Josephine Barnes

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates
    Josephine Barnes
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, WCIN 3BG, London, UK
    Neuroimage 23:574-81. 2004
  2. doi request reprint Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
  3. ncbi request reprint Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integral
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neurobiol Aging 28:1657-63. 2007
  4. ncbi request reprint Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
  5. ncbi request reprint Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
  6. pmc A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 30:1711-23. 2009
  7. doi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
  8. doi request reprint Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
  9. doi request reprint Clinical application of measurement of hippocampal atrophy in degenerative dementias
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Hippocampus 19:510-6. 2009
  10. ncbi request reprint Structural magnetic resonance imaging-derived biomarkers for Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Biomark Med 1:79-92. 2007

Detail Information

Publications63

  1. ncbi request reprint Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates
    Josephine Barnes
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, WCIN 3BG, London, UK
    Neuroimage 23:574-81. 2004
    ..We conclude that HBSI-derived atrophy rates reduce operator time and error, and are at least as effective as the manual equivalent as a diagnostic marker and are a potential marker of progression in longitudinal studies and trials...
  2. doi request reprint Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  3. ncbi request reprint Automatic calculation of hippocampal atrophy rates using a hippocampal template and the boundary shift integral
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neurobiol Aging 28:1657-63. 2007
    ..4 GHz Intel Xeon server, whereas manual delineation of each hippocampal pair took approximately 90 min of operator-intensive labour. This method may be useful diagnostically or in studies where analysis of many scans may be required...
  4. ncbi request reprint Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
    ..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis...
  5. ncbi request reprint Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
    ..To assess hippocampal atrophy rates calculated from fluid registration methods...
  6. pmc A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 30:1711-23. 2009
    ..Mean (95% CIs) annualised hippocampal atrophy rates were found to be 4.66% (95% CI 3.92, 5.40) for AD subjects and 1.41% (0.52, 2.30) for controls. The difference between AD and control subject in this rate was 3.33% (1.73, 4.94)...
  7. doi request reprint A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, UK
    Neuroimage 40:1655-71. 2008
    ..The change over time can then be calculated automatically using boundary shift or fluid measures, with boundary shift giving most similar results to manual...
  8. doi request reprint Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
    ..We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia...
  9. doi request reprint Clinical application of measurement of hippocampal atrophy in degenerative dementias
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Hippocampus 19:510-6. 2009
    ..This article details the progress in using MRI to understand hippocampal changes in the degenerative dementias and also describes attempts to automate hippocampal segmentation in these diseases...
  10. ncbi request reprint Structural magnetic resonance imaging-derived biomarkers for Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Biomark Med 1:79-92. 2007
    ..As such, there has been much research into biomarkers in recent years, with many showing promise in all areas of biomarker utility. This review focuses on the potential of structural imaging as a biomarker in Alzheimer's disease...
  11. ncbi request reprint Atrophy rates of the cingulate gyrus and hippocampus in AD and FTLD
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 28:20-8. 2007
    ..Significantly better discrimination between AD and controls was obtained by hippocampal rather than cingulate rates. In conclusion, cingulate atrophy is as significant a feature of AD and FTLD as hippocampal atrophy...
  12. ncbi request reprint Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging
    J Barnes
    Dementia Research Centre, UCL, Institute of Neurology, London, United Kingdom
    Neurobiol Aging 29:1199-203. 2008
    ..This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial...
  13. ncbi request reprint Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study
    Josephine Barnes
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 19:338-44. 2005
    ..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus...
  14. doi request reprint An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
    ..The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data...
  15. doi request reprint The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls...
  16. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  17. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  18. ncbi request reprint Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
    Kelvin K Leung
    Centre for Medical Image Computing, University College London, WC1E 6BT, UK
    Med Image Comput Comput Assist Interv 13:125-32. 2010
    ..We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rates calculated by the boundary shift integral within these ROIs...
  19. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  20. doi request reprint Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
    ..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns...
  21. doi request reprint Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
    ..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)...
  22. doi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  23. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  24. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  25. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  26. ncbi request reprint Application of automated medial temporal lobe atrophy scale to Alzheimer disease
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, WC1N 3BG, England
    Arch Neurol 64:849-54. 2007
    ..To compare an automated intensity-based measure of medial temporal atrophy in Alzheimer disease (AD) with existing volumetric and visually based methods...
  27. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  28. pmc Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    ..To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD)...
  29. ncbi request reprint An event-based disease progression model and its application to familial Alzheimer's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, Department of Computer Science, University College London, UK
    Inf Process Med Imaging 22:748-59. 2011
    ..We show progression of neuronal atrophy on a much finer level than previous studies, while confirming progression patterns from pathological studies, and integrate clinical events into the model...
  30. ncbi request reprint Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
    ..We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral (CBSI)...
  31. doi request reprint The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimer Dis Assoc Disord 27:168-73. 2013
    ..023) and that the TH expansion rate is more predictive than the TH volume (P=0.036). Prodromal atrophy rates may be useful predictors of future conversion to sporadic AD from amnestic MCI...
  32. ncbi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  33. ncbi request reprint Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study
    Basil H Ridha
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Lancet Neurol 5:828-34. 2006
    ..We used hierarchical modelling to assess how hippocampal and whole-brain volumes change as familial Alzheimer's disease progresses from the presymptomatic stage through to diagnosis...
  34. pmc Using manifold learning for atlas selection in multi-atlas segmentation
    Albert K Hoang Duc
    Centre for Medical Image Computing, University College London, London, United Kingdom
    PLoS ONE 8:e70059. 2013
    ....
  35. doi request reprint STEPS: Similarity and Truth Estimation for Propagated Segmentations and its application to hippocampal segmentation and brain parcelation
    M Jorge Cardoso
    Centre for Medical Image Computing CMIC, University College London, UK
    Med Image Anal 17:671-84. 2013
    ..Comparisons of STEPS with state-of-the-art multi-label fusion algorithms showed statistically significant segmentation accuracy improvements (p<10(-4)) in several key structures...
  36. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  37. doi request reprint Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    ..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy...
  38. pmc Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
    ..Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used...
  39. doi request reprint Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
    ....
  40. pmc Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials
    K Abigail Andrews
    Dementia Research Centre, University College London, London, United Kingdom
    PLoS ONE 8:e58816. 2013
    ..We conclude that hippocampal atrophy may be a feasible outcome measure for secondary prevention studies in asymptomatic amyloidosis...
  41. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  42. doi request reprint Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    Matthew C Evans
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 20:674-82. 2010
    ..To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects...
  43. doi request reprint Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  44. ncbi request reprint Targeted recruitment using cerebrospinal fluid biomarkers: implications for Alzheimer's disease therapeutic trials
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 34:431-7. 2013
    ..Whether targeted recruitment reduces required sample sizes depends critically on assumptions regarding treatment effects...
  45. pmc Mapping the progression of progranulin-associated frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Clin Pract Neurol 4:455-60. 2008
    ..The patient was initially asymptomatic but developed progressive behavioral and cognitive decline characterized by apathy, impaired emotion recognition, mixed aphasia and parietal lobe dysfunction...
  46. pmc APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD
    Emily N Manning
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e97608. 2014
    ....
  47. ncbi request reprint The structural involvement of the cingulate cortex in premanifest and early Huntington's disease
    Nicola Z Hobbs
    Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1684-90. 2011
    ..Cingulate atrophy may contribute to deficits in mood, emotional processing, and visual working memory in Huntington's disease...
  48. pmc Qualitative interview study of communication between parents and children about maternal breast cancer
    J Barnes
    Leopold Muller Centre for Child and Family Mental Health, Dept of Paediatrics and Child Health, Royal Free and University College Medical School, London NW3 2PF, UK
    West J Med 173:385-9. 2000
    ..To examine parents' communication with their children about the diagnosis and initial treatment of breast cancer in the mother...
  49. pmc Qualitative interview study of communication between parents and children about maternal breast cancer
    J Barnes
    Leopold Muller Centre for Child and Family Mental Health, Department of Paediatrics and Child Health, Royal Free and University College Medical School, London NW3 2PF
    BMJ 321:479-82. 2000
    ..To examine parents' communication with their children about the diagnosis and initial treatment of breast cancer in the mother...
  50. ncbi request reprint Are we getting it right? Parents' perceptions of hospice child bereavement support services
    S Wilkinson
    Department of Mental Health Sciences, Royal Free and University College Medical School, University College London, London
    Palliat Med 21:401-7. 2007
    ..To determine parents' experiences and perceptions of a support service for families with bereaved children, provided by a UK charity for cancer patients in seven hospices in the UK...
  51. pmc Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustment
    J M Schott
    Dementia Research Centre, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neurobiol Aging 31:1452-62, 1462.e1-2. 2010
    ..Adjusting for 11 predefined covariates reduced sample sizes by up to 30%. Treatment trials in AD should consider the effects of normal aging; adjusting for baseline characteristics can significantly reduce required sample sizes...
  52. doi request reprint Memory complaints and increased rates of brain atrophy: risk factors for mild cognitive impairment and Alzheimer's disease
    H A Archer
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Int J Geriatr Psychiatry 25:1119-26. 2010
    ..To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline...
  53. ncbi request reprint Onset and progression of pathologic atrophy in Huntington disease: a longitudinal MR imaging study
    N Z Hobbs
    Dementia Research Centre and Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, UK
    AJNR Am J Neuroradiol 31:1036-41. 2010
    ..This may prove useful in assessing disease-modifying treatments. We investigated how caudate and global volumes change as HD progresses from premanifest to early disease...
  54. doi request reprint Tracking progression in frontotemporal lobar degeneration: serial MRI in semantic dementia
    J D Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, UK
    Neurology 71:1445-51. 2008
    ..This study aimed to characterize the pattern of global and regional longitudinal brain atrophy in semantic dementia and to identify imaging biomarkers that could underpin therapeutic trials...
  55. ncbi request reprint Knight's move thinking? Mild cognitive impairment in a chess player
    H A Archer
    The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurocase 11:26-31. 2005
    ....
  56. ncbi request reprint Plasma insulin-like growth factor-1 elevated in mild-to-moderate but not severe heart failure
    M K Al-Obaidi
    National Heart and Lung Institute, Department of Cardiology, Imperial College School of Medicine, London, UK
    Am Heart J 142:E10. 2001
    ..Insulin-like growth factor 1 (IGF-1) promotes favorable cardiac remodeling in heart failure. However, the relation of plasma IGF-1 in patients with various degrees of heart failure is not known...
  57. ncbi request reprint Amnesia, cerebral atrophy, and autoimmunity
    J M Schott
    Dementia Research Group, Institute of Neurology, University College WC1N 3BG, London, UK
    Lancet 361:1266. 2003
  58. ncbi request reprint Laterality in five-year-olds conceived by intracytoplasmic sperm injection, standard in vitro fertilisation and natural conception: a European study
    A G Sutcliffe
    Department of Child Health, Royal Free and University College Medical School, London, UK
    BJOG 112:1397-401. 2005
    ..To assess laterality in a group of European children conceived with the help of assisted reproductive therapy, or naturally conceived...
  59. ncbi request reprint The utility of volunteer home-visiting support to prevent maternal depression in the first year of life
    J Barnes
    Institute for the Study of Children, Families and Social Issues, Birkbeck, University of London, London, UK
    Child Care Health Dev 35:807-16. 2009
    ..The support is not structured and both the frequency and content of visits may vary...
  60. ncbi request reprint Early experiences and their relationship to maternal eating disorder symptoms, both lifetime and during pregnancy
    R Senior
    Leopold Muller Centre for Child and Family Mental Health, London, UK
    Br J Psychiatry 187:268-73. 2005
    ..There is some evidence that early sexual abuse is an aetiological factor for eating disorder. However, there is sparse information from large-scale, non-clinical studies...
  61. ncbi request reprint Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study
    I Banerjee
    Adolescent and General Paediatric Unit, Institute of Child Health, University College London, 250 Euston Road, 6th Floor, London NW1 2PQ, UK
    Reprod Biomed Online 16:376-81. 2008
    ..030) of the questionnaire. The study showed no major ill effects from PGD on the child health. A larger study is needed to confirm the validity of this conclusion...
  62. pmc 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
    ..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials...
  63. ncbi request reprint Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study
    Bethany F Jones
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Cereb Cortex 16:1701-8. 2006
    ....