M P Barrett

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose
    Nadia Lamour
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 280:11902-10. 2005
  2. doi request reprint Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei
    Virginie Coustou
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR 5234 CNRS
    J Biol Chem 283:16342-54. 2008
  3. doi request reprint Metabolomic systems biology of trypanosomes
    Michael P Barrett
    Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom
    Parasitology 137:1285-90. 2010
  4. pmc A molecular mechanism for eflornithine resistance in African trypanosomes
    Isabel M Vincent
    University of Glasgow, Glasgow, UK
    PLoS Pathog 6:e1001204. 2010
  5. ncbi request reprint Perspectives for new drugs against trypanosomiasis and leishmaniasis
    Michael P Barrett
    University of Glasgow, Institute of Biomedical and Life Sciences, Division of Infection and Immunity, The Joseph Black Building, Glasgow, G12 8QQ, U K
    Curr Top Med Chem 2:471-82. 2002
  6. ncbi request reprint The trypanosomiases
    Michael P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, G12 8QQ, Glasgow, UK
    Lancet 362:1469-80. 2003
  7. pmc Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
    M P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Br J Pharmacol 152:1155-71. 2007
  8. ncbi request reprint Uptake of the nitroimidazole drug megazol by African trypanosomes
    M P Barrett
    Division of Infection of Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Biochem Pharmacol 59:615-20. 2000
  9. ncbi request reprint Structure and function of facilitative sugar transporters
    M P Barrett
    Divisions of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    Curr Opin Cell Biol 11:496-502. 1999
  10. ncbi request reprint The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes
    M P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Parasitol Today 15:136-40. 1999

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose
    Nadia Lamour
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 280:11902-10. 2005
    ..These results indicate that the ability of trypanosomes to use proline as an energy source can be regulated depending upon the availability of glucose...
  2. doi request reprint Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei
    Virginie Coustou
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR 5234 CNRS
    J Biol Chem 283:16342-54. 2008
    ..We conclude that trypanosomes develop an elaborate adaptation of their energy production pathways in response to carbon source availability...
  3. doi request reprint Metabolomic systems biology of trypanosomes
    Michael P Barrett
    Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom
    Parasitology 137:1285-90. 2010
    ..Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research...
  4. pmc A molecular mechanism for eflornithine resistance in African trypanosomes
    Isabel M Vincent
    University of Glasgow, Glasgow, UK
    PLoS Pathog 6:e1001204. 2010
    ..The loss of this transporter will be easily identified in the field using a simple PCR test, enabling more appropriate chemotherapy to be administered...
  5. ncbi request reprint Perspectives for new drugs against trypanosomiasis and leishmaniasis
    Michael P Barrett
    University of Glasgow, Institute of Biomedical and Life Sciences, Division of Infection and Immunity, The Joseph Black Building, Glasgow, G12 8QQ, U K
    Curr Top Med Chem 2:471-82. 2002
    ..Therefore we also discuss approaches to designing molecules that can specifically cross the plasma membrane of African trypanosomes via unusual nutrient transporters...
  6. ncbi request reprint The trypanosomiases
    Michael P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, G12 8QQ, Glasgow, UK
    Lancet 362:1469-80. 2003
    ..Growth in recognition of these neglected diseases might result in progress towards control through increased funding for drug development and vector elimination...
  7. pmc Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
    M P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Br J Pharmacol 152:1155-71. 2007
    ..Finally we report on new initiatives that might allow progress to be made in developing new and satisfactory drugs for this terrible disease...
  8. ncbi request reprint Uptake of the nitroimidazole drug megazol by African trypanosomes
    M P Barrett
    Division of Infection of Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Biochem Pharmacol 59:615-20. 2000
    ..The equilibration phase represented a simple passive diffusion, with the subsequent uptake probably being due to metabolism of the drug...
  9. ncbi request reprint Structure and function of facilitative sugar transporters
    M P Barrett
    Divisions of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    Curr Opin Cell Biol 11:496-502. 1999
    ..Recent mutagenesis studies of sugar transporters within the framework of tenable models for the distantly related lactose permease argue that this model is a good paradigm for other members of the major facilitator superfamily...
  10. ncbi request reprint The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes
    M P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Parasitol Today 15:136-40. 1999
    ..Here, Mike Barrett and Alan Fairlamb outline the mechanism underlying this crossresistance, which appears to arise as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs...
  11. ncbi request reprint The rise and fall of sleeping sickness
    Michael P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Lancet 367:1377-8. 2006
  12. ncbi request reprint Uptake and mode of action of drugs used against sleeping sickness
    H Denise
    The Wellcome Centre for Molecular Parasitology, University of Glasgow, The Anderson College, 56 Dumbarton Rd, Glasgow G11 6NU, Scotland, UK
    Biochem Pharmacol 61:1-5. 2001
    ..New drugs are urgently needed and the advent of genome sequencing and target validation using genetic modification will hopefully accelerate this process...
  13. ncbi request reprint Sugar transporters from bacteria, parasites and mammals: structure-activity relationships
    A R Walmsley
    Division of Infection and Immunity, University of Glasgow, UK
    Trends Biochem Sci 23:476-81. 1998
    ..Subtle distinctions in the function of these proteins can be related to particular amino acid residue substitutions...
  14. pmc A large gene family for putative variant antigens shared by human and rodent malaria parasites
    Christoph S Janssen
    Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Proc Biol Sci 269:431-6. 2002
    ..In the rodent malaria P. chabaudi, transcription of members of the gene family was developmentally regulated with maximum expression in late trophozoite stages, which is the developmental stage known to express variant antigen proteins...
  15. ncbi request reprint Sleeping sickness and the brain
    B Enanga
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Scotland, United Kingdom
    Cell Mol Life Sci 59:845-58. 2002
    ....
  16. pmc The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes
    Harry P de Koning
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Antimicrob Agents Chemother 48:1515-9. 2004
    ..We conclude that TbAT1 mediates [(3)H]diminazene transport almost exclusively and that this explains the observed diminazene resistance phenotypes of TbAT1-null mutants and field isolates...
  17. pmc Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites
    Christoph S Janssen
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Nucleic Acids Res 32:5712-20. 2004
    ....
  18. pmc Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes
    Mhairi L Stewart
    Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Eukaryot Cell 9:336-43. 2010
    ..b. brucei mutant, although at a greatly reduced capacity compared to that of the wild type, indicating that an additional adenine-inhibitable adenosine permease, distinct from P2, is present in these cells...
  19. ncbi request reprint Chemotherapy of human African trypanosomiasis
    Richard J S Burchmore
    Iinstitute of Biochemical and Life Sciences, Division of Infection and Immunity, University of Glasgow, UK
    Curr Pharm Des 8:256-67. 2002
    ..This review focuses on what is known about modes of action of current drugs and discusses targets for future drug development...
  20. ncbi request reprint Life in vacuoles--nutrient acquisition by Leishmania amastigotes
    R J Burchmore
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Int J Parasitol 31:1311-20. 2001
    ..The influence of environmental pH on membrane transporter function is discussed, with emphasis on the potential role of a transmembrane proton gradient in active, high affinity transport...
  21. doi request reprint N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift
    C E Ebikeme
    Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA
    Parasitology 135:585-94. 2008
    ..In tsetse flies, however, it seems probable that the effect of GlcNAc is independent of this switch as pre-adaptation to growth in proline had no effect on tsetse infection rate...
  22. ncbi request reprint Gene discovery in Plasmodium chabaudi by genome survey sequencing
    C S Janssen
    Division of Infection and Immunity, IBLS, University of Glasgow, G12 8QQ, Glasgow, UK
    Mol Biochem Parasitol 113:251-60. 2001
    ..Genome survey sequencing in P. chabaudi is a productive strategy in further developing this in vivo model of malaria, in the context of the malaria genome projects...
  23. ncbi request reprint Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance
    Charlotte A Lanteri
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Mol Pharmacol 70:1585-92. 2006
    ....
  24. ncbi request reprint Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test
    Mhairi L Stewart
    University of Glasgow, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Joseph Black Building, Glasgow G12 8QQ, UK
    Lancet 366:486-7. 2005
    ..The two DNA-containing structures in the trypanosome--the nucleus and the kinetoplast--begin to fluoresce within 1 min of introduction of DB99, unless drug resistant...
  25. pmc Trypanocidal activity of melamine-based nitroheterocycles
    Mhairi L Stewart
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Antimicrob Agents Chemother 48:1733-8. 2004
    ..brucei, distinguishing it from some other, mammalian cell toxic, trypanocidal nitroheterocycles...
  26. ncbi request reprint The plastidic DNA replication enzyme complex of Plasmodium falciparum
    Fiona Seow
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Biochem Parasitol 141:145-153. 2005
    ..Pfprex is the first example of a gene encoding contiguous DNA polymerase, DNA primase and DNA helicase components. We propose it has a key role in replication of the malarial plastid genome, a validated drug target...
  27. ncbi request reprint Targeting of toxic compounds to the trypanosome's interior
    Michael P Barrett
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8QQ, UK
    Adv Parasitol 63:125-83. 2006
    ..This review outlines studies that have aimed to exploit trypanosome nutrient uptake routes to selectively carry toxins into these parasites...
  28. doi request reprint Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis
    Caroline M Reid
    WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Bioorg Med Chem Lett 18:5399-401. 2008
    ..Biological testing of these compounds showed highly selective anti-protozoal activity against trypanosomes...
  29. pmc Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis
    Jean Rodgers
    Division of Clinical Neurosciences, Faculty of Medicine, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G41 4TF, UK
    Brain 132:1259-67. 2009
    ....
  30. pmc Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter
    Mhairi L Stewart
    University of Glasgow, Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Glasgow G12 8QQ, United Kingdom
    Antimicrob Agents Chemother 49:5169-71. 2005
    ..Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 transporter, which indicates additional uptake routes for monobenzamidine-derived compounds...
  31. doi request reprint The Toxoplasma gondii plastid replication and repair enzyme complex, PREX
    A Mukhopadhyay
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
    Parasitology 136:747-55. 2009
    ..These studies indicate that prex is conserved across the plastid-bearing apicomplexans and may play an important role in the replication of the plastid genome...
  32. doi request reprint Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles
    Caroline M Reid
    WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Bioorg Med Chem Lett 18:2455-8. 2008
    ..Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen...
  33. pmc Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage
    Bertin Enanga
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Antimicrob Agents Chemother 47:3368-70. 2003
    ..Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to intracellular thiols correlated with resistance...
  34. ncbi request reprint Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan
    Richard J S Burchmore
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 278:23502-7. 2003
    ..Expression of TbNBT1 in Xenopus oocytes further confirmed that this gene encodes the first high affinity nucleobase transporter from protozoa or animals to be identified at the molecular level...
  35. pmc A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter
    Christina M Naula
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 285:29721-8. 2010
    ..The location of these residues in hydrophilic loops supports recent suggestions that substrate recognition is separated from substrate binding and translocation in this important group of transporters...
  36. pmc Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns
    Christopher P Ward
    Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, 120 University Place, Glasgow G12 8TA, United Kingdom
    Antimicrob Agents Chemother 55:2352-61. 2011
    ..The aza analogues of DB75 accumulate more slowly than furamidine itself and reveal less trypanocidal activity in standard in vitro drug sensitivity assays...
  37. ncbi request reprint Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles
    Jennifer M Wilson
    WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow, UK
    Org Biomol Chem 5:3651-6. 2007
    ..Preliminary testing of the biological activity of the compounds revealed significant anti-parasitic activity against bloodstream form African trypanosomes...
  38. ncbi request reprint Energy generation in insect stages of Trypanosoma brucei: metabolism in flux
    Sebastien Besteiro
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, Glasgow G11 6NU, Scotland, UK
    Trends Parasitol 21:185-91. 2005
    ..In this article, we summarize how these recent data have helped to change the view of metabolism in procyclic-form T. brucei...
  39. pmc Transketolase from Leishmania mexicana has a dual subcellular localization
    Nicola J Veitch
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Biochem J 382:759-67. 2004
    ..Transketolase is thus the first enzyme of the nonoxidative branch of the pentose phosphate pathway whose presence has been demonstrated in a peroxisome-like organelle...
  40. pmc Genetic characterization of glucose transporter function in Leishmania mexicana
    Richard J S Burchmore
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 100:3901-6. 2003
    ..These results establish that each glucose transporter isoform has distinct biological functions in the parasite...
  41. ncbi request reprint Waking up to sleeping sickness
    August Stich
    Medical Mission Institute, Department of Tropical Medicine and Epidemic Control, Hermann Schell Str 7, D 97074 Wurzburg, Germany
    Trends Parasitol 19:195-7. 2003
    ..In addition, pan-African initiatives to co-ordinate control efforts have begun. These all provide some hope for the future, but they might not be enough to reverse the resurgence of this deadly disease in the heart of Africa...
  42. ncbi request reprint Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis
    Christophe Dardonville
    Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, CF10 3XF, Cardiff, UK
    Bioorg Med Chem 11:3205-14. 2003
    ..The trypanocidal effect of the compounds was also evaluated in vitro against T. brucei rhodesiense as well as other related trypanosomatid parasites (i.e., Trypanosoma cruzi and Leishmania donovani)...
  43. pmc Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei
    Enock Matovu
    Institute of Cell Biology, CH 3012 Bern, Switzerland
    Eukaryot Cell 2:1003-8. 2003
    ..High-level arsenical resistance therefore appears to involve the loss of more than one transporter...
  44. pmc African sleeping sickness
    Francesco Checchi
    BMJ 336:679-80. 2008
  45. ncbi request reprint Pentamidine uptake and resistance in pathogenic protozoa: past, present and future
    Patrick G Bray
    Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QS, UK
    Trends Parasitol 19:232-9. 2003
    ....
  46. ncbi request reprint Chemotherapy of trypanosomiases and leishmaniasis
    Simon L Croft
    Drugs for Neglected Diseases Initiative, 1 place Saint Gervais, CH 1201 Geneva, Switzerland
    Trends Parasitol 21:508-12. 2005
    ..Financial constraints continue to represent a major hurdle to drug development. However, the appearance of not-for-profit product-development partnerships offers a new paradigm for bringing new drugs to patients...
  47. ncbi request reprint Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites
    Alessandro Baliani
    Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom
    J Med Chem 48:5570-9. 2005
    ..cruzi against which various nitro heterocycles are already registered for use...
  48. ncbi request reprint DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity
    Christophe Dardonville
    Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    J Med Chem 49:3748-52. 2006
    ..From these studies, the 4,4'-diaminodiphenylamine skeleton emerged as a good scaffold for antitrypanosomal drugs...
  49. ncbi request reprint Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates
    Ramasubramanian Sundaramoorthy
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, UK
    FEBS J 274:275-86. 2007
    ..LlPDH can now serve as a model system for structure-based inhibitor design targeting the enzyme from Trypanosoma species...
  50. pmc Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase
    Gian Filippo Ruda
    Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK
    ChemMedChem 2:1169-80. 2007
    ..Most prodrugs caused inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appeared to be related to their stability in aqueous buffer...
  51. ncbi request reprint 6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes
    Stefania Hanau
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Italy
    Curr Med Chem 11:2639-50. 2004
    ..All have shown selective inhibition of the trypanosomal 6-phosphogluconate dehydrogenase and representatives of each have trypanocidal activity...
  52. ncbi request reprint Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues
    Christophe Dardonville
    Welsh School of Pharmacy, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom
    J Med Chem 47:3427-37. 2004
    ..The sulfoxide transition-state analogues showed weak and selective inhibition of the T. brucei enzyme. The hydroxamic derivatives showed potent and selective inhibition of the T. brucei 6PGDH with a Ki in the nanomolar range...
  53. pmc Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei
    Romanico B G Arrighi
    Department of Genetics, Stockholm University, Stockholm, Sweden
    Antimicrob Agents Chemother 52:3414-7. 2008
    ..One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei...
  54. ncbi request reprint Molecular cloning, expression and characterization of ribokinase of Leishmania major
    Patrick O J Ogbunude
    Department of Medical Biochemistry, University of Nigeria, Enugu 1000004, Nigeria
    Acta Biochim Biophys Sin (Shanghai) 39:462-6. 2007
    ..The enzyme product ribose 5-phosphate inhibited the phosphorylation of D-ribose with an apparent K(i) of 0.4 mM, which is close to the K(m) (0.3 mM) of D-ribose, suggesting that it might play a role in regulating flux through the enzyme...
  55. ncbi request reprint Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter
    Laurent Azema
    Groupe de Chimie Organique Biologique, Laboratoire de Synthèse et Physico Chimie de Molécules d Intérêt Biologique, Universite Paul Sabatier, UMR 5068 CNRS, Bât IIR1 118 route de Narbonne, 31062 Toulouse Cedex, France
    Biochem Pharmacol 67:459-67. 2004
    ..This indicates that inhibition of the transporter may be a good means of killing trypanosomes...
  56. ncbi request reprint Polymorphism among alleles of the 6-phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica
    Charles L Greenblatt
    Department of Parasitology, Kuvin Centre for the Study of Infectious and Tropical Diseases, Hebrew University Hadassah School of Medicine, Ein Karem, Jerusalem 91120, Israel
    Mol Biochem Parasitol 125:185-8. 2002
  57. ncbi request reprint New surveyor tools for charting microbial metabolic maps
    Rainer Breitling
    Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands
    Nat Rev Microbiol 6:156-61. 2008
    ..Data integration will play a particularly important part in exploiting the new experimental opportunities...