A Barton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester, UK
    Genes Immun 4:487-91. 2003
  2. pmc Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
  3. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
  4. doi A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    D Plant
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, UK
    Pharmacogenomics J 12:128-33. 2012
  5. pmc PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
  6. ncbi The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis
    L J Gibbons
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Rheumatology (Oxford) 44:1390-3. 2005
  7. pmc Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 64:1311-5. 2005
  8. ncbi High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 10:1901-6. 2001
  9. pmc Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis
    S Eyre
    University of Manchester, Manchester, UK
    Arthritis Rheum 63:1522-6. 2011
  10. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007

Detail Information

Publications27

  1. ncbi Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester, UK
    Genes Immun 4:487-91. 2003
    ..The promoter polymorphisms of MIF, investigated in this study, do not influence the severity of disease outcome by 5 years...
  2. pmc Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci
    Annie McClure
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Rheumatology (Oxford) 48:1369-74. 2009
    ..The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone...
  3. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
    ....
  4. doi A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    D Plant
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, UK
    Pharmacogenomics J 12:128-33. 2012
    ..73 (1.18, 2.52) and year 2, HR 1.49 (1.11, 2.00); correlating with an increased in adverse events. Weak evidence for an effect at the PTPN22 locus was also observed. These findings require replication in other large datasets...
  5. pmc PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population
    Marian L Burr
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK
    Ann Rheum Dis 69:666-70. 2010
    ..However, studies in European populations have produced conflicting results. This study explored the association of the PADI4 genotype with RA in a large UK Caucasian population...
  6. ncbi The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis
    L J Gibbons
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK
    Rheumatology (Oxford) 44:1390-3. 2005
    ..The objective of this study was to test the hypothesis that SUMO4 is a general autoimmune susceptibility gene by investigating whether the SUMO4 polymorphism is associated with RA and/or JIA...
  7. pmc Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 64:1311-5. 2005
    ..Aim: To examine the association between individual PADI4 single nucleotide polymorphisms (SNPs) and haplotypes, with the development and severity of erosions by five years in patients with IP...
  8. ncbi High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
    A Barton
    Arthritis Rheumatism Campaign Epidemiology Research Unit, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 10:1901-6. 2001
    ..The difficult task of identifying a disease mutation from a linkage result should, in this case at least, be facilitated by the combined use of animal and human based investigations...
  9. pmc Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis
    S Eyre
    University of Manchester, Manchester, UK
    Arthritis Rheum 63:1522-6. 2011
    ....
  10. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007
    ....
  11. doi An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene
    F R Ali
    The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester M6 8HD, UK
    Br J Dermatol 168:864-6. 2013
    ..Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways...
  12. pmc The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome
    H Naseem
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Ann Rheum Dis 67:251-5. 2008
    ..The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (IP)...
  13. ncbi The single-nucleotide polymorphism lottery: how useful are a few common SNPs in identifying disease-associated alleles?
    A Barton
    Arthritis Research Campaign s Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Genet Epidemiol 21:S384-9. 2001
    ..As expected, case-control methods were more likely to detect association with individual SNPs but family-based haplotyping methods appeared better able to localize the position of functional polymorphism...
  14. doi Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients
    S A Owen
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK
    Pharmacogenomics J 13:227-34. 2013
    ..Further studies will be required to validate these findings and if confirmed these results could contribute towards a better understanding of and ability to predict MTX response in RA...
  15. doi HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort
    G Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Genes Immun 12:169-75. 2011
    ..In addition, association with three novel independent RA loci in the xMHC region (ZNF391, OR2H1 and C6orf26-RDBP) has been detected...
  16. ncbi Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population
    A Barton
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Brain 127:1717-22. 2004
    ..Our results suggest that the promoter and proximal gene region should be not only included but prioritized in any screening strategy...
  17. pmc Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  18. pmc Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis
    P Y P C Ho
    Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    Ann Rheum Dis 67:677-82. 2008
    ..Our aim was to investigate the role of HLA-Cw*06 and HLA-DRB1 genes (including SE) with psoriatic arthritis (PsA) susceptibility...
  19. doi MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms
    S A Owen
    Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Manchester, UK
    Pharmacogenomics J 13:137-47. 2013
    ..38 (95% CI 0.90-2.12) and OR=1.19 (95% CI 0.80-1.78), respectively). The available evidence suggests that the MTHFR C677T and A1298C gene polymorphisms are not reliable predictors of response to MTX treatment in RA patients...
  20. doi Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy
    H L H├ębert
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, Stopford Building, Manchester, M13 9PT, UK
    Br J Dermatol 166:474-82. 2012
    ..Further, it describes the genetics of treatment response in the two diseases and indicates how susceptibility loci could be used to identify drug response in the future...
  21. pmc Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA
    A Yarwood
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Genes Immun 14:325-9. 2013
    ..03-1.24). The significant enrichment of VDREs at RA-associated loci and the modest association of variants in loci-controlling levels of circulating vitamin D supports the hypothesis that vitamin D has a role in the development of RA. ..
  22. pmc Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis
    A Barton
    University of Manchester, UK
    Ann Rheum Dis 63:280-4. 2004
    ....
  23. pmc Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Anne Barton
    Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK
    Nat Genet 40:1156-9. 2008
    ....
  24. doi Recent advances in the genetics of RA susceptibility
    J Bowes
    ARC EU, Stopford Building, University of Manchester, Manchester, UK
    Rheumatology (Oxford) 47:399-402. 2008
    ..The past few months alone have witnessed the identification of three new RA risk loci. In this review, we aim to give an update on recent progress in RA genetics, focusing mainly on the identification of novel loci...
  25. ncbi Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians
    A Barton
    University of Manchester, UK
    Arthritis Rheum 44:61-5. 2001
    ..The present study was undertaken to investigate association of polymorphisms of TNFRI and TNFRII with RA in subjects in the UK...
  26. pmc History of the development of geriatric medicine in the UK
    A Barton
    Department of Elderly Medicine, St James s University Hospital, Leeds
    Postgrad Med J 79:229-34; quiz 233-4. 2003
    ..The contributions made by nurses and other professionals have been immense, but space does not permit a historical review of their important role...
  27. ncbi Cross-cultural differences in GPs' attitudes towards complementary and alternative medicine: a survey comparing regions of the UK and Germany
    K Schmidt
    Department of Complementary Medicine, School of Sport and Health Sciences, University of Exeter, Exeter, UK
    Complement Ther Med 10:141-7. 2002
    ..To investigate whether there is a difference in general practitioners' attitudes towards CAM in the UK and Germany...