Josephine Barnes

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
  2. ncbi request reprint Targeted recruitment using cerebrospinal fluid biomarkers: implications for Alzheimer's disease therapeutic trials
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 34:431-7. 2013
  3. doi request reprint The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
  4. doi request reprint An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
  5. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
  6. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
  7. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
  8. doi request reprint Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
  9. ncbi request reprint Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
  10. doi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009

Detail Information

Publications40

  1. pmc Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls
    Josephine Barnes
    Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK
    Neurobiol Aging 34:1996-2002. 2013
    ..There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages...
  2. ncbi request reprint Targeted recruitment using cerebrospinal fluid biomarkers: implications for Alzheimer's disease therapeutic trials
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 34:431-7. 2013
    ..Whether targeted recruitment reduces required sample sizes depends critically on assumptions regarding treatment effects...
  3. doi request reprint The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls...
  4. doi request reprint An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease
    Hubert M Fonteijn
    Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroimage 60:1880-9. 2012
    ..The model and its formulation extend naturally to a wide range of other diseases and developmental processes and accommodate cross-sectional and longitudinal input data...
  5. ncbi request reprint Reduced cortical thickness in the posterior cingulate gyrus is characteristic of both typical and atypical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    J Alzheimers Dis 20:587-98. 2010
    ..Reduced cortical thickness in the posterior cingulate gyrus is characteristic of AD pathology in patients with typical and atypical clinical presentations of AD, and may assist a clinical distinction of AD pathology from FTLD pathology...
  6. pmc Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK Centre for Medical Image Computing, University College London, Gower Street, London, WC1E 6BT, UK
    Neuroimage 51:1345-59. 2010
    ..MAPS-HBSI required the lowest sample sizes (78 subjects) for a hypothetical trial. In conclusion, the MAPS and MAPS-HBSI methods give accurate and reliable volumes and atrophy rates across the clinical spectrum from healthy aging to AD...
  7. ncbi request reprint Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations
    Rachael I Scahill
    Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, London, UK
    J Alzheimers Dis 35:199-212. 2013
    ..We conclude that the mechanisms by which APP and PSEN1 mutations cause neuronal loss may differ which furthers our understanding of the neuropathology underlying AD and may inform future therapeutic strategies and trial designs...
  8. doi request reprint Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neurobiol Aging 34:73-82. 2013
    ..These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns...
  9. ncbi request reprint Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression
    Basil H Ridha
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London, WC1N 3BG, UK
    J Neurol 255:567-74. 2008
    ..Both cognitive tests and MRI-based measures have been suggested as outcomes in trials assessing disease-modifying therapies in Alzheimer's disease (AD)...
  10. doi request reprint Patterns of cortical thickness according to APOE genotype in Alzheimer's disease
    Leticia Gutiérrez-Galve
    Dementia Research Centre, Institute of Neurology, University College London UCL, London WC1N 3BG, UK
    Dement Geriatr Cogn Disord 28:476-85. 2009
    ..We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease)...
  11. pmc Brain MAPS: an automated, accurate and robust brain extraction technique using a template library
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 55:1091-108. 2011
    ..In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy...
  12. doi request reprint Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    ..To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy...
  13. ncbi request reprint Automated measurement of hippocampal atrophy using fluid-registered serial MRI in AD and controls
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    J Comput Assist Tomogr 31:581-7. 2007
    ..To assess hippocampal atrophy rates calculated from fluid registration methods...
  14. doi request reprint Global gray matter changes in posterior cortical atrophy: a serial imaging study
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Alzheimers Dement 8:502-12. 2012
    ..However, differential longitudinal atrophy patterns are not well understood...
  15. doi request reprint The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Alzheimer Dis Assoc Disord 27:168-73. 2013
    ..023) and that the TH expansion rate is more predictive than the TH volume (P=0.036). Prodromal atrophy rates may be useful predictors of future conversion to sporadic AD from amnestic MCI...
  16. ncbi request reprint Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study
    Basil H Ridha
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Lancet Neurol 5:828-34. 2006
    ..We used hierarchical modelling to assess how hippocampal and whole-brain volumes change as familial Alzheimer's disease progresses from the presymptomatic stage through to diagnosis...
  17. ncbi request reprint Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study
    Josephine Barnes
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Dement Geriatr Cogn Disord 19:338-44. 2005
    ..To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus...
  18. doi request reprint Clinical application of measurement of hippocampal atrophy in degenerative dementias
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    Hippocampus 19:510-6. 2009
    ..This article details the progress in using MRI to understand hippocampal changes in the degenerative dementias and also describes attempts to automate hippocampal segmentation in these diseases...
  19. ncbi request reprint Atrophy rates of the cingulate gyrus and hippocampus in AD and FTLD
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 28:20-8. 2007
    ..Significantly better discrimination between AD and controls was obtained by hippocampal rather than cingulate rates. In conclusion, cingulate atrophy is as significant a feature of AD and FTLD as hippocampal atrophy...
  20. pmc Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    ..To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD)...
  21. pmc Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:627.e1-627.e12. 2012
    ..These results underline the importance of considering PA in AD diagnosis, particularly in younger patients where medial temporal atrophy may be less conspicuous...
  22. ncbi request reprint Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington's disease
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, UK
    Neuroimage 47:1659-65. 2009
    ..We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral (CBSI)...
  23. ncbi request reprint Basic visual function and cortical thickness patterns in posterior cortical atrophy
    Manja Lehmann
    Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 21:2122-32. 2011
    ..However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation...
  24. ncbi request reprint Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, London, England
    Arch Neurol 63:1434-9. 2006
    ..Patterns of atrophy on magnetic resonance imaging may help distinguish these diseases and aid diagnosis...
  25. pmc Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness
    Gerard R Ridgway
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    Neurology 79:80-4. 2012
    ....
  26. doi request reprint Atrophy patterns in Alzheimer's disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 49:2264-74. 2010
    ....
  27. ncbi request reprint Automated Template-Based Hippocampal Segmentations from MRI: The Effects of 1.5T or 3T Field Strength on Accuracy
    Kate E Macdonald
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroinformatics 12:405-12. 2014
    ..5T and 3T but with a wider CI for their ratios. This study supports the use of our automated hippocampal voluming methods, developed using 1.5T images, with 3T images. ..
  28. pmc Atrophy rates in asymptomatic amyloidosis: implications for Alzheimer prevention trials
    K Abigail Andrews
    Dementia Research Centre, University College London, London, United Kingdom
    PLoS ONE 8:e58816. 2013
    ..We conclude that hippocampal atrophy may be a feasible outcome measure for secondary prevention studies in asymptomatic amyloidosis...
  29. doi request reprint Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease
    Manja Lehmann
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neurobiol Aging 32:1466-76. 2011
    ..These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD...
  30. doi request reprint Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    Matthew C Evans
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Eur Radiol 20:674-82. 2010
    ..To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects...
  31. ncbi request reprint Fast free-form deformation using graphics processing units
    Marc Modat
    Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
    Comput Methods Programs Biomed 98:278-84. 2010
    ..This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets...
  32. doi request reprint Head size, age and gender adjustment in MRI studies: a necessary nuisance?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 53:1244-55. 2010
    ..Division of all volumes by head size is unlikely to be adequate owing to their non-proportional relationship...
  33. pmc A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 30:1711-23. 2009
    ..Mean (95% CIs) annualised hippocampal atrophy rates were found to be 4.66% (95% CI 3.92, 5.40) for AD subjects and 1.41% (0.52, 2.30) for controls. The difference between AD and control subject in this rate was 3.33% (1.73, 4.94)...
  34. pmc Comparison of phantom and registration scaling corrections using the ADNI cohort
    Matthew J Clarkson
    Dementia Research Centre, University College London, Institute of Neurology, London, UK
    Neuroimage 47:1506-13. 2009
    ..Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used...
  35. pmc Mapping the progression of progranulin-associated frontotemporal lobar degeneration
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Nat Clin Pract Neurol 4:455-60. 2008
    ..The patient was initially asymptomatic but developed progressive behavioral and cognitive decline characterized by apathy, impaired emotion recognition, mixed aphasia and parietal lobe dysfunction...
  36. pmc APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD
    Emily N Manning
    Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e97608. 2014
    ....
  37. ncbi request reprint The structural involvement of the cingulate cortex in premanifest and early Huntington's disease
    Nicola Z Hobbs
    Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1684-90. 2011
    ..Cingulate atrophy may contribute to deficits in mood, emotional processing, and visual working memory in Huntington's disease...
  38. doi request reprint Does registration of serial MRI improve diagnosis of dementia?
    Josephine Barnes
    Dementia Research Centre, UCL Institute of Neurology, London, UK
    Neuroradiology 52:987-95. 2010
    ..We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia...
  39. ncbi request reprint Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates
    Josephine Barnes
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, WCIN 3BG, London, UK
    Neuroimage 23:574-81. 2004
    ..We conclude that HBSI-derived atrophy rates reduce operator time and error, and are at least as effective as the manual equivalent as a diagnostic marker and are a potential marker of progression in longitudinal studies and trials...
  40. ncbi request reprint Structural magnetic resonance imaging-derived biomarkers for Alzheimer's disease
    Josephine Barnes
    Dementia Research Centre, University College London, Box 16, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Biomark Med 1:79-92. 2007
    ..As such, there has been much research into biomarkers in recent years, with many showing promise in all areas of biomarker utility. This review focuses on the potential of structural imaging as a biomarker in Alzheimer's disease...