Anne Barton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:752-8. 2005
  2. pmc Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2169-72. 2010
  3. pmc PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
  4. pmc The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    Darren Plant
    ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 50:78-84. 2011
  5. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007
  6. pmc The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome
    H Naseem
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Ann Rheum Dis 67:251-5. 2008
  7. pmc Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients
    Tracey M Farragher
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 62:676-82. 2010
  8. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
  9. pmc Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
    John Bowes
    Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2199-203. 2010
  10. pmc Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1016-9. 2011

Detail Information

Publications84

  1. ncbi request reprint Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:752-8. 2005
    ..The purpose of this study was to investigate the association between the OCTN locus and RA in a Caucasian population...
  2. pmc Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2169-72. 2010
    ..There is strong evidence suggesting that juvenile idiopathic arthritis (JIA) shares many susceptibility loci with other autoimmune diseases...
  3. pmc PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
    ..However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population...
  4. pmc The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    Darren Plant
    ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 50:78-84. 2011
    ..We therefore sought to investigate the role of recently identified RA susceptibility SNP markers in predicting erosive outcome in patients with recent-onset inflammatory polyarthritis (IP)...
  5. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007
    ....
  6. pmc The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome
    H Naseem
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Ann Rheum Dis 67:251-5. 2008
    ..The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (IP)...
  7. pmc Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients
    Tracey M Farragher
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 62:676-82. 2010
    ....
  8. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
    ....
  9. pmc Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
    John Bowes
    Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    Ann Rheum Dis 69:2199-203. 2010
    ..Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population...
  10. pmc Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1016-9. 2011
    ..Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls...
  11. pmc Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1641-4. 2011
    ....
  12. pmc Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort
    Darren Plant
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 64:665-70. 2012
    ....
  13. pmc Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
    John Bowes
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, UK
    Ann Rheum Dis 71:1350-4. 2012
    ..Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA...
  14. ncbi request reprint Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Stu
    J Bluett
    Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Science, University of Manchester, Manchester, UK
    Pharmacogenomics J 14:171-5. 2014
    ..In conclusion, genetic variation in the gene encoding CR1 may alter ESR levels but not DAS28-ESR, indicating no adjustment for CR1 genotype is required in the assessment of patients with severe active RA. ..
  15. ncbi request reprint The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances
    Madhura Castelino
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 53:777-84. 2014
    ..In parallel with genetic studies, characterization of the host microbiota may benefit our understanding of the microbial contribution to disease pathogenesis-knowledge that may eventually inform the development of novel therapeutics. ..
  16. pmc Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
    Ann W Morgan
    NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Arthritis Res Ther 12:R57. 2010
    ..This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort...
  17. pmc Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes
    Anne Barton
    University of Manchester, Manchester, UK
    Hum Mol Genet 18:2518-22. 2009
    ..94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases...
  18. pmc Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 64:1311-5. 2005
    ..Aim: To examine the association between individual PADI4 single nucleotide polymorphisms (SNPs) and haplotypes, with the development and severity of erosions by five years in patients with IP...
  19. pmc Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Anne Barton
    Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK
    Nat Genet 40:1156-9. 2008
    ....
  20. pmc Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
    Anne Barton
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Hum Mol Genet 17:2274-9. 2008
    ..The effect sizes are less than those reported previously but are likely to be a more accurate reflection of the true effect size given the larger size of the cohort investigated in the current study...
  21. pmc Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
    Rachael J L Tan
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1029-35. 2010
    ..The aim of the current study was to investigate the association of markers within confirmed RA susceptibility loci with the response to anti-TNF treatment...
  22. pmc Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
    Anne Hinks
    Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1049-53. 2010
    ..Rheumatoid arthritis (RA) is an autoimmune disease that shares similar clinical and pathological features with JIA and, therefore, recently identified confirmed RA susceptibility loci are also excellent JIA candidate loci...
  23. pmc Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
    ..The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone...
  24. pmc Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    Tracey M Farragher
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:359-69. 2008
    ..To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA)...
  25. doi request reprint Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheumatol 66:24-30. 2014
    ..This study was undertaken to extend our previous RA GWAS in a UK cohort, adding more independent RA cases and healthy controls, with the aim of detecting novel association signals for susceptibility to RA in a homogeneous UK cohort...
  26. pmc Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  27. ncbi request reprint Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis
    Pauline Ho
    University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3596-602. 2005
    ..The SLC22A4 gene has also been associated with rheumatoid arthritis. This study was undertaken to further elucidate associations of PsA with Crohn's disease susceptibility genes...
  28. ncbi request reprint Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
    ....
  29. pmc Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
    Stephen Eyre
    ARC EU, University of Manchester, UK
    Arthritis Res Ther 8:R117. 2006
    ....
  30. pmc Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:251-7. 2009
    ..The aim of this study was to determine whether SNPs within the IL2RA/CD25 gene are associated with juvenile idiopathic arthritis (JIA)...
  31. pmc Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3)...
  32. ncbi request reprint Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p
    William Brintnell
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3823-30. 2004
    ..To investigate whether the large linkage peak on chromosome 6p harbors rheumatoid arthritis (RA) susceptibility loci in addition to the well-characterized HLA-DRB1 gene...
  33. pmc Benefit of early treatment in inflammatory polyarthritis patients with anti-cyclic citrullinated peptide antibodies versus those without antibodies
    Tracey M Farragher
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 62:664-75. 2010
    ..To compare the clinical utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF) testing in predicting both functional outcome and response to treatment in early inflammatory polyarthritis (IP) patients...
  34. pmc Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
    ..The aim of the current study was to validate these potential RA susceptibility markers in a UK population...
  35. ncbi request reprint Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole-genome scan in a further series of 217 UK affected sibling pairs
    Stephen Eyre
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 50:729-35. 2004
    ..Thus, the aim of this study was to investigate in an additional set of RA ASP families linkage to regions showing deviation in expected allele-sharing ratios in the UK WGS and to perform subset analysis on the combined cohort...
  36. pmc Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  37. ncbi request reprint Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:748-52. 2004
    ..The aim of this study was to investigate the association of the CTLA-4 polymorphism with RA...
  38. doi request reprint Investigation of rheumatoid arthritis genetic susceptibility markers in the early rheumatoid arthritis study further replicates the TRAF1 association with radiological damage
    Sebastien Viatte
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    J Rheumatol 40:144-56. 2013
    ..We aimed to test RA genetic susceptibility markers for association with a continuous measure of radiological damage over time using longitudinal modeling techniques...
  39. doi request reprint A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  40. ncbi request reprint A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:1117-21. 2004
    ..In the present study, we investigated the association of single-nucleotide polymorphisms (SNPs) in the PADI4 gene with RA in a UK population...
  41. pmc Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK
    Ann Rheum Dis 70:463-8. 2011
    ..Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases...
  42. pmc Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites
    Sally John
    University of Manchester, Manchester, United Kingdom
    Am J Hum Genet 75:54-64. 2004
    ..The high SNP density allows loci to be defined more precisely and provides a partial scaffold for association studies, substantially reducing the resource requirement for gene-mapping studies...
  43. doi request reprint Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients
    John D Bowes
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Pharmacogenet Genomics 19:319-23. 2009
    ..We conclude that analysis of the common variation in the selected candidate genes did not provide strong evidence to implicate their involvement in varying patient response to anti-TNF treatment...
  44. pmc Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:258-63. 2009
    ..The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA...
  45. pmc Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
    Sebastien Viatte
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 71:1984-90. 2012
    ..The authors therefore investigated confirmed RA susceptibility loci in a large cohort of anti-CCP negative RA subjects...
  46. pmc Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK
    Arthritis Res Ther 13:R12. 2011
    ..We, therefore, hypothesized that two well-established susceptibility loci for AS and Ps, ERAP1 and IL23R, could also confer susceptibility to these JIA subtypes...
  47. pmc Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition
    Eleftheria Zeggini
    Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
    BMC Genet 6:21. 2005
    ..5 kb, we constructed haplotype block maps using published methods and additional methods we have developed. Haplotype tagging SNPs (htSNPs) were identified for each map...
  48. ncbi request reprint Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort
    Stephen Eyre
    University of Manchester, Manchester, UK
    Arthritis Rheum 54:3417-22. 2006
    ..Therefore, we undertook this study to investigate the association of the MHC2TA gene promoter with RA in a UK Caucasian population...
  49. pmc Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:683-6. 2007
    ....
  50. pmc HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  51. pmc Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap
    Anne Hinks
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Ann Rheum Dis 71:1117-21. 2012
    ..A plethora of newly validated RA loci has been reported in the past year. Therefore, the aim of this study was to investigate these single nucleotide polymorphisms (SNP) to determine if they were also associated with JIA...
  52. pmc Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
    Stephen Eyre
    Arthritis Research UK, Epidemiology Unit, Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 12:R175. 2010
    ..Here we have attempted to define overlapping genetic variants between rheumatoid arthritis (RA), type 1 diabetes (T1D) and coeliac disease (CeD)...
  53. pmc Fine mapping of genes within the IDDM8 region in rheumatoid arthritis
    Anne Hinks
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Arthritis Res Ther 8:R145. 2006
    ..Our study has failed to detect evidence of association with any of the known genes mapping to the IDDM8 locus with RA...
  54. pmc Association of the CCR5 gene with juvenile idiopathic arthritis
    A Hinks
    Manchester Academy of Health Sciences, The University of Manchester, UK
    Genes Immun 11:584-9. 2010
    ....
  55. pmc Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
    Charlotte Filer
    University of Manchester, Manchester, UK
    Arthritis Rheum 58:3705-9. 2008
    ..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
  56. pmc Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci
    Darren Plant
    University of Manchester, Manchester, UK
    Arthritis Rheum 63:645-53. 2011
    ..The purpose of this study was to identify genetic predictors of response to anti-TNF therapy in RA and to validate our findings in independent cohorts...
  57. pmc Investigation of association between the TRAF family genes and RA susceptibility
    Catherine Potter
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 66:1322-6. 2007
    ..A study was undertaken to investigate the association between single nucleotide polymorphisms (SNPs) spanning six TRAF genes and RA in a British population...
  58. ncbi request reprint Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data
    Kate McAllister
    University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, and Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheum 65:3058-62. 2013
    ..The aim of this study was to determine whether these potentially significant loci are involved in the pathogenesis of RA, and to explore whether any of the loci are associated with a specific RA serotype...
  59. pmc High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
    Steve Eyre
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Nat Genet 44:1336-40. 2012
    ..Bioinformatic analyses generated strong hypotheses for the causal SNP at seven loci. This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations...
  60. pmc Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
    John Bowes
    Arthritis Research UK, Epidemiology Unit, University of Manchester, Manchester, UK
    Hum Genet 128:627-33. 2010
    ....
  61. ncbi request reprint Polymorphisms in the mannose binding lectin (MBL) gene are not associated with radiographic erosions in rheumatoid or inflammatory polyarthritis
    Anne Barton
    Arthritis and Rheumatism Campaign Epidemiology Unit, University of Manchester, Manchester, UK 1 ser man ac uk
    J Rheumatol 31:442-7. 2004
    ....
  62. pmc Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis
    Marwan Bukhari
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:389-93. 2007
    ..Increasing age at onset has been associated with worse outcome in rheumatoid arthritis, although there are few data from unselected inception cohorts...
  63. pmc Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
    Neil Shephard
    ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    BMC Genet 4:S26. 2003
    ....
  64. ncbi request reprint Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester, UK
    Genes Immun 4:487-91. 2003
    ..The promoter polymorphisms of MIF, investigated in this study, do not influence the severity of disease outcome by 5 years...
  65. ncbi request reprint Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis
    Lis Cordingley
    Manchester Academy of Health Sciences and University of Manchester, Manchester, UK
    Arthritis Care Res (Hoboken) 66:861-8. 2014
    ..We hypothesized that psychological factors (cognitions and mood) would be more strongly associated with patient-reported components of the DAS28 than clinical or biochemical components...
  66. pmc Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis
    Marian L Burr
    Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Res Ther 14:R109. 2012
    ..We aimed therefore to determine the stability of CCP antibody status over time and the prognostic utility of repeated testing in subjects with early inflammatory polyarthritis (IP)...
  67. ncbi request reprint The single-nucleotide polymorphism lottery: how useful are a few common SNPs in identifying disease-associated alleles?
    A Barton
    Arthritis Research Campaign s Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Genet Epidemiol 21:S384-9. 2001
    ..As expected, case-control methods were more likely to detect association with individual SNPs but family-based haplotyping methods appeared better able to localize the position of functional polymorphism...
  68. ncbi request reprint Update on the genetic risk factors for rheumatoid arthritis
    Gisela Orozco
    Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Expert Rev Clin Immunol 6:61-75. 2010
    ..Finally, we discuss what still needs to be accomplished before a more complete picture of the genetic risk to RA can be attained...
  69. doi request reprint Recent advances in the genetics of RA susceptibility
    J Bowes
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Rheumatology (Oxford) 47:399-402. 2008
    ..The past few months alone have witnessed the identification of three new RA risk loci. In this review, we aim to give an update on recent progress in RA genetics, focusing mainly on the identification of novel loci...
  70. ncbi request reprint The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis
    L J Gibbons
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Rheumatology (Oxford) 44:1390-3. 2005
    ..The objective of this study was to test the hypothesis that SUMO4 is a general autoimmune susceptibility gene by investigating whether the SUMO4 polymorphism is associated with RA and/or JIA...
  71. ncbi request reprint Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Brain 127:1717-22. 2004
    ..Our results suggest that the promoter and proximal gene region should be not only included but prioritized in any screening strategy...
  72. doi request reprint Genetic susceptibility factors for psoriatic arthritis
    Madhura Castelino
    ARC Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Manchester, UK
    Curr Opin Rheumatol 22:152-6. 2010
    ..However, using a variety of approaches, some confirmed associations have now been identified with PsA susceptibility, making a review of these recent developments timely...
  73. doi request reprint The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis
    Samantha Louise Smith
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, School of Translational Medicine, University of Manchester, Manchester, UK
    Ann Rheum Dis 72:1118-24. 2013
    ..This review will discuss the implications this promising technology has in predicting treatment response and outline the various advantages and pitfalls associated with its use...
  74. ncbi request reprint The genetics of psoriatic arthritis: lessons from genome-wide association studies
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, United Kingdom
    Discov Med 10:177-83. 2010
    ..Dedicated genome-wide association studies of PsA are underway and are likely to reveal further insights into why some patients with psoriasis develop arthritis whilst the majority do not...
  75. pmc Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis
    P Y P C Ho
    Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    Ann Rheum Dis 67:677-82. 2008
    ..Our aim was to investigate the role of HLA-Cw*06 and HLA-DRB1 genes (including SE) with psoriatic arthritis (PsA) susceptibility...
  76. pmc Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis
    A Barton
    University of Manchester, UK
    Ann Rheum Dis 63:280-4. 2004
    ....
  77. doi request reprint What have genome-wide studies told us about psoriatic arthritis?
    James Bluett
    Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester, England M13 9PT, UK
    Curr Rheumatol Rep 14:364-8. 2012
    ..Most show overlap with psoriasis, whereas the overlap with rheumatoid arthritis is less pronounced. However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus...
  78. doi request reprint Genetic and genomic predictors of anti-TNF response
    Rita Prajapati
    Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Sciences, University of Manchester, Manchester, UK
    Pharmacogenomics 12:1571-85. 2011
    ..Other potential serum biomarkers of response have also been explored including cytokines and autoantibodies, with antibodies developing to the anti-TNF drugs themselves being correlated with treatment failure...
  79. pmc ASSIMILATOR: a new tool to inform selection of associated genetic variants for functional studies
    Paul Martin
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Bioinformatics 27:144-6. 2011
    ..Here, we describe a program designed to quickly assimilate this data called ASSIMILATOR and validate the method by interrogating two regions to show its effectiveness...
  80. ncbi request reprint Genetic approaches to the investigation of rheumatoid arthritis
    Anne Barton
    ARC Epidemiology Unit, University of Manchester, Manchester, UK
    Curr Opin Rheumatol 14:260-9. 2002
    ..This review summarizes the results of many of the HLA and non-HLA studies and tries to draw lessons from the investigation of genetic susceptibility factors in other complex diseases...
  81. ncbi request reprint High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 10:1901-6. 2001
    ..The difficult task of identifying a disease mutation from a linkage result should, in this case at least, be facilitated by the combined use of animal and human based investigations...
  82. ncbi request reprint Approaches to identifying genetic predictors of clinical outcome in rheumatoid arthritis
    Anne Barton
    School of Epidemiology and Health Sciences, University of Manchester, Manchester, England, UK
    Am J Pharmacogenomics 3:181-91. 2003
    ....
  83. ncbi request reprint Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians
    A Barton
    University of Manchester, UK
    Arthritis Rheum 44:61-5. 2001
    ..The present study was undertaken to investigate association of polymorphisms of TNFRI and TNFRII with RA in subjects in the UK...