Martin Baron

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
    Takashi J Fuwa
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, 278 8510 Noda, Chiba, Japan
    Mol Genet Genomics 275:251-63. 2006
  2. ncbi request reprint An overview of the Notch signalling pathway
    Martin Baron
    School of Biological Sciences, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Semin Cell Dev Biol 14:113-9. 2003
  3. ncbi request reprint Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster
    M Baron
    School of Biological Sciences, University of Manchester, UK
    Mol Gen Genet 264:98-104. 2000
  4. ncbi request reprint Multiple levels of Notch signal regulation (review)
    M Baron
    University of Manchester, School of Biological Sciences, UK
    Mol Membr Biol 19:27-38. 2002
  5. ncbi request reprint Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
    Marian B Wilkin
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Stopford Road, Manchester M13 9PT, UK
    Curr Biol 14:2237-44. 2004
  6. ncbi request reprint Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex
    Martin D Jennings
    Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, UK
    J Biol Chem 282:29032-42. 2007
  7. doi request reprint Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway
    Marian Wilkin
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Dev Cell 15:762-72. 2008
  8. ncbi request reprint Down-regulation of Notch target gene expression by Suppressor of deltex
    Sabine L Mazaleyrat
    University of Manchester, School of Biological Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT UK
    Dev Biol 255:363-72. 2003
  9. doi request reprint Endocytic routes to Notch activation
    Martin Baron
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Semin Cell Dev Biol 23:437-42. 2012
  10. pmc The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
    M Cornell
    University of Manchester, School of Biological Sciences, Manchester M13 9PT, United Kingdom
    Genetics 152:567-76. 1999

Collaborators

  • Kenji Matsuno
  • D A Evans
  • Alexander P Golovanov
  • M J Humphries
  • I D Campbell
  • H Okano
  • Masahiro J Go
  • Marian B Wilkin
  • Kazuya Hori
  • Marzena Flasza
  • Marian Wilkin
  • Takashi J Fuwa
  • Maggy Fostier
  • Sabine L Mazaleyrat
  • Jemima Cordle
  • Martin D Jennings
  • Sylvaine Clemence
  • Amber Carmon
  • Johanna M Avis
  • Jenny Higgs
  • Oleg Y Fedoroff
  • Michael Cornell
  • Hanna Aslam
  • M Fostier
  • M S Hicks
  • M B Wilkin
  • Kenta Yamada
  • Nicole Gensch
  • Susan M Lea
  • Penny A Handford
  • Masato Motoki
  • Joyce Zi Yan Tay
  • Maiko Taniguchi-Kanai
  • Christina Redfield
  • Sacha Jensen
  • Steven Johnson
  • Pietro Roversi
  • M Cornell
  • Pajaree Tongngok
  • Emily Franklin
  • Pat Whiteman
  • Hideyuki Shimizu
  • Boquan Jin
  • Beatriz Hernández de Madrid
  • Ross MacIntyre
  • Jana Hassan
  • Richard T Blankley
  • S Artavanis-Tsakonas
  • Robert Clarke
  • Sabine Mazaleyrat
  • Cécile Villemant
  • Ngoc Sa Nguyen Huu
  • Takeshi Sasamura
  • Mikiko Ito
  • Sharon A Townson
  • Ann Marie Carbery
  • Anna Myat
  • Rebecca Roylance
  • Patricia Gorman
  • Ann E Canfield
  • M Wilkin
  • S E Bee
  • V O'Leary
  • R MacIntyre
  • K Cooper
  • I Phan
  • H J Chung
  • M N Becker
  • D Mulvey
  • A Chao
  • M Flasza
  • R Mann
  • M Monthatong

Detail Information

Publications20

  1. ncbi request reprint The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
    Takashi J Fuwa
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, 278 8510 Noda, Chiba, Japan
    Mol Genet Genomics 275:251-63. 2006
    ..Our epistatic analyses suggested that dx functions downstream of the ligands and upstream of activated Su(H). We also uncovered a novel dx activity that suppressed N signaling downstream of N...
  2. ncbi request reprint An overview of the Notch signalling pathway
    Martin Baron
    School of Biological Sciences, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    Semin Cell Dev Biol 14:113-9. 2003
    ..While a consensus model has emerged, in the details there is much that is contentious. This review will primarily focus on our current understanding of the proteolytic events involved in generating and regulating Notch signalling...
  3. ncbi request reprint Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster
    M Baron
    School of Biological Sciences, University of Manchester, UK
    Mol Gen Genet 264:98-104. 2000
    ..Together with genetic interactions with loss- and gain-of-function Notch alleles, these data support a role for wild-type Dcdc42 as a negative regulator of Notch signalling...
  4. ncbi request reprint Multiple levels of Notch signal regulation (review)
    M Baron
    University of Manchester, School of Biological Sciences, UK
    Mol Membr Biol 19:27-38. 2002
    ....
  5. ncbi request reprint Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
    Marian B Wilkin
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Stopford Road, Manchester M13 9PT, UK
    Curr Biol 14:2237-44. 2004
    ..Such intersections between trafficking routes may provide key points at which other signals can modulate Notch activity in both normal development and in the pathological misactivation of Notch...
  6. ncbi request reprint Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex
    Martin D Jennings
    Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, UK
    J Biol Chem 282:29032-42. 2007
    ..The highly conserved tandem arrangement of WW domains in Nedd4 proteins, and similar arrangements in more diverse proteins, suggests domain-domain communication may be integral to regulation of their associated cellular activities...
  7. doi request reprint Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway
    Marian Wilkin
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Dev Cell 15:762-72. 2008
    ..We discuss ways in which these endocytic pathways may modulate ligand-dependent and -independent events, as a mechanism that can potentiate Notch signaling or dampen noise in the signaling network...
  8. ncbi request reprint Down-regulation of Notch target gene expression by Suppressor of deltex
    Sabine L Mazaleyrat
    University of Manchester, School of Biological Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT UK
    Dev Biol 255:363-72. 2003
    ..Using a time-course experiment we show that the phenotype is buffered by feedback regulation illustrating how signalling networks can make development robust to perturbation...
  9. doi request reprint Endocytic routes to Notch activation
    Martin Baron
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Semin Cell Dev Biol 23:437-42. 2012
    ..The resulting signalling network may provide developmental robustness to environmental and genetic variation...
  10. pmc The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
    M Cornell
    University of Manchester, School of Biological Sciences, Manchester M13 9PT, United Kingdom
    Genetics 152:567-76. 1999
    ....
  11. ncbi request reprint Endocytic regulation of Notch activation and down-regulation (review)
    Marian B Wilkin
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Mol Membr Biol 22:279-89. 2005
    ..Furthermore, the utilisation of an alternative mechanism of Notch signalling, independent of Su(H), may depend on driving endocytic Notch into a specific compartment, in response to the activity of the ring finger domain protein, Deltex...
  12. pmc Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling
    M Fostier
    University of Manchester, School of Biological Sciences, Manchester M13 9PT, United Kingdom
    Genetics 150:1477-85. 1998
    ..This corresponds to the period when the Notch protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative regulator of Notch function...
  13. ncbi request reprint Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein
    Marzena Flasza
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Biochem Biophys Res Commun 290:431-7. 2002
    ..We discuss the hypothesis that regulation of splice site usage may modulate the activity of WWP1 and possibly other Nedd4 family proteins...
  14. ncbi request reprint Drosophila dumpy is a gigantic extracellular protein required to maintain tension at epidermal-cuticle attachment sites
    M B Wilkin
    Stopford Building, University of Manchester, School of Biological Sciences, Manchester, M13 9PT, UK
    Curr Biol 10:559-67. 2000
    ..The dumpy gene of the fruit fly Drosophila melanogaster is an example of the latter class, with mutant phenotypes affecting size and shape of the limbs, thoracic cuticle, trachea and mouthparts...
  15. ncbi request reprint DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern
    M S Hicks
    Wellcome Trust Center for Cell Matrix Research, School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Dev Genes Evol 211:263-7. 2001
    ..DrhoGEF3 is subsequently expressed in the visceral mesoderm, at the sites of muscle attachment and in specific groups of sub-epidermal cells. The possible function of such a dynamically expressed signalling molecule is discussed...
  16. ncbi request reprint The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex
    Oleg Y Fedoroff
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P O Box 88, Manchester M60 1QD, United Kingdom
    J Biol Chem 279:34991-5000. 2004
    ..Our data illustrate that arrays of WW domains can exhibit a variety of higher order structures and ligand interaction mechanisms...
  17. pmc A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
    Jemima Cordle
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 15:849-57. 2008
    ..Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor...
  18. ncbi request reprint Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling
    Kazuya Hori
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Development 131:5527-37. 2004
    ....
  19. ncbi request reprint Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch
    Marzena Flasza
    University of Manchester, Faculty of Life Sciences, Michael Smith Building, Manchester
    Mol Membr Biol 23:269-76. 2006
    ..Drosophila Notch similarly regulated the nuclear localization of the Drosophila Nedd4 family protein, Suppressor of deltex, implying conservation of this mechanism during evolution...
  20. pmc Concerted evolution within the Drosophila dumpy gene
    Amber Carmon
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Genetics 176:309-25. 2007
    ....