 84:373-89. 2000
    ..Both methods perform well when tested against simulations with two or four loci...
  13. ncbi request reprint The effect of epistasis on the structure of hybrid zones
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 75:179-98. 2000
    ..For beta > 1, gene number is systematically overestimated and, conversely, when beta < 1, it is underestimated...
  14. ncbi request reprint Why sex and recombination?
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Science 281:1986-90. 1998
    ..Various processes that can cause such an effect have been studied theoretically. It has, however, so far proved hard to discriminate among them empirically...
  15. ncbi request reprint The stability of symmetric solutions to polygenic models
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, Scotland
    Theor Popul Biol 57:249-63. 2000
    ..This allows the stability of symmetrical solutions to be determined. We apply the method to stabilizing and disruptive selection in a single deme and to selection against heterozygotes in a linear cline...
  16. ncbi request reprint The maintenance of reproductive isolation in a mosaic hybrid zone between the fire-bellied toads Bombina bombina and B. variegata
    T H Vines
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
    Evolution 57:1876-88. 2003
    ..The hybrid zone may be approaching a state in which the gene pools are homogenized at all but the selected loci, not dissimilar from an early stage of sympatric divergence...
  17. pmc Evolution of recombination due to random drift
    N H Barton
    School of Biological Sciences, University of Edinburgh, UK
    Genetics 169:2353-70. 2005
    ..Selection for a modifier that increases recombination is highest when linkage among loci is tight, when beneficial alleles rise from low to high frequency, and when the population size is small...
  18. doi request reprint Why sex and recombination?
    N H Barton
    Institute of Science and Technology, A 3400 Klosterneuburg, Austria
    Cold Spring Harb Symp Quant Biol 74:187-95. 2009
    ..It is clear that the rate of species-wide substitutions is typically far too low to generate appreciable selection for recombination. However, local sweeps within a subdivided population may be effective...
  19. ncbi request reprint Clines in polygenic traits
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 74:223-36. 1999
    ..Linkage disequilibria can generate a substantial increase in genetic variance, which is concentrated at sharp gradients in trait means...
  20. pmc What role does natural selection play in speciation?
    N H Barton
    Institute of Science and Technology, Am Campus 1, 3400 Klosterneuburg, Austria
    Philos Trans R Soc Lond B Biol Sci 365:1825-40. 2010
    ..A sharp threshold is only seen if survival in the 'wrong' niche is low; otherwise, strong isolation is impossible. Gene flow from divergent demes makes speciation much easier in parapatry than in sympatry...
  21. doi request reprint Investigating temporal changes in hybridization and introgression in a predominantly bimodal hybridizing population of invasive sika (Cervus nippon) and native red deer (C. elaphus) on the Kintyre Peninsula, Scotland
    H V Senn
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Ecol 19:910-24. 2010
    ..Although we demonstrate that low rates of F1 hybridization can lead to substantial introgression, the progress of hybridization and introgression appears to be unpredictable over the short timescales...
  22. pmc Genetic linkage and natural selection
    N H Barton
    Institute of Science and Technology, Am Campus 1, A 3400 Klosterneuburg, Austria
    Philos Trans R Soc Lond B Biol Sci 365:2559-69. 2010
    ..It is plausible that spatial and temporal fluctuations in selection generate much more fitness variance, and hence selection for recombination, than can be explained by uniformly deleterious mutations or species-wide selective sweeps...
  23. doi request reprint A model for the evolution of assortative mating
    M A R de Cara
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Am Nat 171:580-96. 2008
    ..We find that selection for increased assortment is weak and that where increased assortment is costly, it does not invade...
  24. pmc A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids
    L E Kruuk
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 153:1959-71. 1999
    ..There is a smooth transition between a system in which a set of loci effectively act independently of each other and one in which they act as a single nonrecombining unit...
  25. pmc Testing for epistasis between deleterious mutations
    S A West
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 149:435-44. 1998
    ..We also reconsider experimental data collected on Chlamydomonas moewussi using two of the three methods. Finally, we suggest how the test could be applied to diploid species...
  26. doi request reprint On the application of statistical physics to evolutionary biology
    N H Barton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, UK
    J Theor Biol 259:317-24. 2009
    ..This analogy with statistical thermodynamics brings together previous ideas in a general framework, and justifies a maximum entropy approximation to the dynamics of quantitative traits...
  27. ncbi request reprint Evolutionary biology: how did the human species form?
    N H Barton
    Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, Edinburgh, EH9 3JT, UK
    Curr Biol 16:R647-50. 2006
    ..Although this is consistent with "hybridisation" between the diverging human and chimp lineages, such observations can be explained more simply by the null model of allopatric speciation...
  28. pmc Statistical mechanics and the evolution of polygenic quantitative traits
    N H Barton
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
    Genetics 181:997-1011. 2009
    ..We show how the method can be modified for small mutation rates (4Nmicro --> 0). We outline how this method describes epistatic interactions as, for example, with stabilizing selection...
  29. pmc Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
    N Galtier
    Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom
    Genetics 155:981-7. 2000
    ..An application to sequence data from an African population of Drosophila melanogaster shows that the bottleneck hypothesis is unlikely and that one or several selective sweeps probably occurred in the recent history of this population...
  30. ncbi request reprint Will population bottlenecks and multilocus epistasis increase additive genetic variance?
    Michael Turelli
    Section of Evolution and Ecology, University of California, Davis, California 95616, USA
    Evolution 60:1763-76. 2006
    ..5) are needed for significant conversion of higher-order components. We discuss alternative approaches to modeling multilocus epistasis and understanding its consequences...
  31. ncbi request reprint Mating patterns in a hybrid zone of fire-bellied toads (Bombina): inferences from adult and full-sib genotypes
    B Nürnberger
    Department Biologie II, Ludwig Maximilians Universitat Munchen, Grosshaderner Str 2, 82152 Planegg Martinsried, Germany
    Heredity (Edinb) 94:247-57. 2005
    ..Instead, B. variegata-like individuals among the adults contributed disproportionately to the offspring cohort, consistent with their preference for the type of breeding habitat in which this study was conducted...
  32. pmc Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions
    Michael Turelli
    Section of Evolution and Ecology and Center for Population Biology, University of California, Davis 95616, USA
    Genetics 166:1053-79. 2004
    ..We present numerical results that support our analytical approximations and discuss our results in connection to relevant data and alternative variance-maintaining mechanisms...
  33. ncbi request reprint A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae)
    B Nürnberger
    Department Biologie II, Ludwig Maximilians Universitat, Karlstr 23 25, 80333 München, Germany
    Heredity (Edinb) 91:136-42. 2003
    ..Among the 40 isolated CA microsatellites, we noted a preponderance of compound and frequently interleaved CA-TA repeats as well as a striking polarity at the 5' end of the repeats...