Alastair J Barr

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, United Kingdom
    Proteins 63:1132-6. 2006
  2. ncbi MAPK-specific tyrosine phosphatases: new targets for drug discovery?
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, OX3 7LD, UK
    Trends Pharmacol Sci 27:525-30. 2006
  3. pmc Large-scale structural analysis of the classical human protein tyrosine phosphatome
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Cell 136:352-63. 2009
  4. doi Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Future Med Chem 2:1563-76. 2010
  5. pmc Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK
    Biochem J 395:483-91. 2006
  6. pmc The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    Protein Sci 15:1500-5. 2006
  7. pmc Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states
    Chitra A Shintre
    Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 110:9710-5. 2013
  8. pmc Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class
    Eidarus Salah
    Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK
    J Med Chem 54:2359-67. 2011
  9. ncbi Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3
    Alastair J Barr
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 293:647-52. 2002

Collaborators

Detail Information

Publications9

  1. ncbi Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, United Kingdom
    Proteins 63:1132-6. 2006
  2. ncbi MAPK-specific tyrosine phosphatases: new targets for drug discovery?
    Alastair J Barr
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford, OX3 7LD, UK
    Trends Pharmacol Sci 27:525-30. 2006
    ..We believe that the development of specific inhibitors would provide a valuable set of experimental pharmacological tools for investigating the physiological role of these phosphatases and exploring their emerging role in human disease...
  3. pmc Large-scale structural analysis of the classical human protein tyrosine phosphatome
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Cell 136:352-63. 2009
    ..This phosphatome resource gives an expanded insight into intrafamily PTP diversity, catalytic activity, substrate recognition, and autoregulatory self-association...
  4. doi Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
    Alastair J Barr
    University of Oxford, Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Future Med Chem 2:1563-76. 2010
    ..Here the ongoing challenges and recent significant advances in the field are reviewed. Key novel compounds are highlighted and a perspective on the future of phosphatase inhibitor development is presented...
  5. pmc Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK
    Biochem J 395:483-91. 2006
    ....
  6. pmc The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
    Jeyanthy Eswaran
    Structural Genomics Consortium, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    Protein Sci 15:1500-5. 2006
    ..In agreement, we show that RPTPkappa is monomeric in solution and crystal structure...
  7. pmc Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states
    Chitra A Shintre
    Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 110:9710-5. 2013
    ..These structures indicate that ABC transporters may exist in an open-inwards conformation when nucleotide is bound. We discuss ways in which this observation can be aligned with the current views on mechanisms of ABC transporters...
  8. pmc Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class
    Eidarus Salah
    Structural Genomics Consortium, Oxford University, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK
    J Med Chem 54:2359-67. 2011
    ....
  9. ncbi Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3
    Alastair J Barr
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 293:647-52. 2002
    ..p38MAPK also co-immunoprecipitated with PLC-beta 2. The data suggest that PLC-beta 2 serves an unappreciated role assembling components of the p38MAPK signaling module...