N M Barnes

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Close encounters of the monoamine kind: immune cells betray their nervous disposition
    Elizabeth J Meredith
    MRC Centre for Immune Regulation, The Medical School, University of Vincent Drive, Birmingham B15 2TT, UK
    Immunology 115:289-95. 2005
  2. doi request reprint Harnessing serotonergic and dopaminergic pathways for lymphoma therapy: evidence and aspirations
    Nicholas M Barnes
    Division of Neuroscience, The Medical School, Vincent Drive, Birmingham B15 2TT, United Kingdom
    Semin Cancer Biol 18:218-25. 2008
  3. ncbi request reprint A review of central 5-HT receptors and their function
    N M Barnes
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 38:1083-152. 1999
  4. pmc 5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!
    N M Barnes
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Gut 54:1056-7. 2005
  5. ncbi request reprint Distribution of S(-)-zacopride-insensitive [125I]R(+)-zacopride binding sites in the rat brain and peripheral tissues
    J Ge
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK
    Eur J Pharmacol 332:307-12. 1997
  6. ncbi request reprint 5-hydroxytryptamine3 (5-HT3) receptor-mediated depolarisation of the rat isolated vagus nerve: modulation by trichloroethanol and related alcohols
    K R Bentley
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Eur J Pharmacol 354:25-31. 1998
  7. ncbi request reprint Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine
    R L Stowe
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 37:1611-9. 1998
  8. ncbi request reprint Distribution and characterisation of the [3H](S)-zacopride labelled 5-HT3 receptor in pig forebrain
    S Fletcher
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Brain Res 729:281-4. 1996
  9. pmc Agonist interactions with 5-HT3 receptor recognition sites in the rat entorhinal cortex labelled by structurally diverse radioligands
    J M Barnes
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston
    Br J Pharmacol 105:500-4. 1992
  10. ncbi request reprint Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors
    C A Brady
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 41:282-4. 2001

Collaborators

Detail Information

Publications30

  1. pmc Close encounters of the monoamine kind: immune cells betray their nervous disposition
    Elizabeth J Meredith
    MRC Centre for Immune Regulation, The Medical School, University of Vincent Drive, Birmingham B15 2TT, UK
    Immunology 115:289-95. 2005
    ....
  2. doi request reprint Harnessing serotonergic and dopaminergic pathways for lymphoma therapy: evidence and aspirations
    Nicholas M Barnes
    Division of Neuroscience, The Medical School, Vincent Drive, Birmingham B15 2TT, United Kingdom
    Semin Cancer Biol 18:218-25. 2008
    ..Furthermore, the availability of a number of pharmaceutical agents originally developed to manipulate central monoamine function, offer many suitable drug candidates to test their therapeutic potential in the immune pathology arena...
  3. ncbi request reprint A review of central 5-HT receptors and their function
    N M Barnes
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 38:1083-152. 1999
    ..In support of which, a number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction...
  4. pmc 5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!
    N M Barnes
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Gut 54:1056-7. 2005
    ..Further research is needed to determine the mechanism underlying this widespread clinically important symptom and therapies may be derived from targeting the 5-HT system...
  5. ncbi request reprint Distribution of S(-)-zacopride-insensitive [125I]R(+)-zacopride binding sites in the rat brain and peripheral tissues
    J Ge
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK
    Eur J Pharmacol 332:307-12. 1997
    ..4-6.8 fmol/mg). The present results indicate that specific non-5-HT [125I]R(+)-zacopride sites are heterogeneously distributed throughout the rat brain and are expressed in various peripheral tissues...
  6. ncbi request reprint 5-hydroxytryptamine3 (5-HT3) receptor-mediated depolarisation of the rat isolated vagus nerve: modulation by trichloroethanol and related alcohols
    K R Bentley
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Eur J Pharmacol 354:25-31. 1998
    ..Such an interaction may have relevance to the nausea and vomiting experienced by some patients following recovery from general anaesthesia...
  7. ncbi request reprint Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine
    R L Stowe
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 37:1611-9. 1998
    ..2+/-0.7 fmol mg(-1) protein, pKd=8.78+/-0.05, mean+/-S.E.M., n=3). The development of this 5-HT7 receptor binding assay will aid investigation of the rat native 5-HT7 receptor...
  8. ncbi request reprint Distribution and characterisation of the [3H](S)-zacopride labelled 5-HT3 receptor in pig forebrain
    S Fletcher
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Brain Res 729:281-4. 1996
    ..The pharmacological characterisation of 5-HT3 receptor recognition sites in homogenates of pig cerebral cortex provides further evidence for inter-species variation in the pharmacology of the 5-HT3 receptor...
  9. pmc Agonist interactions with 5-HT3 receptor recognition sites in the rat entorhinal cortex labelled by structurally diverse radioligands
    J M Barnes
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston
    Br J Pharmacol 105:500-4. 1992
    ....
  10. ncbi request reprint Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors
    C A Brady
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 41:282-4. 2001
    ..The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor...
  11. ncbi request reprint Autoradiographic localization of the [3H]-(S)-zacopride labelled 5-HT3 receptor in porcine brain
    S Fletcher
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neurosci Lett 269:91-4. 1999
    ..The distribution of [3H]-(S)-zacopride binding in porcine forebrain provides further evidence for inter-species differences with respect to the differential expression of the 5-HT3 receptor in the forebrain...
  12. ncbi request reprint Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus
    S A Monk
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Neuropharmacology 41:1013-6. 2001
    ..Immunohistochemical labelling was also apparent in cells in the rat hippocampus that displayed the distribution and morphology of interneurones...
  13. pmc Differential modulation of extracellular levels of 5-hydroxytryptamine in the rat frontal cortex by (R)- and (S)-zacopride
    N M Barnes
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 107:233-9. 1992
    ....
  14. ncbi request reprint Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits
    S Fletcher
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 37:397-9. 1998
    ....
  15. doi request reprint Characterisation of the endogenous human peripheral serotonin transporter SLC6A4 reveals surface expression without N-glycosylation
    Anita Chamba
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham, 815 2TT, United Kingdom
    J Neuroimmunol 204:75-84. 2008
    ..Biotinylation of lymphoid cells revealed that the endogenous non-glycosylated 60 kDa but not 70 kDa protein was available at the surface to access exogenous ligands...
  16. ncbi request reprint Lymphocytes transport serotonin and dopamine: agony or ecstasy?
    John Gordon
    MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
    Trends Immunol 24:438-43. 2003
  17. doi request reprint Reversal of sibutramine-induced anorexia with a selective 5-HT(2C) receptor antagonist
    Suzanne Higgs
    School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Psychopharmacology (Berl) 214:941-7. 2011
    ..The monoamine reuptake inhibitor sibutramine reduces food intake but the receptor subtypes mediating the effects of sibutramine on feeding remain to be clearly identified...
  18. ncbi request reprint Identification and functional significance of N-glycosylation of the 5-ht5A receptor
    Alice C Dutton
    Cellular and Molecular Neuropharmacology Research Group, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neurochem Int 52:419-25. 2008
    ....
  19. ncbi request reprint Lymphoma cells protected from apoptosis by dysregulated bcl-2 continue to bind annexin V in response to B-cell receptor engagement: a cautionary tale
    Michelle J Holder
    MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Vincent Drive B15 2TT, UK
    Leuk Res 30:77-80. 2006
    ..These findings advise caution when interpreting studies where Annexin V binding is used as a sole, or major, indicator of apoptotic death among lymphoma B cells...
  20. pmc Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron
    L J Steward
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston
    Br J Pharmacol 116:1781-8. 1995
    ....
  21. ncbi request reprint D(1)-like dopamine receptors on retrogradely labelled sympathoadrenal neurones in the thoracic spinal cord of the rat
    S J Gladwell
    Department of Physiology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Exp Brain Res 128:377-82. 1999
    ....
  22. ncbi request reprint 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors
    Adamantios Serafeim
    MRC Centre for Immune Regulation and the Department of Pharmacology, Medical School, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
    Blood 99:2545-53. 2002
    ..These data indicate that serotonin drives apoptosis in biopsylike BL cells after its entry through an active transport mechanism, and they suggest a novel therapeutic modality for Burkitt lymphoma...
  23. pmc Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma
    Elizabeth J Meredith
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 103:13485-90. 2006
    ..Rational tailoring of drug delivery systems already in development for Parkinson's disease could provide ideal vehicles for carrying the oxidative hit directly to the target populations...
  24. ncbi request reprint Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells
    Adamantios Serafeim
    Medical Research Council Centre for Immune Regulation, School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Blood 101:3212-9. 2003
    ....
  25. doi request reprint Importance of the C-terminus of the human 5-HT3A receptor subunit
    Amy S Butler
    Cellular and Molecular Neuropharmacology Research Group, School of Experimental and Clinical Medicine, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 56:292-302. 2009
    ....
  26. doi request reprint The 5-HT3 receptor--the relationship between structure and function
    Nicholas M Barnes
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 56:273-84. 2009
    ..We conclude by describing recent studies that have identified numerous HTR3A and HTR3B gene polymorphisms that impact upon 5-HT3 receptor function, or expression, and consider their relevance to (patho)physiology...
  27. ncbi request reprint Identification and importance of N-glycosylation of the human 5-hydroxytryptamine3A receptor subunit
    Sarah A Monk
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem Pharmacol 68:1787-96. 2004
    ..The present study demonstrates an important role for N-glycosylation at multiple identified asparagine residues in the N-terminus of the h5-HT3A receptor subunit...
  28. ncbi request reprint The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics
    Elizabeth J Meredith
    Division of Immunity and Infection, The Medical School, Birmingham, UK
    FASEB J 19:1187-9. 2005
    ....
  29. ncbi request reprint mRNA: detection by in situ and northern hybridization
    Alessandra P Princivalle
    Cellular and Molecular Neuropharmacology Research Group, Division of Neuroscience, Department of Pharmacology, The Medical School, University of Birmingham, Birmingham, UK
    Methods Mol Biol 306:51-91. 2005
  30. ncbi request reprint Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
    ..Recently, the neural 5-HT3 receptor received a lot of attention as a possible target in functional bowel diseases. Yet, the 5-HT3 receptor-mediated changes in properties of human enteric neurons is unknown...