Alastair J Barr

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, United Kingdom
    Proteins 63:1132-6. 2006
  2. ncbi MAPK-specific tyrosine phosphatases: new targets for drug discovery?
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, OX3 7LD, UK
    Trends Pharmacol Sci 27:525-30. 2006
  3. ncbi Large-scale structural analysis of the classical human protein tyrosine phosphatome
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Cell 136:352-63. 2009
  4. ncbi Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Future Med Chem 2:1563-76. 2010
  5. ncbi Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK
    Biochem J 395:483-91. 2006
  6. ncbi The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    Protein Sci 15:1500-5. 2006
  7. ncbi Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class
    Eidarus Salah
    Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK
    J Med Chem 54:2359-67. 2011
  8. ncbi Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3
    Alastair J Barr
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 293:647-52. 2002

Collaborators

Detail Information

Publications8

  1. ncbi Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, United Kingdom
    Proteins 63:1132-6. 2006
  2. ncbi MAPK-specific tyrosine phosphatases: new targets for drug discovery?
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, OX3 7LD, UK
    Trends Pharmacol Sci 27:525-30. 2006
    ..We believe that the development of specific inhibitors would provide a valuable set of experimental pharmacological tools for investigating the physiological role of these phosphatases and exploring their emerging role in human disease...
  3. ncbi Large-scale structural analysis of the classical human protein tyrosine phosphatome
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Cell 136:352-63. 2009
    ..This phosphatome resource gives an expanded insight into intrafamily PTP diversity, catalytic activity, substrate recognition, and autoregulatory self-association...
  4. ncbi Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Future Med Chem 2:1563-76. 2010
    ..Here the ongoing challenges and recent significant advances in the field are reviewed. Key novel compounds are highlighted and a perspective on the future of phosphatase inhibitor development is presented...
  5. ncbi Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK
    Biochem J 395:483-91. 2006
    ....
  6. ncbi The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    Protein Sci 15:1500-5. 2006
    ..In agreement, we show that RPTPkappa is monomeric in solution and crystal structure...
  7. ncbi Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class
    Eidarus Salah
    Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK
    J Med Chem 54:2359-67. 2011
    ....
  8. ncbi Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3
    Alastair J Barr
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 293:647-52. 2002
    ..p38MAPK also co-immunoprecipitated with PLC-beta 2. The data suggest that PLC-beta 2 serves an unappreciated role assembling components of the p38MAPK signaling module...